Service : Cristallogenèse et cristallographie

Correspondante Culture scientifique

Publications

2021

2021
Carnitine is a pharmacological allosteric chaperone of the human lysosomal α -glucosidase

Roberta Iacono, Nadia Minopoli, Maria Carmina Ferrara, Antonietta Tarallo, Carla Damiano, Caterina Porto, Sandra Strollo, Véronique Roig-Zamboni, Gianfranco Peluso, Gerlind Sulzenbacher, Beatrice Cobucci-Ponzano, Giancarlo Parenti, Marco Moracci

Journal of Enzyme Inhibition and Medicinal Chemistry 36:2068-2079 (2021)10.1080/14756366.2021.1975694

2020

2020
Snapshots of ADp-ribose bound to Getah virus macro domain reveal an intriguing choreography

Ana Ferreira-Ramos, Gerlind Sulzenbacher, Bruno Canard, Bruno Coutard

Scientific Reports 10 (2020)10.1038/s41598-020-70870-w

2018

2018
Lytic xylan oxidases from wood-decay fungi unlock biomass degradation

Marie Couturier, Simon Ladeveze, Gerlind Sulzenbacher, Luisa Ciano, Mathieu Fanuel, Céline Moreau, Ana Villares, Bernard Cathala, Florence Chaspoul, Kristian Frandsen, Aurore Labourel, Isabelle Herpoël-Gimbert, Sacha Grisel, Mireille Haon, Nicolas Lenfant, Hélène Rogniaux, David Ropartz, Gideon Davies, Marie-Noelle Rosso, Paul Walton, Bernard Henrissat, Jean-Guy Berrin

Nature Chemical Biology 14:306-310 (2018)10.1038/nchembio.2558

2018
Glycosylate and move! The glycosyltransferase Maf is involved in bacterial flagella formation

Gerlind Sulzenbacher, Veronique Roig-Zamboni, Régine Lebrun, Yann Guérardel, Dorothée Murat, Pascal Mansuelle, Nao Yamakawa, Xin-Xin Qian, Renaud Vincentelli, Yves Bourne, Long-Fei Wu, François Alberto

Environmental Microbiology 20:228-240 (2018)10.1111/1462-2920.13975

2018
Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes

Wade Abbott, Orly Alber, Ed Bayer, Jean-Guy Berrin, Alisdair Boraston, Harry Brumer, Ryszard Brzezinski, Anthony Clarke, Beatrice Cobucci-Ponzano, Darrell Cockburn, Pedro Coutinho, Mirjam Czjzek, Bareket Dassa, Gideon John Davies, Vincent Eijsink, Jens Eklof, Alfons Felice, Elizabeth Ficko-Blean, Geoff Pincher, Thierry Fontaine, Zui Fujimoto, Kiyotaka Fujita, Shinya Fushinobu, Harry Gilbert, Tracey Gloster, Ethan Goddard-Borger, Ian Greig, Jan-Hendrik Hehemann, Glyn Hemsworth, Bernard Henrissat, Masafumi Hidaka, Ramon Hurtado-Guerrero, Kiyohiko Igarashi, Takuya Ishida, Stefan Janecek, Seino Jongkees, Nathalie Juge, Satoshi Kaneko, Takane Katayama, Motomitsu Kitaoka, Naotake Konno, Daniel Kracher, Anna Kulminskaya, Alicia Lammerts van Bueren, Sine Larsen, Junho Lee, Markus Linder, Leila Loleggio, Roland Ludwig, Ana Luis, Mirko Maksimainen, Brian Mark, Richard Mclean, Gurvan Michel, Cédric Montanier, Marco Moracci, Haruhide Mori, Hiroyuki Nakai, Wim Nerinckx, Takayuki Ohnuma, Richard Pickersgill, Kathleen Piens, Tirso Pons, Etienne Rebuffet, Peter Reilly, Magali Remaud Simeon, Brian Rempel, Kyle Robinson, David Rose, Juha Rouvinen, Wataru Saburi, Yuichi Sakamoto, Mats Sandgren, Fathima Shaikh, Yuval Shoham, Franz St John, Jerry Stahlberg, Michael Suits, Gerlind Sulzenbacher, Tomomi Sumida, Ryuichiro Suzuki, Birte Svensson, Toki Taira, Ed Taylor, Takashi Tonozuka, Breeanna Urbanowicz, Gustav Vaaje-Kolstad, Wim van den Ende, Annabelle Varrot, Maxime Versluys, Florence Vincent, David Vocadlo, Warren Wakarchuk, Tom Wennekes, Rohan Williams, Spencer Williams, David Wilson, Stephen Withers, Katsuro Yaoi, Vivian Yip, Ran Zhang

