Juan Reguera
Senior researcher
Research group: Viral Macromolecular ComplexesGroup leader
Publications
2021
Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity $in\ vitro$
Phong Quoc Nguyen, Christine Conesa, Elise Rabut, Gabriel Bragagnolo, Célia Gouzerh, Carlos Fernández-Tornero, Pascale Lesage, Juan Reguera, Joël Acker
Journal of Biological Chemistry 297:101093 (2021)10.1016/j.jbc.2021.101093
Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity in vitro
Phong Quoc Nguyen, Christine Conesa, Elise Rabut, Gabriel Bragagnolo, Célia Gouzerh, Carlos Fernández-Tornero, Pascale Lesage, Juan Reguera, Joël Acker
Journal of Biological Chemistry 297:101093 (2021)10.1016/j.jbc.2021.101093
Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors
Kristina Kovacikova, Marina Gorostiola González, Rhian Jones, Juan Reguera, Alba Gigante, María-Jesús Pérez-Pérez, Gerhard Pürstinger, Julia Moesslacher, Thierry Langer, Lak Shin Jeong, Leen Delang, Johan Neyts, Eric Snijder, Gerard van Westen, Martijn van Hemert
Antimicrobial Agents and Chemotherapy 65 (2021)10.1128/AAC.02566-20
2020
Capping pores of alphavirus nsP1 gate membranous viral replication factories
Rhian Jones, Gabriel Bragagnolo, Rocío Arranz, Juan Reguera
Nature 589:615-619 (2020)10.1038/s41586-020-3036-8
Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes
Benoît Arragain, Grégory Effantin, Piotr Gerlach, Juan Reguera, Guy Schoehn, Stephen Cusack, Hélène Malet
Nature Communications 11:3590 (2020)10.1038/s41467-020-17349-4
2019
High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms
Benoît Arragain, Juan Reguera, Ambroise Desfosses, Irina Gutsche, Guy Schoehn, Hélène Malet
eLife 8 (2019)10.7554/eLife.43075
Structure and function of the Toscana virus cap-snatching endonuclease
Rhian Jones, Sana Lessoued, Kristina Meier, Stéphanie Devignot, Sergio Barata-García, Maria Mate, Gabriel Bragagnolo, Friedemann Weber, Maria Rosenthal, Juan Reguera
Nucleic Acids Research 47:10914-10930 (2019)10.1093/nar/gkz838
2017
Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins
Francois Ferron, Friedemann Weber, Juan de La Torre, Juan Reguera
Virus Research 234:118-134 (2017)10.1016/j.virusres.2017.01.018
2015
Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter
Piotr Gerlach, Hélène Malet, Stephen Cusack, Juan Reguera
Cell 161:1267-1279 (2015)10.1016/j.cell.2015.05.006
