{"id":904,"date":"2021-03-23T16:59:14","date_gmt":"2021-03-23T15:59:14","guid":{"rendered":"http:\/\/www.afmb.univ-mrs.fr\/?post_type=member&p=904"},"modified":"2026-03-30T12:52:44","modified_gmt":"2026-03-30T11:52:44","slug":"pascale-marchot","status":"publish","type":"member","link":"https:\/\/www.afmb.univ-mrs.fr\/en\/member\/pascale-marchot\/","title":{"rendered":"Pascale Marchot"},"content":{"rendered":"\n

PI of the Neurobiology<\/strong> theme of the team<\/p>\n\n\n\n

Ph.D. Univ Aix-Marseille-II (now Aix-Marseille Univ.)<\/p>\n\n\n\n

HDR Univ. de la M\u00e9diterran\u00e9e (now Aix-Marseille Univ.)<\/p>\n\n\n\n

DR1-CNRS<\/p>\n\n\n\n

Vice-president of the SFET<\/a><\/p>\n\n\n\n

\n
\"\"
Crystal structure of the pentameric complex formed between AChBP, a soluble surrogate of the extracellular ligand-binding domain of the nicotinic receptor to ACh (yellow), and alpha-conotoxin IM1, a cysteine-rich peptidic toxin from cone snail venom (magenta) (Hansen et al, EMBO J 2005; copyright Yves Bourne & Pascale Marchot, AFMB).<\/figcaption><\/figure><\/div>\n\n
\n
\"\"
Crystal structure of the dimeric complex formed between acetylcholinesterase, a key enzyme for cholinergic synapse functioning (yellow), and fasciculin, a three-fingered toxin from mamba venom (purple) (Bourne et al, Cell 1995; copyright Yves Bourne & Pascale Marchot, AFMB).<\/figcaption><\/figure><\/div>\n\n
\n
\"\"
Crystal structure of the neuroligin dimer (yellow subunits, purple dimerization domain) associated with two neurexin-beta molecules (green). The red spheres on the neuroligin denote the positions of mutations found in some autistic patients (Fabrichny et al, Neuron 2004; Leone et al, EMBO J 2010; design by Michael E. Pique, TSRI, La Jolla, CA; child outline provided by the Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, WI, USA).<\/figcaption><\/figure><\/div>\n\n
\n
\"\"
Crystal structure of the pentameric complex formed between AChBP, a soluble surrogate of the extracellular ligand-binding domain of the nicotinic receptor to ACh (yellow), and alpha-cobratoxin, a three-fingered toxin from cobra venom (purple); the figure background displays the layout of the complexes in the crystal (Bourne et al, EMBO J 2005; copyright Yves Bourne & Pascale Marchot, AFMB).<\/figcaption><\/figure><\/div>\n\n
\n
\"\"
International Associated Laboratory ‘Structure-Guided Investigations into Disease States and Therapeutic Strategies (SGIDSTS)” between the AFMB lab in Marseille, France, and the Palmer Taylor Laboratory, Skaggs School of Pharmacy and Pharmaceutical Sciences (SSPPS) in La Jolla (CA), signed by the CNRS, AMU, and UCSD for years 2013-2016.<\/figcaption><\/figure><\/div>\n\n
\n
\"\"
Banner of the XVth International Symposium on Cholinergic Mechanisms organized in Marseille in Oct-2016 by Pascale Marchot and Yves Bourne.<\/figcaption><\/figure><\/div>\n\n
\n
\"\"

RCSB PDB-101, December 2022<\/a>: the \u201cMolecule of the month\u201d was about click-chemistry with, as an example, our works on acetylcholinesterase in collaboration with K. Barry Sharpless (Bourne et al, PNAS 2004, JACS 2016).<\/figcaption><\/figure><\/div><\/div><\/div>\n\n\n\n
\n

Interests<\/h4>\n\n\n\n
\n

My research addresses the structure-function relationships of animal toxins, enzymes, receptors\/channels, and cell-adhesion molecules that are of a considerable neurobiological interest due to their involvement(s) in the genesis, physiology, pathology, or aging of central and peripheral synaptic structures. My objectives are to document (i) the molecular and structural bases of these enzymes, receptors and adhesion molecules and those of the reactivity and specificity of their peptidic or organic partners; (ii) the molecular mechanisms and dynamic events associated with the formation and stabilization of the complex and leading to a modification of the activity of these enzymes, receptors and adhesion molecules.<\/p>\n\n\n\n

Fields of investigation: Biochemistry – Molecular toxinology, pharmacology and enzymology – Reactivity and structure of biological molecules – Molecular neuroscience and neurobiology – Physiology, pathology, and aging of the synapse.<\/p>\n\n\n\n

HAL<\/a>, ORCID<\/a>,<\/a> Google Scholar<\/a>, Scopus<\/a><\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n

\n

Career<\/h4>\n\n\n\n
\n