{"id":891,"date":"2020-11-09T18:52:03","date_gmt":"2020-11-09T17:52:03","guid":{"rendered":"http:\/\/www.afmb.univ-mrs.fr\/?post_type=team&#038;p=891"},"modified":"2026-01-05T18:15:55","modified_gmt":"2026-01-05T17:15:55","slug":"glycogenomics","status":"publish","type":"team","link":"https:\/\/www.afmb.univ-mrs.fr\/en\/team\/glycogenomics\/","title":{"rendered":"Glycogenomics"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull pageSubHeaderWrapper topSection has-white-color has-dark-blue-background-color has-text-color has-background\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li><a href=\"#presentation\">Introduction<\/a><\/li>\n\n\n\n<li><a href=\"#people\">Members<\/a><\/li>\n\n\n\n<li><a href=\"#publications\">Publications<\/a><\/li>\n\n\n\n<li><a href=\"#network\">Network<\/a><\/li>\n\n\n\n<li><a href=\"#funding\">Funding<\/a><\/li>\n\n\n\n<li><a href=\"#news\">News<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull pageGradientBackground\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns presentationTeamWrapper is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\" id=\"presentation\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"is-style-justified has-large-font-size\">Our team aims at establishing the relationships between the amino acid sequence of carbohydrate-active enzymes and their precise specificity. This work find developments in various areas, from the exploration of the gut microbiota to the search of novel enzymes for bio-fuel production or blood group  conversion.<\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Cazymes classification within CAZy<\/strong><\/h4>\n\n\n\n<p class=\"is-style-justified\">Carbohydrates are crucial for most organisms as carbon sources or as signaling molecules, but also for cell wall synthesis, host pathogen interactions, energy storage etc. We term carbohydrate-active enzymes (CAZymes) the enzymes that assemble and breakdown complex carbohydrates and carbohydrate polymers. <\/p>\n\n\n\n<p class=\"is-style-justified\">Unlike most other classes of enzymes whose sequences carry limited informative power, the peculiarities of CAZymes and of their substrates turn these enzymes into extremely powerful probes to examine and explain the lifestyle of living organisms. During the last 20 years we have developed a classification in sequence-based families that correlate with the structure and catalytic mechanism of CAZymes. <\/p>\n\n\n\n<p class=\"is-style-justified\">This classification currently includes 5 enzyme categories (glycoside hydrolases, glycosyltransferases, carbohydrate esterases, polysaccharide lyases and auxiliary activities) and their appended carbohydrate-binding modules. To make the classification available to the community, we have created the CAZy database (www.cazy.org), which has been meticulously curated and updated since its first version in 1998. Recently, we have coupled various bioinformatics tools to our database explore the CAZyme content of hundreds of eukaryotic and prokaryotic genomes, as well as many metagenomic datasets.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column columnStickyWrapper is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<div class=\"wp-block-group stickyColumnGroup\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"singleTeamLeaders clearfix\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\">Domaines de recherche<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>CAZymes<\/li>\n\n\n\n<li>eukaryotic and prokaryotic genomes<\/li>\n<\/ul>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div id=\"people\" class=\"wp-block-group membresGroupWrapper\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Members<\/h2>\n\n\n<div class=\"membersWrapper\"><div class=\"groupMembersListWrapper clearfix\"><\/div><div id=\"teamAlumniWrapper\" class=\"teamAlumniWrapper\"><h3>Past members<\/h3><div class=\"alumniContent\"><ul>\n<li>Francesca Maria Pia Paragliola<\/li>\n<li>Nicola Curci<\/li>\n<li>Bastian Hornung<\/li>\n<li>Aurore Labourel<\/li>\n<li>Alexandre Albani<\/li>\n<li>Pascal Lapebie<\/li>\n<li>Rajender Kumar<\/li>\n<li>Matthieu Hainaut<\/li>\n<li>Denise Henrissat<\/li>\n<li>Nicolas Lenfant<\/li>\n<li>Keith Mewis<\/li>\n<li>Antony Levasseur<\/li>\n<li>Hema Golaconda Ramulu<\/li>\n<li>Maria-Cecilia Arias<\/li>\n<li>Corinne Rancurel<\/li>\n<li>Brandi Cantarel<\/li>\n<li>Thomas Bernard<\/li>\n<li>Emeline Deleury<\/li>\n<li>Etienne Danchin<\/li>\n<li>Mark Stam<\/li>\n<li>Almudena Aranda-Martinez<\/li>\n<li>Javier Romero-Garcia<\/li>\n<li>Fran\u00e7ois Alberto<\/li>\n<li>Julie Allouch<\/li>\n<li>V\u00e9ronique Receveur-Brechot<\/li>\n<li>Takeshi Nishimura<\/li>\n<\/ul>\n<\/div><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull publicationsGroupWrapper\" id=\"publications\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Publications<\/h2>\n\n\n\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div id=\"network\" class=\"wp-block-group groupBordersColumns\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Main Network<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h6 class=\"has-orange-color has-text-color wp-block-heading\">National<\/h6>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Jean-Guy Berrin\/Marie-No\u00eblle Rosso<\/strong> \u0003\n<ul class=\"wp-block-list\">\n<li>Biodiversit\u00e9 et Biotechnologie Fongique (BBF), Marseille<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Francis Martin<\/strong>\n<ul class=\"wp-block-list\">\n<li>Interactions Arbres-Microorganismes&nbsp;(IAM), Nancy<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Gabrielle Potocki-Veronese<\/strong>\n<ul class=\"wp-block-list\">\n<li>Toulouse Biotechnology Institute (TBI), Toulouse<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>William Helbert<\/strong>\n<ul class=\"wp-block-list\">\n<li>Centre de Recherches sur les Macromol\u00e9cules V\u00e9g\u00e9tales&nbsp;(CERMAV), Grenoble<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>C\u00e9cile Herv\u00e9\/Mirjam Czjzek\/etc.