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Etienne DECROLY

Senior researcher

AFMB Polytech Case 925
Campus de Luminy
163 Avenue de Luminy
13288 Marseille CEDEX 09
Fax: +33 491 82 86 38

phone: 491 82 86 47
etienne.decroly afmb.univ-mrs.fr
 

Viral Replicases : Structure, Mechanism and Drug-Design

 

Curriculum vitae

- 1994 - PhD at the free University of Brussels (ULB):
"Contribution to the study of the HIV envelope glycoprotein (gp160) "
Laboratory of Physical Chemistry of Macromolecules at the Interfaces, Professor J.-M. Ruysschaert (Brussels, Belgium).
- 1995 to 1997: Postdoc fellow at the Institute of Clinical Research of Montreal (IRCM): _  "Study of the involvement of protein convertases in the maturation of the HIV envelope glycoprotein (gp160) "
Laboratory Biochemical Neuroendocrinology, Dr. NG Seidah (Montreal, Canada).
- 1998 to 2001: 2nd post-doctoral fellow and co-team leader at INSERM U372,
"Study of the involvement of the Vif protein of HIV in the control of cellular antiviral defenses"
Laboratory: Pathogenesis of lentivirus infections, Dr. R. Vigne (Marseille, France).
- Since 2005 CNRS researcher (CR1) at the UMR6098 AFMB _  "Identification and characterization of viral enzymes involved in capping of RNA viruses."
Laboratory of viral replication, structure, mechanisms and Drug-design, Dr. B. Canard (Marseille, France).
- 2011 HDR Aix Marseille Université
- 2012 DR2 CNRS
- Teatching * Aix Marseille Université * Institut Pasteur/Université Paris 6 * Université du Sud/Toulon Var

Latest Publications

  1. Gilman MSA, Liu C, Fung A, Behera I, Jordan P, Rigaux P, Ysebaert N, Tcherniuk S, Sourimant J, Eleouet JF, Sutto-Ortiz P, Decroly E , Roymans D, Jin Z, McLellan JS
    Cell in press
  2. Ogando NS, Ferron F, Decroly E , Canard B, Posthuma CC, Snijder EJ
    Front Microbiol 10 1813
  3. Jais PH, Decroly E , Jacquet E, Le Boulch M, Jais A, Jean-Jean O, Eaton H, Ponien P, Verdier F, Canard B, Goncalves S, Chiron S, Le Gall M, Mayeux P, Shmulevitz M
    Nucleic Acids Res 47 2681-2698
  4. Ferreira-Ramos AS, Li C, Eydoux C, Contreras JM, Morice C, Querat G, Gigante A, Perez Perez MJ, Jung ML, Canard B, Guillemot JC, Decroly E , Coutard B
    Antiviral Res 163 59-69
  5. Ringeard M, Marchand V, Decroly E , Motorin Y, Bennasser Y
    Nature 565 500-504

PDB Codes

  1. Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2'-O-Methyltransferase nsp10/nsp16 Complex. (2011)
    Decroly E , Debarnot C, Ferron F, Bouvet M, Coutard B, Imbert I, Gluais L, Papageorgiou N, Sharff A, Bricogne G, Ortiz-Lombardia M, Lescar J, Canard B
    PLoS Pathog 7 e1002059
  2. Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2'-O-Methyltransferase nsp10/nsp16 Complex. (2011)
    Decroly E , Debarnot C, Ferron F, Bouvet M, Coutard B, Imbert I, Gluais L, Papageorgiou N, Sharff A, Bricogne G, Ortiz-Lombardia M, Lescar J, Canard B
    PLoS Pathog 7 e1002059
  3. Crystal Structure and Functional Analysis of the SARS-Coronavirus RNA Cap 2'-O-Methyltransferase nsp10/nsp16 Complex. (2011)
    Decroly E , Debarnot C, Ferron F, Bouvet M, Coutard B, Imbert I, Gluais L, Papageorgiou N, Sharff A, Bricogne G, Ortiz-Lombardia M, Lescar J, Canard B
    PLoS Pathog 7 e1002059
  4. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  5. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  6. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  7. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  8. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  9. Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus. (2009)
    Bollati M, Milani M, Mastrangelo E, Ricagno S, Tedeschi G, Nonnis S, Decroly E , Selisko B, de Lamballerie X, Coutard B, Canard B, Bolognesi M
    J Mol Biol 385 140-52
  10. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. (2007)
    Egloff MP, Decroly E , Malet H, Selisko B, Benarroch D, Ferron F, Canard B
    J Mol Biol 372 723-36
  11. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. (2007)
    Egloff MP, Decroly E , Malet H, Selisko B, Benarroch D, Ferron F, Canard B
    J Mol Biol 372 723-36
  12. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. (2007)
    Egloff MP, Decroly E , Malet H, Selisko B, Benarroch D, Ferron F, Canard B
    J Mol Biol 372 723-36
  13. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. (2007)
    Egloff MP, Decroly E , Malet H, Selisko B, Benarroch D, Ferron F, Canard B
    J Mol Biol 372 723-36
  14. Structural and Functional Analysis of Methylation and 5'-RNA Sequence Requirements of Short Capped RNAs by the Methyltransferase Domain of Dengue Virus NS5. (2007)
    Egloff MP, Decroly E , Malet H, Selisko B, Benarroch D, Ferron F, Canard B
    J Mol Biol 372 723-36

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