Karine Alvarez

Head of the “Medicinal Antiviral Chemistry” thematic group

Lab risk manager

Diplomas

• 2006, HDR (Discipline: Chemical Sciences), Univ Aix-Marseille II. Title: “Contribution to the discovery and development of active compounds against viral polymerases”.
• 1999, PhD in Organic, Mineral and Industrial Chemistry, Univ Montpellier II. Dir Dr J.J. Vasseur, laboratory of Bio-Organic Chemistry. Title : “Prodrogues of oligonucleotides : research of new nucleobase protective groups adapted to the automated synthesis of prooligonucleotides”.
• 1995 D.E.A in Chemistry of Biomolecules, Univ Montpellier II

Professional experiences

• Since 2019, DR2 CNRS, INC section 16, AFMB, CNRS-UMR 7257
• Since 10/2001, CR2 then CR1 CNRS, INC section 16, Laboratory of Architecture and Function of Biological Macromolecules (AFMB), CNRS-UMR 7257
  Project 1 : Finding new nucleotide analogues to circumvent the resistance of HIV RT to nucleoside drugs.
  Project 2: Hepatitis C virus NS5B polymerase as an antiviral target
  Project 3: Bunyavirales nucleases as targets of future therapies: development of screening tools and search for antivirals.
  Project 4: The L protein of the Arenaviridae for a drug design strategy
  Project 5: Contribution to the development of antivirals against SARS-Cov-2 infections
• From 06/2000 to 09/2001, Post-Doctoral internship, Faculty of Physics-Chemistry of Barcelona. Laboratory of Pr E. PEDROSO. EU grant. Subject : “Anthracene conjugates as probes of telomere structure and function”. Development of new telomerase inhibitors based on the association of anthracene derivatives with oligonucleotide and/or peptide macromolecules.