Bruno CANARD

Curriculum vitae

Bruno Canard obtained a PhD in 1991 in Microbiology and Biochemistry from the Université of Paris VII at the Institut Pasteur (mentor: Dr. Stewart T. Cole), Paris, and post-doctoral training in 1995-1998 at Harvard Medical School, Dept. Biological Chemistry and Molecular Pharmacology (mentor: Dr. Charles C. Richardson), Boston. He is currently principal investigator of the team "Viral Replication: Structure, Mechanisms, and Drug Design" at the Architecture and Functions of Biological Macromolecules Laboratory, Aix-Marseille Université, Marseille, France, where he holds a CNRS position as Directeur de Recherche. His current interests are the structure and function of enzymes involved in viral replication and RNA capping, and their use in antiviral drug design.

Dernières publications

1. 3',5'Di-O-trityluridine inhibits in vitro flavivirus replication. (2013)
   De Burghgraeve T, Selisko B, Kaptein S, Chatelain G, Leyssen P, Debing Y, Jacobs M, Van Aerschot A, Canard B , Neyts J
   Antiviral Res S0166-3542 00053-3
2. Nuclear localization of dengue virus nonstructural protein 5 does not strictly correlate with efficient viral RNA replication and inhibition of type I interferon signaling. (2013)
   Kumar A, Buhler S, Selisko B, Davidson A, Mulder K, Canard B , Miller S, Bartenschlager R
   J Virol 87 4545-57
3. Selective Serotonin Reuptake Inhibitor Fluoxetine Inhibits Replication of Human Enteroviruses B and D by Targeting Viral Protein 2C. (2013)
   Ulferts R, van der Linden L, Thibaut HJ, Lanke KH, Leyssen P, Coutard B, De Palma AM, Canard B , Neyts J, van Kuppeveld FJ
   Antimicrob Agents Chemother 57 1952-6
4. Biflavonoids of Dacrydium balansae with Potent Inhibitory Activity on Dengue 2 NS5 Polymerase. (2012)
   Coulerie P, Eydoux C, Hnawia E, Stuhl L, Maciuk A, Lebouvier N, Canard B , Figadere B, Guillemot JC, Nour M
   Planta Med 78 672-7
5. Chemical constituents of Anacolosa pervilleana and their antiviral activities. (2012)
   Bourjot M, Leyssen P, Eydoux C, Guillemot JC, Canard B , Rasoanaivo P, Gueritte F, Litaudon M
   Fitoterapia 83 1076-80