{"id":900,"date":"2020-11-09T18:52:57","date_gmt":"2020-11-09T17:52:57","guid":{"rendered":"http:\/\/www.afmb.univ-mrs.fr\/?post_type=team&#038;p=900"},"modified":"2025-01-20T18:30:23","modified_gmt":"2025-01-20T17:30:23","slug":"viral-macromolecular-complexes","status":"publish","type":"team","link":"https:\/\/www.afmb.univ-mrs.fr\/en\/team\/viral-macromolecular-complexes\/","title":{"rendered":"Viral Macromolecular Complexes"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull pageSubHeaderWrapper topSection has-white-color has-dark-blue-background-color has-text-color has-background\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li><a href=\"#presentation\">Introduction<\/a><\/li>\n\n\n\n<li><a href=\"#people\">Members<\/a><\/li>\n\n\n\n<li><a href=\"#projects\">Projects<\/a><\/li>\n\n\n\n<li><a href=\"#publications\">Publications<\/a><\/li>\n\n\n\n<li><a href=\"#network\">Network<\/a><\/li>\n\n\n\n<li><a href=\"#funding\">Funding<\/a><\/li>\n\n\n\n<li><a href=\"#news\">News<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull pageGradientBackground\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns presentationTeamWrapper is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\" id=\"presentation\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"has-large-font-size\">Our team focuses on understanding viral and pseudo-viral infection mechanisms, mainly ruled by the interplay of viral proteins, cellular factors and nucleic acids assembled into multifunctional complexes. In some cases, like many positive stranded RNA viruses, replication is associated to the generation of membrane organelles where replication and transcription occur. Our aim is to understand the mechanisms by which the multiple enzymatic activities are coordinated and regulated to efficiently carry out infection. For this purpose, understanding the interactions of viral proteins with cellular protein factors and membranes is crucial. To reach our goals we use a broad range of biochemical and biophysical technics combined with X-ray crystallography and electron microscopy.<\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column columnStickyWrapper is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<div class=\"wp-block-group stickyColumnGroup\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"singleTeamLeaders clearfix\"><div class=\"singleTeamContactWrapper\"><h5>Team contacts<\/h5><ul><li><a href=\"mailto:afmb-jr@univ-amu.fr\"><i class=\"far fa-envelope\"><\/i><\/a><\/li><\/ul><\/div><\/div>\n\n\n\n<h5 class=\"wp-block-heading\">Research fields<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>RNA virus<\/li>\n\n\n\n<li>Viral replication and transcription<\/li>\n\n\n\n<li>Viral macromolecular complexes<\/li>\n<\/ul>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div id=\"people\" class=\"wp-block-group membresGroupWrapper\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Members<\/h2>\n\n\n<div class=\"membersWrapper\"><div class=\"groupMembersListWrapper clearfix\"><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div id=\"projects\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Projects<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Alphavirus replication complexes<\/strong><\/h3>\n\n\n\n<p>The mainstream of our research is the functional and structural characterization of the alphavirus replication complex. Alphavirus, like chikungunya virus (CHIK) or eastern equine encephalitis virus (EEEV), cause zoonotic infectious diseases with high impact in global human health. The viral genome replication and gene expression is carried out by the multifunctional viral replication complex associated to membranes.<\/p>\n\n\n\n<p>Interestingly this complex can adopt different functions depending on its state of maturation. Our goal is to structurally and functionally characterize the different functional states of the replication complex in order to propose an integrative mechanistic model accurately describing at the molecular level the viral infection cycle and its regulation. The results will provide invaluable insights and tools for the development of new strategies for the treatment of these concerning infectious diseases.