Notre équipe cherche à comprendre les mécanismes moléculaires de la réplication des virus émergents par la caractérisation des activités enzymatiques et l’analyse structurale des protéines formant le complexe de réplication/transcription. Ces études sont un préalable au développement d’inhibiteurs spécifiques de ces enzymes et devraient permettre le développement de nouvelles stratégies antivirales.

Les virus à génome ARN sont régulièrement associés à l’émergence de maladies infectieuses. Parmi les plus connues, les épidémies liées aux Bunyavirales (LCMV, Lassa, Vallée du Rift…), au Filovirus (Ebola), aux Nidovirales (Coronavirus), aux Flavivirus ( Chikungunya ou le virus de la Dengue) et aux maladies chroniques (HIV, HCV, HBV, HEV) illustrent des problèmes de santé publique générés à l’échelle mondiale.

L’équipe multidisciplinaire « Réplicases Virales : structure, mécanisme et drug–design » s’intéresse à l’ensemble des enzymes de virus émergents impliquées dans la réplication de leur génome et à la synthèse (transcription) de leurs ARN messagers. Ces enzymes sont le plus souvent associées au sein d’un complexe de réplication/transcription (RTC). Nos études portent non seulement sur les polymérases virales qui coordonnent la réplication virale, mais également sur les enzymes impliquées dans des mécanismes de modifications des ARNs (coiffage, édition, correction …) ou encore sur les protéines impliquées dans la régulation de la réplication.

Au delà de l’analyse restreinte au complexe réplicatif, nous nous nous intéressons également à l’interférence entre cette machinerie enzymatique avec les mécanismes de l’immunité innée de la cellule. Les enzymes de la réplication sont donc à double titre des cibles antivirales privilégiées et la compréhension de leur mode de fonctionnement participe à la conception de molécules à haut potentiel antiviral. Pour soutenir ces projets de recherche, le laboratoire s’appuie sur la plateforme de criblage d’inhibiteurs (PCML) et sur une banque de protéines virales recombinantes.

Etude des ARN polymérases ARN-dépendantes

L’étude des polymérases constitue naturellement une des thématiques de recherche importante du laboratoire (HIV, HCV, dengue, West Nile, SARS, BVDV, Coxsackie virus). Nous disposons des outils permettant de suivre leur activité enzymatique. Nos travaux ont notamment permis ces dernières années de résoudre la structure de plusieurs enzymes, de déterminer des mécanismes de fonctionnement, et d’identifier les partenaires actifs dans les complexes multi-protéiques. Nous avons également développé des inhibiteurs originaux et étudié les mécanismes de résistance vis à vis de ces antiviraux.

Structure de la polymérase du virus West Nile

Développement d’antiviraux

Dans la recherche de molécules antivirales, nous utilisons 2 stratégies de découverte : l’une basée sur la synthèse de molécules conçues rationnellement, grâce à la biochimie et la biologie structurale et l’autre basée sur l’optimisation de molécules “hits” issues de résultats de criblages. Dans ces deux approches, nos cibles sont des protéines du système réplicatif des virus. L’originalité et la qualité du travail qui est réalisé sur ces sujets tiennent en grande partie à la multidisciplinarité des projets combinant biochimie, biologie structurale, biologie moléculaire, bio-informatique, modélisation moléculaire, cristallographie, enzymologie, virologie et chimie.

Domaines de recherche
  • activités enzymatiques
  • réplication/transcription
  • stratégies antivirales
  • ARN polymérases
  • nucléases
  • méthyltransférases
  • protéases
  • nucléoproteines

Publications

2024
The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution

Aurelie Chazot, Claire Zimberger, Mikael Feracci, Adel Moussa, Steven Good, Jean-Pierre Sommadossi, Karine Alvarez, Francois Ferron, Bruno Canard

(2024)10.1101/2024.02.16.580631

2024
5′-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2′-O-methyltransferases

Rostom Ahmed-Belkacem, Priscila Sutto-Ortiz, Adrien Delpal, Joris Troussier, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

Bioorganic Chemistry 143:107035 (2024)10.1016/j.bioorg.2023.107035

2024
N-arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2

Rostom Ahmed-Belkacem, Joris Troussier, Adrien Delpal, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

