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Structural Glycobiology and Neurobiology

Heads Yves BOURNE, Pascale MARCHOT

Latest Publications

  1. An evolutionary perspective on the first disulfide bond in members of the cholinesterase-carboxylesterase (COesterase) family: Possible outcomes for cholinesterase expression in prokaryotes. (2019) Chatonnet A, Brazzolotto X, Hotelier T, Lenfant N, Marchot P, Bourne Y. Chem Biol Interact 308 179-184 PMID:31100280
  2. Substrate binding mode and catalytic mechanism of human heparan sulfate d-glucuronyl C5 epimerase. (2019) Debarnot C, Monneau YR, Roig-Zamboni V, Delauzun V, Le Narvor C, Richard E, Henault J, Goulet A, Fadel F, Vives RR, Priem B, Bonnaffe D, Lortat-Jacob H, Bourne Y. Proc Natl Acad Sci U S A 116 6760-6765 PMID:30872481
  3. Overview of the Structure-Function Relationships of Mannose-Specific Lectins from Plants, Algae and Fungi. (2019) Barre A, Bourne Y, Van Damme EJM, Rouge P. Int J Mol Sci 20(2) PMID:30634645
  4. Genetic and enzymatic characterization of 3-O-sulfotransferase SNPs associated with Plasmodium falciparum parasitaemia. (2018) Nguyen NT, Vives RR, Torres M, Delauzun V, Saesen E, Roig-Zamboni V, Lortat-Jacob H, Rihet P, Bourne Y. Glycobiology 28 534-541 PMID:29718295
  5. Lytic xylan oxidases from wood-decay fungi unlock biomass degradation. (2018) Couturier M, Ladeveze S, Sulzenbacher G, Ciano L, Fanuel M, Moreau C, Villares A, Cathala B, Chaspoul F, Frandsen KE, Labourel A, Herpoel-Gimbert I, Grisel S, Haon M, Lenfant N, Rogniaux H, Ropartz D, Davies GJ, Rosso MN, Walton PH, Henrissat B, Berrin JG. Nat Chem Biol 14 306-310 PMID:29377002
  6. Hot spots for protein partnership at the surface of cholinesterases and related alpha/beta hydrolase fold proteins or domains - a structural perspective. (2017) Bourne Y, Marchot P. Molecules 23 35 PMID:29295471
...All publications

Our research projects address the molecular architectures and functional mechanisms of carbohydrate-active enzymes (CAZymes), sensor domains and lectins, and of enzymes, receptors and cell adhesion molecules with a neurobiological interest.

The CAZymes govern the hydrolysis, conversion or recognition of sugar moieties from glycoconjuguates widely found in animals, fungi, plants and bacteria. These conjugates are involved in key biological processes such as development, fertilization, quality control of protein folding, host-pathogen recognition, immune response, and they can be linked to diseases such as neurodegenerative metabolic diseases. In collaboration with the “Glycogenomics” team we pay particular attention to those glycoside hydrolases that are of interest for biomedical and biotechnological applications.

We also address the function, recognition properties and structure of receptors, enzymes and adhesion molecules involved in central and peripheral neurotransmission, with particular interest for their structure-function relationships, specificity of partner and ligand recognition, conformational dynamics and functional regulation. In particular we have accumulated expertise in the study of the enzyme acetylcholinesterase and of the extracellular ligand-binding domain of the nicotinic receptor to acetylcholine whose malfunctioning has been correlated with neurodegenerative diseases, and to cell adhesion molecules structurally related to the cholinesterases or to other families of proteins and associated with developmental neuronal deficiencies.

Our methodological approaches involve recombinant protein expression in prokaryotic and eukaryotic systems and complementary biochemical, biophysical, functional and structural (X-ray crystallography and electron microscopy) characterization means.

Jean-Baptiste BOITEL
Nicola CURCI
Florence VINCENT
Véronique ZAMBONI

Former team members and trainees

- Caroline Peneff, PhD student, 1999-2001
- Jordan Meynard, Master-2 BBSG student, 2003
- David Veesler, Master-1 BBSG student, 2004
- Dorothée Bauguil, 2nd year ESIL (now Polytech Marseille) student, 2004
- Abraham Saliba, Master-2 BBSG student, 2004
- Julien Offant, PhD student, 2003-2005
- Isabelle Dezoize, 2nd year ESIL (now Polytech Marseille) student, 2006
- Alexandra Lipski, Master 2 BBSG and PhD student, 2006-2008
- David Dal Molin, 2nd year ESIL (now Polytech Marseille) student, 2008
- Mahfoud Balki, Master-2 BBSG student, 2009
- Emma Bossion, 2nd yrs BTS student Lycée La Forbine, 2009
- Marie-Cécile Pélissier, Master-2 BBSG and PhD student, 2006-2009 (ATER 2009)
- Goetz Parsiegla, Maître de Conférences, 2001-2010
- Allan Lamontanara, 2nd year ESIL (now Polytech Marseille) student, 2010
- Daniel Gonzales, Master-1 BBSG student, 2010
- Nahla Dhen, Master-2 BBSG student, 2011
- Julie Prats, 2nd year ESIL (now Polytech Marseille) student, 2012
- Guillaume Ponchel, Master-2 BBSG and PhD student, 2008-2012
- Isabelle Mosnier, engineer assistant, 2011-2012
- Claire Zimberger, BTS student Lycée Marie Curie, 1rst and 2nd years, 2011 and 2012
- Thibaud Freyd, Master-2 BBSG student, 2012
- Camille Ribeyre, Master-1 BBSG student, 2013
- Nicolas Lenfant, postdoc/visitor INRA Montpellier, 2011-2013
- Audrey Blanchard, study engineer, 2011-2014
- Supanee Potisopon, postdoc/research engineer, 2014
- Florian Mourey, 2nd year AgroParisTech student, 2014
- Stanley Germany, Master-2 BBSG student, 2014
- Romain La Rocca, L3 student, 2015
- Aurélien Assice-Vivoni, study engineer, 2015
- Julie Baptiste, study engineer, 2015-2016
- Camille Garcia, L3 student, 2016
- Sandy Bezenger, Master-2 BBSG student, 2016
- Farida Nezlioui, Master-2 BBSG student, 2016
- Ahmad Ali-Ahmad, Master-2 BBSG and PhD student, 2011-2016
- Maria Mate, research engineer CNRS, 2013-2017
- Marie-Julie Dejardin, study engineer, 2016-2017
- Adeline Goulet, research engineer, then postdoc FRM, and then CNRS researcher, 2013-2017
- Yoann Crétinon, Master-1 BBSG student, 2017
- Marina Gomes, Master-1 and Master-2 BBSG student, 2016-2017
- Quoc-Phong Nguyen, Master-2 student, 2017
- Melvin Boumedour, 1rst and 2nd yrs BTS student Lycée La Forbine, 2017
- Lamia Mebarki, PhD student, then study/research engineer, 2014-2017
- Amani Ghanem, Master-2 BBSG student, 2018
- Viet-Anh Hoang, Master-2 student, Vietnam, 2018
- Firas Fadel, post-doctoral fellow, 2014-2018
- Elodie Caillol, L3 student, Univ Grenoble Alpes, 2019
- Sarah Coulibaly Martineau, Master-2 Biologie Structurale, Génomique (BSG) 2019
- Djouhaina Benmehidi, 2nd yr Sup’Biotech Paris, 2019
- Antonin Gardais, 4th yr Polytech Marseille, 2019

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