{"id":902,"date":"2020-11-09T18:53:08","date_gmt":"2020-11-09T17:53:08","guid":{"rendered":"http:\/\/www.afmb.univ-mrs.fr\/?post_type=team&#038;p=902"},"modified":"2025-09-16T13:36:32","modified_gmt":"2025-09-16T12:36:32","slug":"viral-replicases-structure-function-and-drug-design","status":"publish","type":"team","link":"https:\/\/www.afmb.univ-mrs.fr\/en\/team\/viral-replicases-structure-function-and-drug-design\/","title":{"rendered":"Viral Replicases: Structure, function and drug-design"},"content":{"rendered":"\n<div class=\"wp-block-group alignfull pageSubHeaderWrapper topSection has-white-color has-dark-blue-background-color has-text-color has-background\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<ul class=\"wp-block-list\">\n<li><a href=\"#presentation\">Introduction<\/a><\/li>\n\n\n\n<li><a href=\"#people\">Members<\/a><\/li>\n\n\n\n<li><a href=\"#publications\">Publications<\/a><\/li>\n\n\n\n<li><a href=\"#network\">Network<\/a><\/li>\n\n\n\n<li><a href=\"#funding\">Funding<\/a><\/li>\n\n\n\n<li><a href=\"#news\">News<\/a><\/li>\n<\/ul>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull pageGradientBackground\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns presentationTeamWrapper is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\" id=\"presentation\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:66.66%\">\n<p class=\"has-large-font-size\">Our team seeks to unravel the molecular mechanisms of emerging viruses by characterizing the structures and the enzymatic activities of proteins forming the viral replication and transcription complex. These studies are a prerequisite for the development of specific inhibitors of these enzymes and should allow the development of new antiviral strategies.<\/p>\n\n\n\n<p>RNA genome viruses are regularly associated with the emergence of infectious diseases. Among the best known, epidemics related to Bunyavirales (LCMV, Lassa, Rift Valley\u2026), Filovirales (Ebola), Nidovirales (Coronavirus), Flavivirales ( Chikungunya or Dengue virus) and chronic diseases (HIV, HCV, HBV, HEV) illustrate public health problems generated on a global scale. <\/p>\n\n\n\n<p>Our studies focus not only on viral polymerases that are at the heart viral replication, but also on the enzymes involved in RNA modifications such as capping and proofreading and proteins involved in the regulation of replication. Beyond the study of the RTC, we are also interested in the interplay of these enzymes with the innate immunity defence mechanism of the cell. The viral replication proteins are privileged antiviral targets and understanding of their structure and function is essential for the design of antiviral molecules with a high potential. To support these research projects, the lab benefits from the support of an inhibitor-screening platform (PCML) and a platform dedicated to the expression of recombinant viral proteins.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"605\" height=\"367\" src=\"http:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/04\/replicases-virales-e1651664534259.jpg\" alt=\"\" class=\"wp-image-708\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/04\/replicases-virales-e1651664534259.jpg 605w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/04\/replicases-virales-e1651664534259-500x303.jpg 500w\" sizes=\"auto, (max-width: 605px) 100vw, 605px\" \/><\/figure><\/div>\n\n\n<h2 class=\"wp-block-heading\">Team organization chart<\/h2>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"951\" height=\"673\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/orga_EBCcharteESeditEN-1.jpg\" alt=\"\" class=\"wp-image-10444\" style=\"width:621px;height:auto\" srcset=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/orga_EBCcharteESeditEN-1.jpg 951w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/orga_EBCcharteESeditEN-1-500x354.jpg 500w, https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/orga_EBCcharteESeditEN-1-768x543.jpg 768w\" sizes=\"auto, (max-width: 951px) 100vw, 951px\" \/><\/figure>\n<\/div>\n\n\n\n<div class=\"wp-block-column columnStickyWrapper is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:33.33%\">\n<div class=\"wp-block-group stickyColumnGroup\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"singleTeamLeaders clearfix\"><\/div>\n\n\n\n<h5 class=\"wp-block-heading\" id=\"domaines-de-recherche\">Domaines de recherche<\/h5>\n\n\n\n<ul class=\"wp-block-list\">\n<li>enzymatic activity<\/li>\n\n\n\n<li>replication\/transcription<\/li>\n\n\n\n<li>antiviral drug-design<\/li>\n\n\n\n<li>RNA