• 1994 – PhD thesis Université Libre de Bruxelles (ULB):
    “Contribution to the study of the envelope glycoprotein (gp160) of HIV-1 virus”.
    Laboratory of Physical Chemistry of Macromolecules at Interfaces, Professor J.-M. Ruysschaert (Brussels, Belgium).
  • 1995 to 1997: Postdoctoral training at the Clinical Research Institute of Montreal (IRCM):
    “Study of the involvement of protein convertases in the maturation process of the envelope glycoprotein (gp160) of the HIV virus”. Neuroendocrine Biochemistry Laboratory, Dr. N.G. Seidah (Montreal, Canada).
  • 1998 to 2001: 2nd post-doctoral internship, Co-leader of the VIF team at INSERM-U372
    “Study of the involvement of the HIV Vif protein in the control of cellular antiviral defenses
    Laboratory: Pathogenesis of Lentivirus Infections, Dr. R. Vigne (Marseille, France).
  • Since 2005 CNRS Research Fellow (CR1) at AFMB-UMR7257
    “Identification and characterization of viral enzymes involved in RNA virus cap formation”.
    AFMB laboratory, Viral replication, structure, mechanisms & Drug-design, Dr. B. Canard (Marseille, France).
  • 2011 HDR Aix Marseille University
  • 2012 DR2 CNRS

Teaching activity at * Aix Marseille University * Institut Pasteur/Université Paris 6 * Université du Sud/Toulon Var

Publications

2022

2022
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, yingxiao Zhu, Xiaodong yan, Hui Shi, Francois Ferron, Bruno Canard

Nature Communications 13 (2022)10.1038/s41467-022-28113-1

2022
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

Daniel L Hurdiss, Priscila El Kazzi, Lisa Bauer, Nicolas Papageorgiou, Francois Ferron, Tim Donselaar, Arno L.W. van Vliet, Tatiana M Shamorkina, Joost Snijder, Bruno Canard, Etienne Decroly, Andrea Brancale, Tzviya Zeev-Ben-Mordehai, Friedrich Förster, Frank J.M. van Kuppeveld, Bruno Coutard

Science Advances 8 (2022)10.1126/sciadv.abj7615

2022
Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs As Inhibitors of SARS-CoV-2 Replication

Dorothée Bardiot, Laura Vangeel, Mohamed Koukni, Philippe Arzel, Marleen Zwaagstra, Heyrhyoung Lyoo, Patrick Wanningen, Shamshad Ahmad, Linlin Zhang, Xinyuanyuan Sun, Adrien Delpal, Cecilia Eydoux, Jean-Claude Guillemot, Eveline Lescrinier, Hugo Klaassen, Pieter Leyssen, Dirk Jochmans, Karolien Castermans, Rolf Hilgenfeld, Colin Robinson, Etienne Decroly, Bruno Canard, Eric J Snijder, Martijn J Van Hemert, Frank Van van Kuppeveld, Patrick Chaltin, Johan Neyts, Steven De de Jonghe, Arnaud Marchand

Molecules 27:1052 (2022)10.3390/molecules27031052

2021

2021
Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication

Natacha S Ogando, Priscila El Kazzi, Jessika C Zevenhoven-Dobbe, Brenda W Bontes, Alice Decombe, Clara C S Posthuma, Volker Thiel, Bruno Canard, Francois Ferron, Etienne Decroly, Eric J Snijder

Proceedings of the National Academy of Sciences of the United States of America (2021)10.1101/2021.05.17.444407

2021
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2

Ilaria Vicenti, Maria Grazia Martina, Adele Boccuto, Marta de Angelis, Giorgia Giavarini, Filippo Dragoni, Serena Marchi, Claudia Maria Trombetta, Emmanuele Crespan, Giovanni Maga, Cecilia Eydoux, Etienne Decroly, Emanuele Montomoli, Lucia Nencioni, Maurizio Zazzi, Marco Radi

European Journal of Medicinal Chemistry 224:113683 (2021)10.1016/j.ejmech.2021.113683