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><a href=\"https:\/\/www.nature.com\/articles\/s41586-020-3036-8\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/ESRF-Fig1-1024x465.jpg\" alt=\"\" class=\"wp-image-2909\" width=\"840\" height=\"381\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/ESRF-Fig1-1024x465.jpg 1024w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/ESRF-Fig1-500x227.jpg 500w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/ESRF-Fig1-768x349.jpg 768w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/ESRF-Fig1-1536x698.jpg 1536w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/ESRF-Fig1-2048x931.jpg 2048w\" sizes=\"auto, (max-width: 840px) 100vw, 840px\" \/><\/a><figcaption class=\"wp-element-caption\"><a href=\"https:\/\/www-nature-com.insb.bib.cnrs.fr\/articles\/s41586-020-3036-8\">Jones et al, Nature 2021<\/a><\/figcaption><\/figure><\/div>\n\n\n<h3 class=\"wp-block-heading\"><strong>Bunyavirus replication machinnery<\/strong><\/h3>\n\n\n\n<p>The Bunyavirales is a very large and diverse order of segmented negative stranded viruses (sNSV) comprising more than 350 species classified in many families including Hantaviridae and Nairoviridae, which count with several human highly pathogenic viruses. Thus, it is necessary to (i) understand their mechanism of infection and (ii) to develop effective drugs to counteract them.<\/p>\n\n\n\n<p>In this context, we study two critical steps of bunyavirus viral cycle: replication and transcription. These reactions are carried out by the multifunctional viral polymerase (L) which specifically interacts with the 3\u2019 and 5\u2019 ends of viral RNA segments. Whereas initiation of replication is performed de novo, without requiring any primer, initiation of transcription is performed by the unique \u2018cap-snatching\u2019 mechanism. The recently atomic resolution structures of Infuenza A and LACV allowed us to propose the first comprehensive structure-based model of bunyavirus replication, possibly applicable also to other NSVs but also led to new essential questions to be answered. Therefore, we aim the structural and functional characterization of Bunyavirus polymerases. &nbsp;<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(15)00553-X\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/Screenshot-2022-01-13-at-18.27.11.png\" alt=\"\" class=\"wp-image-2911\" width=\"528\" height=\"722\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/Screenshot-2022-01-13-at-18.27.11.png 652w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/Screenshot-2022-01-13-at-18.27.11-365x500.png 365w\" sizes=\"auto, (max-width: 528px) 100vw, 528px\" \/><\/a><figcaption class=\"wp-element-caption\"><a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(15)00553-X\">Gerlach et al, Cell 2015<\/a><\/figcaption><\/figure><\/div>\n\n\n<h3 class=\"wp-block-heading\"><strong>Yeast retrotransposon integration<\/strong><\/h3>\n\n\n\n<p>Retroelements replicate by reverse transcription of their RNA genome into a cDNA that is stably integrated into the host-cell genome by their own integrase (IN). Integration does not occur randomly in vivo, revealing a retroelement-specific pattern of preferred sites, which depends mostly of INs interaction with cellular factors that tether integration to specific sites. However, the mechanisms by which these factors interact with IN and contribute to the integration process are still poorly understood. Important understandings on retroviral biology have been gained by studying yeast Ty LTR retrotransposons. Ty1 targets its integration to RNA Polymerase III (Pol III)-transcribed genes, which are gene-poor regions of the yeast genome. This remarkable integration site selectivity has been well studied in vivo and in vitro. However, there is no structural information on the integration process or interaction with Pol III. In this project, we will investigate what are the mechanisms of integration and how the interactions between Ty1 IN and different components of the Pol III machinery contribute to the site selection.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(21)00896-6\/fulltext\"><img loading=\"lazy\" decoding=\"async\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/Ty1.png\" alt=\"\" class=\"wp-image-2913\" width=\"460\" height=\"417\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/Ty1.png 865w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/Ty1-500x453.png 500w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/Ty1-768x696.png 768w\" sizes=\"auto, (max-width: 460px) 100vw, 460px\" \/><\/a><figcaption class=\"wp-element-caption\"><a href=\"https:\/\/www.jbc.org\/article\/S0021-9258(21)00896-6\/fulltext\">Nguyen et al, JBC 2021<\/a><\/figcaption><\/figure><\/div>\n\n\n<h4 class=\"wp-block-heading\"><strong>HT protein production and HT techniques development (Renaud Vincentelli)<\/strong><\/h4>\n\n\n\n<p>Link to the service: <a href=\"https:\/\/www.afmb.univ-mrs.fr\/en\/facility\/structural-biology\/high-throughput-cloning-expression-in-bacteria-purification-and-interaction-of-recombinant-proteins\/\">https:\/\/www.afmb.univ-mrs.fr\/en\/facility\/structural-biology\/high-throughput-cloning-expression-in-bacteria-purification-and-interaction-of-recombinant-proteins\/<\/a><\/p>\n\n\n\n<h4 class=\"wp-block-heading\"><strong>Biophysical techniques (Maria Mate)<\/strong><\/h4>\n\n\n\n<p>Link to the service: <a