2022

2022
Gut microbiome of the largest living rodent harbors unprecedented enzymatic systems to degrade plant polysaccharides

Lucelia Cabral, Gabriela Persinoti, Douglas Paixão, Marcele Martins, Mariana Morais, Mariana Chinaglia, Mariane Domingues, Mauricio Sforca, Renan Pirolla, Wesley Generoso, Clelton Santos, Lucas Maciel, Nicolas Terrapon, Vincent Lombard, Bernard Henrissat, Mario Murakami

Nature Communications 13:629 (2022)10.1038/s41467-022-28310-y

2022
SARS-CoV-2 detection using a nanobody-functionalized voltammetric device

Quentin Pagneux, Alain Roussel, Hiba Saada, Christian Cambillau, Béatrice Amigues, Vincent Delauzun, Ilka Engelmann, Enagnon Kazali Alidjinou, Judith Ogiez, Anne Sophie Rolland, Emmanuel Faure, Julien Poissy, Alain Duhamel, Rabah Boukherroub, David Devos, Sabine Szunerits

Communications Medicine 2:56 (2022)10.1038/s43856-022-00113-8

2022
Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect

Priscila El Kazzi, Nadia Rabah, Célia Chamontin, Lina Poulain, François Ferron, Françoise Debart, Bruno Canard, Dorothée Missé, Bruno Coutard, Sébastien Nisole, Etienne Decroly

Nucleic Acids Research 15:1021 (2022)10.1093/nar/gkac996

2022
Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect

Priscila El Kazzi, Nadia Rabah, Célia Chamontin, Lina Poulain, François Ferron, Françoise Debart, Bruno Canard, Dorothée Missé, Bruno Coutard, Sébastien Nisole, Etienne Decroly

Nucleic Acids Research (2022)10.1093/nar/gkac996

2022
Split-GFP Reassembly Assay: Strengths and Caveats from a Multiparametric Analysis

Christophe Bignon, Antoine Gruet, Sonia Longhi

International Journal of Molecular Sciences 23:13167 (2022)10.3390/ijms232113167

2022
Direct capture, inhibition and crystal structure of HsaD (Rv3569c) from M. tuberculosis

Sarah Barelier, Romain Avellan, Giri Raj Gnawali, Patrick Fourquet, Véronique Roig-Zamboni, Isabelle Poncin, Vanessa Point, Yves Bourne, Stéphane Audebert, Luc Camoin, Christopher Spilling, Stéphane Canaan, Jean‐françois Cavalier, Gerlind Sulzenbacher

FEBS Journal (2022)10.1111/febs.16645

2022
Functional benefit of structural disorder for the replication of measles, Nipah and Hendra viruses

Frank Gondelaud, Giulia Pesce, Juliet F. Nilsson, Christophe Bignon, Denis Ptchelkine, Denis Gerlier, Cyrille Mathieu, Sonia Longhi

Essays in Biochemistry (2022)10.1042/EBC20220045

2022
Quantitative fragmentomics allow affinity mapping of interactomes

Gergo Gogl, Boglarka Zambo, Camille Kostmann, Alexandra Cousido-Siah, Bastien Morlet, Fabien Durbesson, Luc Negroni, Pascal Eberling, Pau Jané, Yves Nominé, Andras Zeke, Søren Østergaard, Élodie Monsellier, Renaud Vincentelli, Gilles Travé

Nature Communications 13:5472 (2022)10.1038/s41467-022-33018-0

2022
1,6- epi -Cyclophellitol Cyclosulfamidate Is a Bona Fide Lysosomal α-Glucosidase Stabilizer for the Treatment of Pompe Disease

Ken Kok, Chi-Lin Kuo, Rebecca Katzy, Lindsey Lelieveld, Liang Wu, Véronique Roig-Zamboni, Gijsbert van der Marel, Jeroen Codée, Gerlind Sulzenbacher, Gideon Davies, Herman Overkleeft, Johannes Aerts, Marta Artola

Journal of the American Chemical Society 144:14819-14827 (2022)10.1021/jacs.2c05666