2021
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2

Ilaria Vicenti, Maria Grazia Martina, Adele Boccuto, Marta de Angelis, Giorgia Giavarini, Filippo Dragoni, Serena Marchi, Claudia Maria Trombetta, Emmanuele Crespan, Giovanni Maga, Cecilia Eydoux, Etienne Decroly, Emanuele Montomoli, Lucia Nencioni, Maurizio Zazzi, Marco Radi

European Journal of Medicinal Chemistry 224:113683 (2021)10.1016/j.ejmech.2021.113683

2021
An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2

Jacques van Helden, Colin Butler, Guillaume Achaz, Bruno Canard, Didier Casane, Jean-Michel Claverie, Fabien Colombo, Virginie Courtier-Orgogozo, Richard Ebright, François Graner, Milton Leitenberg, Serge Morand, Nikolai Petrovsky, Rossana Segreto, Etienne Decroly, José Halloy

The Lancet 398:1402-1404 (2021)10.1016/S0140-6736(21)02019-5

2021
Structure and Sequence Requirements for RNA Capping at the Venezuelan Equine Encephalitis Virus RNA 5′ End

Oney Ortega Granda, Coralie Valle, Ashleigh Shannon, Etienne Decroly, Bruno Canard, Bruno Coutard, Nadia Rabah

Journal of Virology 95 (2021)10.1128/JVI.00777-21

2021
The enzymes for genome size increase and maintenance of large (+)RNA viruses

Francois Ferron, Bhawna Sama, Etienne Decroly, Bruno Canard

Trends in Biochemical Sciences (2021)10.1016/j.tibs.2021.05.006

2021
The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

Priscila Sutto-Ortiz, Sergey Tcherniuk, Nina ysebaert, Pravien Abeywickrema, Mathieu Noël, Alice Decombe, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard, Dirk Roymans, Peter Rigaux, Jean-François Eléouët, Etienne Decroly

PLoS Pathogens 17:e1009562 (2021)10.1371/journal.ppat.1009562

2021
Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review

Erwan Sallard, José Halloy, Didier Casane, Etienne Decroly, Jacques van Helden

Environmental Chemistry Letters 19:769-785 (2021)10.1007/s10311-020-01151-1

2021
Dengue Virus NS5 Transcribes Metabolite-Capped, RIG-I Sensitive vRNAs

Brandon Schweibenz, Mihai Solotchi, Etienne Decroly, Barbara Selisko, Bruno Canard, Smita Patel

Biophysical Journal 120:135a (2021)10.1016/j.bpj.2020.11.1017

2021
COVID-19 epidemiologic surveillance using wastewater

Virender Sharma, Chetan Jinadatha, Eric Lichtfouse, Etienne Decroly, Jacques van Helden, Hosoon Choi, Piyali Chatterjee

Environmental Chemistry Letters 19:1911-1915 (2021)10.1007/s10311-021-01188-w

2021
The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

Priscila Sutto-Ortiz, Sergey Tcherniuk, Nina ysebaert, Pravien Abeywickrema, Mathieu Noël, Alice Decombe, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard, Dirk Roymans, Peter Rigaux, Jean-François Eléouët, Etienne Decroly

PLoS Pathogens 17:1-20 (2021)10.1371/journal.ppat.1009562

2021
First insights into the structural features of Ebola virus methyltransferase activities

Coralie Valle, Baptiste Martin, François Ferron, Véronique Roig-Zamboni, Aline Desmyter, Françoise Debart, Jean Jacques Vasseur, Bruno Canard, Bruno Coutard, Etienne Decroly

Nucleic Acids Research 49:1737-1748 (2021)10.1093/nar/gkaa1276

2021
The WHO mission report struggles to trace the origins of the SARS-CoV-2 epidemic

Etienne Decroly, Jean-Michel Claverie, Bruno Canard

Virologie 1-7 (2021)

2020

2020
Tracing the origins of SARS-CoV-2 in coronavirus phylogenies

Erwan Sallard, José Halloy, Didier Casane, Etienne Decroly, Jacques van Helden

médecine/sciences 36 (2020)10.1051/medsci/2020123

2020
Drugs against SARS‐CoV ‐2: What do we know about their mode of action?

Coralie Valle, Baptiste Martin, Franck Touret, Ashleigh Shannon, Bruno Canard, Jean‐claude Guillemot, Bruno Coutard, Etienne Decroly