RSC Medicinal Chemistry (2024)10.1039/d3md00737e

Voir la liste complète des publications

Publications de l'équipe

2024
The activation chain of the broad-spectrum antiviral bemnifosbuvir at atomic resolution

Aurelie Chazot, Claire Zimberger, Mikael Feracci, Adel Moussa, Steven Good, Jean-Pierre Sommadossi, Karine Alvarez, Francois Ferron, Bruno Canard

(2024)10.1101/2024.02.16.580631

2024
5′-cap RNA/SAM mimetic conjugates as bisubstrate inhibitors of viral RNA cap 2′-O-methyltransferases

Rostom Ahmed-Belkacem, Priscila Sutto-Ortiz, Adrien Delpal, Joris Troussier, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

Bioorganic Chemistry 143:107035 (2024)10.1016/j.bioorg.2023.107035

2024
N-arylsulfonamide-based adenosine analogues to target RNA cap N7-methyltransferase nsp14 of SARS-CoV-2

Rostom Ahmed-Belkacem, Joris Troussier, Adrien Delpal, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

RSC Medicinal Chemistry (2024)10.1039/d3md00737e

2024
Structural flexibility of Toscana virus nucleoprotein in the presence of a single-chain camelid antibody

Nicolas Papageorgiou, Amal Baklouti, Julie Lichière, Aline Desmyter, Bruno Canard, Bruno Coutard, François Ferron

Acta crystallographica Section D : Structural biology [1993-...] 80 (2024)10.1107/S2059798324000196

2023
Structural and mechanistic insights into the inhibition of respiratory syncytial virus polymerase by a non-nucleoside inhibitor

Xiaodi Yu, Pravien Abeywickrema, Brecht Bonneux, Ishani Behera, Brandon Anson, Edgar Jacoby, Amy Fung, Suraj Adhikary, Anusarka Bhaumik, Rodrigo Carbajo, Suzanne de Bruyn, Robyn Miller, Aaron Patrick, Quyen Pham, Madison Piassek, Nick Verheyen, Afzaal Shareef, Priscila Sutto-Ortiz, Nina Ysebaert, Herman van Vlijmen, Tim Jonckers, Florence Herschke, Jason Mclellan, Etienne Decroly, Rachel Fearns, Sandrine Grosse, Dirk Roymans, Sujata Sharma, Peter Rigaux, Zhinan Jin

Communications Biology 6:1074 (2023)10.1038/s42003-023-05451-4

2023
Internal RNA 2′-O-methylations on HIV-1 genome impair reverse transcription.

Alice Decombe, Olve Peersen, Priscila Sutto-Ortiz, Célia Chamontin, Géraldine Piorkowski, Bruno Canard, Sébastien Nisole, Etienne Decroly

Nucleic Acids Research (2023)

2023
Tick‐borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2

Ségolène Gracias, Maxime Chazal, Alice Decombe, Yves Unterfinger, Adrià Sogues, Lauryne Pruvost, Valentine Robert, Sandrine Lacour, Manon Lemasson, Marion Sourisseau, Zhi Li, Jennifer Richardson, Sandra Pellegrini, Etienne Decroly, Vincent Caval, Nolwenn Jouvenet

EMBO Reports 24:e57424 (2023)10.15252/embr.202357424

2023
Development of a novel target-based cell assay, reporter of the activity of Mycobacterium tuberculosis protein- O -mannosyltransferase

Nicolas Géraud, Camille Falcou, Julien Parra, Carine Froment, David Rengel, Odile Burlet-Schiltz, Julien Marcoux, Jérôme Nigou, Michel Rivière, Emeline Fabre

Glycobiology (2023)10.1093/glycob/cwad072

2023
Structural characterisation and inhibition of Arenavirus replication complex elements : assembly, function and inhibition of embedded nucleases

Sergio Hernández, Nicolas Papageorgiou, Maria Spiliopoulou, Mikael Feracci, Laura Garlatti, Barbara Selisko, Afroditi Vaitsopoulou, Thi-Hong van Nguyen, Clemence Mondielli, Magali Saez-Ayala, Elsie Yekwa Laban, Irene Margiolaki, B. Canard, Karine Alvarez, Francois Ferron

