Head of the \u201cViral Genome Stability\u201d thematic group<\/p>\n\n\n\n
Funding: <\/strong>ERC Starting Grant: NidoRep \u2013 101162788 (2025 – 2029)<\/p>\n\n\n\n My research is focused on deciphering the differences in viral replication and transcription between small- and large genome viruses of the order Nidovirales<\/em>. For the most-part, many of these viruses have been neglected, with the exception of the large-genome Coronaviridae (CoV) family (32 kb), which includes the notorious human pathogen SARS-CoV-2. At the other end of the size-spectrum the small-genome Arteriviridae (ArV) family (11 kb) contains several prevalent, animal-infecting pathogens. I am interested in how key viral enzymes, including notably the viral polymerase and its N-terminal unique domain (the NiRAN) have evolved to precisely regulate viral replication at a structural and functional level. In particular, my research aims to determine how these enzymes have been fine-tuned to accommodate the distinct and conflicting replication requirements of such highly diverse nidoviruses.<\/p>\n\n\n\n – <\/strong>October 2023 \u2013 present:<\/strong> CNRS (CRCN) <\/p>\n","protected":false},"excerpt":{"rendered":" Researcher<\/p>\n","protected":false},"author":1,"featured_media":4068,"template":"","class_list":["post-1045","member","type-member","status-publish","has-post-thumbnail","hentry","entry"],"_links":{"self":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/member\/1045","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/member"}],"about":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/types\/member"}],"author":[{"embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":5,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/member\/1045\/revisions"}],"predecessor-version":[{"id":11263,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/member\/1045\/revisions\/11263"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media\/4068"}],"wp:attachment":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media?parent=1045"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
– <\/strong>April 2018 \u2013 September 2023:<\/strong> Postdoctoral researcher AFMB\/UMR7257, R\u00e9plication virale, structure, m\u00e9canismes & Drug-design, Dr. B. Canard (Marseille, France)
– Dec 2016 \u2013 Mar 2018:<\/strong> VAXXAS Industry Research Scientist, Translational Research Institute (TRI), Brisbane, Queensland, Australia
– March 2013 \u2013 June 2017: <\/strong>PhD thesis, School of Chemistry and Molecular Biosciences, University of Queensland, Australia. Supervisors:<\/em> Professor Paul Young and Dr Keith Chappell. Thesis title: <\/em>Dengue virus NS2B-NS3 protease as a target for inhibitor-drugs<\/p>\n\n\n\n<\/h3>\n\n\n\n