Reviews in Medical Virology 30:1-10 (2020)10.1002/rmv.2143

2020
Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro

Joy Thames, Charles Waters, Coralie Valle, Marcella Bassetto, Wahiba Aouadi, Baptiste Martin, Barbara Selisko, Arissa Falat, Bruno Coutard, Andrea Brancale, Bruno Canard, Etienne Decroly, Katherine Seley-Radtke

Bioorganic and Medicinal Chemistry Letters 28:115713 (2020)10.1016/j.bmc.2020.115713

2020
Mutations on VEEV nsP1 relate RNA capping efficiency to ribavirin susceptibility

Nadia Rabah, Oney Ortega Granda, Gilles Quérat, Bruno Canard, Etienne Decroly, Bruno Coutard

Antiviral Research 182:104883 (2020)10.1016/j.antiviral.2020.104883

2020
Structure-based drug repositioning over the human TMPRSS2 protease domain: search for chemical probes able to repress SARS-CoV-2 Spike protein cleavages

Natesh Singh, Etienne Decroly, Abdel-Majid Khatib, Bruno Villoutreix

European Journal of Pharmaceutical Sciences 153:105495 (2020)10.1016/j.ejps.2020.105495

2020
Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Ashleigh Shannon, Barbara Selisko, Nhung-Thi-Tuyet Le, Johanna Huchting, Franck Touret, Géraldine Piorkowski, Véronique Fattorini, Francois Ferron, Etienne Decroly, Chris Meier, Bruno Coutard, Olve Peersen, Bruno Canard

Nature Communications 11:4682 (2020)10.1038/s41467-020-18463-z

2020
Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase

Rostom Ahmed-Belkacem, Priscila Sutto-Ortiz, Mathis Guiraud, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

European Journal of Medicinal Chemistry 201:112557 (2020)10.1016/j.ejmech.2020.112557

2020
In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

Franck Touret, Magali Gilles, Karine Barral, Antoine Nougairède, Jacques van Helden, Etienne Decroly, Xavier de Lamballerie, Bruno Coutard

Scientific Reports 10:13093 (2020)10.1038/s41598-020-70143-6

2020
Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

Rana Abdelnabi, Kristina Kovacikova, Julia Moesslacher, Kim Donckers, Verena Battisti, Pieter Leyssen, Thierry Langer, Gerhard Puerstinger, Gilles Quérat, Changqing Li, Etienne Decroly, Ali Tas, Arnaud Marchand, Patrick Chaltin, Bruno Coutard, Martijn van Hemert, Johan Neyts, Leen Delang

Antimicrobial Agents and Chemotherapy 64 (2020)10.1128/AAC.00649-20

2020
Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

Ashleigh Shannon, Nhung Thi-Tuyet Le, Barbara Selisko, Cecilia Eydoux, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, Olve Peersen, Francois Ferron, Bruno Canard

Antiviral Research 178:104793 (2020)10.1016/j.antiviral.2020.104793

2020
To something, Covid is good: SFV 2.0

Grégory Caignard, Etienne Decroly, Maria Dimitrova, David Gilmer, Anne-Sophie Gosselin-Grenet, Henri Gruffat, Sandra Martin-Latil, Pascale Massin, Sandie Munier, Mylène Ogliastro, Aure Saulnier, Noël Tordo

Virologie 24:133-134 (2020)10.1684/vir.2020.0846

2020
A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae

Francois Ferron, Humberto Julio Debat, Ashleigh Shannon, Etienne Decroly, Bruno Canard

NAR Genomics and Bioinformatics 2 (2020)10.1093/nargab/lqz022

2020
Design, Synthesis and Discovery of N,N’ ‐Carbazoyl‐aryl‐urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication

Sharon Spizzichino, Giulio Mattedi, Kate Lauder, Coralie Valle, Wahiba Aouadi, Bruno Canard, Etienne Decroly, Suzanne Kaptein, Johan Neyts, Carl Graham, Zakary Sule, David Barlow, Romano Silvestri, Daniele Castagnolo

ChemMedChem 15:385-390 (2020)10.1002/cmdc.201900533

2020
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Bruno Coutard, Coralie Valle, Xavier de Lamballerie, Bruno Canard, Nabil G Seidah, Etienne Decroly

