Sonia LONGHI

Sonia LONGHI is Director of Research at the Center for the National Scientific Research (CNRS). She is the head of the "Structural Disorder and Molecular Recognition" group within the AFMB laboratory, Marseille. She obtained a PhD in molecular biology from the Universitá degli Studi of Milan in 1993. She got a HDR in structural virology from the University of Aix-Marseille I in 2003. Her scientific focus is on intrinsically disordered proteins (IDPs) and the mechanistic and functional aspects of the interactions they establish with partners. To date, she has authored 103 scientific publications and edited a book on measles virus nucleoprotein. She also co-edited (with Prof. Vladimir Uversky) a book on the experimental approaches to characterize IDPs and a book on structural disorder within viral proteins(Wiley).

Interview on "flexible viruses"

Latest Publications

1. Modulation of Measles Virus NTAIL Interactions through Fuzziness and Sequence Features of Disordered Binding Sites. (2019)
   Bignon C, Troilo F, Gianni S, Longhi S
   Biomolecules 9
2. Understanding the Intramolecular Crosstalk in an Intrinsically Disordered Protein. (2019)
   Troilo F, Bonetti D, Bignon C, Longhi S , Gianni S
   ACS Chem Biol 14 337-341
3. An arsenal of methods for the experimental characterization of intrinsically disordered proteins - How to choose and combine them? (2019)
   Schramm A, Bignon C, Brocca S, Grandori R, Santambrogio C, Longhi S
   Arch Biochem Biophys 108055
4. Regulation of measles virus gene expression by P protein coiled-coil properties. (2019)
   Bloyet LM, Schramm A, Lazert C, Raynal B, Hologne M, Walker O, Longhi S , Gerlier D.
   Sci Adv 5 eaaw3702
5. Probing the dynamic properties of two sites simultaneously in a protein-protein interaction process: a SDSL-EPR study. (2019)
   Le Breton N, Longhi S , Rockenbauer A, Guigliarelli B, Marque SRA, Belle V, Martinho M.
   Phys Chem Chem Phys 21 22584-22588
6. Binding induced folding: Lessons from the kinetics of interaction between NTAIL and XD (2019)
   Toto A, Troilo F, Visconti, Malangrino F, Bignon C, Longhi S and Gianni S.
   Arch Biochem Biophys. 671 255-261
7. Partner-Mediated Polymorphism of an Intrinsically Disordered Protein. (2018)
   Bignon C, Troilo F, Gianni S, Longhi S
   J Mol Biol 430 2493-2507
8. Experimental Characterization of Fuzzy Protein Assemblies: Interactions of Paramyxoviral NTAIL Domains With Their Functional Partners. (2018)
   Troilo F, Bignon C, Gianni S, Fuxreiter M, Longhi S
   Methods Enzymol 611 137-192
9. Conformational footprinting of proteins using a combination of top-down electron transfer dissociation and ion mobility. (2018)
   Konijnenberg A, Li J, Habchi J, Dosnon M, Rossetti G, Grandori R, Longhi S , Carloni P and Sobott F.
   BioRxiv
10. Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity. (2018)
    Salladini E, Debarnot C, Delauzun V, Murrali MG, Sutto-Ortiz P, Spinelli S, Pierattelli R, Bignon C, Longhi S .
    BioRxiv