Invité direction: Patrick Bron, CBS Montpellier -« Exploring the Dynamics of Biological Complexes through Cryo-EM: From Molecular to Cellular Scales »

Résumé

Transmission electron microscopy (TEM) is a constantly evolving technology. In recent years, its ability to reveal atomic-level details of biological complexes has made it an essential tool in structural biology. However, biological complexes are inherently dynamic, transitioning between multiple conformations and interacting with various partners. Cryo-electron microscopy (cryo-EM), through the development of advanced statistical approaches, allows us to capture and analyze these structural variations, from the molecular to the cellular level. To illustrate these capabilities, I will present two projects: first, the study of the interaction between obefazimod, a candidate drug with anti-inflammatory and antiviral properties, and the cap-binding complex; second, the investigation of the structural organization of replication organelles of the Chikungunya virus within cells.