{"id":8405,"date":"2023-11-10T11:43:09","date_gmt":"2023-11-10T10:43:09","guid":{"rendered":"https:\/\/www.afmb.univ-mrs.fr\/?post_type=event&#038;p=8405"},"modified":"2023-11-23T15:21:53","modified_gmt":"2023-11-23T14:21:53","slug":"invite-equipe-j-reguera-alfredo-castello-univ-de-glasgow-scotland-when-viral-rna-met-the-cell-a-story-of-protein-rna-interactions","status":"publish","type":"event","link":"https:\/\/www.afmb.univ-mrs.fr\/en\/event\/invite-equipe-j-reguera-alfredo-castello-univ-de-glasgow-scotland-when-viral-rna-met-the-cell-a-story-of-protein-rna-interactions\/","title":{"rendered":"J. Reguera&#8217;s team guest: Alfredo Castello, Univ. of Glasgow, Scotland- &#8220;When viral RNA met the cell: a story of protein-RNA interactions&#8221;"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Abstract<\/h2>\n\n\n\n<p>RNA is a central molecule in the lifecycle of RNA viruses, acting not only as messenger (m)RNA but also as a genome. The interactions that viral RNA establishes with the host cell remain, however, largely unknown. My laboratory has developed several approaches to determine systematically and comprehensively the complement of cellular RNA-binding proteins (RBPs) that interact with viral RNA in infected cells. Applied to different viral models, we discovered a new universe of critical host-virus interactions that are largely conserved across viral families. Amongst them, we discover a group of nuclear RBPs that shuttle to the cytosol upon infection to supress viral replication, representing a first line cellular defence against viruses. Moreover, I will explore a new mechanism by which certain viruses ensure the availability of nucleotides to feed viral replication.&nbsp;<\/p>\n","protected":false},"template":"","events_category":[16],"class_list":["post-8405","event","type-event","status-publish","hentry","events_category-webinar","entry"],"_links":{"self":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/event\/8405","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/event"}],"about":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/types\/event"}],"wp:attachment":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media?parent=8405"}],"wp:term":[{"taxonomy":"events_category","embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/events_category?post=8405"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}