2022
Exploring the impact of Verticillium wilt disease on the mechanical properties of elementary flax (Linum usitatissimum L.) fibres

Lucile Nuez, Sylvie Durand, Alessia Melelli, Jean-Guy Berrin, Mireille Haon, Elodie Drula, Johnny Beaugrand, Pierre D’arras, Alain Bourmaud, Christophe Baley

Industrial Crops and Products 182:114900 (2022)10.1016/j.indcrop.2022.114900

2022
Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay

Sergio Hernández, Mikael Feracci, Carolina Trajano de Jesus, Priscila El Kazzi, Rafik Kaci, Laura Garlatti, Clemence Mondielli, Fabrice Bailly, Philippe Cotelle, Franck Touret, Xavier de Lamballerie, Bruno Coutard, Etienne Decroly, Bruno Canard, François Ferron, Karine Alvarez

Antiviral Research 204:105364 (2022)10.1016/j.antiviral.2022.105364

2022
Microbial liberation of N-methylserotonin from orange fiber in gnotobiotic mice and humans

Nathan Han, Jiye Cheng, Omar Delannoy-Bruno, Daniel Webber, Nicolas Terrapon, Bernard Henrissat, Dmitry Rodionov, Aleksandr Arzamasov, Andrei Osterman, David Hayashi, Alexandra Meynier, Sophie Vinoy, Chandani Desai, Stacey Marion, Michael Barratt, Andrew Heath, Jeffrey Gordon

Cell 185:3056-3057 (2022)10.1016/j.cell.2022.07.007

2022
Serum IgG levels to Epstein-Barr and measles viruses in patients with multiple sclerosis during natalizumab and interferon beta treatment

Linn Persson Berg, Marcus Eriksson, Sonia Longhi, Ingrid Kockum, Clemens Warnke, Elisabeth Thomsson, Malin Bäckström, Tomas Olsson, Anna Fogdell-Hahn, Tomas Bergström

BMJ Neurology Open 4:e000271 (2022)10.1136/bmjno-2022-000271

2022
Arenaviridae NP-exonuclease inhibition by bisphosphonate

Thi Hong van Nguyen, Elsie Yekwa, Barbara Selisko, Bruno Canard, Karine Alvarez, Francois Ferron

IUCrJ 9 (2022)10.1107/S2052252522005061

2022
Insights into the atypical autokinase activity of the Pseudomonas aeruginosa GacS histidine kinase and its interaction with RetS

Firas Fadel, Violla Bassim, Vanessa Francis, Steven Porter, Thomas Botzanowski, Pierre Legrand, Maria Maté Perez, Yves Bourne, Sarah Cianférani, Florence Vincent

Structure 22:S0969-2126 (2022)10.1016/j.str.2022.06.002

2022
Patient-derived antibodies reveal the subcellular distribution and heterogeneous interactome of LGI1

Jorge Ramirez-Franco, Kévin Debreux, Johanna Extremet, Yves Maulet, Maya Belghazi, Claude Villard, Marion Sangiardi, Fahamoe Youssouf, Lara El Far, Christian Lévêque, Claire Debarnot, P. Marchot, Sofija Paneva, Dominique Debanne, Michael Russier, Michael Seagar, Sarosh Irani, Oussama El Far

Brain - A Journal of Neurology awac218 (2022)10.1093/brain/awac218

2022
The Land–Sea Connection: Insights Into the Plant Lineage from a Green Algal Perspective

Charles Bachy, Fabian Wittmers, Jan Muschiol, Maria Hamilton, Bernard Henrissat, Alexandra Worden

Annual Review of Plant Biology 73 (2022)10.1146/annurev-arplant-071921-100530

2022
Molecular basis for substrate recognition and septum cleavage by AtlA, the major N-acetylglucosaminidase of Enterococcus faecalis

Véronique Roig-Zamboni, Sarah Barelier, Robert Dixon, Nicola Galley, Amani Ghanem, Quoc Phong Nguyen, Héloize Cahuzac, Bartłomiej Salamaga, Peter Davis, Yves Bourne, Stéphane Mesnage, Florence Vincent

