Publications
2022
Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides
Lucelia Cabral, Gabriela Persinoti, Douglas Paixão, Marcele Martins, Mariana Morais, Mariana Chinaglia, Mariane Domingues, Mauricio Sforca, Renan Pirolla, Wesley Generoso, Clelton Santos, Lucas Maciel, Nicolas Terrapon, Vincent Lombard, Bernard Henrissat, Mario Murakami
Nature Communications 13:629 (2022)10.1038/s41467-022-28310-y
SARS-CoV-2 detection using a nanobody-functionalized voltammetric device
Quentin Pagneux, Alain Roussel, Hiba Saada, Christian Cambillau, Béatrice Amigues, Vincent Delauzun, Ilka Engelmann, Enagnon Kazali Alidjinou, Judith Ogiez, Anne Sophie Rolland, Emmanuel Faure, Julien Poissy, Alain Duhamel, Rabah Boukherroub, David Devos, Sabine Szunerits
Communications Medicine 2:56 (2022)10.1038/s43856-022-00113-8
Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect
Priscila El Kazzi, Nadia Rabah, Célia Chamontin, Lina Poulain, François Ferron, Françoise Debart, Bruno Canard, Dorothée Missé, Bruno Coutard, Sébastien Nisole, Etienne Decroly
Nucleic Acids Research 15:1021 (2022)10.1093/nar/gkac996
Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect
Priscila El Kazzi, Nadia Rabah, Célia Chamontin, Lina Poulain, François Ferron, Françoise Debart, Bruno Canard, Dorothée Missé, Bruno Coutard, Sébastien Nisole, Etienne Decroly
Nucleic Acids Research (2022)10.1093/nar/gkac996
Split-GFP Reassembly Assay: Strengths and Caveats from a Multiparametric Analysis
Christophe Bignon, Antoine Gruet, Sonia Longhi
International Journal of Molecular Sciences 23:13167 (2022)10.3390/ijms232113167
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis
Sarah Barelier, Romain Avellan, Giri Raj Gnawali, Patrick Fourquet, Véronique Roig-Zamboni, Isabelle Poncin, Vanessa Point, Yves Bourne, Stéphane Audebert, Luc Camoin, Christopher Spilling, Stéphane Canaan, Jean‐françois Cavalier, Gerlind Sulzenbacher
FEBS Journal (2022)10.1111/febs.16645
The long-awaited structure of human fucosidase FucA1 opens novel avenues for the treatment of fucosidosis
Sarah Barelier, Gerlind Sulzenbacher
Structure 30:1369-1371 (2022)10.1016/j.str.2022.09.002
Functional benefit of structural disorder for the replication of measles, Nipah and Hendra viruses
Frank Gondelaud, Giulia Pesce, Juliet F. Nilsson, Christophe Bignon, Denis Ptchelkine, Denis Gerlier, Cyrille Mathieu, Sonia Longhi
Essays in Biochemistry (2022)10.1042/EBC20220045
Quantitative fragmentomics allow affinity mapping of interactomes
Gergo Gogl, Boglarka Zambo, Camille Kostmann, Alexandra Cousido-Siah, Bastien Morlet, Fabien Durbesson, Luc Negroni, Pascal Eberling, Pau Jané, Yves Nominé, Andras Zeke, Søren Østergaard, Élodie Monsellier, Renaud Vincentelli, Gilles Travé
Nature Communications 13:5472 (2022)10.1038/s41467-022-33018-0
1,6- epi -Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease
Ken Kok, Chi-Lin Kuo, Rebecca Katzy, Lindsey Lelieveld, Liang Wu, Véronique Roig-Zamboni, Gijsbert van der Marel, Jeroen Codée, Gerlind Sulzenbacher, Gideon Davies, Herman Overkleeft, Johannes Aerts, Marta Artola
Journal of the American Chemical Society 144:14819-14827 (2022)10.1021/jacs.2c05666
