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Viral Molecular Complexes

Team’s publications

Head Juan REGUERA

2021

  1. Community-Wide Experimental Evaluation of the PROSS Stability-Design Method (2021)
    Peleg Y, Vincentelli R, Collins BM, Chen KE, Livingstone EK, Weeratunga S, Leneva N, Guo Q, Remans K, Perez K, Bjerga GEK, Larsen O, Vanek O, Skorepa O, Jacquemin S, Poterszman A, Kjaer S, Christodoulou E, Albeck S, Dym O, Ainbinder E, Unger T, Schuetz A, Matthes S, Bader M, de Marco A, Storici P, Semrau MS, Stolt-Bergner P, Aigner C, Suppmann S, Goldenzweig A, Fleishman SJ.
    J Mol Biol 433 166964 PMID:33781758
  2. Host PDZ-containing proteins targeted by SARS-Cov-2 (2021)
    Caillet-Saguy C, Durbesson F, Rezelj VV, Gogl G, Dinh Tran Q, Twizere JC, Vignuzzi M, Vincentelli R, Wolff N.
    FEBS J in press PMID:33864728
  3. Structural insights into the mechanisms of action of functionally distinct classes of Chikungunya virus nonstructural protein 1 inhibitors (2021)
    Kovacikova K, Gonzalez MG, Jones R, Reguera J, Gigante A, Perez-Perez MJ, Purstinger G, Moesslacher J, Langer T, Jeong LS, Delang L, Neyts J, Snijder EJ, van Westen GJP, van Hemert MJ.
    Antimicrob Agents Chemother 65 e0256620 PMID:33875421
  4. A High-Affinity Peptide Ligand Targeting Syntenin Inhibits Glioblastoma (2021)
    Haugaard-Kedstrom LM, Clemmensen LS, Sereikaite V, Jin Z, Fernandes EFA, Wind B, Abalde-Gil F, Daberger J, Vistrup-Parry M, Aguilar-Morante D, Leblanc R, Egea-Jimenez AL, Albrigtsen M, Jensen KE, Jensen TMT, Ivarsson Y, Vincentelli R, Hamerlik P, Andersen JH, Zimmermann P, Lee W, Stromgaard K.
    J Med Chem 64 1423-1434 PMID:33502198
  5. Capping pores of alphavirus nsP1 gate membranous viral replication factories (2021)
    Jones R, Bragagnolo G, Arranz R, Reguera J.
    Nature 589 615-619 PMID:33328629

2020

  1. Interactomic affinity profiling by holdup assay: Acetylation and distal residues impact the PDZome-binding specificity of PTEN phosphatase (2020)
    Jane P, Gogl G, Kostmann C, Bich G, Girault V, Caillet-Saguy C, Eberling P, Vincentelli R, Wolff N, Trave G, Nomine Y.
    PLoS One 15 e0244613 PMID:33382810
  2. Dual Specificity PDZ- and 14-3-3-Binding Motifs: A Structural and Interactomics Study (2020)
    Gogl G, Jane P, Caillet-Saguy C, Kostmann C, Bich G, Cousido-Siah A, Nyitray L, Vincentelli R, Wolff N, Nomine Y, Sluchanko NN, Trave G.
    Structure 28 747-759.e3 PMID:32294469
  3. A Venomics Approach Coupled to High-Throughput Toxin Production Strategies Identifies the First Venom-Derived Melanocortin Receptor Agonists (2020)
    Reynaud S, Ciolek J, Degueldre M, Saez NJ, Sequeira AF, Duhoo Y, Bras JLA, Meudal H, Cabo Diez M, Fernandez Pedrosa V, Verdenaud M, Boeri J, Pereira Ramos O, Ducancel F, Vanden Driessche M, Fourmy R, Violette A, Upert G, Mourier G, Beck-Sickinger AG, Morl K, Landon C, Fontes CMGA, Minambres Herraiz R, Rodriguez de la Vega RC, Peigneur S, Tytgat J, Quinton L, De Pauw E, Vincentelli R, Servent D, Gilles N.
    J Med Chem 63 8250-8264 PMID:32602722
  4. Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes (2020)
    Arragain B, Effantin G, Gerlach P, Reguera J, Schoehn G, Cusack S, Malet H.
    Nat Commun 11 3590 PMID:32681014

