Publications

2021

2021
Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity in vitro

Phong Quoc Nguyen, Christine Conesa, Elise Rabut, Gabriel Bragagnolo, Célia Gouzerh, Carlos Fernández-Tornero, Pascale Lesage, Juan Reguera, Joël Acker

Journal of Biological Chemistry 297:101093 (2021)10.1016/j.jbc.2021.101093

2021
Ty1 integrase is composed of an active N-terminal domain and a large disordered C-terminal module dispensable for its activity $in\ vitro$

Phong Quoc Nguyen, Christine Conesa, Elise Rabut, Gabriel Bragagnolo, Célia Gouzerh, Carlos Fernández-Tornero, Pascale Lesage, Juan Reguera, Joël Acker

Journal of Biological Chemistry 297:101093 (2021)10.1016/j.jbc.2021.101093

2021
Structural Insights into the Mechanisms of Action of Functionally Distinct Classes of Chikungunya Virus Nonstructural Protein 1 Inhibitors

Kristina Kovacikova, Marina Gorostiola González, Rhian Jones, Juan Reguera, Alba Gigante, María-Jesús Pérez-Pérez, Gerhard Pürstinger, Julia Moesslacher, Thierry Langer, Lak Shin Jeong, Leen Delang, Johan Neyts, Eric Snijder, Gerard van Westen, Martijn van Hemert

Antimicrobial Agents and Chemotherapy 65 (2021)10.1128/AAC.02566-20

2020

2020
Capping pores of alphavirus nsP1 gate membranous viral replication factories

Rhian Jones, Gabriel Bragagnolo, Rocío Arranz, Juan Reguera

Nature 589:615-619 (2020)10.1038/s41586-020-3036-8

2020
Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes

Benoît Arragain, Grégory Effantin, Piotr Gerlach, Juan Reguera, Guy Schoehn, Stephen Cusack, Hélène Malet

Nature Communications 11:3590 (2020)10.1038/s41467-020-17349-4

2019

2019
High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms

Benoît Arragain, Juan Reguera, Ambroise Desfosses, Irina Gutsche, Guy Schoehn, Hélène Malet

eLife 8 (2019)10.7554/eLife.43075

2019
Structure and function of the Toscana virus cap-snatching endonuclease

Rhian Jones, Sana Lessoued, Kristina Meier, Stéphanie Devignot, Sergio Barata-García, Maria Mate, Gabriel Bragagnolo, Friedemann Weber, Maria Rosenthal, Juan Reguera

Nucleic Acids Research 47:10914-10930 (2019)10.1093/nar/gkz838

2017

2017
Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins

Francois Ferron, Friedemann Weber, Juan de la Torre, Juan Reguera

Virus Research 234:118-134 (2017)10.1016/j.virusres.2017.01.018

2015

2015
Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter

Piotr Gerlach, Hélène Malet, Stephen Cusack, Juan Reguera

Cell 161:1267-1279 (2015)10.1016/j.cell.2015.05.006