Exploring the impact of Verticillium wilt disease on the mechanical properties of elementary flax (Linum usitatissimum L.) fibres
Lucile Nuez, Sylvie Durand, Alessia Melelli, Jean-Guy Berrin, Mireille Haon, Elodie Drula, Johnny Beaugrand, Pierre D’arras, Alain Bourmaud, Christophe Baley
Industrial Crops and Products 182:114900 (2022)10.1016/j.indcrop.2022.114900
Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay
Sergio Hernández, Mikael Feracci, Carolina Trajano de Jesus, Priscila El Kazzi, Rafik Kaci, Laura Garlatti, Clemence Mondielli, Fabrice Bailly, Philippe Cotelle, Franck Touret, Xavier de Lamballerie, Bruno Coutard, Etienne Decroly, Bruno Canard, François Ferron, Karine Alvarez
Antiviral Research 204:105364 (2022)10.1016/j.antiviral.2022.105364
Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans
Nathan Han, Jiye Cheng, Omar Delannoy-Bruno, Daniel Webber, Nicolas Terrapon, Bernard Henrissat, Dmitry Rodionov, Aleksandr Arzamasov, Andrei Osterman, David Hayashi, Alexandra Meynier, Sophie Vinoy, Chandani Desai, Stacey Marion, Michael Barratt, Andrew Heath, Jeffrey Gordon
Cell 185:3056-3057 (2022)10.1016/j.cell.2022.07.007
Serum IgG levels to Epstein-Barr and measles viruses in patients with multiple sclerosis during natalizumab and interferon beta treatment
Linn Persson Berg, Marcus Eriksson, Sonia Longhi, Ingrid Kockum, Clemens Warnke, Elisabeth Thomsson, Malin Bäckström, Tomas Olsson, Anna Fogdell-Hahn, Tomas Bergström
BMJ Neurology Open 4:e000271 (2022)10.1136/bmjno-2022-000271
Arenaviridae NP-exonuclease inhibition by bisphosphonate
Thi Hong van Nguyen, Elsie Yekwa, Barbara Selisko, Bruno Canard, Karine Alvarez, Francois Ferron
IUCrJ 9 (2022)10.1107/S2052252522005061
Insights into the atypical autokinase activity of the Pseudomonas aeruginosa GacS histidine kinase and its interaction with RetS
Firas Fadel, Violla Bassim, Vanessa Francis, Steven Porter, Thomas Botzanowski, Pierre Legrand, Maria Maté Perez, Yves Bourne, Sarah Cianférani, Florence Vincent
Structure 22:S0969-2126 (2022)10.1016/j.str.2022.06.002
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1
Jorge Ramirez-Franco, Kévin Debreux, Johanna Extremet, Yves Maulet, Maya Belghazi, Claude Villard, Marion Sangiardi, Fahamoe Youssouf, Lara El Far, Christian Lévêque, Claire Debarnot, P. Marchot, Sofija Paneva, Dominique Debanne, Michael Russier, Michael Seagar, Sarosh Irani, Oussama El Far
Brain - A Journal of Neurology awac218 (2022)10.1093/brain/awac218
The Land–Sea Connection: Insights Into the Plant Lineage from a Green Algal Perspective
Charles Bachy, Fabian Wittmers, Jan Muschiol, Maria Hamilton, Bernard Henrissat, Alexandra Worden
Annual Review of Plant Biology 73 (2022)10.1146/annurev-arplant-071921-100530
Molecular basis for substrate recognition and septum cleavage by AtlA, the major N-acetylglucosaminidase of Enterococcus faecalis
Véronique Roig-Zamboni, Sarah Barelier, Robert Dixon, Nicola Galley, Amani Ghanem, Quoc Phong Nguyen, Héloize Cahuzac, Bartłomiej Salamaga, Peter Davis, Yves Bourne, Stéphane Mesnage, Florence Vincent
Journal of Biological Chemistry 298:101915 (2022)10.1016/j.jbc.2022.101915
A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors
K.Y. Chen, T. Krischuns, L. Ortega Varga, E. Harigua-Souiai, S. Paisant, A. Zettor, J. Chiaravalli, A. Delpal, D. Courtney, A. O'Brien, S.C. Baker, Etienne Decroly, C. Isel, F. Agou, Y. Jacob, A. Blondel, Nadia Naffakh
Antiviral Research 201:105272 (2022)10.1016/j.antiviral.2022.105272
Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues
Rostom Ahmed-Belkacem, Marcel Hausdorff, Adrien Delpal, Priscila Sutto-Ortiz, Agathe M G Colmant, Franck Touret, Natacha S Ogando, Eric J Snijder, Bruno Canard, Bruno Coutard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart
Journal of Medicinal Chemistry 65:6231-6249 (2022)10.1021/acs.jmedchem.2c00120
Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity
Rachid Essalmani, Jaspreet Jain, Delia Susan-Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Etienne Decroly, Tram Nq Pham, Éric Cohen, Nabil Seidah
Journal of Virology 96 (2022)10.1128/jvi.00128-22
Functional exploration of the glycoside hydrolase family GH113
Marie Couturier, Mélanie Touvrey-Loiodice, Nicolas Terrapon, Elodie Drula, Laurine Buon, Christine Chirat, Bernard Henrissat, William Helbert
PLoS ONE 17:1-14 (2022)10.1371/journal.pone.0267509
Replication of the coronavirus genome: A paradox among positive-strand RNA viruses
Emeline Grellet, India l'Hôte, Adeline Goulet, Isabelle Imbert
Journal of Biological Chemistry 298 (2022)10.1016/j.jbc.2022.101923
Mechanistic insights into consumption of the food additive xanthan gum by the human gut microbiota
Matthew Ostrowski, Sabina Leanti La Rosa, Benoit Kunath, Andrew Robertson, Gabriel Pereira, Live Hagen, Neha Varghese, Ling Qiu, Tianming Yao, Gabrielle Flint, James Li, Sean Mcdonald, Duna Buttner, Nicholas Pudlo, Matthew Schnizlein, Vincent Young, Harry Brumer, Thomas Schmidt, Nicolas Terrapon, Vincent Lombard, Bernard Henrissat, Bruce Hamaker, Emiley Eloe-Fadrosh, Ashootosh Tripathi, Phillip Pope, Eric Martens
Nature Microbiology 7:556-569 (2022)10.1038/s41564-022-01093-0
Distribution of Charged Residues Affects the Average Size and Shape of Intrinsically Disordered Proteins
Greta Bianchi, Marco Mangiagalli, Alberto Barbiroli, Sonia Longhi, Rita Grandori, Carlo Santambrogio, Stefania Brocca
Biomolecules 12:561 (2022)10.3390/biom12040561
Generation of a Library of Carbohydrate-Active Enzymes for Plant Biomass Deconstruction
Vânia Cardoso, Joana Brás, Inês Costa, Luís Ferreira, Luís Gama, Renaud Vincentelli, Bernard Henrissat, Carlos Fontes
International Journal of Molecular Sciences 23:4024 (2022)10.3390/ijms23074024
Evolutionary transition to the ectomycorrhizal habit in the genomes of a hyperdiverse lineage of mushroom‐forming fungi
Brian Looney, Shingo Miyauchi, Emmanuelle Morin, Elodie Drula, Pierre Emmanuel Courty, Annegret Kohler, Alan Kuo, Kurt Labutti, Jasmyn Pangilinan, Anna Lipzen, Robert Riley, William Andreopoulos, Guifen He, Jenifer Johnson, Matt Nolan, Andrew Tritt, Kerrie Barry, Igor Grigoriev, László Nagy, David Hibbett, Bernard Henrissat, P. Brandon Matheny, Jesse Labbé, Francis Martin
New Phytologist 233:2294-2309 (2022)10.1111/nph.17892
Phylogenomics and Comparative Genomics Highlight Specific Genetic Features in Ganoderma Species
