Invité direction: Hugo Bisio, IGS, Marseille – « Systematic Characterization of the Mimivirus-Acanthamoeba Virocell »

Résumé

The virocell concept posits that the infected host cell, rather than the virion, represents the functional state of a virus. While virus-host interactions have been extensively characterized, the dynamics of the virocell itself remain poorly understood. Giant viruses provide a particularly powerful model system, as their large genomes encode more than a thousand proteins, many of which are predicted to modulate cellular physiology and influence virocell fitness. Here, I will present preliminary results from a spatiotemporal proteomic analysis of the Mimivirus virocell cycle, with particular emphasis on the organization of viral factories and the remodeling of mitochondrial activity. Both organelles show significant modification on their function across the cycle.