polymerase<\/li>\n\n\n\n<li>nuclease<\/li>\n\n\n\n<li>methyltransferase<\/li>\n\n\n\n<li>protease<\/li>\n\n\n\n<li>nucleoprotein<\/li>\n<\/ul>\n<\/div><\/div>\n<\/div>\n<\/div>\n\n\n\n<div id=\"people\" class=\"wp-block-group membresGroupWrapper\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\" id=\"members\">Members<\/h2>\n\n\n<div class=\"membersWrapper\"><div class=\"groupMembersListWrapper clearfix\"><\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull publicationsGroupWrapper\" id=\"publications\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<h2 class=\"wp-block-heading\" id=\"publications\">Publications<\/h2>\n\n\n\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull groupBordersColumns\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\"><\/div>\n<\/div>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"reseau\">Network<\/h2>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h6 class=\"wp-block-heading has-orange-color has-text-color\">National<\/h6>\n\n\n\n<ul class=\"wp-block-list\">\n<li><\/li>\n<\/ul>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h6 class=\"wp-block-heading has-orange-color has-text-color\">Europ\u00e9en<\/h6>\n\n\n\n<ul class=\"wp-block-list\">\n<li><\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<h6 class=\"wp-block-heading has-orange-color has-text-color\">International<\/h6>\n\n\n\n<ul class=\"wp-block-list\">\n<li><\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div class=\"wp-block-columns is-layout-flex wp-container-core-columns-is-layout-9d6595d7 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\" style=\"flex-basis:100%\">\n<h2 class=\"wp-block-heading\">Funding<\/h2>\n<\/div>\n<\/div>\n\n\n\n<p>L&#8217;\u00e9quipe tient \u00e0 remercier ses soutiens institutionnels et priv\u00e9s<\/p>\n\n\n\n<p><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"262\" height=\"193\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/FRM2-3.jpg\" alt=\"\" class=\"wp-image-3187\" style=\"width:114px;height:84px\"\/><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"321\" height=\"157\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2021\/07\/logo-AID.png\" alt=\"\" class=\"wp-image-1440\" style=\"width:161px;height:79px\"\/><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"351\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-amu-1024x351.png\" alt=\"\" class=\"wp-image-451\" style=\"width:176px;height:59px\"\/><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"144\" height=\"94\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/ANRS-e1642084220563.png\" alt=\"\" class=\"wp-image-2829\"\/><\/figure><\/div>\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"150\" height=\"94\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/infectiopole-Sud-e1642084260785.png\" alt=\"\" class=\"wp-image-2823\"\/><\/figure>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"149\" height=\"94\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/i0Dzu1O_400x400-e1642084327156.jpg\" alt=\"\" class=\"wp-image-2237\"\/><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"141\" height=\"94\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/union-europe\u0301enne-e1642084284557.png\" alt=\"\" class=\"wp-image-2819\"\/><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"94\" height=\"94\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/mediterrannee-infection-e1642084273376.jpeg\" alt=\"\" class=\"wp-image-2821\"\/><\/figure><\/div>\n\n<div class=\"wp-block-image\">\n<figure class=\"alignleft size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"234\" height=\"94\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2022\/01\/horizon-europe-UEE-2021-2027-e1642084234705.jpeg\" alt=\"\" class=\"wp-image-2827\"\/><\/figure><\/div>\n\n\n<figure class=\"wp-block-image size-full\"><img loading=\"lazy\" decoding=\"async\" width=\"94\" height=\"94\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2020\/11\/logo-cnrs-e1642084627438.png\" alt=\"\" class=\"wp-image-450\"\/><\/figure>\n\n\n\n<p><\/p>\n<\/div><\/div>\n\n\n\n<div class=\"wp-block-group alignfull\" id=\"news\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\"><div class=\"singleTeamNewsWrapper clearfix\"><h2>News<\/h2><div class=\"row clearfix\"><div class=\"postInListWrapper col-md-4\"><div class=\"postInList  fadeIn\">\n\n            \n\n        <a class=\"postThumbnailLink\" href=\"https:\/\/www.afmb.univ-mrs.fr\/en\/2026\/01\/06\/congratulations-to-lana-weber-jaime-fernandez-and-vincent-wilde-the-2024-phds-of-the-afmb-lab\/\">\n            \n            \n           \n            \n            <div class=\"postThumbnailWrapper \">\n                                            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2026\/01\/montageENG-scaled-e1767714919883-1000x560.jpg\" width=\"1000\" height=\"560\" alt=\"\" class=\"lazyload\" \/>\n                         <\/div>\n            \n\n            <div class=\"postInListInfosWrapper\">\n                \n               \n                \n                <h4 class=\"postTitle\">Congratulations to Lana Weber, Jaime Fernandez and Vincent Wilde \u2013 the 2025 PhDs of the AFMB lab!