The Marseille integrative structural biology facility (PBSIM) coordinated by the AFMB lab gathers 6 services offering a state-of-the-art equipment and available to a broad scientific community from the academic and industrial fields.
The facility offers a large panel of complementary techniques and expertise to tackle the tridimensional structures of proteins or macromolecular assemblies from synthetic genes and selected vectors/plasmids. The facility represents one node of the French infrastructure for integrated structural biology (FRISBI) aimed at promoting technological transfer between industries and academic labs for technological developments and some therapeutic applications. It is also recognized by the IBiSA and AMU national labels.
This service provides access to an automated infrastructure for the screening of hundreds of crystallization conditions using very small amounts of biological samples, along with regular observation of the crystallization trays.
Using its own high-throughput methods, this service performs all the necessary steps from cloning genes to purified proteins.
The team develops strategies for its own research projects that are constantly evolving and enriching its service portfolio for its collaborators and clients.