CNRS - AIX MARSEILLE UNIV: UMR7257

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Cécilia EYDOUX

Research engineer

AFMB Polytech Case 925
Campus de Luminy
163 Avenue de Luminy
13288 Marseille CEDEX 09
Fax: +33 491 82 86 38

phone: 491 82 86 46
Cecilia.Eydoux afmb.univ-mrs.fr
 

Viral Replicases : Structure, Mechanism and Drug-Design

 

Facilities : Screening Platform Marseille-Luminy (PCML)

 

2007-2020 : Research Engineer (AFMB – UMR7257) - PCML Operational manager Subject : Drug design against the emergent virus. Production/purification of recombinant proteins (bacteria). In vitro RNA synthesis. Radioactive and fluorescent enzymatic activity tests on RNA polymerases of different viruses (Dengue, Zika, HCV...), inhibitor screening and in vitro inhibition studies. Development of new technologies (fluorescence (HTRF...),radioactivity, robotisation, miniaturisation). Data base management. Students management.

2004-2007 : PhD (EIPL - UPR9025 Marseille). Subject : Biochemical and structural studies of HPLRP2. Production/purification of recombinant proteins (yeast). Determination of biochemical, enzymatic and physiological properties. Immuno-histological studies on human tissues, fluids and biopsies. HPLRP2 crystallization. In vitro inhibition studies.

Latest Publications

  1. Vicenti I, Martina MG, Boccuto A, De Angelis M, Giavarini G, Dragoni F, Marchi S, Trombetta C M, Crespan E, Maga G, Eydoux C , Decroly E, Montomoli E, Nencioni L, Zazzi M, Radi M
    Eur J Med Chem In press
  2. Lo HS, Hui KPY, Lai HM, Khan KS, Kaur S, Huang J, Li JHZ, Chan AKN, Cheung HY, Ng KC, Ho JCW, Chen YW, Ma B, Cheung PMH, Shin D, Wang K, Lee MH, Selisko B, Eydoux C , Guillemot JC, Canard B, Wu KP, Liang PH, Dikic I, Zhong Zuo, Chan F K. L, Hui D S. C., Mok V C. T., Wong KB, Ko H, Shen Aik W, Chi Wai Chan M, Ng WL
    ACS Cent Sci 7 792-802
  3. Eydoux C , Fattorini V, Shannon A, Le TT, Didier B, Canard B, Guillemot JC
    J Virol Methods 288 114013
  4. Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527 (2021)
    Shannon A, Fattorini V, Sama B, Selisko B, Feracci M, Falcou C, Gauffre P, El Kazzi P, Decroly E, Raba N, Alvarez K, Eydoux C , Guillemot JC, Debart F, Vasseur JJ, Noel M, Moussa A, Good S, Lin K, Sommadossi JP, Zhu Y, Yan X, Shi H, Ferron F, Canard B
    bioRxiv 2021.03.23.436564
  5. Quintana VM, Selisko B, Brunetti JE, Eydoux C , Guillemot JC, Canard B, Damonte EB, Julander JG, Castilla V
    Antiviral Res 176 104749

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