href=\"https:\/\/www.afmb.univ-mrs.fr\/en\/facility\/structural-biology\/biophysical-techniques\/\">https:\/\/www.afmb.univ-mrs.fr\/en\/facility\/structural-biology\/biophysical-techniques\/<\/a><\/p>\n\n\n\n<div class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Join the team<\/h2>\n\n\n\n<p>The team is open to spontaneous applications besides of regular calls for Post Docs and PhD students. We are in constant search for motivated young students and post docs pursuing to develope a scientific career. If you would like to join us do not hesitate to send us a short motivation letter explaining the reasons why you would like to join our research program and a short CV to the following mail:<\/p>\n\n\n\n<p><a href=\"mailto:juan.reguera@univ-amu.fr\">juan.reguera@univ-amu.fr<\/a><\/p>\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull publicationsGroupWrapper\" id=\"publications\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Publications<\/h2>\n\n\n\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull groupBordersColumns\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div id=\"network\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Network<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h6 class=\"has-orange-color has-text-color wp-block-heading\">National<\/h6>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Helene Malet\n<ul class=\"wp-block-list\">\n<li>IBS, Grenoble<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Ali Amara<\/strong> \u0003\n<ul class=\"wp-block-list\">\n<li>Hosp. St Louis, Paris <\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Ignacio Casuso<\/strong>\n<ul class=\"wp-block-list\">\n<li>AFMlab Marseille<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li><strong>Pascale Lesage<\/strong>\n<ul class=\"wp-block-list\">\n<li>Hosp. St Louis, Paris<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Bruno Canard\n<ul class=\"wp-block-list\">\n<li>AFMB lab, Marseille<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h6 class=\"has-orange-color has-text-color wp-block-heading\">International<\/h6>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Rocio Coloma\u0003\n<ul class=\"wp-block-list\">\n<li>CNB, Madrid, Spain<\/li>\n<\/ul>\n<\/li>\n\n\n\n<li>Carlos Fdez Tornero\n<ul class=\"wp-block-list\">\n<li>CIB, Madrid, Spain<\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<\/div>\n<\/div>\n<\/div><\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<div id=\"funding\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\">Funding<\/h2>\n\n\n\n<p><\/p>\n\n\n\n<figure class=\"wp-block-gallery has-nested-images columns-4 logosGallery wp-block-gallery-1 is-layout-flex wp-block-gallery-is-layout-flex\">\n<figure class=\"wp-block-image size-large\"><img decoding=\"async\" data-id=\"450\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-cnrs.png\" alt=\"\" class=\"wp-image-450\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"351\" data-id=\"451\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-amu-1024x351.png\" alt=\"\" class=\"wp-image-451\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"419\" data-id=\"452\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-anr-1024x419.png\" alt=\"\" class=\"wp-image-452\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-anr-1024x419.png 1024w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-anr-300x123.png 300w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-anr-768x314.png 768w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-anr.png 1467w\" sizes=\"auto, (max-width: 740px) 100vw, 740px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"600\" height=\"600\" data-id=\"453\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-erc.png\" alt=\"\" class=\"wp-image-453\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-erc.png 600w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-erc-300x300.png 300w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-erc-150x150.png 150w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-erc-500x500.png 500w\" sizes=\"auto, (max-width: 600px) 100vw, 600px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"880\" data-id=\"3182\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/FBS-1-1024x880.jpg\" alt=\"\" class=\"wp-image-3182\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/FBS-1-1024x880.jpg 1024w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/FBS-1-500x430.jpg 500w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/FBS-1-768x660.jpg 768w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/FBS-1.jpg 1128w\" sizes=\"auto, (max-width: 740px) 100vw, 740px\" \/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"155\" height=\"131\" data-id=\"3184\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/research_pasteur-logo-atip-1.jpg\" alt=\"\" class=\"wp-image-3184\"\/><\/figure>\n\n\n\n<figure