(2023)

2023
Protéine 2C d’Entérovirus : protéine clé de la réplication virale et cible antivirale

Priscila El Kazzi, Carole Yaacoub, Ziad Fajloun, Patrice Vanelle, Etienne Decroly, Bruno Coutard, Karine Barral

Virologie 27:173-188 (2023)10.1684/vir.2023.1001

2023
Le complexe nsp14:nsp10 du SARS-CoV-2 stabilisé par un nanobody

Pierre Gauffre, Anaïs Gaubert, Maria Mate-Perez, Bruno Canard, François Ferron

27:48-49 (2023)10.1684/vir.2023.993

2023
Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Etienne Decroly, Nadia Rabah, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Françoise Debart, Jean-Jacques Vasseur, Mathieu Noel, Adel Moussa, Steven Good, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, François Ferron, Bruno Canard

(2023)10.1101/2021.03.23.436564

2023
Structural basis and dynamics of Chikungunya alphavirus RNA capping by nsP1 capping pores

Rhian Jones, Michael Hons, Nadia Rabah, Noelia Zamarreño, Rocío Arranz, Juan Reguera

Proceedings of the National Academy of Sciences of the United States of America 120 (2023)10.1073/pnas.2213934120

2023
Discovery of a PDZ Domain Inhibitor Targeting the Syndecan/Syntenin Protein–Protein Interaction: A Semi-Automated “Hit Identification-to-Optimization” Approach

Laurent Hoffer, Manon Garcia, Raphael Leblanc, Mikael Feracci, Stéphane Betzi, Khaoula Ben Yaala, Avais Daulat, Pascale Zimmermann, Philippe Roche, Karine Barral, Xavier Morelli

Journal of Medicinal Chemistry (2023)10.1021/acs.jmedchem.2c01569

2023
Interplay of RNA 2′-O-methylations with viral replication

Alice Decombe, Priscila El Kazzi, Etienne Decroly

Current Opinion in Virology 59:101302 (2023)10.1016/j.coviro.2023.101302

2023
Design and synthesis of naturally-inspired SARS-CoV-2 inhibitors

Haitham Hassan, Jeanne Chiavaralli, Afnan Hassan, Loay Bedda, Tim Krischuns, Kuang-Yu Chen, Alice Shi Ming Li, Adrien Delpal, Etienne Decroly, Masoud Vedadi, Nadia Naffakh, Fabrice Agou, Sergio Mallart, Reem Arafa, Paola Arimondo

RSC Medicinal Chemistry 14:507-519 (2023)10.1039/D2MD00149G

2023
Biochemistry of the Respiratory Syncytial Virus L Protein Embedding RNA Polymerase and Capping Activities

Priscila Sutto-Ortiz, Jean-François Eléouët, François Ferron, Etienne Decroly

Viruses 15:341 (2023)10.3390/v15020341

2023
Notch activation shifts the fate decision of senescent progenitors toward myofibrogenesis in human adipose tissue

Nathalie Boulet, Anaïs Briot, Valentin Jargaud, David Estève, Anne Rémaury, Chloé Belles, Pénélope Viana, Jessica Fontaine, Lucie Murphy, Catherine Déon, Marie Guillemot, Catherine Pech, Yaligara Veeranagouda, Michel Didier, Pauline Decaunes, Etienne Mouisel, Christian Carpéné, Jason S Iacovoni, Alexia Zakaroff-Girard, Jean-Louis Grolleau, Jean Galitzky, Séverine Ledoux, Jean-Claude Guillemot, Anne Bouloumié

Aging Cell e13776 (2023)10.1111/acel.13776

2023
Macro1 domain residue F156: A hallmark of SARS-CoV-2 de-MARylation specificity

Oney Ortega Granda, Karine Alvarez, Maria J Mate-Perez, Bruno Canard, François Ferron, Nadia Rabah

