Véronique Fattorini
Engineer
Research group: Viral Replicases: Structure, function and drug-design
Current position:
Biological Techniques Engineer CNRS (AFMB-UMR7257) since 2016
Prevention Assistant at AFMB-Polytech site since 2018
Laser Safety Manager since 2020
Research topics:
Enzymatic and structural characterizations of emerging virus replicases (Dengue, Zika, SARS-CoV-2 etc…).
Activities :
Molecular cloning, site-directed mutagenesis, expression of recombinant proteins in bacterial systems, protein purification, radioactive and fluorescent enzyme assays, inhibition assays, crystallogenesis, student supervision and training of new entrants.
Diploma :
Master 2 Microbiology, Plant Biology and Biotechnology (MBVB)
Publications
2024
The effects of Remdesivir's functional groups on its antiviral potency and resistance against the SARS-CoV-2 polymerase
Bhawna Sama, Barbara Selisko, Camille Falcou, Véronique Fattorini, Géraldine Piorkowski, Franck Touret, Kim Donckers, Johan Neyts, Dirk Jochmans, Ashleigh Shannon, Bruno Coutard, Bruno Canard
Antiviral Research 232 (2024)10.1016/j.antiviral.2024.106034
2023
AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5
Mikael Feracci, Cécilia Eydoux, Véronique Fattorini, Lea Lo Bello, Pierre Gauffre, Barbara Selisko, Priscila Sutto-Ortiz, Ashleigh Shannon, Hongjie Xia, Pei-Yong Shi, Mathieu Noel, Françoise Debart, Jean-Jacques Vasseur, Steve Good, Kai Lin, Adel Moussa, Jean-Pierre Sommadossi, Aurélie Chazot, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, François Ferron, Bruno Canard
Antiviral Research 212:105574 (2023)10.1016/j.antiviral.2023.105574
2022
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, Francois Ferron, Bruno Canard
Nature Communications 13 (2022)10.1038/s41467-022-28113-1
2021
A fluorescence-based high throughput-screening assay for the SARS-CoV RNA synthesis complex
Cecilia Eydoux, Veronique Fattorini, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Bruno Didier, Bruno Canard, Jean-Claude Guillemot
Journal of Virological Methods 288:114013 (2021)10.1016/j.jviromet.2020.114013
2020
Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis
Ashleigh Shannon, Barbara Selisko, Nhung-Thi-Tuyet Le, Johanna Huchting, Franck Touret, Géraldine Piorkowski, Véronique Fattorini, Francois Ferron, Etienne Decroly, Chris Meier, Bruno Coutard, Olve Peersen, Bruno Canard
Nature Communications 11:4682 (2020)10.1038/s41467-020-18463-z
2017
Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2′-modified nucleotide analogues
Supanee Potisopon, Francois Ferron, Véronique Fattorini, Barbara Selisko, Bruno Canard
Antiviral Research 140:25-36 (2017)10.1016/j.antiviral.2016.12.021
