CNRS - AIX MARSEILLE UNIV: UMR7257

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Glycogenomics

Head Bernard HENRISSAT

Latest Publications

  1. Revisiting old questions and new approaches to investigate the fungal cell wall construction (2020) Blatzer M, Beauvais A, Henrissat B, Latge JP. Curr Top Microbiol Immunol in press PMID:32418033
  2. A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment (2020) Li J, Zhong H, Ramayo-Caldas Y, Terrapon N, Lombard V, Potocki-Veronese G, Estelle J, Popova M, Yang Z, Zhang H, Li F, Tang S, Yang F, Chen W, Chen B, Li J, Guo J, Martin C, Maguin E, Xu X, Yang H, Wang J, Madsen L, Kristiansen K, Henrissat B, Ehrlich SD, Morgavi DP. Gigascience 9(6) giaa057 PMID:32473013
  3. Conserved white rot enzymatic mechanism for wood decay in the Basidiomycota genus Pycnoporus (2020) Miyauchi S, Hage H, Drula E, Lesage-Meessen L, Berrin JG, Navarro D, Favel A, Chaduli D, Grisel S, Haon M, Piumi F, Levasseur A, Lomascolo A, Ahrendt S, Barry K, LaButti KM, Chevret D, Daum C, Mariette J, Klopp C, Cullen D, de Vries RP, Gathman AC, Hainaut M, Henrissat B, Hilden KS, Kues U, Lilly W, Lipzen A, Makela MR, Martinez AT, Morel-Rouhier M, Morin E, Pangilinan J, Ram AFJ, Wosten HAB, Ruiz-Duenas FJ, Riley R, Record E, Grigoriev IV, Rosso MN. DNA Res in press PMID:32531032
  4. Infection cushions of Fusarium graminearum are fungal arsenals for wheat infection (2020) Mentges M, Glasenapp A, Boenisch M, Malz S, Henrissat B, Frandsen RJN, Guldener U, Munsterkotter M, Bormann J, Lebrun MH, Schafer W, Martinez-Rocha AL. Mol Plant Pathol in press PMID:32573086
  5. Genome sequencing of Rigidoporus microporus provides insights on genes important for wood decay, latex tolerance and interspecific fungal interactions. (2020) Oghenekaro OA, Kovalchuk A, Raffaello T, Camarero S, Gressler M, Henrissat B, Lee J, Liu M, Martinez AT, Miettinen O, Mihaltcheva S, Pangilinan J, Ren F, Riley R, Ruiz-Duenasc FJ, Serrano A, Thon MR, Wen Z, Zeng Z, Barry K, Grigoriev IV, Martin F, Asiegbu FO. Sci. Rep. 10 5250 PMID:32251355
  6. 101 Dothideomycetes genomes: a test case for predicting lifestyles and emergence of pathogens. (2020) Haridas S, R. Binder AM, Bloem J, LaButti K, Salamov A, Andreopoulos B, Baker SE, Barry K, Bills G, Bluhm BH , Cannon C, Castanera R, Culley DE, Daum C, Ezra D, Gonzalez JB, Henrissat B, Kuo A, Liang C, Lipzen A, Lutzoni F, Magnuson J, Mondo SJ, Nolan M, Ohm RA, Pangilinan J, Park HJ, Ramirez L, Alfaro M, Sun H, Tritt A, Yoshinaga Y, Zwiers LH, Turgeon BG, Goodwin SB, Spatafora JW, Crous PW, Grigoriev IV. Studies Mycol. 96 141-153 PMID:32206138
...All publications

Our team aims at establishing the relationships between the aminoacid sequence of carbohydrate-active enzymes and their precise specificity. This work find developments in various areas, from the exploration of the gut microbiota to the search of novel enzymes for biofuel production or for the conversion of blood groups.

Cazymes classification within CAZy

Carbohydrates are crucial for most organisms as carbon sources or as signaling molecules, but also for cell wall synthesis, host pathogen interactions, energy storage etc. We term carbohydrate-active enzymes (CAZymes) the enzymes that assemble and breakdown complex carbohydrates and carbohydrate polymers. Unlike most other classes of enzymes whose sequences carry limited informative power, the peculiarities of CAZymes and of their substrates turn these enzymes into extremely powerful probes to examine and explain the lifestyle of living organisms. During the last 20 years we have developed a classification in sequence-based families that correlate with the structure and catalytic mechanism of CAZymes. This classification currently includes 5 enzyme categories (glycoside hydrolases, glycosyltransferases, carbohydrate esterases, polysaccharide lyases and auxiliary activities) and their appended carbohydrate-binding modules. To make the classification available to the community, we have created the CAZy database (www.cazy.org), which has been meticulously curated and updated since its first version in 1998. Recently, we have coupled various bioinformatics tools to our database explore the CAZyme content of hundreds of eukaryotic and prokaryotic genomes, as well as many metagenomic datasets


Pedro M COUTINHO
Elodie DRULA
Marie-Line GARRON
Bernard HENRISSAT
UNK
Bastian HORNUNG
Aurore LABOUREL
Vincent LOMBARD
Nicolas TERRAPON

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