Journal of Biological Chemistry 298:101915 (2022)10.1016/j.jbc.2022.101915

2022
A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

K.Y. Chen, T. Krischuns, L. Ortega Varga, E. Harigua-Souiai, S. Paisant, A. Zettor, J. Chiaravalli, A. Delpal, D. Courtney, A. O'Brien, S.C. Baker, Etienne Decroly, C. Isel, F. Agou, Y. Jacob, A. Blondel, Nadia Naffakh

Antiviral Research 201:105272 (2022)10.1016/j.antiviral.2022.105272

2022
Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues

Rostom Ahmed-Belkacem, Marcel Hausdorff, Adrien Delpal, Priscila Sutto-Ortiz, Agathe M G Colmant, Franck Touret, Natacha S Ogando, Eric J Snijder, Bruno Canard, Bruno Coutard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

Journal of Medicinal Chemistry 65:6231-6249 (2022)10.1021/acs.jmedchem.2c00120

2022
Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

Rachid Essalmani, Jaspreet Jain, Delia Susan-Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Etienne Decroly, Tram Nq Pham, Éric Cohen, Nabil Seidah

Journal of Virology 96 (2022)10.1128/jvi.00128-22

2022
Functional exploration of the glycoside hydrolase family GH113

Marie Couturier, Mélanie Touvrey-Loiodice, Nicolas Terrapon, Elodie Drula, Laurine Buon, Christine Chirat, Bernard Henrissat, William Helbert

PLoS ONE 17:1-14 (2022)10.1371/journal.pone.0267509

2022
Replication of the coronavirus genome: A paradox among positive-strand RNA viruses

Emeline Grellet, India l'Hôte, Adeline Goulet, Isabelle Imbert

Journal of Biological Chemistry 298 (2022)10.1016/j.jbc.2022.101923

2022
Mechanistic insights into consumption of the food additive xanthan gum by the human gut microbiota

Matthew Ostrowski, Sabina Leanti La Rosa, Benoit Kunath, Andrew Robertson, Gabriel Pereira, Live Hagen, Neha Varghese, Ling Qiu, Tianming Yao, Gabrielle Flint, James Li, Sean Mcdonald, Duna Buttner, Nicholas Pudlo, Matthew Schnizlein, Vincent Young, Harry Brumer, Thomas Schmidt, Nicolas Terrapon, Vincent Lombard, Bernard Henrissat, Bruce Hamaker, Emiley Eloe-Fadrosh, Ashootosh Tripathi, Phillip Pope, Eric Martens

Nature Microbiology 7:556-569 (2022)10.1038/s41564-022-01093-0

2022
Distribution of Charged Residues Affects the Average Size and Shape of Intrinsically Disordered Proteins

Greta Bianchi, Marco Mangiagalli, Alberto Barbiroli, Sonia Longhi, Rita Grandori, Carlo Santambrogio, Stefania Brocca

Biomolecules 12:561 (2022)10.3390/biom12040561

2022
Generation of a Library of Carbohydrate-Active Enzymes for Plant Biomass Deconstruction

Vânia Cardoso, Joana Brás, Inês Costa, Luís Ferreira, Luís Gama, Renaud Vincentelli, Bernard Henrissat, Carlos Fontes

International Journal of Molecular Sciences 23:4024 (2022)10.3390/ijms23074024

2022
Evolutionary transition to the ectomycorrhizal habit in the genomes of a hyperdiverse lineage of mushroom‐forming fungi

Brian Looney, Shingo Miyauchi, Emmanuelle Morin, Elodie Drula, Pierre Emmanuel Courty, Annegret Kohler, Alan Kuo, Kurt Labutti, Jasmyn Pangilinan, Anna Lipzen, Robert Riley, William Andreopoulos, Guifen He, Jenifer Johnson, Matt Nolan, Andrew Tritt, Kerrie Barry, Igor Grigoriev, László Nagy, David Hibbett, Bernard Henrissat, P. Brandon Matheny, Jesse Labbé, Francis Martin