<\/h4>\n                                <p class=\"dateWrapper\">January 6, 2026<\/p>\n            <\/div>\n            \n            \n            \n        <\/a>\n\n<\/div><!-- postInList -->\n<\/div><div class=\"postInListWrapper col-md-4\"><div class=\"postInList  fadeIn\">\n\n            \n\n        <a class=\"postThumbnailLink\" href=\"https:\/\/www.afmb.univ-mrs.fr\/en\/2025\/11\/24\/congratulation-to-maeva-cunha-mederic-degardin-ing-m-sc-a-and-florian-chardon-who-won-respectively-1st-2nd-and-3rd-price-for-the-180-sec-afmb-competition-during-our-annual-lab-retreat-and-thank\/\">\n            \n            \n           \n            \n            <div class=\"postThumbnailWrapper \">\n                                            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2025\/11\/IMG_3643small.jpg\" width=\"567\" height=\"302\" alt=\"\" class=\"lazyload\" \/>\n                         <\/div>\n            \n\n            <div class=\"postInListInfosWrapper\">\n                \n               \n                \n                <h4 class=\"postTitle\">Congratulations to Ma\u00ebva Cunha, M\u00e9d\u00e9ric D\u00e9gardin and Florian Chardon, who respectively won the 1st, 2nd and 3rd prizes for the 180-sec competition during the 2025 AFMB lab days &#8211; and thanks to Yves for the improvised &#8220;Bourne Prize&#8221; \ud83d\ude09<\/h4>\n                                <p class=\"dateWrapper\">November 24, 2025<\/p>\n            <\/div>\n            \n            \n            \n        <\/a>\n\n<\/div><!-- postInList -->\n<\/div><div class=\"postInListWrapper col-md-4\"><div class=\"postInList  fadeIn\">\n\n            \n\n        <a class=\"postThumbnailLink\" href=\"https:\/\/www.afmb.univ-mrs.fr\/en\/2025\/11\/12\/congratulations-to-bruno-canard-etienne-decroly-and-nicolas-terrapon-who-have-been-included-in-the-clarivate-2025-list\/\">\n            \n            \n           \n            \n            <div class=\"postThumbnailWrapper \">\n                                            <img loading=\"lazy\" decoding=\"async\" src=\"https:\/\/www.afmb.univ-mrs.fr\/wp-content\/uploads\/2025\/11\/highlycitetated2025-1000x560.jpg\" width=\"1000\" height=\"560\" alt=\"\" class=\"lazyload\" \/>\n                         <\/div>\n            \n\n            <div class=\"postInListInfosWrapper\">\n                \n               \n                \n                <h4 class=\"postTitle\">Congratulations to Bruno Canard, Etienne Decroly and Nicolas Terrapon, who have been included in the Clarivate 2025 list<\/h4>\n                                <p class=\"dateWrapper\">November 12, 2025<\/p>\n            <\/div>\n            \n            \n            \n        <\/a>\n\n<\/div><!-- postInList -->\n<\/div><\/div><\/div>\n<\/div><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Unravel the molecular mechanisms of emerging viruses by characterizing the structures and the enzymatic activities of proteins forming the viral replication and transcription complex. Develop new antiviral strategies.<\/p>\n","protected":false},"author":1,"featured_media":720,"template":"","class_list":["post-902","team","type-team","status-publish","has-post-thumbnail","hentry","entry"],"_links":{"self":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/902","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team"}],"about":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/types\/team"}],"author":[{"embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/users\/1"}],"version-history":[{"count":18,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/902\/revisions"}],"predecessor-version":[{"id":10454,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/team\/902\/revisions\/10454"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media\/720"}],"wp:attachment":[{"href":"https:\/\/www.afmb.univ-mrs.fr\/en\/wp-json\/wp\/v2\/media?parent=902"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}