{"id":1004,"date":"2021-03-29T15:32:28","date_gmt":"2021-03-29T14:32:28","guid":{"rendered":"http:\/\/www.afmb.univ-mrs.fr\/?post_type=member&#038;p=1004"},"modified":"2022-10-10T19:36:29","modified_gmt":"2022-10-10T19:36:29","slug":"karine-alvarez","status":"publish","type":"member","link":"https:\/\/www.afmb.univ-mrs.fr\/en\/member\/karine-alvarez\/","title":{"rendered":"Karine Alvarez"},"content":{"rendered":"\n<p>Head of the &#8220;Medicinal Antiviral Chemistry&#8221; thematic group<\/p>\n\n\n\n<p>Lab risk manager<\/p>\n\n\n\n<p>Diplomas<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>2006, HDR (Discipline: Chemical Sciences), Univ Aix-Marseille II. Title: &#8220;Contribution to the discovery and development of active compounds against viral polymerases&#8221;.<\/li><li>1999, PhD in Organic, Mineral and Industrial Chemistry, Univ Montpellier II. Dir Dr J.J. Vasseur, laboratory of Bio-Organic Chemistry. Title : &#8220;Prodrogues of oligonucleotides : research of new nucleobase protective groups adapted to the automated synthesis of prooligonucleotides&#8221;.<\/li><li>1995 D.E.A in Chemistry of Biomolecules, Univ Montpellier II<\/li><\/ul>\n\n\n\n<p>Professional experiences<\/p>\n\n\n\n<ul class=\"wp-block-list\"><li>Since 2019, DR2 CNRS, INC section 16, AFMB, CNRS-UMR 7257<\/li><li>Since 10\/2001, CR2 then CR1 CNRS, INC section 16, Laboratory of Architecture and Function of Biological Macromolecules (AFMB), CNRS-UMR 7257<br>Project 1 : Finding new nucleotide analogues to circumvent the resistance of HIV RT to nucleoside drugs.<br>Project 2: Hepatitis C virus NS5B polymerase as an antiviral target<br>Project 3: Bunyavirales nucleases as targets of future therapies: development of screening tools and search for antivirals.<br>Project 4: The L protein of the Arenaviridae for a drug design strategy<br>Project 5: Contribution to the development of antivirals against SARS-Cov-2 infections<\/li><li>From 06\/2000 to 09\/2001, Post-Doctoral internship, Faculty of Physics-Chemistry of Barcelona. Laboratory of Pr E. PEDROSO. EU grant. Subject : &#8220;Anthracene conjugates as probes of telomere structure and function&#8221;. Development of new telomerase inhibitors based on the association of anthracene derivatives with oligonucleotide and\/or peptide macromolecules.<\/li><\/ul>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Senior researcher<\/p>\n","protected":false},"author":1,"featured_media":4038,"template":"","class_list":["post-1004","member","type-member","status-publish","has-post-thumbnail","hentry","entry"],"_links":{"self":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/member\/1004","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/member"}],"about":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/types\/member"}],"author":[{"embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":20,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/member\/1004\/revisions"}],"predecessor-version":[{"id":5058,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/member\/1004\/revisions\/5058"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media\/4038"}],"wp:attachment":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media?parent=1004"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}