Virology 587:109845 (2023)10.1016/j.virol.2023.109845

2023
AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5

Mikael Feracci, Cécilia Eydoux, Véronique Fattorini, Lea Lo Bello, Pierre Gauffre, Barbara Selisko, Priscila Sutto-Ortiz, Ashleigh Shannon, Hongjie Xia, Pei-Yong Shi, Mathieu Noel, Françoise Debart, Jean-Jacques Vasseur, Steve Good, Kai Lin, Adel Moussa, Jean-Pierre Sommadossi, Aurélie Chazot, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, François Ferron, Bruno Canard

Antiviral Research 212:105574 (2023)10.1016/j.antiviral.2023.105574

2023
Amino Acid Polymorphisms on the Brazilian Strain of Yellow Fever Virus Methyltransferase Are Related to the Host’s Immune Evasion Mediated by Type I Interferon

Nathália Dias Furtado, Iasmim Silva de Mello, Andre Schutzer de Godoy, Gabriela Dias Noske, Glaucius Oliva, Bruno Canard, Etienne Decroly, Myrna Bonaldo

Viruses 15:191 (2023)10.3390/v15010191

2023
Structure-guided optimization of adenosine mimetics as selective and potent inhibitors of coronavirus nsp14 N7-methyltransferases

Marcel Hausdorff, Adrien Delpal, Sarah Barelier, Laura Nicollet, Bruno Canard, Franck Touret, Agathe Colmant, Bruno Coutard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

European Journal of Medicinal Chemistry (2023)10.1016/j.ejmech.2023.115474

2023
2C protein of Enterovirus: key protein of viral replication and antiviral target

Priscila El Kazzi, Carole Yaacoub, Ziad Fajloun, Patrice Vanelle, Etienne Decroly, Bruno Coutard, Karine Barral

Virologie 27:35-49 (2023)10.1684/vir.2023.1002

2022
Internal RNA 2′O-methylation in the HIV-1 genome counteracts ISG20 nuclease-mediated antiviral effect

Priscila El Kazzi, Nadia Rabah, Célia Chamontin, Lina Poulain, François Ferron, Françoise Debart, Bruno Canard, Dorothée Missé, Bruno Coutard, Sébastien Nisole, Etienne Decroly

Nucleic Acids Research (2022)10.1093/nar/gkac996

2022
A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome

Ashleigh Shannon, Bhawna Sama, Pierre Gauffre, Théo Guez, Françoise Debart, Jean-Jacques Vasseur, Etienne Decroly, Bruno Canard, François Ferron

Nucleic Acids Research 50:11186-11198 (2022)10.1093/nar/gkac876

2022
The SARS-CoV nsp12 Polymerase Active Site Is Tuned for Large-Genome Replication

Grace Campagnola, Vishnu Govindarajan, Annelise Pelletier, Bruno Canard, Olve Peersen

Journal of Virology 96 (2022)10.1128/jvi.00671-22

2022
A highly specific N7-guanine RNA cap methyltransferase in an unusual locus of large RNA virus genome

A. Shannon, B. Sama, P. Gauffre, B. Makem-Tamekem, E. Decroly, B. Canard, Francois Ferron

Acta Crystallographica Section A : Foundations and Advances [2014-...] 78:e324-e324 (2022)10.1107/S2053273322094049

2022
Identification of potent inhibitors of arenavirus and SARS-CoV-2 exoribonucleases by fluorescence polarization assay

Sergio Hernández, Mikael Feracci, Carolina Trajano de Jesus, Priscila El Kazzi, Rafik Kaci, Laura Garlatti, Clemence Mondielli, Fabrice Bailly, Philippe Cotelle, Franck Touret, Xavier de Lamballerie, Bruno Coutard, Etienne Decroly, Bruno Canard, François Ferron, Karine Alvarez

Antiviral Research 204:105364 (2022)10.1016/j.antiviral.2022.105364

2022
A Versatile Class of 1,4,4-Trisubstituted Piperidines Block Coronavirus Replication In Vitro

Sonia de Castro, Annelies Stevaert, Miguel Maldonado, Adrien Delpal, Julie Vandeput, Benjamin van Loy, Cecilia Eydoux, Jean-Claude Guillemot, Etienne Decroly, Federico Gago, Bruno Canard, Maria-Jose Camarasa, Sonsoles Velázquez, Lieve Naesens