Glycobiology 28:3-8 (2018)10.1093/glycob/cwx089

2017

2017
Structure of human lysosomal acid α-glucosidase-a guide for the treatment of Pompe disease

Véronique Roig-Zamboni, Beatrice Cobucci-Ponzano, Roberta Iacono, Maria Ferrara, Stanley Germany, Yves Bourne, Giancarlo Parenti, Marco Moracci, Gerlind Sulzenbacher

Nature Communications (2017)10.1038/s41467-017-01263-3

2017
Structure of human lysosomal acid α-glucosidase–a guide for the treatment of Pompe disease

Veronique Roig-Zamboni, Beatrice Cobucci-Ponzano, Roberta Iacono, Maria Carmina Ferrara, Stanley Germany, Yves Bourne, Giancarlo Parenti, Marco Moracci, Gerlind Sulzenbacher

Nature Communications 8:1111 (2017)10.1038/s41467-017-01263-3

2016

2016
The Quaternary Structure of a Glycoside Hydrolase Dictates Specificity toward β-Glucans

Mickael Lafond, Gerlind Sulzenbacher, Thibaud Freyd, Bernard Henrissat, Jean-Guy Berrin, Marie-Line Garron

Journal of Biological Chemistry 291:7183-7194 (2016)10.1074/jbc.M115.695999

2015

2015
Marine Macrocyclic Imines, Pinnatoxins A and G: Structural Determinants and Functional Properties to Distinguish Neuronal α7 from Muscle α12βγδ nAChRs.

Yves Bourne, Gerlind Sulzenbacher, Zoran Radić, Rómulo Aráoz, Morgane Reynaud, Evelyne Benoit, Armen Zakarian, Denis Servent, Jordi Molgó, Palmer Taylor, P. Marchot

Structure (London, England : 1993) 23:1106-15 (2015)10.1016/j.str.2015.04.009

2015
Structural basis for carbohydrate binding properties of a plant chitinase-like agglutinin with conserved catalytic machinery

Gerlind Sulzenbacher, Veronique Roig-Zamboni, Willy J. Peumans, Bernard Henrissat, Els J. M. Damme, Yves Bourne

Journal of Structural Biology 190:115-121 (2015)10.1016/j.jsb.2015.01.013

2014

2014
Functional characterization of a vacuolar invertase from Solanum lycopersicum: Post-translational regulation by N-glycosylation and a proteinaceous inhibitor

Alexandra Tauzin, Gerlind Sulzenbacher, Mickael Lafond, Véronique Desseaux, Ida Reca, Josette Perrier, Daniela Bellincampi, Patrick Fourquet, Christian Lévêque, Thierry Giardina

Biochimie (2014)10.1016/j.biochi.2013.12.013

2012

2012
Exploitation of β -glycosyl azides for the preparation of α -glycosynthases

Beatrice Cobucci-Ponzano, Carmela Zorzetti, Andrea Strazzulli, Emiliano Bedini, Maria Corsaro, Gerlind Sulzenbacher, Mos Rossi, Marco Moracci

Biocatalysis and Biotransformation (2012)10.3109/10242422.2012.679814

2011

2011
α-Galactosidase/Sucrose Kinase (AgaSK), a Novel Bifunctional Enzyme from the Human Microbiome Coupling Galactosidase and Kinase Activities

Laëtitia Bruel, Gerlind Sulzenbacher, Marine Tison, Ange Pujol, Cendrine Nicoletti, Josette Perrier, Anne Galinier, David Ropartz, Michel Fons, Frederique Pompeo, Thierry Giardina

Journal of Biological Chemistry 286:40814-40823 (2011)10.1074/jbc.M111.286039

2010

2010
Crystal Structure of the GalNAc/Gal-Specific Agglutinin from the Phytopathogenic Ascomycete Sclerotinia sclerotiorum Reveals Novel Adaptation of a β-Trefoil Domain

Gerlind Sulzenbacher, Véronique Roig-Zamboni, Willy Peumans, Pierre Rougé, Els van Damme, Yves Bourne

Journal of Molecular Biology 400:715-723 (2010)10.1016/j.jmb.2010.05.038

2010
A novel α-N-acetylgalactosaminidase family with an NAD+-dependent catalytic mechanism suitable for enzymatic removal of blood group A antigens

