Priscila El-Kazzi
Post-doctorante
Équipe : Complexes Macromoléculaires Viraux
Prix de thèse ANRS 2023 (Plus d’infos ici) :
Lauréate de la médaille d’argent 2020 de la Fondation « Méditerranée Infection » pour son travail de thèse!
Publications
2024
A specific domain within the 3′ untranslated region of Usutu virus confers resistance to the exonuclease ISG20
Jim Zoladek, Priscila El Kazzi, Vincent Caval, Valérie Vivet-Boudou, Marion Cannac, Emma Davies, Soléna Rossi, Inès Bribes, Lucile Rouilly, Yannick Simonin, Nolwenn Jouvenet, Etienne Decroly, Jean-Christophe Paillart, Sam J Wilson, Sébastien Nisole
Nature Communications 15:8528 (2024)10.1038/s41467-024-52870-w
Effets de la 2′-O-méthylation de l’ARN génomique du VIH-1 sur la réplication virale
Alice Decombe, Priscila El-Kazzi, Sébastien Nisole, Étienne Decroly
Médecine/Sciences 40:421-427 (2024)10.1051/medsci/2024046
2023
ADDovenom: Thermostable Protein-Based ADDomer Nanoparticles as New Therapeutics for Snakebite Envenoming
Stefanie Menzies, Raquel Arinto-Garcia, Fernanda Gobbi Amorim, Iara Aimê Cardoso, Camille Abada, Thomas Crasset, Fabien Durbesson, Rebecca Edge, Priscila El-Kazzi, Sophie Hall, Damien Redureau, Richard Stenner, Johara Boldrini-França, Huan Sun, António Roldão, Paula Alves, Robert Harrison, Renaud Vincentelli, Imre Berger, Loïc Quinton, Nicholas Casewell, Christiane Schaffitzel
Toxins 15:673 (2023)10.3390/toxins15120673
Protéine 2C d’Entérovirus : protéine clé de la réplication virale et cible antivirale
Priscila El Kazzi, Carole Yaacoub, Ziad Fajloun, Patrice Vanelle, Etienne Decroly, Bruno Coutard, Karine Barral
Virologie 27:173-188 (2023)10.1684/vir.2023.1001
Interplay of RNA 2′-O-methylations with viral replication
Alice Decombe, Priscila El Kazzi, Etienne Decroly
Current Opinion in Virology 59:101302 (2023)10.1016/j.coviro.2023.101302
2C protein of Enterovirus: key protein of viral replication and antiviral target
Priscila El Kazzi, Carole Yaacoub, Ziad Fajloun, Patrice Vanelle, Etienne Decroly, Bruno Coutard, Karine Barral
Virologie 27:35-49 (2023)10.1684/vir.2023.1002
2022
Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect
Priscila El Kazzi, Nadia Rabah, Célia Chamontin, Lina Poulain, François Ferron, Françoise Debart, Bruno Canard, Dorothée Missé, Bruno Coutard, Sébastien Nisole, Etienne Decroly
Nucleic Acids Research (2022)10.1093/nar/gkac996
Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay
Sergio Hernández, Mikael Feracci, Carolina Trajano de Jesus, Priscila El Kazzi, Rafik Kaci, Laura Garlatti, Clemence Mondielli, Fabrice Bailly, Philippe Cotelle, Franck Touret, Xavier de Lamballerie, Bruno Coutard, Etienne Decroly, Bruno Canard, François Ferron, Karine Alvarez
Antiviral Research 204:105364 (2022)10.1016/j.antiviral.2022.105364
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, Francois Ferron, Bruno Canard
Nature Communications 13 (2022)10.1038/s41467-022-28113-1
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex
Daniel L Hurdiss, Priscila El Kazzi, Lisa Bauer, Nicolas Papageorgiou, Francois Ferron, Tim Donselaar, Arno L.W. van Vliet, Tatiana M Shamorkina, Joost Snijder, Bruno Canard, Etienne Decroly, Andrea Brancale, Tzviya Zeev-Ben-Mordehai, Friedrich Förster, Frank J.M. van Kuppeveld, Bruno Coutard
Science Advances 8 (2022)10.1126/sciadv.abj7615
2021
Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication
Natacha S Ogando, Priscila El Kazzi, Jessika C Zevenhoven-Dobbe, Brenda W Bontes, Alice Decombe, Clara C S Posthuma, Volker Thiel, Bruno Canard, Francois Ferron, Etienne Decroly, Eric J Snijder
Proceedings of the National Academy of Sciences of the United States of America (2021)10.1101/2021.05.17.444407
2019
Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner
Lisa Bauer, Roberto Manganaro, Birgit Zonsics, Jeroen Strating, Priscila El Kazzi, Moira Lorenzo Lopez, Rachel Ulferts, Clara van Hoey, Maria Mate, Thierry Langer, Bruno Coutard, Andrea Brancale, Frank van Kuppeveld
ACS Infectious Diseases 5:1609-1623 (2019)10.1021/acsinfecdis.9b00179
