CNRS - AIX MARSEILLE UNIV: UMR7257

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Glycogenomics

Head Bernard HENRISSAT

Latest Publications

  1. The functional and structural characterization of Trichoderma reesei dehydrogenase belonging to the PQQ dependent family of Carbohydrate-Active Enzymes Family AA12. (2019) Turbe-Doan A, Record E, Lombard V, Kumar R, Levasseur A, Henrissat B, Garron ML. Appl Environ Microbiol in press PMID:31604773
  2. Comparative genomic analyses reveal diverse virulence factors and antimicrobial resistance mechanisms in clinical Elizabethkingia meningoseptica strains. (2019) Chen S, Soehnlen M, Blom J, Terrapon N, Henrissat B, Walker ED. PLoS One 14 e0222648 PMID:31600234
  3. Discovery of hyperstable carbohydrate-active enzymes through metagenomics of extreme environments. (2019) Strazzulli A, Cobucci-Ponzano B, Iacono R, Giglio R, Maurelli L, Curci N, Schiano-di-Cola C, Santangelo A, Contursi P, Lombard V, Henrissat B, Lauro FM, Fontes CMGA, Moracci M. FEBS J in press PMID:31595646
  4. The Cellulosome Paradigm in An Extreme Alkaline Environment. (2019) Phitsuwan P, Morais S, Dassa B, Henrissat B, Bayer EA. Microorganisms 7 PMID:31547347
  5. The continuing expansion of CAZymes and their families. (2019) Garron ML, Henrissat B. Curr Opin Chem Biol 53 82-87 PMID:31550558
  6. Interspecies competition impacts targeted manipulation of human gut bacteria by fiber-derived glycans. (2019) Patnode ML, Beller ZW, Han ND, Cheng J, Peters SL, Terrapon N, Henrissat B, Le Gall S, Saulnier L, Hayashi DK, Meynier A, Vinoy S, Giannone RJ, Hettich RL, Gordon JI. Cell 179 59-73.e13 PMID:31539500
...All publications

Our team aims at establishing the relationships between the aminoacid sequence of carbohydrate-active enzymes and their precise specificity. This work find developments in various areas, from the exploration of the gut microbiota to the search of novel enzymes for biofuel production or for the conversion of blood groups.

Cazymes classification within CAZy

Carbohydrates are crucial for most organisms as carbon sources or as signaling molecules, but also for cell wall synthesis, host pathogen interactions, energy storage etc. We term carbohydrate-active enzymes (CAZymes) the enzymes that assemble and breakdown complex carbohydrates and carbohydrate polymers. Unlike most other classes of enzymes whose sequences carry limited informative power, the peculiarities of CAZymes and of their substrates turn these enzymes into extremely powerful probes to examine and explain the lifestyle of living organisms. During the last 20 years we have developed a classification in sequence-based families that correlate with the structure and catalytic mechanism of CAZymes. This classification currently includes 5 enzyme categories (glycoside hydrolases, glycosyltransferases, carbohydrate esterases, polysaccharide lyases and auxiliary activities) and their appended carbohydrate-binding modules. To make the classification available to the community, we have created the CAZy database (www.cazy.org), which has been meticulously curated and updated since its first version in 1998. Recently, we have coupled various bioinformatics tools to our database explore the CAZyme content of hundreds of eukaryotic and prokaryotic genomes, as well as many metagenomic datasets


Pedro M COUTINHO
Elodie DRULA
Marie-Line GARRON
Bernard HENRISSAT
Aurore LABOUREL
Vincent LOMBARD
Nicolas TERRAPON
UNK
Alexander VIBORG

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