Gerlind Sulzenbacher, Qiyong Liu, Eric Bennett, Steven Levery, Yves Bourne, Guillaume Ponchel, Henrik Clausen, Bernard Henrissat

Biocatalysis and Biotransformation 28:22-32 (2010)10.3109/10242420903424259

2009

2009
b-Glycosyl Azides as Substrates for a-Glycosynthases: Preparation of Efficient a-L-Fucosynthases

Beatrice Cobucci-Ponzano, Fiorella Conte, Emiliano Bedini, Maria Corsaro, Michelangelo Parrilli, Gerlind Sulzenbacher, Alexandra Lipski, Dal Fabrizio, Laura Lepore, Mosè Rossi, Marco Moracci

Chemistry and Biology (2009)10.1016/j.chembiol.2009.09.013

2009
Structural determinants for interaction of partial agonists with acetylcholine binding protein and neuronal α7 nicotinic acetylcholine receptor

Ryan Hibbs, Gerlind Sulzenbacher, Jianxin Shi, Todd Talley, Sandrine Conrod, William Kem, Palmer Taylor, P. Marchot, Yves Bourne

EMBO Journal 28:3040-3051 (2009)10.1038/emboj.2009.227

2008

2008
Glycosyltransferases, glycoside hydrolases: surprise, surprise!

Bernard Henrissat, Gerlind Sulzenbacher, Yves Bourne

Current Opinion in Structural Biology (2008)10.1016/j.sbi.2008.09.003

2008
Glycosyltransferases, glycoside hydrolases: surprise, surprise!

Bernard Henrissat, Gerlind Sulzenbacher, Yves Bourne

Current Opinion in Structural Biology 18:527-533 (2008)10.1016/j.sbi.2008.09.003

2008
Identification of a GH110 Subfamily of ␣1,3-Galactosidases: NOVEL ENZYMES FOR REMOVAL OF THE ␣3GAL XENOTRANSPLANTATION ANTIGEN

Qiyong Liu, Huaiping Yuan, Eric Bennett, Steven Levery, Edward Nudelman, Jean Spence, Greg Pietz, Kristen Saunders, Thayer White, Martin Olsson, Bernard Henrissat, Gerlind Sulzenbacher, Henrik Clausen

Journal of Biological Chemistry 283:8545-8554 (2008)10.1074/jbc.M709020200

2007

2007
Structural Analysis of the Synaptic Protein Neuroligin and Its β-Neurexin Complex: Determinants for Folding and Cell Adhesion

Igor Fabrichny, Philippe Leone, Gerlind Sulzenbacher, Davide Comoletti, Meghan Miller, Palmer Taylor, Yves Bourne, P. Marchot

Neuron 56:979-991 (2007)10.1016/j.neuron.2007.11.013

2007
Des glycosidases bactériennes pour du sang universel

Gerlind Sulzenbacher, Yves Bourne, Bernard Henrissat

médecine/sciences (2007)10.1051/medsci/20072389703

2007
Crystal Structure of the RNA Polymerase Domain of the West Nile Virus Non-structural Protein 5

Hélène Malet, Marie-Pierre Egloff, Barbara Selisko, Rebecca Butcher, Peter Wright, Michael Roberts, Arnaud Gruez, Gerlind Sulzenbacher, Clemens Vonrhein, Gérard Bricogne, Jason Mackenzie, Alexander Khromykh, Andrew Davidson, Bruno Canard

Journal of Biological Chemistry (2007)10.1074/jbc.M607273200

2007
Bacterial glycosidases for the production of universal red blood cells

Qiyong Liu, Gerlind Sulzenbacher, Huaiping Yuan, Eric Bennett, Greg Pietz, Kristen Saunders, Jean Spence, Edward Nudelman, Steven Levery, Thayer White, John Neveu, William Lane, Yves Bourne, Martin Olsson, Bernard Henrissat, Henrik Clausen

Nature Biotechnology (2007)10.1038/nbt1298

2006

2006
Substrate and product trafficking through the active center gorge of acetylcholinesterase analyzed by crystallography and equilibrium binding.

