Barbara Selisko
Research engineer
Research group: Viral Replicases: Structure, function and drug-design
Radiation protection advisor (CRP)
Research Associate (IR1 Aix Marseille University) team Dr. Bruno Canard and screening platform Marseille-Luminy (PCML)
Research subject: Activity and inhibition studies of viral replicative enzymes
Experience:
- 1990 PhD in Biochemistry Martin-Luther-Universität Halle/Germany
- 1991 Postdoctoral Fellow Humboldt-Universität Berlin/Germany
- 1992 to 1993 Postdoctoral Fellow at the University of London/United Kingdom supported by the British Council and the German Academic Exchange Service
- 1994 to 2000 Postdoctoral Fellow at the Universidad National Autonoma de Mexico supported in part by the Humboldt-Foundation Germany
- 2001 to date AFMB Marseille
Publications
2023
AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5
Mikael Feracci, Cécilia Eydoux, Véronique Fattorini, Lea Lo Bello, Pierre Gauffre, Barbara Selisko, Priscila Sutto-Ortiz, Ashleigh Shannon, Hongjie Xia, Pei-Yong Shi, Mathieu Noel, Françoise Debart, Jean-Jacques Vasseur, Steve Good, Kai Lin, Adel Moussa, Jean-Pierre Sommadossi, Aurélie Chazot, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, François Ferron, Bruno Canard
Antiviral Research 212:105574 (2023)10.1016/j.antiviral.2023.105574
2022
Arenaviridae NP-exonuclease inhibition by bisphosphonate
Thi Hong van Nguyen, Elsie Yekwa, Barbara Selisko, Bruno Canard, Karine Alvarez, Francois Ferron
International Union of Crystallography journal 9 (2022)10.1107/S2052252522005061
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, Francois Ferron, Bruno Canard
Nature Communications 13 (2022)10.1038/s41467-022-28113-1
2021
Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir
Ho Sing Lo, Kenrie Pui Yan Hui, Hei-Ming Lai, Xu He, Khadija Shahed Khan, Simranjeet Kaur, Junzhe Huang, Zhongqi Li, Anthony Chan, Hayley Hei-Yin Cheung, Ka-Chun Ng, John Chi Wang Ho, Yu Wai Chen, Bowen Ma, Peter Man-Hin Cheung, Donghyuk Shin, Kaidao Wang, Meng-Hsuan Lee, Barbara Selisko, Cecilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Kuen-Phon Wu, Po-Huang Liang, Ivan Dikic, Zhong Zuo, Francis Chan, David Hui, Vincent Mok, Kam-Bo Wong, Chris Ka Pun Mok, Ho Ko, Wei Shen Aik, Michael Chi Wai Chan, Wai-Lung Ng
ACS Central Science 7:792-802 (2021)10.1021/acscentsci.0c01186
Dengue Virus NS5 Transcribes Metabolite-Capped, RIG-I Sensitive vRNAs
Brandon Schweibenz, Mihai Solotchi, Etienne Decroly, Barbara Selisko, Bruno Canard, Smita Patel
Biophysical Journal 120:135a (2021)10.1016/j.bpj.2020.11.1017
2020
Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro
Joy Thames, Charles Waters, Coralie Valle, Marcella Bassetto, Wahiba Aouadi, Baptiste Martin, Barbara Selisko, Arissa Falat, Bruno Coutard, Andrea Brancale, Bruno Canard, Etienne Decroly, Katherine Seley-Radtke
Bioorganic and Medicinal Chemistry Letters 28:115713 (2020)10.1016/j.bmc.2020.115713
Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis
Ashleigh Shannon, Barbara Selisko, Nhung-Thi-Tuyet Le, Johanna Huchting, Franck Touret, Géraldine Piorkowski, Véronique Fattorini, Francois Ferron, Etienne Decroly, Chris Meier, Bruno Coutard, Olve Peersen, Bruno Canard
Nature Communications 11:4682 (2020)10.1038/s41467-020-18463-z
Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
Ashleigh Shannon, Nhung Thi-Tuyet Le, Barbara Selisko, Cecilia Eydoux, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, Olve Peersen, Francois Ferron, Bruno Canard
Antiviral Research 178:104793 (2020)10.1016/j.antiviral.2020.104793
2018
Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases
Barbara Selisko, Nicolas Papageorgiou, Francois Ferron, Bruno Canard
Viruses 10:59 (2018)10.3390/v10020059
2017
Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2′-modified nucleotide analogues
Supanee Potisopon, Francois Ferron, Véronique Fattorini, Barbara Selisko, Bruno Canard
Antiviral Research 140:25-36 (2017)10.1016/j.antiviral.2016.12.021
Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives
Bruno Coutard, Karine Barral, Julie Lichiere, Barbara Selisko, Baptiste Martin, Wahiba Aouadi, Miguel Ortiz Lombardia, Françoise Debart, Jean-Jacques Vasseur, Jean Claude Guillemot, Bruno Canard, Etienne Decroly
Journal of Virology 91:2202-2218 (2017)10.1128/JVI.02202-16
2016
The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain (vol 42, pg 11642, 2014)
Supanee Potisopon, Stephane Priet, Axelle Collet, Etienne Decroly, Bruno Canard, Barbara Selisko
Nucleic Acids Research 44:2974 (2016)10.1093/nar/gkv1294
2015
The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family
Lonneke van Der Linden, Laia Vives-Adrián, Barbara Selisko, Cristina Ferrer-Orta, Xinran Liu, Kjerstin Lanke, Rachel Ulferts, Armando M. de Palma, Federica Tanchis, Nesya Goris, David Lefebvre, Kris de Clercq, Pieter Leyssen, Céline Lacroix, Gerhard Pürstinger, Bruno Coutard, Bruno Canard, David D. Boehr, Jamie J. Arnold, Craig E. Cameron, Nuria Verdaguer, Johan Neyts, Frank J. M van Kuppeveld
PLoS Pathogens 11 (2015)10.1371/journal.ppat.1004733.s010
2014
The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain
Supanee Potisopon, Stéphane Priet, Axelle Collet, Etienne Decroly, Bruno Canard, Barbara Selisko
Nucleic Acids Research 42 (2014)10.1093/nar/gku666
2012
Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome
Barbara Selisko, Supanee Potisopon, Rym Agred, Stephane Priet, Isabelle Varlet, Yann Thillier, Corinne Sallamand, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard
PLoS Pathogens 8:e1002912 (2012)10.1371/journal.ppat.1002912
2007
Crystal Structure of the RNA Polymerase Domain of the West Nile Virus Non-structural Protein 5
Hélène Malet, Marie-Pierre Egloff, Barbara Selisko, Rebecca E Butcher, Peter J Wright, Michael Roberts, Arnaud Gruez, Gerlind Sulzenbacher, Clemens Vonrhein, Gérard Bricogne, Jason M Mackenzie, Alexander A Khromykh, Andrew D Davidson, Bruno Canard
Journal of Biological Chemistry (2007)10.1074/jbc.M607273200
2006
Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases
Barbara Selisko, Hélène Dutartre, Jean-Claude Guillemot, Claire Debarnot, Delphine Benarroch, Alexander Khromykh, Philippe Desprès, Marie-Pierre Egloff, Bruno Canard
Virology 351:145-158 (2006)10.1016/j.virol.2006.03.026