Antiviral Research 176:104742 (2020)10.1016/j.antiviral.2020.104742

2020
The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation

Coralie Valle, Baptiste Martin, Françoise Debart, Jean-Jacques Vasseur, Isabelle Imbert, Bruno Canard, Bruno Coutard, Etienne Decroly

Journal of Virology 94:e00520-20 (2020)10.1128/JVI.00520-20

2019

2019
Structure of the Respiratory Syncytial Virus Polymerase Complex

Morgan S A Gilman, Cheng Liu, Amy Fung, Ishani Behera, Paul Jordan, Peter Rigaux, Nina ysebaert, Sergey Tcherniuk, Julien Sourimant, Jean-Francois Eleouet, Priscila Sutto-Ortiz, Etienne Decroly, Dirk Roymans, Zhinan Jin, Jason S Mclellan

Cell 179:193-204.e14 (2019)10.1016/j.cell.2019.08.014

2019
The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

Natacha S Ogando, Francois Ferron, Etienne Decroly, Bruno Canard, Clara C Posthuma, Eric J Snijder

Frontiers in Microbiology 10 (2019)10.3389/fmicb.2019.01813

2019
C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system

Philippe H Jaïs, Etienne Decroly, Eric Jacquet, Marine Le boulch, Aurélien Jaïs, Olivier Jean-Jean, Heather Eaton, Prishila Ponien, Frédérique Verdier, Bruno Canard, Sergio Gonçalves, Stéphane Chiron, Maude Le Gall, Patrick Mayeux, Maya Shmulevitz

Nucleic Acids Research 47:2681-2698 (2019)10.1093/nar/gkz069

2019
Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay

Ana Ferreira-Ramos, Changqing Li, Cecilia Eydoux, Jean Marie Contreras, Christophe Morice, Gilles Querat, Alba Gigante, María-Jesús Pérez Pérez, Marie-Louise Jung, Bruno Canard, Jean-Claude Guillemot, Etienne Decroly, Bruno Coutard

Antiviral Research 163:59-69 (2019)10.1016/j.antiviral.2019.01.003

2019
FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing

Mathieu Ringeard, Virginie Marchand, Etienne Decroly, yuri Motorin, yamina Bennasser

Nature 565:500-504 (2019)10.1038/s41586-018-0841-4

2019
Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors

Jessica Hernandez, Laurent Hoffer, Bruno Coutard, Gilles Quérat, Philippe Roche, Xavier Morelli, Etienne Decroly, Karine Barral

European Journal of Medicinal Chemistry 161:323-333 (2019)10.1016/j.ejmech.2018.09.056

2019
Synthesis of Adenine Dinucleosides 2′,5′-Bridged by Sulfur-Containing Linkers as Bisubstrate SAM Analogues for Viral RNA 2′- O -Methyltransferases

Rostom Ahmed-Belkacem, Priscila Sutto Ortiz, Etienne Decroly, Jean-Jacques Vasseur, Françoise Debart

European Journal of Organic Chemistry 2019 (2019)10.1002/ejoc.201901120

2018

2018
Ebola virus L protein harbors a new enzymatic activity involved in the internal methylation of RNAs

Baptiste Martin, Coralie Valle, Bruno Coutard, Bruno Canard, Françoise Debart, Etienne Decroly

médecine/sciences 34:919-921 (2018)10.1051/medsci/2018230

2018
The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

Baptiste Martin, Bruno Coutard, Théo Guez, Guido Paesen, Bruno Canard, Françoise Debart, Jean-Jacques Vasseur, Jonathan Grimes, Etienne Decroly

Nucleic Acids Research 46:7902-7912 (2018)10.1093/nar/gky637

2018
Innate immunity evasion mechanisms of filoviruses

Baptiste Martin, Etienne Decroly

Med Sci (Paris) 34:671-677 (2018)10.1051/medsci/20183408013

2018
Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors

Ludovic Halby, Nils Marechal, Dany Pechalrieu, Vincent Cura, Don-Marc Franchini, Céline Faux, Frédéric Alby, Nathalie Troffer-Charlier, Srikanth Kudithipudi, Albert Jeltsch, Wahiba Aouadi, Etienne Decroly, Jean-Claude Guillemot, Patrick Page, Clotilde Ferroud, Luc Bonnefond, Dominique Guianvarc'H, Jean Cavarelli, Paola Arimondo

