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The AFMB structural biology facility gathers a state-of-the-art equipement available to a broad scientific community from academic and industrial origins. The facility offers a large panel of complementary techniques and expertise to tackle the tridimensional structure of proteins or macromolecular assemblies from the corresponding genes. The facility represents one node of the French infrastructure for integrated structural biology (FRISBI, http://frisbi.eu) aimed at promoting technological transfer between industries and academic labs for technological developments and some therapeutic applications.