CNRS - AIX MARSEILLE UNIV: UMR7257

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Glycogenomics

Head Nicolas TERRAPON

Latest Publications

  1. Secreted pectin monooxygenases drive plant infection by pathogenic oomycetes (2021) Sabbadin F, Urresti S, Henrissat B, Avrova AO, Welsh LRJ, Lindley PJ, Csukai M, Squires JN, Walton PH, Davies GJ, Bruce NC, Whisson SC, McQueen-Mason SJ. Science 373 774-779 PMID:34385392
  2. C-type cytochrome-initiated reduction of bacterial lytic polysaccharide monooxygenases (2021) Branch J, Rajagopal BS, Paradisi A, Yates N, Lindley PJ, Smith J, Hollingsworth K, Turnbull B, Henrissat B, Parkin A, Berry A, Hemsworth GR. Biochem. J. in press PMID:34240737
  3. Symbiotic nitrogen fixation in the reproductive structures of a basidiomycete fungus (2021) Koch RA, Yoon GM, Aryal UK, Lail K, Amirebrahimi M, LaButti K, Lipzen A, Riley R, Barry K, Henrissat B, Grigoriev IV, Herr JR, Aime MC. Curr. Biol. in press PMID:34245690
  4. Evaluating microbiome-directed fibre snacks in gnotobiotic mice and humans (2021) Delannoy-Bruno O, Desai C, Raman AS, Chen RY, Hibberd MC, Cheng J, Han N, Castillo JJ, Couture G, Lebrilla CB, Barve RA, Lombard V, Henrissat B, Leyn SA, Rodionov DA, Osterman AL, Hayashi DK, Meynier A, Vinoy S, Kirbach K, Wilmot T, Heath AC, Klein S, Barratt MJ, Gordon JI. Nature 595 91-95 PMID:34163075
  5. Display of the human mucinome with defined O-glycans by gene engineered cells (2021) Nason R, Bull C, Konstantinidi A, Sun L, Ye Z, Halim A, Du W, Sorensen DM, Durbesson F, Furukawa S, Mandel U, Joshi HJ, Dworkin LA, Hansen L, David L, Iverson TM, Bensing BA, Sullam PM, Varki A, Vries E, de Haan CAM, Vincentelli R, Henrissat B, Vakhrushev SY, Clausen H, Narimatsu Y. Nat Commun 12(1) 4070 PMID:34210959
  6. Polysaccharide utilization loci-driven enzyme discovery reveals BD-FAE: a bifunctional feruloyl and acetyl xylan esterase active on complex natural xylans (2021) Hameleers L, Penttinen L, Ikonen M, Jaillot L, Faure R, Terrapon N, Deuss PJ, Hakulinen N, Master ER, Jurak E. Biotechnol Biofuels 14 127 PMID:34059129
...All publications

Our team aims at establishing the relationships between the aminoacid sequence of carbohydrate-active enzymes and their precise specificity. This work find developments in various areas, from the exploration of the gut microbiota to the search of novel enzymes for biofuel production or for the conversion of blood groups.

Cazymes classification within CAZy

Carbohydrates are crucial for most organisms as carbon sources or as signaling molecules, but also for cell wall synthesis, host pathogen interactions, energy storage etc. We term carbohydrate-active enzymes (CAZymes) the enzymes that assemble and breakdown complex carbohydrates and carbohydrate polymers. Unlike most other classes of enzymes whose sequences carry limited informative power, the peculiarities of CAZymes and of their substrates turn these enzymes into extremely powerful probes to examine and explain the lifestyle of living organisms. During the last 20 years we have developed a classification in sequence-based families that correlate with the structure and catalytic mechanism of CAZymes. This classification currently includes 5 enzyme categories (glycoside hydrolases, glycosyltransferases, carbohydrate esterases, polysaccharide lyases and auxiliary activities) and their appended carbohydrate-binding modules. To make the classification available to the community, we have created the CAZy database (www.cazy.org), which has been meticulously curated and updated since its first version in 1998. Recently, we have coupled various bioinformatics tools to our database explore the CAZyme content of hundreds of eukaryotic and prokaryotic genomes, as well as many metagenomic datasets


Pedro M COUTINHO
Elodie DRULA
Marie-Line GARRON
Bernard HENRISSAT
Bastian HORNUNG
Vincent LOMBARD
Nicolas TERRAPON

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