CNRS - AIX MARSEILLE UNIV: UMR7257

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Host-pathogen interactions

Head Alain ROUSSEL

Latest Publications

  1. Ubiquitous Carbohydrate Binding Modules Decorate 936 Lactococcal Siphophage Virions. (2019) Hayes S, Mahony J, Vincentelli R, Ramond L, Nauta A, van Sinderen D, Cambillau C,. Viruses 11 PMID:31324000
  2. High-Throughput Protein Production Combined with High- Throughput SELEX Identifies an Extensive Atlas of Ciona robusta Transcription Factor DNA-Binding Specificities. (2019) Nitta KR, Vincentelli R, Jacox E, Cimino A, Ohtsuka Y, Sobral D, Satou Y, Cambillau C, Lemaire P. Methods Mol Biol 2025 487-517 PMID:31267468
  3. Novel ACTN1 variants in cases of thrombocytopenia. (2019) Vincenot A, Saultier P, Kunishima S, Poggi M, Hurtaud-Roux MF, Roussel A, Schlegel N, Alessi MC. Hum Mutat in press PMID:31237726
  4. Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity. (2019) Gauthier L, Morel A, Anceriz N, Rossi B, Blanchard-Alvarez A, Grondin G, Trichard S, Cesari C, Sapet M, Bosco F, Rispaud-Blanc H, Guillot F, Cornen S, Roussel A, Amigues B, Habif G, Caraguel F, Arrufat S, Remark R, Romagne F, Morel Y, Narni-Mancinelli E, Vivier E. Cell 177 1701-1713 PMID:31155232
  5. Blocking Antibodies Targeting the CD39/CD73 Immunosuppressive Pathway Unleash Immune Responses in Combination Cancer Therapies. (2019) Perrot I, Michaud HA, Giraudon-Paoli M, Augier S, Docquier A, Gros L, Courtois R, Dejou C, Jecko D, Becquart O, Rispaud-Blanc H, Gauthier L, Rossi B, Chanteux S, Gourdin N, Amigues B, Roussel A, Bensussan A, Eliaou JF, Bastid J, Romagne F, Morel Y, Narni-Mancinelli E, Vivier E, Paturel C, Bonnefoy N. Cell Rep 27 2411-2425.e9 PMID:31116985
  6. A simple and versatile microfluidic device for efficient biomacromolecule crystallization and structural analysis by serial crystallography. (2019) de Wijn R, Hennig O, Roche J, Engilberge S, Rollet K, Fernandez-Millan P, Brillet K, Betat H, Morl M, Roussel A, Girard E, Mueller-Dieckmann C, Fox GC, Olieric V, Gavira JA, Lorber B, Sauter C. IUCrJ 6 454-464 PMID:31098026
...All publications

Our group aims at understanding and analyzing the interactions of pathogens with their host, leading to its infection and its possible destruction. Our targets of interest are diverse, they gather i) bacteriophages infecting, among others, the lactic acid bacterium Lactococcus lactis used in the dairy industry, ii) bacterial secretion systems of type 6 and type 9, iii) the immune innate response of Drosophila after microbial or viral infection.

Understanding of host-pathogen interactions is at the heart of fighting pathogens involved in infectious diseases (bacteria, viruses). During the last ten years, we studied the structure and adhesion mechanism of bacteriophages (viruses that infect bacteria) infecting the bacterium used in the milk industry Lactococcus lactis. We have determined the structures of several phage virions by electron microscopy, and of the anti-receptor or the baseplate (1-2 MDa), eventually complexed to the receptor, by X-ray diffraction. We found that some phages, but not all, require an activation step by the calcium ion. More recently, we have addressed the study of type VI (T6SS) and Type IX (T9SS) secretion systems. We determined the structure and interactions of some of the 13 components of the T6SS, and we pursue the study of the system, including the trans-membrane domains. We wish to reconstruct the whole system by a "hybrid" approach, including electron microscopy and diffraction. The same approach is applied to T9SS. Finally, we have chosen the Drosophila model organism to study the innate immune response of the host. Genetic analysis has delineated two major regulatory pathways, the Toll and Imd pathways, that control the expression of anti microbial peptides (AMP) genes in response to microbial infection. We have solved the structure of recognition proteins (PGRP and GNBP) upstream of these two pathways.


Béatrice AMIGUES
UNK
Céline ARNAUD
Christian CAMBILLAU
UNK
Allele-Boubou COULIBALY
Hervé DARBON
Vincent DELAUZUN
Olivier FUCHSBAUER
Anaïs GAUBERT
Adeline GOULET
Magali GRANGE
UNK
Emeline GRELLET
Pierre HARDOUIN
Isabelle IMBERT
Philippe LEONE
Alain ROUSSEL
UNK
Amal SALHI
Silvia SPINELLI
UNK
Claire ZIMBERGER

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