Juan Reguera
Senior researcher
Publications
2023
Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration
Phong Quoc Nguyen, Sonia Huecas, Amna Asif-Laidin, Adrián Plaza-Pegueroles, Beatrice Capuzzi, Noé Palmic, Christine Conesa, Joël Acker, Juan Reguera, Pascale Lesage, Carlos Fernández-Tornero
Nature Communications 14:1729 (2023)10.1038/s41467-023-37109-4
Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication
Quentin Durieux Trouilleton, Sergio Barata-García, Benoît Arragain, Juan Reguera, Hélène Malet
Nature Communications 14:2954 (2023)10.1038/s41467-023-38555-w
Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores
Rhian Jones, Michael Hons, Nadia Rabah, Noelia Zamarreño, Rocío Arranz, Juan Reguera
Proceedings of the National Academy of Sciences of the United States of America 120 (2023)10.1073/pnas.2213934120
Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores
Rhian Jones, Michael Hons, Nadia Rabah, Noelia Zamarreño, Rocío Arranz, Juan Reguera
Proceedings of the National Academy of Sciences of the United States of America 120 (2023)10.1073/pnas.2213934120
2021
Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity $in\ vitro$
Phong Quoc Nguyen, Christine Conesa, Elise Rabut, Gabriel Bragagnolo, Célia Gouzerh, Carlos Fernández-Tornero, Pascale Lesage, Juan Reguera, Joël Acker
Journal of Biological Chemistry 297:101093 (2021)10.1016/j.jbc.2021.101093
Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors
Kristina Kovacikova, Marina Gorostiola González, Rhian Jones, Juan Reguera, Alba Gigante, María-Jesús Pérez-Pérez, Gerhard Pürstinger, Julia Moesslacher, Thierry Langer, Lak Shin Jeong, Leen Delang, Johan Neyts, Eric Snijder, Gerard van Westen, Martijn van Hemert
Antimicrobial Agents and Chemotherapy 65 (2021)10.1128/AAC.02566-20
2020
Capping pores of alphavirus nsP1 gate membranous viral replication factories
Rhian Jones, Gabriel Bragagnolo, Rocío Arranz, Juan Reguera
Nature 589:615-619 (2020)10.1038/s41586-020-3036-8
Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes
Benoît Arragain, Grégory Effantin, Piotr Gerlach, Juan Reguera, Guy Schoehn, Stephen Cusack, Hélène Malet
Nature Communications 11:3590 (2020)10.1038/s41467-020-17349-4
2019
High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms
Benoît Arragain, Juan Reguera, Ambroise Desfosses, Irina Gutsche, Guy Schoehn, Hélène Malet
eLife 8 (2019)10.7554/eLife.43075
Structure and function of the Toscana virus cap-snatching endonuclease
Rhian Jones, Sana Lessoued, Kristina Meier, Stéphanie Devignot, Sergio Barata-García, Maria Mate, Gabriel Bragagnolo, Friedemann Weber, Maria Rosenthal, Juan Reguera
Nucleic Acids Research 47:10914-10930 (2019)10.1093/nar/gkz838
2017
Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins
Francois Ferron, Friedemann Weber, Juan de La Torre, Juan Reguera
Virus Research 234:118-134 (2017)10.1016/j.virusres.2017.01.018
2015
Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter
Piotr Gerlach, Hélène Malet, Stephen Cusack, Juan Reguera
Cell 161:1267-1279 (2015)10.1016/j.cell.2015.05.006