New Phytologist 233:2294-2309 (2022)10.1111/nph.17892

2022
Phylogenomics and Comparative Genomics Highlight Specific Genetic Features in Ganoderma Species

Yi-Fei Sun, Annie Lebreton, Jia-Hui Xing, Yu-Xuan Fang, Jing Si, Emmanuelle Morin, Shingo Miyauchi, Elodie Drula, Steven Ahrendt, Kelly Cobaugh, Anna Lipzen, Maxim Koriabine, Robert Riley, Annegret Kohler, Kerrie Barry, Bernard Henrissat, Igor Grigoriev, Francis Martin, Bao-Kai Cui

Journal of Fungi 8:311 (2022)10.3390/jof8030311

2022
The ectomycorrhizal basidiomycete Laccaria bicolor releases a GH28 polygalacturonase that plays a key role in symbiosis establishment

Feng Zhang, Aurore Labourel, Mireille Haon, Minna Kemppainen, Emilie da Silva Machado, Nicolas Brouilly, Claire Veneault-Fourrey, Annegret Kohler, Marie‐noëlle Rosso, Alejandro Pardo, Bernard Henrissat, Jean‐guy Berrin, Francis Martin

New Phytologist 233:2534-2547 (2022)10.1111/nph.17940

2022
Assembly and synthesis of the extracellular matrix in brown algae

Lisa Mazéas, Rina Yonamine, Tristan Barbeyron, Bernard Henrissat, Elodie Drula, Nicolas Terrapon, Chikako Nagasato, Cécile Hervé

Seminars in Cell and Developmental Biology (2022)10.1016/j.semcdb.2022.03.005

2022
Phenotypic and Genomic Diversification in Complex Carbohydrate-Degrading Human Gut Bacteria

Nicholas Pudlo, Karthik Urs, Ryan Crawford, Ali Pirani, Todd Atherly, Roberto Jimenez, Nicolas Terrapon, Bernard Henrissat, Daniel Peterson, Cherie Ziemer, Evan Snitkin, Eric Martens

mSystems 7:e0094721 (2022)10.1128/msystems.00947-21

2022
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, Francois Ferron, Bruno Canard

Nature Communications 13 (2022)10.1038/s41467-022-28113-1

2022
Structural and functional analyses of the Porphyromonas gingivalis type IX secretion system PorN protein

Olivier Fuchsbauer, Ignacio Lunar Silva, Eric Cascales, Alain Roussel, Philippe Leone

Journal of Biological Chemistry 298 (2022)10.1016/j.jbc.2022.101618

2022
Experimental Evidence of Intrinsic Disorder and Amyloid Formation by the Henipavirus W Proteins

Giulia Pesce, Frank Gondelaud, Denis Ptchelkine, Juliet F Nilsson, Christophe Bignon, Jérémy Cartalas, Patrick Fourquet, Sonia Longhi

International Journal of Molecular Sciences 23:923 (2022)10.3390/ijms23020923

2022
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

Daniel L Hurdiss, Priscila El Kazzi, Lisa Bauer, Nicolas Papageorgiou, Francois Ferron, Tim Donselaar, Arno L.W. van Vliet, Tatiana M Shamorkina, Joost Snijder, Bruno Canard, Etienne Decroly, Andrea Brancale, Tzviya Zeev-Ben-Mordehai, Friedrich Förster, Frank J.M. van Kuppeveld, Bruno Coutard

