CNRS - AIX MARSEILLE UNIV: UMR7257

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Karine ALVAREZ

Senior researcher

AFMB UMR 7257 Case 932
Campus de Luminy
163 Avenue de Luminy
13288 Marseille CEDEX 09
Fax : +33 491 26 67 20

phone: 491 82 55 70
Karine.Alvarez afmb.univ-mrs.fr
 

Viral Replicases : Structure, Mechanism and Drug-Design

 

Antiviral Medicinal Chemistry

EDUCATION

  • 2006, HDR in Chemical Sciences, Univ Aix-Marseille II. "Contribution to the discovery and development of compounds active against viral polymerases".
  • 1999, Ph. D., Organic Chemistry. Laboratory of Bio-Organic Chemistry, Univ Montpellier II. Supervisor : Dr J.-J. VASSEUR. "Prodrugs of oligonucleotides : New nucleobase protecting groups for the solid phase synthesis of prooligonucleotides’’.
  • 1995 D.E.A Biomolecular Chemistry. Laboratory of Bio-Organic Chemistry, Univ Montpellier II (France). ’’New class of nucleobases protecting groups’’.

PROFESSIONAL EXPERIENCE

  • Since 10/2001, CR CNRS, AFMB CNRS-UMR 6098 (Dir. Yves BOURNE).
    Project 1: Find nucleotide analogs to circumvent the resistance of the HIV RT (1 patent, 8 publications)
    Project 2: Development of a chemotherapy against Flaviviruses. (8 publications)
    Project 3: The polymerase NS5B of Hepatitis C as a target for antiviral drugs. (3 publications)
    Project 4: The L protein of Arenaviridae for drug-design strategy (1 publication)
  • 06/2000 to 09/2001, Post-Doctoral position, University of Chemistry Barcelone, Spain. Supervisor : Pr E. PEDROSO. European Fellowship. "Anthracene conjugates as probes of telomere structure and function’’.

Latest Publications

  1. A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases (2021)
    Hernandez S, Feracci M, Trajano De Jesus C, El-Kazzi P, Kaci R, Garlatti L, Decroly E, Canard B, Ferron F, Alvarez K
    bioRxiv 2021.04.02.437736
  2. Papageorgiou N, Vaitsopoulou A, Diop A, Nguyen THV, Canard B, Alvarez K , Ferron F
    FEBS Open Bio 11 1076-1083
  3. Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527 (2021)
    Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, Gauffre P, El Kazzi P, Decroly E, Raba N, Alvarez K , Eydoux C, Guillemot JC, Debart F, Vasseur JJ, Noel M, Moussa A, Good S, Lin K, Sommadossi JP, Zhu Y, Yan X, Shi H, Ferron F, Canard B
    bioRxiv 2021.03.23.436564
  4. Papageorgiou N, Vaitsopoulou A, Diop A, Nguyen THV, Canard B, Alvarez K , Ferron F
    FEBS Open Bio 11 1076-1083
  5. Papageorgiou N, Spiliopoulou M, Van Nguyen TH, Vaitsopoulou A, Laban EY, Alvarez K , Margiolaki I, Canard B, Ferron F
    Viruses 12 772

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