Isabelle IMBERT

EDUCATION
 2003: PhD in Molecular and Cellular Biology at University Louis Pasteur,
Institut de Virologie - INSERM U544, Strasbourg/France

 1999: Engineer (equivalent to Master) in Biotechnology at Ecole Supérieure d’Ingénieurs de Luminy (ESIL-GBMA), Marseille/France

PROFESSIONAL EXPERIENCE
 Since September 2008: Assistant professor at UMR 6098 – AFMB Lab, Marseille/France. Viral replicases Group : Structure, Mechanism & Drug-design. B. Canard’ group.

• Teaching : at the Engineer school of Marseille Luminy, biotechnology department
• Research : Elucidation of coronavirus unique viral replication mechanism.

 October 2003 – August 2008: Post-doc Fellow at UMR 6098 - AFMB Lab, Marseille/France. Viral replicases Group : Structure, Mechanism & Drug-design. Group of Dr Bruno Canard.
I have studied replication complex of the newly emerged coronavirus as the causative agent of Severe Acute Respiratory Syndrome (SARS-CoV).

 January 2000 – September 2003: PhD student at Institut de Virologie - INSERM U544, Strasbourg/France. Thesis advisor : Dr. Catherine Schuster
I have studied the early infection stage by Hepatitis C Virus (HCV) and more precisely, I focused on viral genome replication mechanisms.

Latest Publications

1. The C-terminal domain of the Sudan ebolavirus L protein is essential for RNA binding and methylation. (2020)
   Valle C, Martin B, Debart F, Vasseur JJ, Imbert I , Canard B, Coutard B, Decroly E
   J Virol 94 e00520-20
2. Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA. (2018)
   Ferron F, Subissi L, Silveira De Morais AT, Le NTT, Sevajol M, Gluais L, Decroly E, Vonrhein C, Bricogne G, Canard B, Imbert I
   Proc Natl Acad Sci U S A 115 E162-E171
3. Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes. (2014)
   Bouvet M, Lugari A, Posthuma CC, Zevenhoven JC, Bernard S, Betzi S, Imbert I , Canard B, Guillemot JC, Lecine P, Pfefferle S, Drosten C, Snijder EJ, Decroly E, Morelli X
   J Biol Chem 289 25783-96
4. One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities. (2014)
   Subissi L, Posthuma CC, Collet A, Zevenhoven-Dobbe JC, Gorbalenya AE, Decroly E, Snijder EJ, Canard B, Imbert I
   Proc Natl Acad Sci U S A 111 E3900-9
5. Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus. (2014)
   Sevajol M, Subissi L, Decroly E, Canard B, Imbert I
   Virus Res 194 90-99