Publications

2023

2023
Structural basis of Ty1 integrase tethering to RNA polymerase III for targeted retrotransposon integration

Phong Quoc Nguyen, Sonia Huecas, Amna Asif-Laidin, Adrián Plaza-Pegueroles, Beatrice Capuzzi, Noé Palmic, Christine Conesa, Joël Acker, Juan Reguera, Pascale Lesage, Carlos Fernández-Tornero

Nature Communications 14:1729 (2023)10.1038/s41467-023-37109-4

2023
Structures of active Hantaan virus polymerase uncover the mechanisms of Hantaviridae genome replication

Quentin Durieux Trouilleton, Sergio Barata-García, Benoît Arragain, Juan Reguera, Hélène Malet

Nature Communications 14:2954 (2023)10.1038/s41467-023-38555-w

2023
Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores

Rhian Jones, Michael Hons, Nadia Rabah, Noelia Zamarreño, Rocío Arranz, Juan Reguera

Proceedings of the National Academy of Sciences of the United States of America 120 (2023)10.1073/pnas.2213934120

2023
Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores

Rhian Jones, Michael Hons, Nadia Rabah, Noelia Zamarreño, Rocío Arranz, Juan Reguera

Proceedings of the National Academy of Sciences of the United States of America 120 (2023)10.1073/pnas.2213934120

2021

2021
Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity $in\ vitro$

Phong Quoc Nguyen, Christine Conesa, Elise Rabut, Gabriel Bragagnolo, Célia Gouzerh, Carlos Fernández-Tornero, Pascale Lesage, Juan Reguera, Joël Acker

Journal of Biological Chemistry 297:101093 (2021)10.1016/j.jbc.2021.101093

2021
Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors

Kristina Kovacikova, Marina Gorostiola González, Rhian Jones, Juan Reguera, Alba Gigante, María-Jesús Pérez-Pérez, Gerhard Pürstinger, Julia Moesslacher, Thierry Langer, Lak Shin Jeong, Leen Delang, Johan Neyts, Eric Snijder, Gerard van Westen, Martijn van Hemert

Antimicrobial Agents and Chemotherapy 65 (2021)10.1128/AAC.02566-20

2020

2020
Capping pores of alphavirus nsP1 gate membranous viral replication factories

Rhian Jones, Gabriel Bragagnolo, Rocío Arranz, Juan Reguera

Nature 589:615-619 (2020)10.1038/s41586-020-3036-8

2020
Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes

Benoît Arragain, Grégory Effantin, Piotr Gerlach, Juan Reguera, Guy Schoehn, Stephen Cusack, Hélène Malet

Nature Communications 11:3590 (2020)10.1038/s41467-020-17349-4

2019

2019
High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms

Benoît Arragain, Juan Reguera, Ambroise Desfosses, Irina Gutsche, Guy Schoehn, Hélène Malet

eLife 8 (2019)10.7554/eLife.43075

2019
Structure and function of the Toscana virus cap-snatching endonuclease

Rhian Jones, Sana Lessoued, Kristina Meier, Stéphanie Devignot, Sergio Barata-García, Maria Mate, Gabriel Bragagnolo, Friedemann Weber, Maria Rosenthal, Juan Reguera

Nucleic Acids Research 47:10914-10930 (2019)10.1093/nar/gkz838

2017

2017
Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins

Francois Ferron, Friedemann Weber, Juan de La Torre, Juan Reguera

Virus Research 234:118-134 (2017)10.1016/j.virusres.2017.01.018

2015

2015
Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter

Piotr Gerlach, Hélène Malet, Stephen Cusack, Juan Reguera

Cell 161:1267-1279 (2015)10.1016/j.cell.2015.05.006