Pharmaceuticals 15:1021 (2022)10.3390/ph15081021

2022
Arenaviridae NP-exonuclease inhibition by bisphosphonate

Thi Hong van Nguyen, Elsie Yekwa, Barbara Selisko, Bruno Canard, Karine Alvarez, Francois Ferron

IUCrJ 9 (2022)10.1107/S2052252522005061

2022
Structural and functional characterization of the Protein-O-MannosylTransferase of Mycobacterium tuberculosis

Chloé Rivière, Nicolas Géraud, Camille Falcou, Émeline Fabre, Michel Rivière

(2022)

2022
A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases

Sergio Hernández, Mikael Feracci, Carolina Trajano de Jesus, Priscila El-Kazzi, Rafik Kaci, Laura Garlatti, Etienne Decroly, Bruno Canard, Francois Ferron, Karine Alvarez

(2022)10.1101/2021.04.02.437736

2022
A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

K.Y. Chen, T. Krischuns, L. Ortega Varga, E. Harigua-Souiai, S. Paisant, A. Zettor, J. Chiaravalli, A. Delpal, D. Courtney, A. O'Brien, S.C. Baker, Etienne Decroly, C. Isel, F. Agou, Y. Jacob, A. Blondel, Nadia Naffakh

Antiviral Research 201:105272 (2022)10.1016/j.antiviral.2022.105272

2022
Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues

Rostom Ahmed-Belkacem, Marcel Hausdorff, Adrien Delpal, Priscila Sutto-Ortiz, Agathe M G Colmant, Franck Touret, Natacha S Ogando, Eric J Snijder, Bruno Canard, Bruno Coutard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

Journal of Medicinal Chemistry 65:6231-6249 (2022)10.1021/acs.jmedchem.2c00120

2022
Distinctive Roles of Furin and TMPRSS2 in SARS-CoV-2 Infectivity

Rachid Essalmani, Jaspreet Jain, Delia Susan-Resiga, Ursula Andréo, Alexandra Evagelidis, Rabeb Mouna Derbali, David Huynh, Frédéric Dallaire, Mélanie Laporte, Adrien Delpal, Priscila Sutto-Ortiz, Bruno Coutard, Claudine Mapa, Keith Wilcoxen, Etienne Decroly, Tram Nq Pham, Éric Cohen, Nabil Seidah

Journal of Virology 96 (2022)10.1128/jvi.00128-22

2022
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, Francois Ferron, Bruno Canard

Nature Communications 13 (2022)10.1038/s41467-022-28113-1

2022
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

Daniel L Hurdiss, Priscila El Kazzi, Lisa Bauer, Nicolas Papageorgiou, Francois Ferron, Tim Donselaar, Arno L.W. van Vliet, Tatiana M Shamorkina, Joost Snijder, Bruno Canard, Etienne Decroly, Andrea Brancale, Tzviya Zeev-Ben-Mordehai, Friedrich Förster, Frank J.M. van Kuppeveld, Bruno Coutard

Science Advances 8 (2022)10.1126/sciadv.abj7615

2022
1H, 13C, 15N backbone resonance assignment of apo and ADP-ribose bound forms of the macro domain of Hepatitis E virus through solution NMR spectroscopy

Maria Politi, Angelo Gallo, Georgios Bouras, Maria Birkou, Bruno Canard, Bruno Coutard, Georgios Spyroulias

Biomolecular NMR Assignments (2022)10.1007/s12104-022-10111-5

2022
Facile access to 4′-( N -acylsulfonamide) modified nucleosides and evaluation of their inhibitory activity against SARS-CoV-2 RNA cap N 7-guanine-methyltransferase nsp14

Romain Amador, Adrien Delpal, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart, Guillaume Clavé, Michael Smietana

Organic & Biomolecular Chemistry 20:7582-7586 (2022)10.1039/d2ob01569b

2022
Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs As Inhibitors of SARS-CoV-2 Replication