2019

  1. Structure and function of the Toscana virus cap-snatching endonuclease. (2019)
    Jones R, Lessoued S, Meier K, Devignot S, Barata-Garcia S, Mate M, Bragagnolo G, Weber F, Rosenthal M, Reguera J.
    Nucleic Acids Res 47 10914-10930 PMID:31584100
  2. The fungal ribonuclease-like effector protein CSEP0064/BEC1054 represses plant immunity and interferes with degradation of host ribosomal RNA. (2019)
    Pennington HG, Jones R, Kwon S, Bonciani G, Thieron H, Chandler T, Luong P, Morgan SN, Przydacz M, Bozkurt T, Bowden S, Craze M, Wallington EJ, Garnett J, Kwaaitaal M, Panstruga R, Cota E, Spanu PD.
    PLoS Pathog 15 e1007620 PMID:30856238
  3. Structure-based optimization of a PDZ-binding motif within a viral peptide stimulates neurite outgrowth. (2019)
    Khan Z, Terrien E, Delhommel F, Lefebvre-Omar C, Bohl D, Vitry S, Bernard C, Ramirez J, Chaffotte A, Ricquier K, Vincentelli R, Buc H, Prehaud C, Wolff N, Lafon M.
    J Biol Chem 294 13755-13768 PMID:31346033
  4. High-Throughput Production of a New Library of Human Single and Tandem PDZ Domains Allows Quantitative PDZ-Peptide Interaction Screening Through High-Throughput Holdup Assay. (2019)
    Duhoo Y, Girault V, Turchetto J, Ramond L, Durbesson F, Fourquet P, Nomine Y, Cardoso V, Sequeira AF, Bras JLA, Fontes CMGA, Trave G, Wolff N, Vincentelli R.
    Methods Mol Biol 2025 439-476 PMID:31267466
  5. High-Throughput Production of Oxidized Animal Toxins in Escherichia coli. (2019)
    Duhoo Y, Sequeira AF, Saez NJ, Turchetto J, Ramond L, Peysson F, Bras JLA, Gilles N, Darbon H, Fontes CMGA, Vincentelli R.
    Methods Mol Biol 2025 165-190 PMID:31267452
  6. Sizes of actin networks sharing a common environment are determined by the relative rates of assembly. (2019)
    Antkowiak A, Guillotin A, Boiero Sanders M, Colombo J, Vincentelli R, Michelot A.
    PLoS Biol 17 e3000317 PMID:31181075
  7. High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms. (2019)
    Arragain B, Reguera J, Desfosses A, Gutsche I, Schoehn G, Malet H.
    Elife 8 e43075 PMID:30638449
  8. Discovery of novel carbohydrate-active enzymes through the rational exploration of the protein sequences space. (2019)
    Helbert W, Poulet L, Drouillard S, Mathieu S, Loiodice M, Couturier M, Lombard V, Terrapon N, Turchetto J, Vincentelli R, Henrissat B.
    Proc Natl Acad Sci U S A 116 6063-6068 PMID:30850540
  9. Rewiring of RSK-PDZ Interactome by Linear Motif Phosphorylation. (2019)
    Gogl G, Biri-Kovacs B, Durbesson F, Jane P, Nomine Y, Kostmann C, Bilics V, Simon M, Remenyi A, Vincentelli R, Trave G, Nyitray L.
    J Mol Biol 431 1234-1249 PMID:30726710

2018

  1. A gated relaxation oscillator mediated by FrzX controls morphogenetic movements in Myxococcus xanthus. (2018)
    Guzzo M, Murray SM, Martineau E, Lhospice S, Baronian G, My L, Zhang Y, Espinosa L, Vincentelli R, Bratton BP, Shaevitz JW, Molle V, Howard M, Mignot T.
    Nat Microbiol 3 948-959 PMID:30013238

2017

  1. Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins. (2017)
    Ferron F, Weber F, de la Torre JC, Reguera J.
    Virus Res 234 118-134 PMID:28137457
  2. Structural insights into reptarenavirus cap-snatching machinery. (2017)
    Rosenthal M, Gogrefe N, Vogel D, Reguera J, Rauschenberger B, Cusack S, Gunther S, Reindl S.
    PLoS Pathog 13 e1006400 PMID:28505175
  3. Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection. (2017)
    Santiago C, Mudgal G, Reguera J, Recacha R, Albrecht S, Enjuanes L, Casasnovas JM.
    Sci Rep 7 46045 PMID:28393915

2016

  1. Towards a structural understanding of RNA synthesis by negative strand RNA viral polymerases. (2016)
    Reguera J, Gerlach P, Cusack S.
    Curr Opin Struct Biol 36 75-84 PMID:26826467
  2. Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases. (2016)
    Reguera J, Gerlach P, Rosenthal M, Gaudon S, Coscia F, Gunther S, Cusack S.
    PLoS Pathog 12 e1005636 PMID:27304209
  3. Atomic Structure and Biochemical Characterization of an RNA Endonuclease in the N Terminus of Andes Virus L Protein. (2016)
    Fernandez-Garcia Y, Reguera J, Busch C, Witte G, Sanchez-Ramos O, Betzel C, Cusack S, Gunther S, Reindl S.
    PLoS Pathog 12 e1005635 PMID:27300328

2015

  1. Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter. (2015)
    Gerlach P, Malet H, Cusack S, Reguera J.
    Cell 161 1267-79 PMID:26004069
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