CNRS - AIX MARSEILLE UNIV: UMR7257

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Glycogenomics

Head Bernard HENRISSAT

Latest Publications

  1. Interspecies competition impacts targeted manipulation of human gut bacteria by fiber-derived glycans. (2019) Patnode ML, Beller ZW, Han ND, Cheng J, Peters SL, Terrapon N, Henrissat B, Le Gall S, Saulnier L, Hayashi DK, Meynier A, Vinoy S, Giannone RJ, Hettich RL, Gordon JI. Cell 179 59-73.e13 PMID:31539500
  2. A subfamily roadmap for functional glycogenomics of the evolutionarily diverse Glycoside Hydrolase Family 16 (GH16). (2019) Viborg AH, Terrapon N, Lombard V, Michel G, Czjzek M, Henrissat B, Brumer H. J Biol Chem in press PMID:31501245
  3. Comprehensive genomic and transcriptomic analysis of polycyclic aromatic hydrocarbon degradation by a mycoremediation fungus, Dentipellis sp. KUC8613. (2019) Park H, Min B, Jang Y, Kim J, Lipzen A, Sharma A, Andreopoulos B, Johnson J, Riley R, Spatafora JW, Henrissat B, Kim KH, Grigoriev IV, Kim JJ, Choi IG. Appl Microbiol Biotechnol in press PMID:31482283
  4. Insights into an unusual Auxiliary Activity 9 family member lacking the histidine brace motif of lytic polysaccharide monooxygenases. (2019) Frandsen KEH, Tovborg M, Jorgensen CI, Spodsberg N, Rosso MN, Hemsworth GR, Garman EF, Grime GW, Poulsen JN, Batth TS, Miyauchi S, Lipzen A, Daum C, Grigoriev IV, Johansen KS, Henrissat B, Berrin JG, Lo Leggio L. J Biol Chem in press PMID:31471321
  5. Substrate specificity, regiospecificity, and processivity in glycoside hydrolase family 74. (2019) Arnal G, Stogios PJ, Asohan J, Attia M, Skarina T, Viborg AH, Henrissat B, Savchenko A, Brumer H. J Biol Chem in press PMID:31324716
  6. Multi-omic analyses of exogenous nutrient bag decomposition by the black morel Morchella importuna reveal sustained carbon acquisition and transferring. (2019) Tan H, Kohler A, Miao R, Liu T, Zhang Q, Zhang B, Jiang L, Wang Y, Xie L, Tang J, Li X, Liu L, Grigoriev IV, Daum C, LaButti K, Lipzen A, Kuo A, Morin E, Drula E, Henrissat B, Wang B, Huang Z, Gan B, Peng W, Martin FM. Environ Microbiol in press PMID:31314937
...All publications

Our team aims at establishing the relationships between the aminoacid sequence of carbohydrate-active enzymes and their precise specificity. This work find developments in various areas, from the exploration of the gut microbiota to the search of novel enzymes for biofuel production or for the conversion of blood groups.

Cazymes classification within CAZy

Carbohydrates are crucial for most organisms as carbon sources or as signaling molecules, but also for cell wall synthesis, host pathogen interactions, energy storage etc. We term carbohydrate-active enzymes (CAZymes) the enzymes that assemble and breakdown complex carbohydrates and carbohydrate polymers. Unlike most other classes of enzymes whose sequences carry limited informative power, the peculiarities of CAZymes and of their substrates turn these enzymes into extremely powerful probes to examine and explain the lifestyle of living organisms. During the last 20 years we have developed a classification in sequence-based families that correlate with the structure and catalytic mechanism of CAZymes. This classification currently includes 5 enzyme categories (glycoside hydrolases, glycosyltransferases, carbohydrate esterases, polysaccharide lyases and auxiliary activities) and their appended carbohydrate-binding modules. To make the classification available to the community, we have created the CAZy database (www.cazy.org), which has been meticulously curated and updated since its first version in 1998. Recently, we have coupled various bioinformatics tools to our database explore the CAZyme content of hundreds of eukaryotic and prokaryotic genomes, as well as many metagenomic datasets


Pedro M COUTINHO
Elodie DRULA
Marie-Line GARRON
Bernard HENRISSAT
Aurore LABOUREL
Vincent LOMBARD
Nicolas TERRAPON
UNK
Alexander VIBORG

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