Mikael Feracci
Post-doctorant
Publications
2023
Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach
Laurent Hoffer, Manon Garcia, Raphael Leblanc, Mikael Feracci, Stéphane Betzi, Khaoula Ben Yaala, Avais Daulat, Pascale Zimmermann, Philippe Roche, Karine Barral, Xavier Morelli
Journal of Medicinal Chemistry (2023)10.1021/acs.jmedchem.2c01569
AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5
Mikael Feracci, Cécilia Eydoux, Véronique Fattorini, Lea Lo Bello, Pierre Gauffre, Barbara Selisko, Priscila Sutto-Ortiz, Ashleigh Shannon, Hongjie Xia, Pei-Yong Shi, Mathieu Noel, Françoise Debart, Jean-Jacques Vasseur, Steve Good, Kai Lin, Adel Moussa, Jean-Pierre Sommadossi, Aurélie Chazot, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, François Ferron, Bruno Canard
Antiviral Research 212:105574 (2023)10.1016/j.antiviral.2023.105574
2022
Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay
Sergio Hernández, Mikael Feracci, Carolina Trajano de Jesus, Priscila El Kazzi, Rafik Kaci, Laura Garlatti, Clemence Mondielli, Fabrice Bailly, Philippe Cotelle, Franck Touret, Xavier de Lamballerie, Bruno Coutard, Etienne Decroly, Bruno Canard, François Ferron, Karine Alvarez
Antiviral Research 204:105364 (2022)10.1016/j.antiviral.2022.105364
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, Francois Ferron, Bruno Canard
Nature Communications 13 (2022)10.1038/s41467-022-28113-1
2021
Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread
Manon Garcia, Laurent Hoffer, Raphaël Leblanc, Fatiha Benmansour, Mikael Feracci, Carine Derviaux, Antonio Luis Egea-Jimenez, Philippe Roche, Pascale Zimmermann, Xavier Morelli, Karine Barral
European Journal of Medicinal Chemistry 223:113601 (2021)10.1016/j.ejmech.2021.113601
2020
Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo
R. Leblanc, R. Kashyap, K. Barral, A.L. Egea‐jimenez, D. Kovalskyy, M. Feracci, M. Garcia, C. Derviaux, S. Betzi, R. Ghossoub, M. Platonov, P. Roche, X. Morelli, L. Hoffer, Pascale Zimmermann
Journal of Extracellular Vesicles 10 (2020)10.1002/jev2.12039
In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor
Jeremy Ariey‐bonnet, Kendall Carrasco, Marion Le Grand, Laurent Hoffer, Stéphane Betzi, Mikael Feracci, Philipp A Tsvetkov, François Devred, Yves Collette, Xavier Morelli, Pedro Ballester, Eddy Pasquier
Molecular Oncology 14:3083-3099 (2020)10.1002/1878-0261.12810
2017
Binding site density enables paralog-specific activity of SLM2 and Sam68 proteins in Neurexin2 AS4 splicing control
Marina Danilenko, Caroline Dalgliesh, Vittoria Pagliarini, Chiara Naro, Ingrid Ehrmann, Mikael Feracci, Mahsa Kheirollahi-Chadegani, Alison Tyson-Capper, Gavin Clowry, Philippe Fort, Cyril Dominguez, Claudio Sette, David Elliott
Nucleic Acids Research 45:gkw1277 (2017)10.1093/nar/gkw1277
2014
Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase.
Olivier Bornet, Matthieu Nouailler, Michaël Feracci, Corinne Sebban-Kreuzer, Deborah Byrne, Hubert Halimi, Xavier Morelli, Ali Badache, Francoise Guerlesquin
FEBS Letters 588:2031-6 (2014)10.1016/j.febslet.2014.04.029
2012
Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation
Latifa Elantak, Marion Espeli, Annie Boned, Olivier Bornet, Jeremy Bonzi, Laurent Gauthier, Mikael Feracci, Philippe Roche, Francoise Guerlesquin, Claudine Schiff
Journal of Biological Chemistry 287:44703-44713 (2012)10.1074/jbc.m112.395152
Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation.
Latifa El Antak, Marion Espeli, Annie Boned, Olivier Bornet, Jeremy Bonzi, Laurent Gauthier, Mikael Feracci, Philippe Roche, Françoise Guerlesquin, Claudine Schiff
Journal of Biological Chemistry 287:44703-13 (2012)10.1074/jbc.M112.395152
2011
MEMO associated with an ErbB2 receptor phosphopeptide reveals a new phosphotyrosine motif.
Mikael Feracci, Cyril Pimentel, Olivier Bornet, Philippe Roche, Danièle Salaün, Ali Badache, Françoise Guerlesquin
FEBS Letters 585:2688-92 (2011)10.1016/j.febslet.2011.07.048
2009
NMR and MD investigations of human galectin-1/oligosaccharide complexes.
Christophe Meynier, Mikael Feracci, Marion Espeli, Florence Chaspoul, Philippe Gallice, Claudine Schiff, Françoise Guerlesquin, Roche Philippe
Biophysical Journal 97:3168-77 (2009)10.1016/j.bpj.2009.09.026
