CNRS - AIX MARSEILLE UNIV: UMR7257

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François FERRON

Researcher

AFMB Polytech Case 925
Campus de Luminy
163 Avenue de Luminy
13288 Marseille CEDEX 09
Fax: +33 491 82 86 38

phone: 491 82 86 28
Francois.Ferron afmb.univ-mrs.fr
 

Viral Replicases : Structure, Mechanism and Drug-Design

 

- François Ferron obtained his Ph.D. in 2005 in Biochemistry and Bioinformatics from the Université de la Méditerranée of Marseilles at the Centre National pour la Recherche Scientifique (CNRS) (mentors: Dr. B. Canard and Dr. S. Longhi). He got post-doctoral training in structural biology, at Boston Biomedical Research Institute in Boston, U.S.A. and became a research fellow at University of Pennsylvania, School of Medicine, Physiology Dept., Philadelphia, U.S.A. (mentor: Prof. R. Dominguez). In late 2008 he joined the CNRS team “Proteins from Emergent Viruses and Parasitology” in Marseilles, France (mentor: Dr. J. Lescar) to work on Phlebovirus viral genome packaging. Since 2010, he holds a CNRS researcher position in the team “Viral Replication: Structure, Mechanisms, and Drug Design” at the Architecture and Functions of Biological Macromolecules Laboratory – Aix-Marseille Université, Marseilles, France. His current interests are focused on the structural assembly of macromolecular complexes forming viral replication machineries.

Latest Publications

  1. Ferron F , Sama B, Decroly E, Canard B
    Trends Biochem Sc in press
  2. A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases (2021)
    Hernandez S, Feracci M, Trajano De Jesus C, El-Kazzi P, Kaci R, Garlatti L, Decroly E, Canard B, Ferron F , Alvarez K
    bioRxiv 2021.04.02.437736
  3. Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex (2021)
    Hyrduss DL, El Kazzi P, Bauer L, Papageorgiou N, Ferron F P, Donselaar T, Van Vliet ALW, Canard B, Decroly E, Brancale A, Zeev Ben Mordehai T, Forster F, Van Kuppeveld FJM, Coutard B
    bioRxiv 2021.04.26.440876
  4. Papageorgiou N, Vaitsopoulou A, Diop A, Nguyen THV, Canard B, Alvarez K, Ferron F
    FEBS Open Bio 11 1076-1083
  5. Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527 (2021)
    Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, Gauffre P, El Kazzi P, Decroly E, Raba N, Alvarez K, Eydoux C, Guillemot JC, Debart F, Vasseur JJ, Noel M, Moussa A, Good S, Lin K, Sommadossi JP, Zhu Y, Yan X, Shi H, Ferron F , Canard B
    bioRxiv 2021.03.23.436564
  6. Papageorgiou N, Vaitsopoulou A, Diop A, Nguyen THV, Canard B, Alvarez K, Ferron F
    FEBS Open Bio 11 1076-1083
  7. Valle C, Martin B, Ferron F , Roig-Zamboni V, Desmyter A, Debart F, Vasseur JJ, Canard B, Coutard B, Decroly E
    Nucleic Acids Res 49 1737-1748

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