Dorothée Bardiot, Laura Vangeel, Mohamed Koukni, Philippe Arzel, Marleen Zwaagstra, Heyrhyoung Lyoo, Patrick Wanningen, Shamshad Ahmad, Linlin Zhang, Xinyuanyuan Sun, Adrien Delpal, Cecilia Eydoux, Jean-Claude Guillemot, Eveline Lescrinier, Hugo Klaassen, Pieter Leyssen, Dirk Jochmans, Karolien Castermans, Rolf Hilgenfeld, Colin Robinson, Etienne Decroly, Bruno Canard, Eric J Snijder, Martijn J Van Hemert, Frank Van van Kuppeveld, Patrick Chaltin, Johan Neyts, Steven De de Jonghe, Arnaud Marchand

Molecules 27:1052 (2022)10.3390/molecules27031052

2021
Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication

Natacha S Ogando, Priscila El Kazzi, Jessika C Zevenhoven-Dobbe, Brenda W Bontes, Alice Decombe, Clara C S Posthuma, Volker Thiel, Bruno Canard, Francois Ferron, Etienne Decroly, Eric J Snijder

Proceedings of the National Academy of Sciences of the United States of America (2021)10.1101/2021.05.17.444407

2021
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2

Ilaria Vicenti, Maria Grazia Martina, Adele Boccuto, Marta de Angelis, Giorgia Giavarini, Filippo Dragoni, Serena Marchi, Claudia Maria Trombetta, Emmanuele Crespan, Giovanni Maga, Cecilia Eydoux, Etienne Decroly, Emanuele Montomoli, Lucia Nencioni, Maurizio Zazzi, Marco Radi

European Journal of Medicinal Chemistry 224:113683 (2021)10.1016/j.ejmech.2021.113683

2021
Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread

Manon Garcia, Laurent Hoffer, Raphaël Leblanc, Fatiha Benmansour, Mikael Feracci, Carine Derviaux, Antonio Luis Egea-Jimenez, Philippe Roche, Pascale Zimmermann, Xavier Morelli, Karine Barral

European Journal of Medicinal Chemistry 223:113601 (2021)10.1016/j.ejmech.2021.113601

2021
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

Daniel L Hurdiss, Priscila El Kazzi, Lisa Bauer, Nicolas Papageorgiou, Francois Ferron, Tim Donselaar, Arno L W van Vliet, Bruno Canard, Etienne Decroly, Andrea Brancale, Tzviya Zeev-Ben-Mordehai, Friedrich Förster, Frank J M van Kuppeveld, Bruno Coutard

(2021)10.1101/2021.04.26.440876

2021
An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2

Jacques van Helden, Colin Butler, Guillaume Achaz, Bruno Canard, Didier Casane, Jean-Michel Claverie, Fabien Colombo, Virginie Courtier-Orgogozo, Richard Ebright, François Graner, Milton Leitenberg, Serge Morand, Nikolai Petrovsky, Rossana Segreto, Etienne Decroly, José Halloy

The Lancet 398:1402-1404 (2021)10.1016/S0140-6736(21)02019-5

2021
Structure and Sequence Requirements for RNA Capping at the Venezuelan Equine Encephalitis Virus RNA 5′ End

Oney Ortega Granda, Coralie Valle, Ashleigh Shannon, Etienne Decroly, Bruno Canard, Bruno Coutard, Nadia Rabah

Journal of Virology 95 (2021)10.1128/JVI.00777-21

2021
The enzymes for genome size increase and maintenance of large (+)RNA viruses

Francois Ferron, Bhawna Sama, Etienne Decroly, Bruno Canard

Trends in Biochemical Sciences (2021)10.1016/j.tibs.2021.05.006

2021
Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir

Ho Sing Lo, Kenrie Pui Yan Hui, Hei-Ming Lai, Xu He, Khadija Shahed Khan, Simranjeet Kaur, Junzhe Huang, Zhongqi Li, Anthony Chan, Hayley Hei-Yin Cheung, Ka-Chun Ng, John Chi Wang Ho, Yu Wai Chen, Bowen Ma, Peter Man-Hin Cheung, Donghyuk Shin, Kaidao Wang, Meng-Hsuan Lee, Barbara Selisko, Cecilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Kuen-Phon Wu, Po-Huang Liang, Ivan Dikic, Zhong Zuo, Francis Chan, David Hui, Vincent Mok, Kam-Bo Wong, Chris Ka Pun Mok, Ho Ko, Wei Shen Aik, Michael Chi Wai Chan, Wai-Lung Ng

