Sarah Barelier
Post-doctorante
Publications
2022
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis
Sarah Barelier, Romain Avellan, Giri Raj Gnawali, Patrick Fourquet, Véronique Roig-Zamboni, Isabelle Poncin, Vanessa Point, Yves Bourne, Stéphane Audebert, Luc Camoin, Christopher Spilling, Stéphane Canaan, Jean‐françois Cavalier, Gerlind Sulzenbacher
FEBS Journal (2022)10.1111/febs.16645
The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis
Sarah Barelier, Gerlind Sulzenbacher
Structure 30:1369-1371 (2022)10.1016/j.str.2022.09.002
Molecular basis for substrate recognition and septum cleavage by AtlA, the major N-acetylglucosaminidase of Enterococcus faecalis
Véronique Roig-Zamboni, Sarah Barelier, Robert Dixon, Nicola Galley, Amani Ghanem, Quoc Phong Nguyen, Héloize Cahuzac, Bartłomiej Salamaga, Peter Davis, Yves Bourne, Stéphane Mesnage, Florence Vincent
Journal of Biological Chemistry 298:101915 (2022)10.1016/j.jbc.2022.101915
2015
The Recognition of Identical Ligands by Unrelated Proteins
Sarah Barelier, Teague Sterling, Matthew O’meara, Brian Shoichet
ACS Chemical Biology 10:2772-2784 (2015)10.1021/acschembio.5b00683
Lineage-Specific Viral Hijacking of Non-canonical E3 Ubiquitin Ligase Cofactors in the Evolution of Vif Anti-APOBEC3 Activity
Joshua R. Kane, David J. Stanley, Judd F. Hultquist, Jeffrey R. Johnson, Nicole Mietrach, Jennifer M. Binning, Stefán R. Jónsson, Sarah Barelier, Billy W. Newton, Tasha L. Johnson, Kathleen E. Franks-Skiba, Ming Li, William L. Brown, Hörður Gunnarsson, Adalbjorg Adalbjornsdóttir, James S. Fraser, Reuben S. Harris, Valgerður Andrésdóttir, John D. Gross, Nevan J. Krogan
Cell Reports 11:1236-1250 (2015)10.1016/j.celrep.2015.04.038
2014
Increasing Chemical Space Coverage by Combining Empirical and Computational Fragment Screens
Sarah Barelier, Oliv Eidam, Inbar Fish, Johan Hollander, Francis Figaroa, Ruta Nachane, John Irwin, Brian Shoichet, Gregg Siegal
ACS Chemical Biology 9:1528-1535 (2014)10.1021/cb5001636
Substrate Deconstruction and the Nonadditivity of Enzyme Recognition
Sarah Barelier, Jennifer Cummings, Alissa Rauwerdink, Daniel Hitchcock, Jeremiah Farelli, Steven Almo, Frank Raushel, Karen Allen, Brian Shoichet
Journal of the American Chemical Society 136:7374-7382 (2014)10.1021/ja501354q
2013
Roles for Ordered and Bulk Solvent in Ligand Recognition and Docking in Two Related Cavities
Sarah Barelier, Sarah Boyce, Inbar Fish, Marcus Fischer, David Goodin, Brian Shoichet
PLoS ONE 8:e69153 (2013)10.1371/journal.pone.0069153
2012
Fragment-guided design of subnanomolar beta-lactamase inhibitors active in vivo
Oliv Eidam, Chiara Romagnoli, Guillaume Dalmasso, Sarah Barelier, Emilia Caselli, Richard Bonnet, Brian K. Shoichet, Fabio Prati
Proceedings of the National Academy of Sciences of the United States of America 109:17448-17453 (2012)10.1073/pnas.1208337109
2011
Ligand specificity, privileged substructures and protein druggability from fragment-based screening
Sarah Barelier, Isabelle Krimm
Current Opinion in Chemical Biology 15:469-474 (2011)10.1016/j.cbpa.2011.02.020
Aspartate 458 of human glutathione synthetase is important for cooperativity and active site structure
Teresa Brown, Michael Drummond, Sarah Barelier, Amanda Crutchfield, Adriana Dinescu, Kerri Slavens, Thomas Cundari, Mary Anderson
Biochemical and Biophysical Research Communications 411:536-542 (2011)10.1016/j.bbrc.2011.06.166
2010
The role of the glycine triad in human glutathione synthetase
Adriana Dinescu, Teresa Brown, Sarah Barelier, Thomas Cundari, Mary Anderson
Biochemical and Biophysical Research Communications 400:511-516 (2010)10.1016/j.bbrc.2010.08.081
Ligand Specificity in Fragment-Based Drug Design
Sarah Barelier, Julien Pons, Kalle Gehring, Jean-Marc Lancelin, Isabelle Krimm
Journal of Medicinal Chemistry 53:5256-5266 (2010)10.1021/jm100496j
Fragment-Based Deconstruction of Bcl-xL Inhibitors
Sarah Barelier, Julien Pons, Olivier Marcillat, Jean-Marc Lancelin, Isabelle Krimm
Journal of Medicinal Chemistry 53:2577-2588 (2010)10.1021/jm100009z
Discovery of Fragment Molecules That Bind the Human Peroxiredoxin 5 Active Site
Sarah Barelier, Dominique Linard, Julien Pons, André Clippe, Bernard Knoops, Jean-Marc Lancelin, Isabelle Krimm
PLoS ONE 5:e9744 (2010)10.1371/journal.pone.0009744
2009
Tumor Protein 53–Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function
Carla E Cano, Julien Gommeaux, Sylvia Pietri, Marcel Culcasi, Stéphane Garcia, Mylène Seux, Sarah Barelier, Sophie Vasseur, Rose P Spoto, Marie-Josèphe Pébusque, Nelson J Dusetti, Juan Lucio Iovanna, Alice Carrier
Cancer Research 69:219-226 (2009)10.1158/0008-5472.CAN-08-2320
