Yoann Aldon

Developing novel immunogens, vaccines and other biotherapeutics using deep learning-guided protein design. Our work places a special emphasis on viral glycoproteins and pathogens targeting mucosal sites.

PI of the Protein Design for Biotherapeutics team – PD4Bio

Yoann Aldon is a CNRS Professeur Junior at AFMB, where he leads the Protein Design for Biotherapeutics (PD4Bio) team. He obtained his PhD in 2019 at Imperial College London in the laboratory of Prof. Robin J. Shattock, focusing on vaccine design, adjuvantation, and the development of HIV-1 Envelope immunogens that progressed to a Phase I clinical trial. He subsequently carried out postdoctoral research with Prof. Rogier W. Sanders at the University of Amsterdam on the design of HIV-1 Env germline-targeting, shaping and polishing immunogens (currently under clinical evaluation), as well as on antibodies for therapeutic purposes. He further broadened his expertise to AI-based protein design methods in the laboratory of Dr. Neil P. King at the Institute for Protein Design (IPD), University of Washington.

His work now focuses on the development of next-generation immunogens, vaccines, and other biotherapeutics through AI-guided protein engineering, with a special interest in viral glycoproteins and other mucosa-targeting pathogens.