Invité équipe J. Reguera: Alfredo Castello, Université de Glasgow, Ecosse- “When viral RNA met the cell: a story of protein-RNA interactions”

Résumé

RNA is a central molecule in the lifecycle of RNA viruses, acting not only as messenger (m)RNA but also as a genome. The interactions that viral RNA establishes with the host cell remain, however, largely unknown. My laboratory has developed several approaches to determine systematically and comprehensively the complement of cellular RNA-binding proteins (RBPs) that interact with viral RNA in infected cells. Applied to different viral models, we discovered a new universe of critical host-virus interactions that are largely conserved across viral families. Amongst them, we discover a group of nuclear RBPs that shuttle to the cytosol upon infection to supress viral replication, representing a first line cellular defence against viruses. Moreover, I will explore a new mechanism by which certain viruses ensure the availability of nucleotides to feed viral replication.