<\/strong>\n<ul class=\"wp-block-list\">\n<li>Station Biologique de Roscoff<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h6 class=\"has-orange-color has-text-color wp-block-heading\">European<\/h6>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>David Bolam\/Elisabeth Lowe\/Fiona Cuskin<\/strong> \u0003\n<ul class=\"wp-block-list\">\n<li>Newcastle University, England<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Gideon Davies\/Paul Walton<\/strong>\n<ul class=\"wp-block-list\">\n<li>Department of Chemistry, University of York, England<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>James McDonald\/Peter Golyshin<\/strong>\n<ul class=\"wp-block-list\">\n<li>University of Bangor, Wales<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>B\u00f8rge&nbsp;Westereng\/Philip Pope<\/strong>\n<ul class=\"wp-block-list\">\n<li>Norwegian University of Life Sciences,&nbsp;\u00c5s, Norway<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Marco Moracci<\/strong>\n<ul class=\"wp-block-list\">\n<li>Department of Biology, University of Napoli, Italy<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h6 class=\"has-orange-color has-text-color wp-block-heading\">International<\/h6>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Jeffrey Gordon<\/strong> \u0003\n<ul class=\"wp-block-list\">\n<li>School of Medecine, St. Louis University, USA<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Igor Grigoriev<\/strong>\n<ul class=\"wp-block-list\">\n<li>Joint Genome Institute (JGI), University of California, USA<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Eric Martens<\/strong>\n<ul class=\"wp-block-list\">\n<li>Medical School, University of Michigan, USA<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Harry Brumer<\/strong>\n<ul class=\"wp-block-list\">\n<li>Michael Smith Laboratories, The University of British Columbia, Canada<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Mario Murakami<\/strong>\n<ul class=\"wp-block-list\">\n<li>Brazilian Biorenewables National Laboratory (LNBR)&nbsp;Campinas, Brazil<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div id=\"funding\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div style=\"height:80px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h2 class=\"wp-block-heading\">Funding<\/h2>\n\n\n\n<p><strong>Current projects:<\/strong> <a rel=\"noreferrer noopener\" href=\"https:\/\/www.cobiotech.eu\/funded-projects\/2nd-call\/synbiogas\" target=\"_blank\">SYNBIOGAS<\/a>, <a rel=\"noreferrer noopener\" href=\"https:\/\/anr.fr\/Projet-ANR-20-CE20-0022\" target=\"_blank\">ODE<\/a>, <a rel=\"noreferrer noopener\" href=\"https:\/\/anr.fr\/Project-ANR-20-CE44-0011\" target=\"_blank\">BROWNSUGAR<\/a>, <a rel=\"noreferrer noopener\" href=\"https:\/\/anr.fr\/Project-ANR-17-CE20-0032\" target=\"_blank\">PUL marin<\/a>, and <a rel=\"noreferrer noopener\" href=\"https:\/\/novonordiskfonden.dk\/en\/news\/major-research-project-will-focus-on-fungal-feeding-habits\/\" target=\"_blank\">OXYMIST<\/a>.<\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-6 logosGallery wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"655\" height=\"220\" data-id=\"1580\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/09\/logo-CoBioTech.jpg\" alt=\"\" class=\"wp-image-1580\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/09\/logo-CoBioTech.jpg 655w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/09\/logo-CoBioTech-500x168.jpg 500w\" sizes=\"auto, (max-width: 655px) 100vw, 655px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"419\" data-id=\"452\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-anr-1024x419.png\" alt=\"\" class=\"wp-image-452\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-anr-1024x419.png 1024w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-anr-300x123.png 300w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-anr-768x314.png 768w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-anr.png 1467w\" sizes=\"auto, (max-width: 740px) 100vw, 740px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"715\" height=\"560\" data-id=\"1588\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/09\/logo-novonordiskfonden-1.jpg\" alt=\"\" class=\"wp-image-1588\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/09\/logo-novonordiskfonden-1.jpg 715w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/09\/logo-novonordiskfonden-1-500x392.jpg 500w\" sizes=\"auto, (max-width: 715px) 100vw, 