CNRS - AIX MARSEILLE UNIV: UMR7257

Home page > en > Research > Teams > Glycogenomics

Glycogenomics

Head Nicolas TERRAPON

Latest Publications

  1. Functional diversity of three tandem C-terminal carbohydrate-binding modules of a b-mannanase (2021) Moeller MS, El Bouaballati S, Henrissat B, Svensson B. J. Biol. Chem. in press PMID:33838183
  2. Discovery of fungal oligosaccharide-oxidising flavo-enzymes with previously unknown substrates, redox-activity profiles and interplay with LPMOs (2021) Haddad Momeni M, Fredslund F, Bissaro B, Raji O, Vuong TV, Meier S, Nielsen TS, Lombard V, Guigliarelli B, Biaso F, Haon M, Grisel S, Henrissat B, Welner DH, Master ER, Berrin JG, Abou Hachem M. Nat. Commun. 12(1) 2132 PMID:33837197
  3. Clinical evidence of the role of Methanobrevibacter smithii in severe acute malnutrition (2021) Camara A, Konate S, Tidjani Alou M, Kodio A, Togo AH, Cortaredona S, Henrissat B, Thera MA, Doumbo OK, Raoult D, Million M. Sci Rep 11(1) 5426 PMID:33686095
  4. Strain-level functional variation in the human gut microbiota based on bacterial binding to artificial food particles (2021) Patnode ML, Guruge JL, Castillo JJ, Couture GA, Lombard V, Terrapon N, Henrissat B, Lebrilla CB, Gordon JI. Cell Host Microbe in press PMID:33571448
  5. Gene family expansions and transcriptome signatures uncover fungal adaptations to wood decay (2021) Hage H, Miyauchi S, Viragh M, Drula E, Min B, Chaduli D, Navarro D, Favel A, Norest M, Lesage-Meessen L, Balint B, Merenyi Z, de Eugenio L, Morin E, Martinez AT, Baldrian P, Stursova M, Martinez MJ, Novotny C, Magnuson JK, Spatafora JW, Maurice S, Pangilinan J, Andreopoulos W, LaButti K, Hundley H, Na H, Kuo A, Barry K, Lipzen A, Henrissat B, Riley R, Ahrendt S, Nagy LG, Grigoriev IV, Martin F, Rosso MN. Environ Microbiol in press PMID:33538380
  6. Characterization of three bacterial glycoside hydrolase family 9 endoglucanases with different modular architectures isolated from a compost metagenome (2021) Ayme L, Hebert A, Henrissat B, Lombard V, Franche N, Perret S, Jourdier E, Heiss-Blanquet S. Biochim Biophys Acta Gen Subj 1865 129848 PMID:33460770
...All publications

Our team aims at establishing the relationships between the aminoacid sequence of carbohydrate-active enzymes and their precise specificity. This work find developments in various areas, from the exploration of the gut microbiota to the search of novel enzymes for biofuel production or for the conversion of blood groups.

Cazymes classification within CAZy

Carbohydrates are crucial for most organisms as carbon sources or as signaling molecules, but also for cell wall synthesis, host pathogen interactions, energy storage etc. We term carbohydrate-active enzymes (CAZymes) the enzymes that assemble and breakdown complex carbohydrates and carbohydrate polymers. Unlike most other classes of enzymes whose sequences carry limited informative power, the peculiarities of CAZymes and of their substrates turn these enzymes into extremely powerful probes to examine and explain the lifestyle of living organisms. During the last 20 years we have developed a classification in sequence-based families that correlate with the structure and catalytic mechanism of CAZymes. This classification currently includes 5 enzyme categories (glycoside hydrolases, glycosyltransferases, carbohydrate esterases, polysaccharide lyases and auxiliary activities) and their appended carbohydrate-binding modules. To make the classification available to the community, we have created the CAZy database (www.cazy.org), which has been meticulously curated and updated since its first version in 1998. Recently, we have coupled various bioinformatics tools to our database explore the CAZyme content of hundreds of eukaryotic and prokaryotic genomes, as well as many metagenomic datasets


Pedro M COUTINHO
Elodie DRULA
Marie-Line GARRON
Bernard HENRISSAT
Bastian HORNUNG
UNK
Insaf KHERBANI
Vincent LOMBARD
Nicolas TERRAPON

© AFMB UMR7257  W3C validation