CNRS - AIX MARSEILLE UNIV: UMR7257

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Glycogenomics

Heads Bernard HENRISSAT, Nicolas TERRAPON

Latest Publications

  1. Characterization of the CAZy Repertoire from the Marine-Derived Fungus Stemphylium lucomagnoense in Relation to Saline Conditions (2020) Ben Ali W, Navarro D, Kumar A, Drula E, Turbe-Doan A, Correia LO, Baumberger S, Bertrand E, Faulds CB, Henrissat B, Sciara G, Mechichi T, Record E. Mar Drugs 18(9) E461 PMID:32916905
  2. Proteome specialization of anaerobic fungi during ruminal degradation of recalcitrant plant fiber (2020) Hagen LH, Brooke CG, Shaw CA, Norbeck AD, Piao H, Arntzen MO, Olson HM, Copeland A, Isern N, Shukla A, Roux S, Lombard V, Henrissat B, O'Malley MA, Grigoriev IV, Tringe SG, Mackie RI, Pasa-Tolic L, Pope PB, Hess M. ISME J. in press PMID:32929206
  3. Characterization of the b-glucuronidase Pn3Pase as the founding member of glycoside hydrolase family GH169 (2020) Wantuch PL, Jella S, Duke JA, Mousa JJ, Henrissat B, Glushka J, Avci FY. Glycobiology in press PMID:32810871
  4. Analysis of the diversity of the glycoside hydrolase family 130 in mammal gut microbiomes reveals a novel mannoside-phosphorylase function (2020) Li A, Laville E, Tarquis L, Lombard V, Ropartz D, Terrapon N, Henrissat B, Guieysse D, Esque J, Durand J, Morgavi DP, Potocki-Veronese G. Microb Genom in press PMID:32667876
  5. Revisiting old questions and new approaches to investigate the fungal cell wall construction (2020) Blatzer M, Beauvais A, Henrissat B, Latge JP. Curr Top Microbiol Immunol 425 331-369 PMID:32418033
  6. A catalog of microbial genes from the bovine rumen unveils a specialized and diverse biomass-degrading environment (2020) Li J, Zhong H, Ramayo-Caldas Y, Terrapon N, Lombard V, Potocki-Veronese G, Estelle J, Popova M, Yang Z, Zhang H, Li F, Tang S, Yang F, Chen W, Chen B, Li J, Guo J, Martin C, Maguin E, Xu X, Yang H, Wang J, Madsen L, Kristiansen K, Henrissat B, Ehrlich SD, Morgavi DP. Gigascience 9 giaa057 PMID:32473013
...All publications

Our team aims at establishing the relationships between the aminoacid sequence of carbohydrate-active enzymes and their precise specificity. This work find developments in various areas, from the exploration of the gut microbiota to the search of novel enzymes for biofuel production or for the conversion of blood groups.

Cazymes classification within CAZy

Carbohydrates are crucial for most organisms as carbon sources or as signaling molecules, but also for cell wall synthesis, host pathogen interactions, energy storage etc. We term carbohydrate-active enzymes (CAZymes) the enzymes that assemble and breakdown complex carbohydrates and carbohydrate polymers. Unlike most other classes of enzymes whose sequences carry limited informative power, the peculiarities of CAZymes and of their substrates turn these enzymes into extremely powerful probes to examine and explain the lifestyle of living organisms. During the last 20 years we have developed a classification in sequence-based families that correlate with the structure and catalytic mechanism of CAZymes. This classification currently includes 5 enzyme categories (glycoside hydrolases, glycosyltransferases, carbohydrate esterases, polysaccharide lyases and auxiliary activities) and their appended carbohydrate-binding modules. To make the classification available to the community, we have created the CAZy database (www.cazy.org), which has been meticulously curated and updated since its first version in 1998. Recently, we have coupled various bioinformatics tools to our database explore the CAZyme content of hundreds of eukaryotic and prokaryotic genomes, as well as many metagenomic datasets


Pedro M COUTINHO
Elodie DRULA
Marie-Line GARRON
Bernard HENRISSAT
UNK
Bastian HORNUNG
Aurore LABOUREL
Vincent LOMBARD
Nicolas TERRAPON

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