Sonia LONGHI

Sonia LONGHI is Director of Research at the Center for the National Scientific Research (CNRS). Since 2005 she is the head of the "Structural Disorder and Molecular Recognition" group within the AFMB laboratory, Marseille. She obtained a PhD in molecular biology from the Universitá degli Studi of Milan in 1993. She got a HDR in structural virology from the University of Aix-Marseille I in 2003. Her scientific focus is on health relevant intrinsically disordered proteins (IDPs) and the mechanistic and functional aspects of the interactions they establish with partners. To date, she has authored 137 scientific publications and edited a book on measles virus nucleoprotein. She also co-edited (with Prof. Vladimir Uversky) a book on the experimental approaches to characterize IDPs and a book on structural disorder within viral proteins(Wiley).

Interview on "flexible viruses"

Latest Publications

1. Identification of a Region in the Common Amino-terminal Domain of Hendra Virus P, V, and W Proteins Responsible for Phase Transition and Amyloid Formation (2021)
   Salladini E, Gondelaud F, Nilsson JF, Pesce G, Bignon C, Murrali MG, Fabre R, Pierattelli R, Kajava AV, Horvat B, Gerlier D, Mathieu C, Longhi S
   Biomolecules 11(9) 1324
2. Insights into the evolutionary forces that shape the codon usage in the viral genome segments encoding intrinsically disordered protein regions. (2021)
   Kumar N, Kaushik R, Tennakoon C, Uversky VN, Longhi S , Zhang KYJ, Bhatia S
   Brief Bioinform in press
3. Comprehensive Intrinsic Disorder Analysis of 6108 Viral Proteomes: From the Extent of Intrinsic Disorder Penetrance to Functional Annotation of Disordered Viral Proteins (2021)
   Kumar N, Kaushik R, Tennakoon C, Uversky VN, Longhi S , Zhang KYJ, Bhatia S
   J Prot Res 20 2704-2713
4. Structural and Functional Characterization of the ABA-Water Deficit Stress Domain from Wheat and Barley: An Intrinsically Disordered Domain behind the Versatile Functions of the Plant Abscissic Acid, Stress and Ripening Protein Family (2021)
   Yacoubi I, Hamdi K, Fourquet P, Bignon C, Longhi S
   Int J Mol Sci 22 2314
5. Structural and dynamics analysis of intrinsically disordered proteins by high-speed atomic force microscopy. (2021)
   Kodera N, Noshiro D, Dora SK, Mori T, Habchi J, Blocquel D, Gruet A, Dosnon M, Salladini E, Bignon C, Fujioka Y, Oda T, Noda NN, Sato M, Lotti M, Mizuguchi M, Longhi S , Ando T
   Nat Nanotechnol 16 181-189
6. Liquid-Liquid Phase Separation by Intrinsically Disordered Protein Regions of Viruses: Roles in Viral Life Cycle and Control of Virus Host Interactions (2020)
   Brocca S, Grandori R, Longhi S , Uversky V
   Int J Mol Sci 21 9045
7. Ensemble description of the intrinsically disordered N-terminal domain of the Nipah virus P/V protein from combined NMR and SAXS (2020)
   Schiavina M, Salladini E, Murrali MG, Tria G, Felli I, Pierattelli R, Longhi S
   Sci Rep 10 19574
8. PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins (2020)
   Lazar T, Martinez-Perez E, Quaglia F, Hatos A, Chemes LB, Iserte JA, Mendez NA, Garrone NA, Saldano TE, Marchetti J, Velez Rueda AJ, Bernado P, Blackledge M, Cordeiro TN, Fagerberg E, Forman-Kay JD, Fornasari MS, Gibson TJ, Gomes GNW, Gradinaru CC, Head-Gordon T, Jensen M, Lemke EA, Longhi S , Marino-Buslje C, Minervini G, Mittag T, Monzon AM, Pappu RV, Parisi G, Ricard-Blum S, Ruff KM, Salladini E, Skepo M, Svergun D, Vallet SD, Varadi M, Tompa P, Tosatto SCE, Piovesan D
   Nucleic Acids Res 49(D1) D404-D411
9. Predicting substitutions to modulate disorder and stability in coiled-coils (2020)
   Karami Y, Saighi P, Vanderhaegen R, Gerlier D, Longhi S , Laine E, Carbone A
   BMC Bioinformatics 21(Suppl 19) 573
10. Relevance of Electrostatic Charges in Compactness, Aggregation, and Phase Separation of Intrinsically Disordered Proteins (2020)
    Bianchi G, Longhi S , Grandori R, Brocca S
    Int J Mol Sci 21 E6208