715px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"652\" height=\"220\" data-id=\"1576\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/09\/logo-inrae.jpg\" alt=\"\" class=\"wp-image-1576\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/09\/logo-inrae.jpg 652w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/09\/logo-inrae-500x169.jpg 500w\" sizes=\"auto, (max-width: 652px) 100vw, 652px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"351\" data-id=\"451\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-amu-1024x351.png\" alt=\"\" class=\"wp-image-451\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"450\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-cnrs.png\" alt=\"\" class=\"wp-image-450\"\/><\/figure>\n<\/figure>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull\" id=\"news\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"singleTeamNewsWrapper clearfix\"><h2>News<\/h2><div class=\"row clearfix\"><div class=\"postInListWrapper col-md-4\"><div class=\"postInList  fadeIn\">\n\n            \n\n        <a class=\"postThumbnailLink\" href=\"https:\/\/www.afmb.univ-mrs.fr\/en\/2025\/11\/12\/congratulations-to-bruno-canard-etienne-decroly-and-nicolas-terrapon-who-have-been-included-in-the-clarivate-2025-list\/\">\n            \n            \n           \n            \n            <div class=\"postThumbnailWrapper \">\n                                            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2025\/11\/highlycitetated2025-1000x560.jpg\" width=\"1000\" height=\"560\" alt=\"\" class=\"lazyload\" \/>\n                         <\/div>\n            \n\n            <div class=\"postInListInfosWrapper\">\n                \n               \n                \n                <h4 class=\"postTitle\">Congratulations to Bruno Canard, Etienne Decroly and Nicolas Terrapon, who have been included in the Clarivate 2025 list<\/h4>\n                                <p class=\"dateWrapper\">November 12, 2025<\/p>\n            <\/div>\n            \n            \n            \n        <\/a>\n\n<\/div><!-- postInList -->\n<\/div><div class=\"postInListWrapper col-md-4\"><div class=\"postInList  fadeIn\">\n\n            \n\n        <a class=\"postThumbnailLink\" href=\"https:\/\/www.afmb.univ-mrs.fr\/en\/2025\/09\/23\/congratulations-to-juliette-patricio-for-her-poster-award-at-the-gordon-research-conference-grc-2025-dedicated-to-glycobiology\/\">\n            \n            \n           \n            \n            <div class=\"postThumbnailWrapper \">\n                                            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2025\/09\/GRCposterPRIZEsmall-1-1000x542.jpg\" width=\"1000\" height=\"542\" alt=\"\" class=\"lazyload\" \/>\n                         <\/div>\n            \n\n            <div class=\"postInListInfosWrapper\">\n                \n               \n                \n                <h4 class=\"postTitle\">Congratulations to Juliette Patricio for her poster award at the Gordon Research Conference (GRC) 2025 dedicated to glycobiology<\/h4>\n                                <p class=\"dateWrapper\">September 23, 2025<\/p>\n            <\/div>\n            \n            \n            \n        <\/a>\n\n<\/div><!-- postInList -->\n<\/div><div class=\"postInListWrapper col-md-4\"><div class=\"postInList  fadeIn\">\n\n            \n\n        <a class=\"postThumbnailLink\" href=\"https:\/\/www.afmb.univ-mrs.fr\/en\/2024\/09\/19\/five-anr-grants-provided-to-afmb-teams-in-2023-and-2024\/\">\n            \n            \n           \n            \n            <div class=\"postThumbnailWrapper \">\n                                            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2024\/09\/ANRs2023-2024-1000x560.jpg\" width=\"1000\" height=\"560\" alt=\"\" class=\"lazyload\" \/>\n                         <\/div>\n            \n\n            <div class=\"postInListInfosWrapper\">\n                \n               \n                \n                <h4 class=\"postTitle\">Four ANR grants provided to AFMB teams in 2023 and 2024!<\/h4>\n                                <p class=\"dateWrapper\">September 19, 2024<\/p>\n            <\/div>\n            \n            \n            \n        <\/a>\n\n<\/div><!-- postInList -->\n<\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Establish the relationships between the aminoacid sequence of CAZymes and their specificity. We work in various areas from the exploration of the gut microbiota to the search of novel enzymes for biofuel production or blood group conversion.<\/p>\n","protected":false},"author":1,"featured_media":650,"template":"","class_list":["post-891","team","type-team","status-publish","has-post-thumbnail","hentry","entry"],"_links":{"self":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/891","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team"}],"about":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/types\/team"}],"author":[{"embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":13,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/891\/revisions"}],"predecessor-version":[{"id":8163,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/891\/revisions\/8163"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media\/650"}],"wp:attachment":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media?parent=891"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}