CNRS - AIX MARSEILLE UNIV: UMR7257

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Glycogenomics

Head Bernard HENRISSAT

Latest Publications

  1. Effects of microbiota-directed foods in gnotobiotic animals and undernourished children. (2019) Gehrig JL, Venkatesh S, Chang HW, Hibberd MC, Kung VL, Cheng J, Chen RY, Subramanian S, Cowardin CA, Meier MF, O'Donnell D, Talcott M, Spears LD, Semenkovich CF, Henrissat B, Giannone RJ, Hettich RL, Ilkayeva O, Muehlbauer M, Newgard CB, Sawyer C, Head RD, Rodionov DA, Arzamasov AA, Leyn SA, Osterman AL, Hossain MI, Islam M, Choudhury N, Sarker SA, Huq S, Mahmud I, Mostafa I, Mahfuz M, Barratt MJ, Ahmed T, Gordon JI. Science 365 (6449) pii: eaau4732 PMID:31296738
  2. Investigating Host Microbiota Relationships Through Functional Metagenomics. (2019) Laville E, Perrier J, Bejar N, Maresca M, Esque J, Tauzin AS, Bouhajja E, Leclerc M, Drula E, Henrissat B, Berdah S, Di Pasquale E, Robe P, Potocki-Veronese G. Front Microbiol 10 1286 PMID:31275257
  3. Comparative genomics reveals unique wood-decay strategies and fruiting body development in the Schizophyllaceae. (2019) Almasi E, Sahu N, Krizsan K, Balint B, Kovacs GM, Kiss B, Cseklye J, Drula E, Henrissat B, Nagy I, Chovatia M, Adam C, LaButti K, Lipzen A, Riley R, Grigoriev IV, Nagy LG. New Phytol in press PMID:31257601
  4. Evolution and comparative genomics of the most common Trichoderma species. (2019) Kubicek CP, Steindorff AS, Chenthamara K, Manganiello G, Henrissat B, Zhang J, Cai F, Kopchinskiy AG, Kubicek EM, Kuo A, Baroncelli R, Sarrocco S, Noronha EF, Vannacci G, Shen Q, Grigoriev IV, Druzhinina IS. BMC Genomics 20 485 PMID:31189469
  5. Tracking of enzymatic biomass deconstruction by fungal secretomes highlights markers of lignocellulose recalcitrance. (2019) Paes G, Navarro D, Benoit Y, Blanquet S, Chabbert B, Chaussepied B, Coutinho PM, Durand S, Grigoriev IV, Haon M, Heux L, Launay C, Margeot A, Nishiyama Y, Raouche S, Rosso MN, Bonnin E, Berrin JG. Biotechnol Biofuels 12 76 PMID:30976326
  6. Poplar carbohydrate-active enzymes - whole genome annotation and functional analyses based on RNA expression data. (2019) Kumar V, Hainaut M, Delhomme N, Mannapperuma C, Immerzeel P, Street NR, Henrissat B, Mellerowicz EJ. Plant J in press PMID:31111606
...All publications

Our team aims at establishing the relationships between the aminoacid sequence of carbohydrate-active enzymes and their precise specificity. This work find developments in various areas, from the exploration of the gut microbiota to the search of novel enzymes for biofuel production or for the conversion of blood groups.

Cazymes classification within CAZy

Carbohydrates are crucial for most organisms as carbon sources or as signaling molecules, but also for cell wall synthesis, host pathogen interactions, energy storage etc. We term carbohydrate-active enzymes (CAZymes) the enzymes that assemble and breakdown complex carbohydrates and carbohydrate polymers. Unlike most other classes of enzymes whose sequences carry limited informative power, the peculiarities of CAZymes and of their substrates turn these enzymes into extremely powerful probes to examine and explain the lifestyle of living organisms. During the last 20 years we have developed a classification in sequence-based families that correlate with the structure and catalytic mechanism of CAZymes. This classification currently includes 5 enzyme categories (glycoside hydrolases, glycosyltransferases, carbohydrate esterases, polysaccharide lyases and auxiliary activities) and their appended carbohydrate-binding modules. To make the classification available to the community, we have created the CAZy database (www.cazy.org), which has been meticulously curated and updated since its first version in 1998. Recently, we have coupled various bioinformatics tools to our database explore the CAZyme content of hundreds of eukaryotic and prokaryotic genomes, as well as many metagenomic datasets


Elodie DRULA
Marie-Line GARRON
Bernard HENRISSAT
Aurore LABOUREL
Vincent LOMBARD
Pedro MALDONADO COUTINHO
Nicolas TERRAPON

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