CNRS - AIX MARSEILLE UNIV: UMR7257

Home page > en > Research > Teams > Glycogenomics

Glycogenomics

Head Bernard HENRISSAT

Latest Publications

  1. From proteins to polysaccharides: lifestyle and genetic evolution of Coprothermobacter proteolyticus. (2018) Kunath BJ, Delogu F, Naas AE, Arntzen MO, Eijsink VGH, Henrissat B, Hvidsten TR, Pope PB. ISME J in press PMID:30315317
  2. Leveraging single-cell genomics to expand the fungal tree of life. (2018) Ahrendt SR, Quandt CA, Ciobanu D, Clum A, Salamov A, Andreopoulos B, Cheng JF, Woyke T, Pelin A, Henrissat B, Reynolds NK, Benny GL, Smith ME, James TY, Grigoriev IV. Nat Microbiol in press PMID:30297742
  3. The human gut microbe Bacteroides thetaiotaomicron encodes the founding member of a novel glycosaminoglycan-degrading polysaccharide lyase family PL29. (2018) Ndeh D, Munoz-Munoz J, Cartmell A, Bulmer D, Wills C, Henrissat B, Gray J. J Biol Chem in press PMID:30262663
  4. Functional metagenomics identifies an exosialidase with an inverting catalytic mechanism that defines a new glycoside hydrolase family (GH156). (2018) Chuzel L, Ganatra MB, Rapp E, Henrissat B, Taron CH. J Biol Chem in press PMID:30249617
  5. Rapid divergence of genome architectures following the origin of an ectomycorrhizal symbiosis in the genus Amanita. (2018) Hess J, Skrede I, De Mares MC, Hainaut M, Henrissat B, Pringle A. Mol Biol Evol in press PMID:30239843
  6. Development and characterization of stable anaerobic thermophilic methanogenic microbiomes fermenting switchgrass at decreasing residence times. (2018) Liang X, Whitham JM, Holwerda EK, Shao X, Tian L, Wu YW, Lombard V, Henrissat B, Klingeman DM, Yang ZK, Podar M, Richard TL, Elkins JG, Brown SD, Lynd LR. Biotechnol Biofuels 11 243 PMID:30202438
...All publications

Our team aims at establishing the relationships between the aminoacid sequence of carbohydrate-active enzymes and their precise specificity. This work find developments in various areas, from the exploration of the gut microbiota to the search of novel enzymes for biofuel production or for the conversion of blood groups.

Cazymes classification within CAZy

Carbohydrates are crucial for most organisms as carbon sources or as signaling molecules, but also for cell wall synthesis, host pathogen interactions, energy storage etc. We term carbohydrate-active enzymes (CAZymes) the enzymes that assemble and breakdown complex carbohydrates and carbohydrate polymers. Unlike most other classes of enzymes whose sequences carry limited informative power, the peculiarities of CAZymes and of their substrates turn these enzymes into extremely powerful probes to examine and explain the lifestyle of living organisms. During the last 20 years we have developed a classification in sequence-based families that correlate with the structure and catalytic mechanism of CAZymes. This classification currently includes 5 enzyme categories (glycoside hydrolases, glycosyltransferases, carbohydrate esterases, polysaccharide lyases and auxiliary activities) and their appended carbohydrate-binding modules. To make the classification available to the community, we have created the CAZy database (www.cazy.org), which has been meticulously curated and updated since its first version in 1998. Recently, we have coupled various bioinformatics tools to our database explore the CAZyme content of hundreds of eukaryotic and prokaryotic genomes, as well as many metagenomic datasets


Elodie DRULA
Marie-Line GARRON
Bernard HENRISSAT
Pascal LAPEBIE
Vincent LOMBARD
Pedro MALDONADO COUTINHO
Nicolas TERRAPON

© AFMB UMR7257  W3C validation