Yi-Fei Sun, Annie Lebreton, Jia-Hui Xing, Yu-Xuan Fang, Jing Si, Emmanuelle Morin, Shingo Miyauchi, Elodie Drula, Steven Ahrendt, Kelly Cobaugh, Anna Lipzen, Maxim Koriabine, Robert Riley, Annegret Kohler, Kerrie Barry, Bernard Henrissat, Igor Grigoriev, Francis Martin, Bao-Kai Cui
Journal of Fungi 8:311 (2022)10.3390/jof8030311
The ectomycorrhizal basidiomycete Laccaria bicolor releases a GH28 polygalacturonase that plays a key role in symbiosis establishment
Feng Zhang, Aurore Labourel, Mireille Haon, Minna Kemppainen, Emilie da Silva Machado, Nicolas Brouilly, Claire Veneault-Fourrey, Annegret Kohler, Marie‐noëlle Rosso, Alejandro Pardo, Bernard Henrissat, Jean‐guy Berrin, Francis Martin
New Phytologist 233:2534-2547 (2022)10.1111/nph.17940
Assembly and synthesis of the extracellular matrix in brown algae
Lisa Mazéas, Rina Yonamine, Tristan Barbeyron, Bernard Henrissat, Elodie Drula, Nicolas Terrapon, Chikako Nagasato, Cécile Hervé
Seminars in Cell and Developmental Biology (2022)10.1016/j.semcdb.2022.03.005
Phenotypic and Genomic Diversification in Complex Carbohydrate-Degrading Human Gut Bacteria
Nicholas Pudlo, Karthik Urs, Ryan Crawford, Ali Pirani, Todd Atherly, Roberto Jimenez, Nicolas Terrapon, Bernard Henrissat, Daniel Peterson, Cherie Ziemer, Evan Snitkin, Eric Martens
mSystems 7:e0094721 (2022)10.1128/msystems.00947-21
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, Francois Ferron, Bruno Canard
Nature Communications 13 (2022)10.1038/s41467-022-28113-1
Structural and functional analyses of the Porphyromonas gingivalis type IX secretion system PorN protein
Olivier Fuchsbauer, Ignacio Lunar Silva, Eric Cascales, Alain Roussel, Philippe Leone
Journal of Biological Chemistry 298 (2022)10.1016/j.jbc.2022.101618
Experimental Evidence of Intrinsic Disorder and Amyloid Formation by the Henipavirus W Proteins
Giulia Pesce, Frank Gondelaud, Denis Ptchelkine, Juliet F Nilsson, Christophe Bignon, Jérémy Cartalas, Patrick Fourquet, Sonia Longhi
International Journal of Molecular Sciences 23:923 (2022)10.3390/ijms23020923
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex
Daniel L Hurdiss, Priscila El Kazzi, Lisa Bauer, Nicolas Papageorgiou, Francois Ferron, Tim Donselaar, Arno L.W. van Vliet, Tatiana M Shamorkina, Joost Snijder, Bruno Canard, Etienne Decroly, Andrea Brancale, Tzviya Zeev-Ben-Mordehai, Friedrich Förster, Frank J.M. van Kuppeveld, Bruno Coutard
Science Advances 8 (2022)10.1126/sciadv.abj7615
DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation
Federica Quaglia, Bálint Mészáros, Edoardo Salladini, András Hatos, Rita Pancsa, Lucía B Chemes, Mátyás Pajkos, Tamas Lazar, Samuel Peña-Díaz, Jaime Santos, Veronika Ács, Nazanin Farahi, Erzsébet Fichó, Maria Cristina Aspromonte, Claudio Bassot, Anastasia Chasapi, Norman E Davey, Radoslav Davidović, Laszlo Dobson, Arne Elofsson, Gábor Erdős, Pascale Gaudet, Michelle Giglio, Juliana Glavina, Javier Iserte, Valentín Iglesias, Zsófia Kálmán, Matteo Lambrughi, Emanuela Leonardi, Sonia Longhi, Sandra Macedo-Ribeiro, Emiliano Maiani, Julia Marchetti, Cristina Marino-Buslje, Attila Mészáros, Alexander Miguel Monzon, Giovanni Minervini, Suvarna Nadendla, Juliet F Nilsson, Marian Novotný, Christos A Ouzounis, Nicolás Palopoli, Elena Papaleo, Pedro José Barbosa Pereira, Gabriele Pozzati, Vasilis J Promponas, Jordi Pujols, Alma Carolina Sanchez Rocha, Martin Salas, Luciana Rodriguez Sawicki, Eva Schad, Aditi Shenoy, Tamás Szaniszló, Konstantinos D Tsirigos, Nevena Veljkovic, Gustavo Parisi, Salvador Ventura, Zsuzsanna Dosztányi, Peter Tompa, Silvio C E Tosatto, Damiano Piovesan
