CNRS - AIX MARSEILLE UNIV: UMR7257

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Viral Replicases: Structure, function and drug-design

Head Bruno CANARD

Latest Publications

  1. The enzymes for genome size increase and maintenance of large (+)RNA viruses (2021) Ferron F, Sama B, Decroly E, Canard B . Trends Biochem Sc in press PMID:34172362
  2. System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2 (2021) Vicenti I, Martina MG, Boccuto A, De Angelis M, Giavarini G, Dragoni F, Marchi S, Trombetta C M, Crespan E, Maga G, Eydoux C, Decroly E, Montomoli E, Nencioni L, Zazzi M, Radi M. Eur J Med Chem In press PMID:34273661
  3. Structure and sequence requirements for RNA capping at the Venezuelan Equine Encephalitis Virus RNA 5'-end (2021) Ortega Granda O, Valle C, Shannon A, Decroly E, Canard B, Coutard B, Rabah N. J Virol In press PMID:34011549
  4. Simeprevir potently suppresses SARS-CoV-2 replication and synergizes with remdesivir (2021) Lo HS, Hui KPY, Lai HM, Khan KS, Kaur S, Huang J, Li JHZ, Chan AKN, Cheung HY, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PMH, Shin D, Wang K, Lee MH, Selisko B, Eydoux C, Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zhong Zuo, Chan F K. L, Hui D S. C., Mok V C. T., Wong KB, Ko H, Shen Aik W, Chi Wai Chan M, Ng WL . ACS Cent Sci 7 792-802 PMID:34075346
  5. The WHO mission report struggles to trace the origins of the SARS-CoV-2 epidemic (tribune) (2021) Decroly E, Claverie JM, Canard B. Virologie (Montrouge) In press PMID:34112630
  6. The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2 O methylation (2021) Sutto-Ortiz P, Tcherniuk S, Ysebaert N, Abeywickrema P, Noel M, Decombe A, Debart F, Vasseur JJ, Canard B, Roymans D, Rigaux P, Eleouet JF, Decroly E. Plos Pathogens May 6 PMID:33956914
...All publications

Our team seeks to unravel the molecular mechanisms of emerging viruses by characterizing the structures and the enzymatic activities of proteins forming the viral replication and transcription complex. These studies are a prerequisite for the development of specific inhibitors of these enzymes and should allow the development of new antiviral strategies.

RNA viruses are often associated with the emergence of infectious diseases. Among the best known, epidemics related to Ebola, SARS coronavirus and MERS, chikungunya or dengue virus illustrate the worldwide public health concern related to viral infections. The team "Viral replicase: structure, mechanism and drug-design" characterizes enzymes and proteines from emerging viruses involved in the replication of their genome and transcription of their messenger RNAs. These enzymes are associated in a replication/transcription complex (RTC). Our studies focus not only on viral polymerases that are at the heart viral replication, but also on the enzymes involved in RNA modifications such as capping and proofreading and proteins involved in the regulation of replication. Beyond the study of the RTC, we are also interested in the interplay of these enzymes with the innate immunity defence mechanism of the cell. The viral replication proteins are privileged antiviral targets and understanding of their structure and function is essential for the design of antiviral molecules with a high potential. To support these research projects, the lab benefits from the support of an inhibitor-screening platform (PCML) and a platform dedicated to the expression of recombinant viral proteins.


Karine ALVAREZ
Bruno CANARD
Alice DECOMBE
Etienne DECROLY
UNK
Adrien DELPAL
UNK
Priscila EL-KAZZI
Cécilia EYDOUX
UNK
Camille FALCOU
Véronique FATTORINI
UNK
Mikael FERACCI
François FERRON
UNK
Laura GARLATTI
Pierre GAUFFRE
Jean-Claude GUILLEMOT
Sergio HERNANDEZ
Rafik KACI
UNK
Lea LO BELLO
Oney ORTEGA-GRANDA
Nicolas PAPAGEORGIOU
Axel PRIVAT MEUNIER
Nadia RABAH
Bhawna SAMA
Barbara SELISKO
Ashleigh SHANNON
Priscila SUTTO-ORTIZ

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