{"id":11968,"date":"2026-03-20T07:22:30","date_gmt":"2026-03-20T06:22:30","guid":{"rendered":"https:\/\/www.afmb.univ-mrs.fr\/?post_type=team&#038;p=11968"},"modified":"2026-09-21T15:11:38","modified_gmt":"2026-09-21T14:11:38","slug":"ingenierie-des-proteines-pour-les-biotherapies","status":"publish","type":"team","link":"https:\/\/www.afmb.univ-mrs.fr\/en\/team\/ingenierie-des-proteines-pour-les-biotherapies\/","title":{"rendered":"Protein Design for Biotherapeutics"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull pageSubHeaderWrapper topSection has-white-color has-dark-blue-background-color has-text-color has-background\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li><a href=\"#presentation\">Pr\u00e9sentation<\/a><\/li>\n\n\n\n<li><a href=\"#projects\">Projets<\/a><\/li>\n\n\n\n<li><a href=\"#funding\">Financement<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull pageGradientBackground\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns presentationTeamWrapper is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\" id=\"presentation\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"has-normal-font-size wp-block-paragraph\">Our team focuses on developing novel immunogens, vaccines, and other therapeutic biomolecules using AI-guided protein engineering. Our research places particular emphasis on viral glycoproteins and mucosal pathogens.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column columnStickyWrapper is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<div class=\"wp-block-group stickyColumnGroup\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"singleTeamLeaders clearfix\"><\/div>\n\n\n\n<h5 id=\"domaines-de-recherche\" class=\"wp-block-heading\">Research fields<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>AI protein design<\/li>\n\n\n\n<li>Immunogens and vaccines<\/li>\n\n\n\n<li>Structural biology<\/li>\n\n\n\n<li>Viral glycoproteins<\/li>\n<\/ul>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div id=\"people\" class=\"wp-block-group membresGroupWrapper\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div id=\"projects\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 id=\"projets\" class=\"wp-block-heading\">Projects<\/h2>\n\n\n\n<h4 id=\"mecanisme-de-replication-des-bunyavirus\" class=\"wp-block-heading\">Development of AI-designed trimers for HIV vaccination<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">One of our group&#8217;s main goals is to develop new vaccine approaches against HIV. Thanks to artificial intelligence, we can now design molecules with novel properties, opening up new opportunities for vaccine research.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In particular, we are developing HIV-1 envelope (Env) trimers displaying gp120 subunits without gp41. These new structures are designed to limit the exposure of specific viral regions that typically trigger immune responses that are ineffective against infection. Through this innovative platform, we are exploring new strategies for developing vaccines capable of inducing broadly neutralizing antibodies against HIV-1.<\/p>\n\n\n\n<h4 id=\"production-de-proteines-a-haut-debit-dans-e-coli-purification-et-interaction-renaud-vincentelli\" class=\"wp-block-heading\"><em>De novo<\/em> gp120 monomers for HIV-1 vaccines<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">This project focuses on developing innovative immunogens derived from HIV-1 envelope gp120 monomers. These new monomers are designed to adopt a molecular structure that closely resembles that of prefusion closed Env trimers. They aim to specifically stimulate B cells capable of producing broadly neutralizing antibodies. These molecules are engineered to preserve the native structure of the gp120 subunit before its interaction with CD4, while masking specific regions that could divert the immune response.<br><br>The ability of these new molecules to activate specific B cells and guide their maturation is being evaluated in collaboration with the teams of Drs. Pancera and Stamatatos (Fred Hutch Cancer Center, Seattle, USA). With this work, we aim to develop new immunogens that can foster focused responses leading to B cell maturation towards neutralizing breadth.<\/p>\n\n\n\n<h4 id=\"mecanisme-de-replication-des-bunyavirus\" class=\"wp-block-heading\">AI-guided design of binders and immunogens<\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">Beyond HIV, our group is expanding its research to other pathogens for which effective vaccines are not yet available. We are particularly interested in viral glycoproteins and use artificial intelligence to design novel immunogens capable of eliciting targeted immune responses.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In parallel, we collaborate with other research teams to develop binders, engineered proteins designed to specifically recognize and bind molecular targets. By leveraging AI-guided protein design methods, we aim to address a wide range of needs, from fundamental research to the development of new biomedical applications.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n<\/div><\/div>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull groupBordersColumns\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-8f761849 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div id=\"funding\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 id=\"financement\" class=\"wp-block-heading\">Funding<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"875\" height=\"863\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/LOGO_CNRS_BLEU.png\" alt=\"\" class=\"wp-image-12551\" style=\"aspect-ratio:1.013921022704992;width:210px;height:auto\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/LOGO_CNRS_BLEU.png 875w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/LOGO_CNRS_BLEU-500x493.png 500w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/LOGO_CNRS_BLEU-768x757.png 768w\" sizes=\"auto, (max-width: 875px) 100vw, 875px\" \/><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"444\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/Aix-Marseille_Universite\u0301_Logo_2024-1024x444.png\" alt=\"\" class=\"wp-image-12550\" style=\"width:192px;height:auto\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/Aix-Marseille_Universite\u0301_Logo_2024-1024x444.png 1024w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/Aix-Marseille_Universite\u0301_Logo_2024-500x217.png 500w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/Aix-Marseille_Universite\u0301_Logo_2024-766x332.png 766w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/Aix-Marseille_Universite\u0301_Logo_2024-1536x665.png 1536w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/Aix-Marseille_Universite\u0301_Logo_2024-2048x887.png 2048w\" sizes=\"auto, (max-width: 740px) 100vw, 740px\" \/><\/figure>\n<\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"123\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/gatesfoundationlogo-1-1024x123.png\" alt=\"\" class=\"wp-image-12552\" style=\"aspect-ratio:8.327214170692432;width:296px;height:auto\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/gatesfoundationlogo-1-1024x123.png 1024w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/gatesfoundationlogo-1-500x60.png 500w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/gatesfoundationlogo-1-763x92.png 763w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/03\/gatesfoundationlogo-1.png 1178w\" sizes=\"auto, (max-width: 740px) 100vw, 740px\" \/><\/figure>\n<\/div><\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\"><\/div><\/div>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\"><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Our team focuses on developing novel immunogens, vaccines, and other therapeutic biomolecules using AI-guided protein engineering. Our research places particular [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":0,"template":"","class_list":["post-11968","team","type-team","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/11968","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team"}],"about":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/types\/team"}],"author":[{"embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/users\/3"}],"version-history":[{"count":19,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/11968\/revisions"}],"predecessor-version":[{"id":12582,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/11968\/revisions\/12582"}],"wp:attachment":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media?parent=11968"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}