Yves Bourne, Zoran Radic, Gerlind Sulzenbacher, Esther Kim, Palmer Taylor, P. Marchot

Journal of Biological Chemistry 281:29256-67 (2006)10.1074/jbc.M603018200

2006
LppX is a lipoprotein required for the translocation of phthiocerol dimycocerosates to the surface of Mycobacterium tuberculosis

Gerlind Sulzenbacher, Stéphane Canaan, Yann Bordat, Olivier Neyrolles, Gustavo Stadthagen, Véronique Roig-Zamboni, Jean Rauzier, Damien Maurin, Françoise Laval, Mamadou Daffé, Christian Cambillau, Brigitte Gicquel, Yves Bourne, Mary Jackson

EMBO Journal (2006)10.1038/sj.emboj.7601048

2006
Respective importance of protein folding and glycosylation in the thermal stability of recombinant feruloyl esterase A

Isabelle Benoit, Michèle Asther, Gerlind Sulzenbacher, Eric Record, Laurence Marmuse, Goetz Parsiegla, Isabelle Gimbert, Marcel Asther, Christophe Bignon

FEBS Letters 580:5815-5821 (2006)10.1016/j.febslet.2006.09.039

2006
Structural characterization of agonist and antagonist-bound acetylcholine-binding protein from Aplysia californica.

Scott B Hansen, Gerlind Sulzenbacher, Tom Huxford, P. Marchot, Yves Bourne, Palmer Taylor

Journal of Molecular Neuroscience 30:101-2 (2006)

2006
Structural comparison of three crystalline complexes of a peptidic toxin with a synaptic acetylcholine recognition protein.

Yves Bourne, Scott B Hansen, Gerlind Sulzenbacher, Todd T Talley, Tom Huxford, Palmer Taylor, P. Marchot

Journal of Molecular Neuroscience 30:103-4 (2006)

2005

2005
Crystal structure of the conserved hypothetical protein Rv1155 from Mycobacterium tuberculosis

Stéphane Canaan, Gerlind Sulzenbacher, Véronique Roig-Zamboni, Loréna Scappuccini-Calvo, Frédéric Frassinetti, Damien Maurin, Christian Cambillau, Yves Bourne, Christian Griesinger

FEBS Letters (2005)10.1016/j.febslet.2004.11.069

2005
Structures of Aplysia AChBP complexes with nicotinic agonists and antagonists reveal distinctive binding interfaces and conformations

Scott Hansen, Gerlind Sulzenbacher, Tom Huxford, P. Marchot, Palmer Taylor, Yves Bourne

EMBO Journal 24:3635-3646 (2005)10.1038/sj.emboj.7600828

2004

2004
Structure of Escherichia coli YhdH, a putative quinone oxidoreductase

Gerlind Sulzenbacher, Véronique Roig-Zamboni, Fabienne Pagot, Sacha Grisel, Aurelia Salomoni, Christel Valencia, Valérie Campanacci, Renaud Vincentelli, Mariella Tegoni, Hans Eklund, Christian Cambillau

Acta crystallographica Section D : Structural biology [1993-...] (2004)10.1107/S0907444904020220

2004
The Three-dimensional Structure of Invertase (β-Fructosidase) from Thermotoga maritima Reveals a Bimodular Arrangement and an Evolutionary Relationship between Retaining and Inverting Glycosidases

Francois Alberto, Christophe Bignon, Gerlind Sulzenbacher, Bernard Henrissat, Mirjam Czjzek

Journal of Biological Chemistry 279:18903-18910 (2004)10.1074/jbc.M313911200

2004
Crystal Structure of Thermotoga maritima ␣-L-Fucosidase INSIGHTS INTO THE CATALYTIC MECHANISM AND THE MOLECULAR BASIS FOR FUCOSIDOSIS

Gerlind Sulzenbacher, Christophe Bignon, Takeshi Nishimura, Chris Tarling, Stephen Withers, Bernard Henrissat, Yves Bourne

Journal of Biological Chemistry (2004)10.1074/jbc.M313783200

2004
Crystal Structure of E. coli Alcohol Dehydrogenase YqhD: Evidence of a Covalently Modified NADP Coenzyme

Gerlind Sulzenbacher, Karine Alvarez, Robert van den Heuvel, Cees Versluis, Silvia Spinelli, Valé Rie Campanacci, Christel Valencia, Christian Cambillau, Hans Eklund, Mariella Tegoni

Journal of Molecular Biology 342:489-502 (2004)10.1016/j.jmb.2004.07.034

2004
Crystal Structure of E. coli YddE Protein Reveals a Striking Homology With Diaminopimelate Epimerase

Alice Grassick, Gerlind Sulzenbacher, Véronique Roig-Zamboni, Valérie Campanacci, Christian Cambillau, Yves Bourne