Philosophical Transactions of the Royal Society B: Biological Sciences 373:20170072 (2018)10.1098/rstb.2017.0072

2018
Filovirus proteins for antiviral drug discovery: Structure/function of proteins involved in assembly and budding

Baptiste Martin, Olivier Reynard, Viktor Volchkov, Etienne Decroly

Antiviral Research 150:183-192 (2018)10.1016/j.antiviral.2017.12.022

2018
Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

Francois Ferron, Lorenzo Subissi, Ana Theresa Silveira de Morais, Nhung Thi Tuyet Le, Marion Sevajol, Laure Gluais, Etienne Decroly, Clemens Vonrhein, Gérard Bricogne, Bruno Canard, Isabelle Imbert

Proceedings of the National Academy of Sciences of the United States of America 115:E162-E171 (2018)10.1073/pnas.1718806115

2017

2017
Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay

Wahiba Aouadi, C Ecilia Eydoux, Bruno Coutard, Baptiste Martin, Françoise Debart, Jean-Jacques Vasseur, Jean Marie Contreras, Christophe Morice, Gilles Quérat, Marie-Louise Jung, Bruno Canard, Jean-Claude Guillemot, Etienne Decroly

Antiviral Research 144:330-339 (2017)10.1016/j.antiviral.2017.06.021

2017
Biochemical principles and inhibitors to interfere with viral capping pathways

Etienne Decroly, Bruno Canard

Current Opinion in Virology 24:87-96 (2017)10.1016/j.coviro.2017.04.003

2017
2017
Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design

Fatiha Benmansour, Iuni Trist, Bruno Coutard, Etienne Decroly, Gilles Querat, Andrea Brancale, Karine Barral

European Journal of Medicinal Chemistry 125:865-880 (2017)10.1016/j.ejmech.2016.10.007

2017
Binding of the Methyl Donor S -Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2′- O -Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10

Wahiba Aouadi, Alexandre Blanjoie, Jean-Jacques Vasseur, Françoise Debart, Bruno Canard, Etienne Decroly

Journal of Virology 91:1103-1119 (2017)10.1128/JVI.02217-16

2017
Antiviral activity of [1,2,3]triazolo[4,5- d ]pyrimidin-7(6 H )-ones against chikungunya virus targeting the viral capping nsP1

Alba Gigante, Asier Gómez-Sanjuan, Leen Delang, Changqing Li, Oskía Bueno, Ana-María Gamo, Eva-María Priego, María-José Camarasa, Dirk Jochmans, Pieter Leyssen, Etienne Decroly, Bruno Coutard, Gilles Querat, Johan Neyts, María-Jesús Pérez-Pérez

Antiviral Research 144:216-222 (2017)10.1016/j.antiviral.2017.06.003

2017
Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

Bruno Coutard, Karine Barral, Julie Lichiere, Barbara Selisko, Baptiste Martin, Wahiba Aouadi, Miguel Ortiz Lombardia, Françoise Debart, Jean-Jacques Vasseur, Jean Claude Guillemot, Bruno Canard, Etienne Decroly

Journal of Virology 91:2202-2218 (2017)10.1128/JVI.02202-16

2016

2016
2016
The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain (vol 42, pg 11642, 2014)

Supanee Potisopon, Stephane Priet, Axelle Collet, Etienne Decroly, Bruno Canard, Barbara Selisko

Nucleic Acids Research 44:2974 (2016)10.1093/nar/gkv1294

2016
Reevaluation of possible outcomes of infections with human immunodeficiency virus

C. Tamalet, Philippe Colson, Etienne Decroly, C. Dhiver, I. Ravaux, A. Stein, Didier Raoult

Clinical Microbiology and Infection 22:299-311 (2016)10.1016/j.cmi.2015.11.022

2016
The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection

L. Delang, C. Li, A. Tas, G. Querat, I. C. Albulescu, T. de Burghgraeve, N. A. Segura Guerrero, A. Gigante, G. Piorkowski, Etienne Decroly, D. Jochmans, B. Canard, E. J. Snijder, M. J. Perez-Perez, M. J. Van Hemert, B. Coutard, P. Leyssen, J. Neyts

