CNRS - AIX MARSEILLE UNIV: UMR7257

Home page > staff > Karine ALVAREZ

Karine ALVAREZ

Researcher

AFMB UMR 7257 Case 932
Campus de Luminy
163 Avenue de Luminy
13288 Marseille CEDEX 09
Fax : +33 491 26 67 20

phone: 491 82 55 70
Karine.Alvarez afmb.univ-mrs.fr
 

Viral Replicases : Structure, Mechanism and Drug-Design

 

EDUCATION

  • 2006, HDR in Chemical Sciences, Univ Aix-Marseille II. ‘’ contribution to the discovery and development of compounds active against viral polymerases‘’.
  • 1999, Ph. D., Organic Chemistry. Laboratory of Bio-Organic Chemistry, Univ Montpellier II. Supervisor : Dr J.-J. VASSEUR. "Prodrugs of oligonucleotides : New nucleobase protecting groups for the solid phase synthesis of prooligonucleotides’’
  • 1995 D.E.A Biomolecular Chemistry. Laboratory of Bio-Organic Chemistry, Univ Montpellier II (France). ’’ New class of nucleobases protecting groups’’.

PROFESSIONAL EXPERIENCE

  • Since 10/2001, CR CNRS, AFMB CNRS-UMR 6098 (Dir. Yves BOURNE).
    Project 1: Find nucleotide analogs to circumvent the resistance of the HIV RT (1 patent, 8 publications)
    Project 2: Development of a chemotherapy against Flaviviruses. (8 publications)
    Project 3: The polymerase NS5B of Hepatitis C as a target for antiviral drugs. (3 publications)
    Project 4: The L protein of Arenaviridae for drug-design strategy (1 publication)
  • See Antiviral Medicinal Chemistry
  • 06/2000 to 09/2001, Post-Doctoral position, University of Chemistry Barcelone, Spain. Supervisor : Pr E. PEDROSO. European Fellowship. ‘’anthracene conjugates as probes of telomere structure and function’’.

Latest Publications

  1. Saez-Ayala M, Yekwa EL, Carcelli M, Canard B, Alvarez K , Ferron F
    IUCrJ 5 223-235
  2. Pasquier A, Alais S, Roux L, Thoulouze MI, Alvarez K , Journo C, Dutartre H, Mahieux R
    Front Microbiol 9 278
  3. Laux WH, Priet S, Alvarez K , Peyrottes S, Perigaud C
    Antivir Chem Chemother 26 2040206618757636
  4. Benmansour F, Eydoux C, Querat G, de Lamballerie X, Canard B, Alvarez K , Guillemot JC, Barral K
    Eur J Med Chem 109 146-56
  5. Ovadia R, Lebrun A, Barvik I, Vasseur JJ, Baraguey C, Alvarez K
    Org Biomol Chem 13 11052-71

© AFMB UMR7257  W3C validation