Nucleic Acids Research 50:D480-D487 (2022)10.1093/nar/gkab1082
The carbohydrate-active enzyme database: functions and literature
Elodie Drula, Marie-Line Garron, Suzan Dogan, Vincent Lombard, Bernard Henrissat, Nicolas Terrapon
Nucleic Acids Research 50:D571-D577 (2022)10.1093/nar/gkab1045
Multi-omics integrated analysis reveals significant metabolic disorders from 2D and 3D HepaRG eparg cells after exposure to amiodarone and DEHP
N. Papaioannou, A.Papageorgiou Koufidou, Z.D. Schultz, I. Frydas, C Gabriel, S. Karakitsios, S. Langouet, E. Blanc, K. Audouze, D.A. Sarigiannis
Toxicology Letters 368:S214-S214 (2022)10.1016/j.toxlet.2022.07.580
Facile access to 4′-( N -acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N 7-guanine-methyltransferase nsp14
Romain Amador, Adrien Delpal, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart, Guillaume Clavé, Michael Smietana
Organic & Biomolecular Chemistry 20:7582-7586 (2022)10.1039/d2ob01569b
Report from the 27th (Virtual) Meeting on Toxinology, “Toxins: Mr Hyde or Dr Jekyll?”, Organized by the French Society of Toxinology, 9–10 December 2021
Daniel Ladant, P. Marchot, Sylvie Diochot, Gilles Prévost, Michel Popoff, Evelyne Benoit
Toxins 14-E110:1-32 (2022)10.3390/toxins14020110
Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs As Inhibitors of SARS-CoV-2 Replication
Dorothée Bardiot, Laura Vangeel, Mohamed Koukni, Philippe Arzel, Marleen Zwaagstra, Heyrhyoung Lyoo, Patrick Wanningen, Shamshad Ahmad, Linlin Zhang, Xinyuanyuan Sun, Adrien Delpal, Cecilia Eydoux, Jean-Claude Guillemot, Eveline Lescrinier, Hugo Klaassen, Pieter Leyssen, Dirk Jochmans, Karolien Castermans, Rolf Hilgenfeld, Colin Robinson, Etienne Decroly, Bruno Canard, Eric J Snijder, Martijn J Van Hemert, Frank Van van Kuppeveld, Patrick Chaltin, Johan Neyts, Steven De de Jonghe, Arnaud Marchand
Molecules 27:1052 (2022)10.3390/molecules27031052
A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome
Ashleigh Shannon, Bhawna Sama, Pierre Gauffre, Théo Guez, Françoise Debart, J.J. Vasseur, Etienne Decroly, Bruno Canard, Francois Ferron
Nucleic Acids Research (2022)
[Review] The role of the surface ligand on the performance of electrochemical SARS-CoV-2 antigen biosensors
Sabine Szunerits, Quentin Pagneux, Abir Swaidan, Vladyslav Mishyn, Alain Roussel, Christian Cambillau, David Devos, Ilka Engelmann, Enagnon Kazali Alidjinou, Henri Happy, Rabah Boukherroub
Analytical and Bioanalytical Chemistry 414:pp 103-113 (2022)10.1007/s00216-020-03137-y
The crystal structure of CbpD clarifies substrate-specificity motifs in chitin-active lytic polysaccharide monooxygenases
Christopher Dade, Badreddine Douzi, Christian Cambillau, Genevieve Ball, Romé Voulhoux, Katrina Forest
Acta crystallographica Section D : Structural biology [1993-...] 78 (2022)10.1107/S2059798322007033