class=\"wp-block-image size-large\"><img loading=\"lazy\" decoding=\"async\" width=\"262\" height=\"193\" data-id=\"3186\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/FRM2-3.jpg\" alt=\"\" class=\"wp-image-3186\"\/><\/figure>\n<\/figure>\n<\/div><\/div>\n<\/div>\n<\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull\" id=\"news\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"singleTeamNewsWrapper clearfix\"><h2>News<\/h2><div class=\"row clearfix\"><div class=\"postInListWrapper col-md-4\"><div class=\"postInList  fadeIn\">\n\n            \n\n        <a class=\"postThumbnailLink\" href=\"https:\/\/www.afmb.univ-mrs.fr\/en\/2026\/01\/06\/congratulations-to-lana-weber-jaime-fernandez-and-vincent-wilde-the-2024-phds-of-the-afmb-lab\/\">\n            \n            \n           \n            \n            <div class=\"postThumbnailWrapper \">\n                                            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/01\/montageENG-scaled-e1767714919883-1000x560.jpg\" width=\"1000\" height=\"560\" alt=\"\" class=\"lazyload\" \/>\n                         <\/div>\n            \n\n            <div class=\"postInListInfosWrapper\">\n                \n               \n                \n                <h4 class=\"postTitle\">Congratulations to Lana Weber, Jaime Fernandez and Vincent Wilde \u2013 the 2025 PhDs of the AFMB lab!<\/h4>\n                                <p class=\"dateWrapper\">January 6, 2026<\/p>\n            <\/div>\n            \n            \n            \n        <\/a>\n\n<\/div><!-- postInList -->\n<\/div><div class=\"postInListWrapper col-md-4\"><div class=\"postInList  fadeIn\">\n\n            \n\n        <a class=\"postThumbnailLink\" href=\"https:\/\/www.afmb.univ-mrs.fr\/en\/2025\/04\/25\/co-supervised-thesis-offer-between-the-afmb-and-lcb-laboratories\/\">\n            \n            \n           \n            \n            <div class=\"postThumbnailWrapper \">\n                                            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/03\/DSC_0317-1000x560.jpg\" width=\"1000\" height=\"560\" alt=\"\" class=\"lazyload\" \/>\n                         <\/div>\n            \n\n            <div class=\"postInListInfosWrapper\">\n                \n               \n                \n                <h4 class=\"postTitle\">Co-supervised thesis offer between the AFMB and LCB laboratories &#8211; cancelled<\/h4>\n                                <p class=\"dateWrapper\">April 25, 2025<\/p>\n            <\/div>\n            \n            \n            \n        <\/a>\n\n<\/div><!-- postInList -->\n<\/div><div class=\"postInListWrapper col-md-4\"><div class=\"postInList  fadeIn\">\n\n            \n\n        <a class=\"postThumbnailLink\" href=\"https:\/\/www.afmb.univ-mrs.fr\/en\/2024\/10\/16\/juan-reguera-wins-the-lucien-tartois-prize-from-la-fondation-pour-la-recherche-medicale-congratulations\/\">\n            \n            \n           \n            \n            <div class=\"postThumbnailWrapper \">\n                                            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2024\/10\/PrixFRM2024-scaled-e1729097179893-1000x560.jpg\" width=\"1000\" height=\"560\" alt=\"\" class=\"lazyload\" \/>\n                         <\/div>\n            \n\n            <div class=\"postInListInfosWrapper\">\n                \n               \n                \n                <h4 class=\"postTitle\">Juan Reguera wins the Lucien Tartois prize from the Fondation pour la Recherche M\u00e9dicale, congratulations!<\/h4>\n                                <p class=\"dateWrapper\">October 16, 2024<\/p>\n            <\/div>\n            \n            \n            \n        <\/a>\n\n<\/div><!-- postInList -->\n<\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Identify, isolate and characterize the structure and function of multifunctional macromolecular complexes that rule essential processes of viral infection involving viral replication, transcription and host interactions.<\/p>\n","protected":false},"author":1,"featured_media":0,"template":"","class_list":["post-900","team","type-team","status-publish","hentry","entry"],"_links":{"self":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/900","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team"}],"about":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/types\/team"}],"author":[{"embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":21,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/900\/revisions"}],"predecessor-version":[{"id":5716,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/900\/revisions\/5716"}],"wp:attachment":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media?parent=900"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}