{"id":5041,"date":"2022-10-03T15:36:22","date_gmt":"2022-10-03T15:36:22","guid":{"rendered":"https:\/\/www.afmb.univ-mrs.fr\/?post_type=event&#038;p=5041"},"modified":"2022-10-11T14:13:30","modified_gmt":"2022-10-11T14:13:30","slug":"directors-guest-cyrille-sabot-university-of-rouen","status":"publish","type":"event","link":"https:\/\/www.afmb.univ-mrs.fr\/en\/event\/directors-guest-cyrille-sabot-university-of-rouen\/","title":{"rendered":"Director&#8217;s guest: Cyrille Sabot, University of Rouen &#8211; &#8220;Nouvelles ligations pour la synth\u00e8se d\u2019inhibiteurs enzymatiques contr\u00f4l\u00e9e par la cible biologique&#8221;"},"content":{"rendered":"\n<p><\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p> La chimie click mise \u00e0 l\u2019honneur cette ann\u00e9e \u00e0 travers le prix Nobel de chimie, a \u00e9t\u00e9 utilis\u00e9e en KTGS (<em>Kinetic Target-Guided Synthesis<\/em>) pour la premi\u00e8re fois par Finn et Sharpless pour identifier des inhibiteurs dim\u00e9riques de l\u2019ac\u00e9tylcholinesterase (AChE), en utilisant l\u2019enzyme m\u00eame comme v\u00e9ritable r\u00e9acteur chimique. Dans ce contexte, notre laboratoire s\u2019est int\u00e9ress\u00e9 au d\u00e9veloppement d\u2019inhibiteurs de l\u2019AChE d\u2019origine humaine par chimie click <em>in situ<\/em>, puis \u00e0 de nouvelles ligations biocompatibles (thiol-Michael, thiol-yne) capables d\u2019\u00eatre acc\u00e9l\u00e9r\u00e9es par la cible biologique.<\/p>\n","protected":false},"template":"","events_category":[16],"class_list":["post-5041","event","type-event","status-publish","hentry","events_category-webinar","entry"],"_links":{"self":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/event\/5041","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/event"}],"about":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/types\/event"}],"wp:attachment":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media?parent=5041"}],"wp:term":[{"taxonomy":"events_category","embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/events_category?post=5041"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}