Publications

2022

2022
Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues

Rostom Ahmed-Belkacem, Marcel Hausdorff, Adrien Delpal, Priscila Sutto-Ortiz, Agathe M G Colmant, Franck Touret, Natacha S Ogando, Eric J Snijder, Bruno Canard, Bruno Coutard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

Journal of Medicinal Chemistry 65:6231-6249 (2022)10.1021/acs.jmedchem.2c00120

2021

2021
The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

Priscila Sutto-Ortiz, Sergey Tcherniuk, Nina Ysebaert, Pravien Abeywickrema, Mathieu Noël, Alice Decombe, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard, Dirk Roymans, Peter Rigaux, Jean-François Eléouët, Etienne Decroly

PLoS Pathogens 17:e1009562 (2021)10.1371/journal.ppat.1009562

2021
The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

Priscila Sutto-Ortiz, Sergey Tcherniuk, Nina Ysebaert, Pravien Abeywickrema, Mathieu Noël, Alice Decombe, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard, Dirk Roymans, Peter Rigaux, Jean-François Eléouët, Etienne Decroly

PLoS Pathogens 17:1-20 (2021)10.1371/journal.ppat.1009562

2020

2020
Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase

Rostom Ahmed-Belkacem, Priscila Sutto-Ortiz, Mathis Guiraud, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

European Journal of Medicinal Chemistry 201:112557 (2020)10.1016/j.ejmech.2020.112557

2019

2019
Structure of the Respiratory Syncytial Virus Polymerase Complex

Morgan S A Gilman, Cheng Liu, Amy Fung, Ishani Behera, Paul Jordan, Peter Rigaux, Nina Ysebaert, Sergey Tcherniuk, Julien Sourimant, Jean-Francois Eleouet, Priscila Sutto-Ortiz, Etienne Decroly, Dirk Roymans, Zhinan Jin, Jason S Mclellan

Cell 179:193-204.e14 (2019)10.1016/j.cell.2019.08.014

2019
Synthesis of Adenine Dinucleosides 2′,5′-Bridged by Sulfur-Containing Linkers as Bisubstrate SAM Analogues for Viral RNA 2′- O -Methyltransferases

Rostom Ahmed-Belkacem, Priscila Sutto Ortiz, Etienne Decroly, Jean-Jacques Vasseur, Françoise Debart

European Journal of Organic Chemistry 2019 (2019)10.1002/ejoc.201901120

2018

2018
Galactolipase activity of Talaromyces thermophilus lipase on galactolipid micelles, monomolecular films and UV-absorbing surface-coated substrate

Inès Belhaj, Sawsan Amara, Goetz Parsiegla, Priscila Sutto-Ortiz, Moulay Sahaka, Hafedh Belghith, Audric Rousset, Dominique Lafont, Frédéric Carriere

Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863:1006-1015 (2018)10.1016/j.bbalip.2018.05.016

2018
IR spectroscopy analysis of pancreatic lipase-related protein 2 interaction with phospholipids: 2. Discriminative recognition of various micellar systems and characterization of PLRP2-DPPC-bile salt complexes

Eduardo Mateos-Diaz, Priscila Sutto-Ortiz, Moulay Sahaka, Deborah Byrne, Hélène Gaussier, Frédéric Carrière

Chemistry and Physics of Lipids 211:66-76 (2018)10.1016/j.chemphyslip.2017.11.012

2018
IR spectroscopy analysis of pancreatic lipase-related protein 2 interaction with phospholipids: 3. Monitoring DPPC lipolysis in mixed micelles

Eduardo Mateos-Diaz, Priscila Sutto-Ortiz, Moulay Sahaka, Jorge Rodriguez, Frédéric Carrière

Chemistry and Physics of Lipids 211:77-85 (2018)10.1016/j.chemphyslip.2017.11.009