Proteins - Structure, Function and Bioinformatics 55:764-767 (2004)10.1002/prot.20025

2003

2003
Identification of the Catalytic Nucleophile of the Family 29 α-L-Fucosidase from Thermotoga maritima through Trapping of a Covalent Glycosyl-Enzyme Intermediate and Mutagenesis

Chris Tarling, Shouming He, Gerlind Sulzenbacher, Christophe Bignon, Yves Bourne, Bernard Henrissat, Stephen Withers

Journal of Biological Chemistry (2003)10.1074/jbc.M306610200

2003
Medium-Scale Structural Genomics: Strategies for Protein Expression and Crystallization

Renaud Vincentelli, Christophe Bignon, Arnaud Gruez, Stéphane Canaan, Gerlind Sulzenbacher, Mariella Tegoni, Rie Campanacci, Christian Cambillau

Accounts of Chemical Research (2003)10.1021/ar010130s

2002

2002
A medium-throughput crystallization approach

Gerlind Sulzenbacher, Arnaud Gruez, Véronique Roig-Zamboni, Silvia Spinelli, Christel Valencia, Fabienne Pagot, Renaud Vincentelli, Christophe Bignon, Aurelia Salomoni, Sacha Grisel, Damien Maurin, Céline Huyghe, Kent Johansson, Alice Grassick, Alain Roussel, Yves Bourne, Sophie Perrier, Linda Miallau, Phillippe Cantau, Eric Blanc, Michel Genevois, Alain Grossi, André Zenatti, Valérie Campanacci, Christian Cambillau

Acta crystallographica Section D : Structural biology [1993-...] 58:2109-2115 (2002)10.1107/s0907444902013938

2001

2001
Crystal Structure of Streptococcus pneumoniae N -Acetylglucosamine-1-phosphate Uridyltransferase Bound to Acetyl-coenzyme A Reveals a Novel Active Site Architecture

Gerlind Sulzenbacher, Laurent Gal, Caroline Peneff, Florence Fassy, Yves Bourne

Journal of Biological Chemistry 276:11844-11851 (2001)10.1074/jbc.M011225200

1999

1999
Catalysis and specificity in enzymatic glycoside hydrolysis: a 2,5B conformation for the glycosyl-enzyme intermediate revealed by the structure of the Bacillus agaradhaerens family 11 xylanase

Elisabetta Sabini, Gerlind Sulzenbacher, Miroslava Dauter, Zbigniew Dauter, Per LinÅ Jørgensen, Martin Schülein, Claude Dupont, Gideon Davies, Keith Wilson

Chemistry and Biology 6:483-492 (1999)10.1016/s1074-5521(99)80066-0

1999
The Crystal Structure of a 2-Fluorocellotriosyl Complex of the Streptomyces lividans Endoglucanase CelB2 at 1.2 Å Resolution

Gerlind Sulzenbacher, Lloyd Mackenzie, Keith Wilson, Stephen Withers, Claude Dupont, Gideon Davies

Biochemistry 38:4826-4833 (1999)10.1021/bi982648i

1998

1998
Crystal structure of the family 7 endoglucanase I (Cel7B) from Humicola insolens at 2.2 Å resolution and identification of the catalytic nucleophile by trapping of the covalent glycosyl-enzyme intermediate

Lloyd Mackenzie, Gerlind Sulzenbacher, Christina Divne, T. Alwyn Jones, Helle WÖldike, Martin Schülein, Stephen Withers, Gideon Davies

Biochemical Journal 335:409-416 (1998)10.1042/bj3350409

1997

1997
The Streptomyces lividans Family 12 Endoglucanase: Construction of the Catalytic Core, Expression, and X-ray Structure at 1.75 Å Resolution

Gerlind Sulzenbacher, François Shareck, Rolf Morosoli, Claude Dupont, Gideon Davies

Biochemistry 36:16032-16039 (1997)10.1021/bi972407v

1993

1993
Structural versatility of peptides from C α, α -disubstituted glycines: Crystal-state conformational analysis of homopeptides from C α -methyl, C α -benzylglycine [(αMe)Phe] n

Giovanni Valle, Monica Pantano, Fernando Formaggio, Marco Crisma, Claudio Toniolo, Gilles Précigoux, Gerlind Sulzenbacher, Wilhelmus Boesten, Quirinus Broxterman, Hans Schoemaker, Johan Kamphuis

Biopolymers 33:1617-1625 (1993)10.1002/bip.360331011