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Structural Glycobiology and Neurobiology

Heads Yves BOURNE, Pascale MARCHOT

Our research projects address the molecular architectures and functional mechanisms of carbohydrate-active enzymes (CAZymes), sensor domains and lectins, and of enzymes, receptors and cell adhesion molecules with a neurobiological interest.

The CAZymes govern the hydrolysis, conversion or recognition of sugar moieties from glycoconjuguates widely found in animals, fungi, plants and bacteria. These conjugates are involved in key biological processes such as development, fertilization, quality control of protein folding, host-pathogen recognition, immune response, and they can be linked to diseases such as neurodegenerative metabolic diseases. In collaboration with the “Glycogenomics” team we pay particular attention to those glycoside hydrolases that are of interest for biomedical and biotechnological applications.

We also address the function, recognition properties and structure of receptors, enzymes and adhesion molecules involved in central and peripheral neurotransmission, with particular interest for their structure-function relationships, specificity of partner and ligand recognition, conformational dynamics and functional regulation. In particular we have accumulated expertise in the study of the enzyme acetylcholinesterase and of the extracellular ligand-binding domain of the nicotinic receptor to acetylcholine whose malfunctioning has been correlated with neurodegenerative diseases, and to cell adhesion molecules structurally related to the cholinesterases or to other families of proteins and associated with developmental neuronal deficiencies.

Our methodological approaches involve recombinant protein expression in prokaryotic and eukaryotic systems and complementary biochemical, biophysical, functional and structural (X-ray crystallography and electron microscopy) characterization means.

Florence VINCENT
Véronique ZAMBONI

Former team members and trainees

- Goetz Parsiegla, Maître de Conférences, 2001-2010
- Jordan Meynard, Master-2 BBSG student, 2003
- David Veesler, Master-1 BBSG student, 2004
- Dorothée Bauguil, 2nd year Polytech-Marseille student, 2004
- Abraham Saliba, Master-2 BBSG student, 2004
- Isabelle Dezoize, 2nd year Polytech-Marseille student, 2006
- Alexandra Lipski, Master 2 BBSG and PhD student, 2006-2008
- David Dal Molin, 2nd year Polytech-Marseille student, 2008
- Mahfoud Balki, Master-2 BBSG student, 2009
- Marie-Cécile Pélissier, Master-2 BBSG and PhD student, 2006-2009
- Allan Lamontanara, 2nd year Polytech-Marseille student, 2010
- Daniel Gonzales, Master-1 BBSG student, 2010
- Nahla Dhen, Master-2 BBSG student, 2011
- Julie Prats, 2nd year ESIL (now Polytech) student, 2012
- Guillaume Ponchel, Master-2 BBSG and PhD student, 2008-2012
- Isabelle Mosnier, engineer assistant, 2011-2012
- Claire Zimberger, BTS student Lycée Marie Curie, 2012
- Thibaud Freyd, Master-2 BBSG student, 2012
- Camille Ribeyre, Master-1 BBSG student, 2013
- Nicolas Lenfant, postdoc/visitor INRA Montpellier, 2011-2013
- Audrey Blanchard, study engineer, 2011-2014
- Supanee Potisopon, postdoc/research engineer, 2014
- Florian Mourey, 2nd year AgroParisTech student, 2014
- Stanley Germany, Master-2 BBSG student, 2014
- Aurélien Assice-Vivoni, study engineer, 2015
- Julie Baptiste, study engineer, 2015-2016
- Sandy Bezenger, Master-2 BBSG student, 2016
- Farida Nezlioui, Master-2 BBSG student, 2016
- Ahmad Ali-Ahmad, Master-2 BBSG and PhD student, 2011-2016
- Maria Mate, research engineer CNRS, 2013-2017
- Marie-Julie Dejardin, study engineer, 2016-2017
- Adeline Goulet, research engineer, then postdoc FRM, and then CNRS researcher, 2013-2017
- Yoann Crétinon, Master-1 BBSG student, 2017
- Marina Gomes, Master-1 and Master-2 BBSG student, 2016-2017
- Quoc Phong Nguyen, Master-2 student, 2017
- Melvin Boumedour, BTS student Lycée La Forbine, 2017

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