Scientific Reports 6:31819 (2016)10.1038/srep31819

2016
Involvement of an Arginine Triplet in M1 Matrix Protein Interaction with Membranes and in M1 Recruitment into Virus-Like Particles of the Influenza A(H1N1)pdm09 Virus

Adeline Kerviel, Shantoshini Dash, Olivier Moncorgé, Baptiste Panthu, Jan Prchal, Didier Decimo, Théophile Ohlmann, Bruno Lina, Cyril Favard, Etienne Decroly, Michèle Ottmann, Philippe Roingeard, Delphine Muriaux

PLoS ONE 11:e0165421 (2016)10.1371/journal.pone.0165421

2015

2015
mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research

Changqing Li, Jaime Guillen, Nadia Rabah, Alexandre Blanjoie, Francoise Debart, Jean-Jacques Vasseur, Bruno Canard, Etienne Decroly, Bruno Coutard

Journal of Virology 89:8292-8303 (2015)10.1128/JVI.00599-15

2015
X-ray structure and activities of an essential Mononegavirales L-protein domain

Guido C. Paesen, Axelle Collet, Corinne Sallamand, Francoise Debart, Jean-Jacques Vasseur, Bruno Canard, Etienne Decroly, Jonathan M. Grimes

Nature Communications 6:8749 (2015)10.1038/ncomms9749

2014

2014
The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

Supanee Potisopon, Stéphane Priet, Axelle Collet, Etienne Decroly, Bruno Canard, Barbara Selisko

Nucleic Acids Research 42 (2014)10.1093/nar/gku666

2014
Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

Mickaël Bouvet, Adrien Lugari, Clara C. Posthuma, Jessika C. Zevenhoven, Stéphanie Bernard, Stéphane Betzi, Isabelle Imbert, Bruno Canard, Jean-Claude Guillemot, Patrick Lécine, Susanne Pfefferle, Christian Drosten, Eric J. Snijder, Etienne Decroly, Xavier Morelli

Journal of Biological Chemistry 289:25783-25796 (2014)10.1074/jbc.M114.577353

2014
Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

Bruno Coutard, Etienne Decroly, Changqing Li, Andrew Sharff, Julien Lescar, Gérard Bricogne, Karine Barral

Antiviral Research 106:61-70 (2014)10.1016/j.antiviral.2014.03.013

2013

2013
Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

Karine Barral, Corinne Sallamand, Christiane Petzold, Bruno Coutard, Axelle Collet, yann Thillier, Jan Zimmermann, Jean-Jacques Vasseur, Bruno Canard, Jacques Rohayem, Françoise Debart, Etienne Decroly

Antiviral Research 99:292-300 (2013)10.1016/j.antiviral.2013.06.001

2012

2012
Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N 7)-methyl transferase

yann Thillier, Etienne Decroly, François Morvan, Bruno Canard, Jean-Jacques Vasseur, Françoise Debart

RNA 18:856-868 (2012)10.1261/rna.030932.111

2011

2011
Crystallization and diffraction analysis of the SARS coronavirus nsp10-nsp16 complex.

Claire Debarnot, Isabelle Imbert, Francois Ferron, Laure Gluais, Isabelle Varlet, Nicolas Papageorgiou, Mickaël Bouvet, Julien Lescar, Etienne Decroly, Bruno Canard

Acta crystallographica Section F : Structural biology communications [2014-...] 67:404-8 (2011)10.1107/S1744309111002867

2007

2007
High-yield production of short GppA- and 7Me GppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions.

F. Peyrane, B. Selisko, Etienne Decroly, J.-J. Vasseur, D. Benarroch, B. Canard, K. Alvarez

Nucleic Acids Research 35:1-11 (2007)

2001

2001
Interaction of human immunodeficiency virus type 1 Vif with Gag and Gag-Pol precursors : co-encapsidation and interference with viral protease-mediated Gag processing

Martine Bardy, Bernard Gay, Stéphanie Pébernard, Nathalie Chazal, Marianne Courcoul, Robert Vigne, Etienne Decroly, Pierre Boulanger

Journal of General Virology 82:2719-2733 (2001)10.1099/0022-1317-82-11-2719