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Etienne DECROLY

Senior researcher

AFMB Polytech Case 925
Campus de Luminy
163 Avenue de Luminy
13288 Marseille CEDEX 09
Fax: +33 491 82 86 38

phone: 491 82 86 47
etienne.decroly afmb.univ-mrs.fr
 

Viral Replicases : Structure, Mechanism and Drug-Design

 

Curriculum vitae

- 1994 - PhD at the free University of Brussels (ULB):
"Contribution to the study of the HIV envelope glycoprotein (gp160) "
Laboratory of Physical Chemistry of Macromolecules at the Interfaces, Professor J.-M. Ruysschaert (Brussels, Belgium).
- 1995 to 1997: Postdoc fellow at the Institute of Clinical Research of Montreal (IRCM): _  "Study of the involvement of protein convertases in the maturation of the HIV envelope glycoprotein (gp160) "
Laboratory Biochemical Neuroendocrinology, Dr. NG Seidah (Montreal, Canada).
- 1998 to 2001: 2nd post-doctoral fellow and co-team leader at INSERM U372,
"Study of the involvement of the Vif protein of HIV in the control of cellular antiviral defenses"
Laboratory: Pathogenesis of lentivirus infections, Dr. R. Vigne (Marseille, France).
- Since 2005 CNRS researcher (CR1) at the UMR6098 AFMB _  "Identification and characterization of viral enzymes involved in capping of RNA viruses."
Laboratory of viral replication, structure, mechanisms and Drug-design, Dr. B. Canard (Marseille, France).
- 2011 HDR Aix Marseille Université
- 2012 DR2 CNRS
- Teatching * Aix Marseille Université * Institut Pasteur/Université Paris 6 * Université du Sud/Toulon Var

Latest Publications

  1. Van Helden J, Butter CD, Achaz G, Canard B, Casane D, Claverie JM, Colombo F, Courtier V, Ebright H, Graner F, Leitenberg M, Morand S, Petrovsky N, Segreto R, Decroly E , Halloy J
    The Lancet 20
  2. Ferron F, Sama B, Decroly E , Canard B
    Trends Biochem Sc in press
  3. Vicenti I, Martina MG, Boccuto A, De Angelis M, Giavarini G, Dragoni F, Marchi S, Trombetta C M, Crespan E, Maga G, Eydoux C, Decroly E , Montomoli E, Nencioni L, Zazzi M, Radi M
    Eur J Med Chem In press
  4. Ortega Granda O, Valle C, Shannon A, Decroly E , Canard B, Coutard B, Rabah N
    J Virol In press
  5. Decroly E , Claverie JM, Canard B
    Virologie (Montrouge) In press

PDB Codes

  1. Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2'-O-Methyltransferase nsp10/nsp16 Complex. (2011)
    Decroly E , Debarnot C, Ferron F, Bouvet M, Coutard B, Imbert I, Gluais L, Papageorgiou N, Sharff A, Bricogne G, Ortiz-Lombardia M, Lescar J, Canard B
    PLoS Pathog 7 e1002059
  2. Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2'-O-Methyltransferase nsp10/nsp16 Complex. (2011)
    Decroly E , Debarnot C, Ferron F, Bouvet M, Coutard B, Imbert I, Gluais L, Papageorgiou N, Sharff A, Bricogne G, Ortiz-Lombardia M, Lescar J, Canard B
    PLoS Pathog 7 e1002059
  3. Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2'-O-Methyltransferase nsp10/nsp16 Complex. (2011)
    Decroly E , Debarnot C, Ferron F, Bouvet M, Coutard B, Imbert I, Gluais L, Papageorgiou N, Sharff A, Bricogne G, Ortiz-Lombardia M, Lescar J, Canard B
    PLoS Pathog 7 e1002059
  4. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  5. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  6. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  7. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  8. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  9. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  10. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. (2007)
    Egloff MP, Decroly E , Malet H, Selisko B, Benarroch D, Ferron F, Canard B
    J Mol Biol 372 723-36
  11. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. (2007)
    Egloff MP, Decroly E , Malet H, Selisko B, Benarroch D, Ferron F, Canard B
    J Mol Biol 372 723-36
  12. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. (2007)
    Egloff MP, Decroly E , Malet H, Selisko B, Benarroch D, Ferron F, Canard B
    J Mol Biol 372 723-36
  13. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. (2007)
    Egloff MP, Decroly E , Malet H, Selisko B, Benarroch D, Ferron F, Canard B
    J Mol Biol 372 723-36
  14. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. (2007)
    Egloff MP, Decroly E , Malet H, Selisko B, Benarroch D, Ferron F, Canard B
    J Mol Biol 372 723-36

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