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Systemic amyloidoses are a group of life-threatening diseases whereby large deposits of amyloid fibrils are accumulated in one or several internal organs causing tissue alterations and organ failure. Using single particle Cryo-electron microscopy (Cryo-EM) we characterize amyloid deposits directly extracted from the tissue of affected individuals, allowing the direct analysis of the pathologic misfolded assemblies. Cryo-EM structure of amyloids extracted from cardiac and renal tissues of patients affected by Light Chain amyloidosis, from kidneys of patients from AA amyloidosis will be presented and discussed.

Publié le février 20, 2023