Science Advances 8 (2022)10.1126/sciadv.abj7615

2022
DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation

Federica Quaglia, Bálint Mészáros, Edoardo Salladini, András Hatos, Rita Pancsa, Lucía B Chemes, Mátyás Pajkos, Tamas Lazar, Samuel Peña-Díaz, Jaime Santos, Veronika Ács, Nazanin Farahi, Erzsébet Fichó, Maria Cristina Aspromonte, Claudio Bassot, Anastasia Chasapi, Norman E Davey, Radoslav Davidović, Laszlo Dobson, Arne Elofsson, Gábor Erdős, Pascale Gaudet, Michelle Giglio, Juliana Glavina, Javier Iserte, Valentín Iglesias, Zsófia Kálmán, Matteo Lambrughi, Emanuela Leonardi, Sonia Longhi, Sandra Macedo-Ribeiro, Emiliano Maiani, Julia Marchetti, Cristina Marino-Buslje, Attila Mészáros, Alexander Miguel Monzon, Giovanni Minervini, Suvarna Nadendla, Juliet F Nilsson, Marian Novotný, Christos A Ouzounis, Nicolás Palopoli, Elena Papaleo, Pedro José Barbosa Pereira, Gabriele Pozzati, Vasilis J Promponas, Jordi Pujols, Alma Carolina Sanchez Rocha, Martin Salas, Luciana Rodriguez Sawicki, Eva Schad, Aditi Shenoy, Tamás Szaniszló, Konstantinos D Tsirigos, Nevena Veljkovic, Gustavo Parisi, Salvador Ventura, Zsuzsanna Dosztányi, Peter Tompa, Silvio C E Tosatto, Damiano Piovesan

Nucleic Acids Research 50:D480-D487 (2022)10.1093/nar/gkab1082

2022
The carbohydrate-active enzyme database: functions and literature

Elodie Drula, Marie-Line Garron, Suzan Dogan, Vincent Lombard, Bernard Henrissat, Nicolas Terrapon

Nucleic Acids Research 50:D571-D577 (2022)10.1093/nar/gkab1045

2022
Multi-omics integrated analysis reveals significant metabolic disorders from 2D and 3D HepaRG eparg cells after exposure to amiodarone and DEHP

N. Papaioannou, A.Papageorgiou Koufidou, Z.D. Schultz, I. Frydas, C Gabriel, S. Karakitsios, S. Langouet, E. Blanc, K. Audouze, D.A. Sarigiannis

Toxicology Letters 368:S214-S214 (2022)10.1016/j.toxlet.2022.07.580

2022
Facile access to 4′-( N -acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N 7-guanine-methyltransferase nsp14

Romain Amador, Adrien Delpal, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart, Guillaume Clavé, Michael Smietana

Organic & Biomolecular Chemistry 20:7582-7586 (2022)10.1039/d2ob01569b

2022
2022
A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome

Ashleigh Shannon, Bhawna Sama, Pierre Gauffre, Théo Guez, Françoise Debart, J.J. Vasseur, Etienne Decroly, Bruno Canard, Francois Ferron

Nucleic Acids Research (2022)

2022
Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs As Inhibitors of SARS-CoV-2 Replication

Dorothée Bardiot, Laura Vangeel, Mohamed Koukni, Philippe Arzel, Marleen Zwaagstra, Heyrhyoung Lyoo, Patrick Wanningen, Shamshad Ahmad, Linlin Zhang, Xinyuanyuan Sun, Adrien Delpal, Cecilia Eydoux, Jean-Claude Guillemot, Eveline Lescrinier, Hugo Klaassen, Pieter Leyssen, Dirk Jochmans, Karolien Castermans, Rolf Hilgenfeld, Colin Robinson, Etienne Decroly, Bruno Canard, Eric J Snijder, Martijn J Van Hemert, Frank Van van Kuppeveld, Patrick Chaltin, Johan Neyts, Steven De de Jonghe, Arnaud Marchand

Molecules 27:1052 (2022)10.3390/molecules27031052

2022
[Review] The role of the surface ligand on the performance of electrochemical SARS-CoV-2 antigen biosensors

Sabine Szunerits, Quentin Pagneux, Abir Swaidan, Vladyslav Mishyn, Alain Roussel, Christian Cambillau, David Devos, Ilka Engelmann, Enagnon Kazali Alidjinou, Henri Happy, Rabah Boukherroub

Analytical and Bioanalytical Chemistry 414:pp 103-113 (2022)10.1007/s00216-020-03137-y

2022
The crystal structure of CbpD clarifies substrate-specificity motifs in chitin-active lytic polysaccharide monooxygenases

Christopher Dade, Badreddine Douzi, Christian Cambillau, Genevieve Ball, Romé Voulhoux, Katrina Forest

Acta crystallographica Section D : Structural biology [1993-...] 78 (2022)10.1107/S2059798322007033