Publications

2022

2022
Molecular basis for substrate recognition and septum cleavage by AtlA, the major N-acetylglucosaminidase of Enterococcus faecalis

Véronique Roig-Zamboni, Sarah Barelier, Robert Dixon, Nicola Galley, Amani Ghanem, Quoc Phong Nguyen, Héloize Cahuzac, Bartłomiej Salamaga, Peter Davis, Yves Bourne, Stéphane Mesnage, Florence Vincent

Journal of Biological Chemistry 298:101915 (2022)10.1016/j.jbc.2022.101915

2015

2015
The Recognition of Identical Ligands by Unrelated Proteins

Sarah Barelier, Teague Sterling, Matthew O’meara, Brian Shoichet

ACS Chemical Biology 10:2772-2784 (2015)10.1021/acschembio.5b00683

2015
Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity

Joshua R. Kane, David J. Stanley, Judd F. Hultquist, Jeffrey R. Johnson, Nicole Mietrach, Jennifer M. Binning, Stefán R. Jónsson, Sarah Barelier, Billy W. Newton, Tasha L. Johnson, Kathleen E. Franks-Skiba, Ming Li, William L. Brown, Hörður Gunnarsson, Adalbjorg Adalbjornsdóttir, James S. Fraser, Reuben S. Harris, Valgerður Andrésdóttir, John D. Gross, Nevan J. Krogan

Cell Reports 11:1236-1250 (2015)10.1016/j.celrep.2015.04.038

2014

2014
Increasing Chemical Space Coverage by Combining Empirical and Computational Fragment Screens

Sarah Barelier, Oliv Eidam, Inbar Fish, Johan Hollander, Francis Figaroa, Ruta Nachane, John Irwin, Brian Shoichet, Gregg Siegal

ACS Chemical Biology 9:1528-1535 (2014)10.1021/cb5001636

2014
Substrate Deconstruction and the Nonadditivity of Enzyme Recognition

Sarah Barelier, Jennifer Cummings, Alissa Rauwerdink, Daniel Hitchcock, Jeremiah Farelli, Steven Almo, Frank Raushel, Karen Allen, Brian Shoichet

Journal of the American Chemical Society 136:7374-7382 (2014)10.1021/ja501354q

2013

2013
Roles for Ordered and Bulk Solvent in Ligand Recognition and Docking in Two Related Cavities

Sarah Barelier, Sarah Boyce, Inbar Fish, Marcus Fischer, David Goodin, Brian Shoichet

PLoS ONE 8:e69153 (2013)10.1371/journal.pone.0069153

2012

2012
Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo

Oliv Eidam, Chiara Romagnoli, Guillaume Dalmasso, Sarah Barelier, Emilia Caselli, Richard Bonnet, Brian K. Shoichet, Fabio Prati

Proceedings of the National Academy of Sciences of the United States of America 109:17448-17453 (2012)10.1073/pnas.1208337109

2011

2011
Ligand specificity, privileged substructures and protein druggability from fragment-based screening

Sarah Barelier, Isabelle Krimm

Current Opinion in Chemical Biology 15:469-474 (2011)10.1016/j.cbpa.2011.02.020

2011
Aspartate 458 of human glutathione synthetase is important for cooperativity and active site structure

Teresa Brown, Michael Drummond, Sarah Barelier, Amanda Crutchfield, Adriana Dinescu, Kerri Slavens, Thomas Cundari, Mary Anderson

Biochemical and Biophysical Research Communications 411:536-542 (2011)10.1016/j.bbrc.2011.06.166

2010

2010
The role of the glycine triad in human glutathione synthetase

Adriana Dinescu, Teresa Brown, Sarah Barelier, Thomas Cundari, Mary Anderson

Biochemical and Biophysical Research Communications 400:511-516 (2010)10.1016/j.bbrc.2010.08.081

2010
Ligand Specificity in Fragment-Based Drug Design

Sarah Barelier, Julien Pons, Kalle Gehring, Jean-Marc Lancelin, Isabelle Krimm

Journal of Medicinal Chemistry 53:5256-5266 (2010)10.1021/jm100496j

2010
Fragment-Based Deconstruction of Bcl-xL Inhibitors

Sarah Barelier, Julien Pons, Olivier Marcillat, Jean-Marc Lancelin, Isabelle Krimm

Journal of Medicinal Chemistry 53:2577-2588 (2010)10.1021/jm100009z

2010
Discovery of Fragment Molecules That Bind the Human Peroxiredoxin 5 Active Site

Sarah Barelier, Dominique Linard, Julien Pons, André Clippe, Bernard Knoops, Jean-Marc Lancelin, Isabelle Krimm

PLoS ONE 5:e9744 (2010)10.1371/journal.pone.0009744

2009

2009
Tumor Protein 53–Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function

Carla E Cano, Julien Gommeaux, Sylvia Pietri, Marcel Culcasi, Stéphane Garcia, Mylène Seux, Sarah Barelier, Sophie Vasseur, Rose P Spoto, Marie-Josèphe Pébusque, Nelson J Dusetti, Juan Lucio Iovanna, Alice Carrier

Cancer Research 69:219-226 (2009)10.1158/0008-5472.CAN-08-2320