Gender Equality Referent

Degrees

– 2021 Habilitation to Supervise Research (HDR). Life and health sciences. University of Toulon.

– 2007 Doctoral thesis (Ph.D.) Division of Experimental Medicine. McGill University. Montreal. Canada.

– 2000 Bachelor’s degree (B.Sc.) Molecular biology and biotechnology. University of Quebec at Montreal (UQAM). Montreal. Canada.

Professional experience

– 2014 – Lecturer. University of Toulon- AMU- AFMB (Architecture and Function of biological macromolecules). Marseille. France.  “Elucidation of biochemical and molecular mechanisms involved in processes related to viral infections due to RNA viruses”.

Project 1: Functional characterization of the different methyl and guanylyl transferase activities of alpha-like viruses.

Project 2: Study of the role of ORF 1 proteins of hepatitis E virus (HEV) in viral escape.

Project 3 : Macro domain as a new target for antiviral development in polarity-positive RNA viruses.

– 2010 -2013 Associate Professor. University of Toulon- MAPIEM (Materials – Polymers – Interfaces – Marine Environment). Toulon. France.  “New approach against biofouling: Targeting the bacterial communication system (Quorum Sensing)”.

– 2009 – 2010 Researcher-postdoc CNRS-AFMB (Architecture and function of biological macromolecules). Marseille. France. “Involvement of Alphavirus non-structural proteins in viral escape: Applications as new targets for antiviral agents”.

– 2008 -2009 Researcher-postdoc Institut Paoli Calmettes-INSERM. Marseille. France. “Biomarkers: from fundamental discovery to targeted therapies in cancerology”.

– 2007 Researcher-doctoral fellow Clinical Research Institute of Montreal. Montreal. Canada. “Production and molecular characterization of the pro-protein convertase1/3”.

Publications

2023

2023
Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores

Rhian Jones, Michael Hons, Nadia Rabah, Noelia Zamarreño, Rocío Arranz, Juan Reguera

Proceedings of the National Academy of Sciences of the United States of America 120 (2023)10.1073/pnas.2213934120

2023
Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores

Rhian Jones, Michael Hons, Nadia Rabah, Noelia Zamarreño, Rocío Arranz, Juan Reguera

Proceedings of the National Academy of Sciences of the United States of America 120 (2023)10.1073/pnas.2213934120

2023
Macro1 domain residue F156: A hallmark of SARS-CoV-2 de-MARylation specificity

Oney Ortega Granda, Karine Alvarez, Maria J Mate-Perez, Bruno Canard, François Ferron, Nadia Rabah

Virology 587:109845 (2023)10.1016/j.virol.2023.109845

2022

2022
Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect

Priscila El Kazzi, Nadia Rabah, Célia Chamontin, Lina Poulain, François Ferron, Françoise Debart, Bruno Canard, Dorothée Missé, Bruno Coutard, Sébastien Nisole, Etienne Decroly

Nucleic Acids Research (2022)10.1093/nar/gkac996

2021

2021
Structure and Sequence Requirements for RNA Capping at the Venezuelan Equine Encephalitis Virus RNA 5′ End

Oney Ortega Granda, Coralie Valle, Ashleigh Shannon, Etienne Decroly, Bruno Canard, Bruno Coutard, Nadia Rabah

Journal of Virology 95 (2021)10.1128/JVI.00777-21

2020

2020
Mutations on VEEV nsP1 relate RNA capping efficiency to ribavirin susceptibility

Nadia Rabah, Oney Ortega Granda, Gilles Quérat, Bruno Canard, Etienne Decroly, Bruno Coutard

Antiviral Research 182:104883 (2020)10.1016/j.antiviral.2020.104883

2015

2015
Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection

Rami Sommerstein, Lukas Flatz, Melissa M. Remy, Pauline Malinge, Giovanni Magistrelli, Nicolas Fischer, Mehmet Sahin, Andreas Bergthaler, Sebastien Igonet, Jan Ter Meulen, Dorothee Rigo, Paolo Meda, Nadia Rabah, Bruno Coutard, Thomas A. Bowden, Paul-Henri Lambert, Claire-Anne Siegrist, Daniel D. Pinschewer

PLoS Pathogens 11 (2015)10.1371/journal.ppat.1005276

2015
Modulation of violacein production and phenotypes associated with biofilm by exogenous quorum sensing N-acylhomoserine lactones in the marine bacterium Pseudoalteromonas ulvae TC14

Armande Mireille Ayé, Maryse Bonnin-Jusserand, Florence Brian-Jaisson, Annick Ortalo-Magné, Gérald Culioli, Rose Koffi Nevry, Nadia Rabah, Yves Blache, Maëlle Molmeret

Microbiology 161:2039-2051 (2015)10.1099/mic.0.000147

2015
mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research

Changqing Li, Jaime Guillen, Nadia Rabah, Alexandre Blanjoie, Francoise Debart, Jean-Jacques Vasseur, Bruno Canard, Etienne Decroly, Bruno Coutard

Journal of Virology 89:8292-8303 (2015)10.1128/JVI.00599-15

2015
Structural and biophysical analysis of sequence insertions in the Venezuelan Equine Encephalitis Virus macro domain

Jaime Guillen, Julie Lichiere, Nadia Rabah, Brett F. Beitzel, Bruno Canard, Bruno Coutard

Virus Research 201:94-100 (2015)10.1016/j.virusres.2015.02.018

2007

2007
Carboxyl-Terminal Disulfide Bond of Acid Sphingomyelinase Is Critical for Its Secretion and Enzymatic Function

Ching Yin Lee, Taku Tamura, Nadia Rabah, Dong-Young Donna Lee, Isabelle Ruel, Anouar Hafiane, Iulia Iatan, Dana Nyholt, Frédéric Laporte, Claude Lazure, Ikuo Wada, Larbi Krimbou, Jacques Genest

Biochemistry 46:14969-14978 (2007)10.1021/bi700817g

2007
The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro

Nadia Rabah, Dany Gauthier, Jimmy Dikeakos, Timothy Reudelhuber, Claude Lazure

FEBS Journal 274:3482-3491 (2007)10.1111/j.1742-4658.2007.05883.x

2006

2006
Single Amino Acid Substitution in the PC1/3 Propeptide Can Induce Significant Modifications of Its Inhibitory Profile toward Its Cognate Enzyme

Nadia Rabah, Dany Gauthier, Brian Wilkes, Daniel Gauthier, Claude Lazure

Journal of Biological Chemistry 281:7556-7567 (2006)10.1074/jbc.M510607200

2004

2004
Improved PC1/3 production through recombinant expression in insect cells and larvae

Nadia Rabah, Daniel Gauthier, Dany Gauthier, Claude Lazure

Protein Expression and Purification 37:377-384 (2004)10.1016/j.pep.2004.06.014

2003

2003
Barley Serine Proteinase Inhibitor 2-Derived Cyclic Peptides as Potent and Selective Inhibitors of Convertases PC1/3 and Furin

Michèle Villemure, Alain Fournier, Dany Gauthier, Nadia Rabah, Brian Wilkes, Claude Lazure

Biochemistry 42:9659-9668 (2003)10.1021/bi034418w