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AFMB UMR 7257 Case 932
Campus de Luminy
163 Avenue de Luminy
13288 Marseille CEDEX 09
Fax : +33 491 26 67 20

phone: 491 82 55 70

Viral Replicases : Structure, Mechanism and Drug-Design


Antiviral Medicinal Chemistry


  • 2006, HDR in Chemical Sciences, Univ Aix-Marseille II. "Contribution to the discovery and development of compounds active against viral polymerases".
  • 1999, Ph. D., Organic Chemistry. Laboratory of Bio-Organic Chemistry, Univ Montpellier II. Supervisor : Dr J.-J. VASSEUR. "Prodrugs of oligonucleotides : New nucleobase protecting groups for the solid phase synthesis of prooligonucleotides’’.
  • 1995 D.E.A Biomolecular Chemistry. Laboratory of Bio-Organic Chemistry, Univ Montpellier II (France). ’’New class of nucleobases protecting groups’’.


  • Since 10/2001, CR CNRS, AFMB CNRS-UMR 6098 (Dir. Yves BOURNE).
    Project 1: Find nucleotide analogs to circumvent the resistance of the HIV RT (1 patent, 8 publications)
    Project 2: Development of a chemotherapy against Flaviviruses. (8 publications)
    Project 3: The polymerase NS5B of Hepatitis C as a target for antiviral drugs. (3 publications)
    Project 4: The L protein of Arenaviridae for drug-design strategy (1 publication)
  • 06/2000 to 09/2001, Post-Doctoral position, University of Chemistry Barcelone, Spain. Supervisor : Pr E. PEDROSO. European Fellowship. "Anthracene conjugates as probes of telomere structure and function’’.

Latest Publications

  1. Shannon A, Tuyet Le NT, Selisko B, Eydoux C, Alvarez K , Guillemot JC, Decroly E, Peersen O, Ferron F, Canard B
    Antiviral Res 178 104793
  2. Saez-Ayala M, Laban Yekwa E, Mondielli C, Roux L, Hernandez S, Bailly F, Cotelle P, Rogolino D, Canard B, Ferron F, Alvarez K
    Antiviral Res. 162 79-89
  3. Kamoun J, Rahier R, Sellami M, Koubaa I, Mansuelle P, Lebrun R, Berlioz-Barbier A, Fiore M, Alvarez K , Abousalham A, Carriere F, Aloulou A
    Food Funct 10 469-478
  4. Saez-Ayala M, Yekwa EL, Carcelli M, Canard B, Alvarez K , Ferron F
    IUCrJ 5 223-235
  5. Pasquier A, Alais S, Roux L, Thoulouze MI, Alvarez K , Journo C, Dutartre H, Mahieux R
    Front Microbiol 9 278

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