This PBSIM service offers a large panel of state-of-the-art equipment for the characterization of molecular complexes and the screening or analysis of molecular interactions, in solution or on solid support.
These tools are particularly adapted to the study of various complexes such as:
- protein/nucleic acid
- protein/small molecule
Academia and industries
To be defined from the service requested.
- Isothermal titration calorimetry (ITC): MicroCal iTC200 (Malvern Panalytical)
- Microscale thermophoresis (MST): Monolith NT.115 (NanoTemper Technologies GmbH)
- Size exclusion chromatography/multi-angle light scattering/ refractometry (SEC-MALS) :
- HPLC Ultimate 3000 (Thermo Scientific)/ Dawn 8 (Wyatt)/ Optilab (Wyatt)
- Bio-layer interferometry (BLI) : Octet RED96 et Blitz (ForteBio, Molecular Devices)
- Fluorescence-detection size exclusion chromatography (FSEC): HPLC Dionex/ Fluorescence detector (Thermo Scientific)
- Nano differential scanning fluorimetry (nanoDSF): Tycho (NanoTemper Technologies GmbH)
- Dynamic light scattering (DLS): Zetasizer (Malvern Panalytical)
- Circular dichroism (CD): J-810 (Jasco)