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Head Nicolas TERRAPON

Latest Publications

  1. A-Galactosidase and Sucrose-Kinase Relationships in a Bi-functional AgaSK Enzyme Produced by the Human Gut Symbiont Ruminococcus gnavus E1 (2020) Lafond M, Tauzin AS, Bruel L, Laville E, Lombard V, Esque J, Andre I, Vidal N, Pompeo F, Quinson N, Perrier J, Fons M, Potocki-Veronese G, Giardina T. Front Microbiol. 11 579521 PMID:33281771
  2. Galactosaminogalactan activates the inflammasome to provide host protection (2020) Briard B, Fontaine T, Samir P, Place DE, Muszkieta L, Malireddi RKS, Karki R, Christgen S, Bomme P, Vogel P, Beau R, Mellado E, Ibrahim-Granet O, Henrissat B, Kalathur RC, Robinson C, Latge JP, Kanneganti TD. Nature 588 688-692 PMID:33268895
  3. Identification of the molecular determinants driving the substrate specificity of fungal lytic polysaccharide monooxygenases (LPMOs) (2020) Frandsen KEH, Haon M, Grisel S, Henrissat B, Lo Leggio L, Berrin JG. J Biol Chem in press PMID:33199373
  4. Genomic analysis enlightens Agaricales lifestyle evolution and increasing peroxidase diversity (2020) Ruiz-Duenas FJ, Barrasa JM, Sanchez-Garcia M, Camarero S, Miyauchi S, Serrano A, Linde D, Babiker R, Drula E, Ayuso-Fernandez I, Pacheco R, Padilla G, Ferreira P, Barriuso J, Kellner H, Castanera R, Alfaro M, Ramirez L, Pisabarro AG, Riley R, Kuo A, Andreopoulos W, LaButti K, Pangilinan J, Tritt A, Lipzen A, He G, Yan M, Ng V, Grigoriev IV, Cullen D, Martin F, Rosso MN, Henrissat B, Hibbett D, Martinez AT. Mol Biol Evol in press PMID:33211093
  5. Microbiota-directed fibre activates both targeted and secondary metabolic shifts in the distal gut (2020) Michalak L, Gaby JC, Lagos L, La Rosa SL, Hvidsten TR, Tetard-Jones C, Willats WGT, Terrapon N, Lombard V, Henrissat B, Droge J, Arntzen MO, Hagen LH, Overland M, Pope PB, Westereng B. Nature Commun. 11 5773 PMID:33188211
  6. Investigating the multi-modularity of a GH10 xylanase found in termite gut metagenome (2020) Wu H, Ioannou E, Henrissat B, Montanier CY, Bozonnet S, O'Donohue MJ, Dumon C. Appl. Environ. Microbiol. in press PMID:33187992
...All publications

Our team aims at establishing the relationships between the aminoacid sequence of carbohydrate-active enzymes and their precise specificity. This work find developments in various areas, from the exploration of the gut microbiota to the search of novel enzymes for biofuel production or for the conversion of blood groups.

Cazymes classification within CAZy

Carbohydrates are crucial for most organisms as carbon sources or as signaling molecules, but also for cell wall synthesis, host pathogen interactions, energy storage etc. We term carbohydrate-active enzymes (CAZymes) the enzymes that assemble and breakdown complex carbohydrates and carbohydrate polymers. Unlike most other classes of enzymes whose sequences carry limited informative power, the peculiarities of CAZymes and of their substrates turn these enzymes into extremely powerful probes to examine and explain the lifestyle of living organisms. During the last 20 years we have developed a classification in sequence-based families that correlate with the structure and catalytic mechanism of CAZymes. This classification currently includes 5 enzyme categories (glycoside hydrolases, glycosyltransferases, carbohydrate esterases, polysaccharide lyases and auxiliary activities) and their appended carbohydrate-binding modules. To make the classification available to the community, we have created the CAZy database (, which has been meticulously curated and updated since its first version in 1998. Recently, we have coupled various bioinformatics tools to our database explore the CAZyme content of hundreds of eukaryotic and prokaryotic genomes, as well as many metagenomic datasets

Elodie DRULA
Marie-Line GARRON

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