ACS Central Science 7:792-802 (2021)10.1021/acscentsci.0c01186

2021
The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

Priscila Sutto-Ortiz, Sergey Tcherniuk, Nina Ysebaert, Pravien Abeywickrema, Mathieu Noël, Alice Decombe, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard, Dirk Roymans, Peter Rigaux, Jean-François Eléouët, Etienne Decroly

PLoS Pathogens 17:e1009562 (2021)10.1371/journal.ppat.1009562

2021
Analyse structurale de la nouvelle N7 guanine-MTase du virus de la Brème bordelière

Pierre Gauffre, Ashleigh Shannon, Bhawna Sama, Bruno Canard, François Ferron

25:68-74 (2021)10.1684/vir.2021.0892

2021
Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review

Erwan Sallard, José Halloy, Didier Casane, Etienne Decroly, Jacques van Helden

Environmental Chemistry Letters 19:769-785 (2021)10.1007/s10311-020-01151-1

2021
Observation of arenavirus nucleoprotein heptamer assembly

Nicolas Papageorgiou, Afroditi Vaitsopoulou, Awa Diop, Thi Hong van Nguyen, Bruno Canard, Karine Alvarez, Francois Ferron

FEBS Open Bio (2021)10.1002/2211-5463.13106

2021
A fluorescence-based high throughput-screening assay for the SARS-CoV RNA synthesis complex

Cecilia Eydoux, Veronique Fattorini, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Bruno Didier, Bruno Canard, Jean-Claude Guillemot

Journal of Virological Methods 288:114013 (2021)10.1016/j.jviromet.2020.114013

2021
Dengue Virus NS5 Transcribes Metabolite-Capped, RIG-I Sensitive vRNAs

Brandon Schweibenz, Mihai Solotchi, Etienne Decroly, Barbara Selisko, Bruno Canard, Smita Patel

Biophysical Journal 120:135a (2021)10.1016/j.bpj.2020.11.1017

2021
COVID-19 epidemiologic surveillance using wastewater

Virender Sharma, Chetan Jinadatha, Eric Lichtfouse, Etienne Decroly, Jacques van Helden, Hosoon Choi, Piyali Chatterjee

Environmental Chemistry Letters 19:1911-1915 (2021)10.1007/s10311-021-01188-w

2021
The WHO mission report struggles to trace the origins of the SARS-CoV-2 epidemic

Etienne Decroly, Jean-Michel Claverie, Bruno Canard

Virologie 1-7 (2021)

2021
Combining Antivirals and Immunomodulators to Fight COVID-19

Vincent Feuillet, Bruno Canard, Alain Trautmann

Trends in Immunology 42:31-44 (2021)10.1016/j.it.2020.11.003

2021
First insights into the structural features of Ebola virus methyltransferase activities

Coralie Valle, Baptiste Martin, François Ferron, Véronique Roig-Zamboni, Aline Desmyter, Françoise Debart, Jean Jacques Vasseur, Bruno Canard, Bruno Coutard, Etienne Decroly

Nucleic Acids Research 49:1737-1748 (2021)10.1093/nar/gkaa1276

2020
Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase

A. Shannon, B. Selisko, Ntt Le, J. Huchting, F. Touret, G. Piorkowski, V. Fattorini, F. Ferron, Etienne Decroly, C Meier, B. Coutard, O. Peersen, B. Canard

(2020)10.1101/2020.05.15.098731

2020
Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo

R. Leblanc, R. Kashyap, K. Barral, A.L. Egea‐jimenez, D. Kovalskyy, M. Feracci, M. Garcia, C. Derviaux, S. Betzi, R. Ghossoub, M. Platonov, P. Roche, X. Morelli, L. Hoffer, Pascale Zimmermann

Journal of Extracellular Vesicles 10 (2020)10.1002/jev2.12039

2020
Tracing the origins of SARS-CoV-2 in coronavirus phylogenies

Erwan Sallard, José Halloy, Didier Casane, Etienne Decroly, Jacques van Helden

Médecine/Sciences 36 (2020)10.1051/medsci/2020123

2020
Targeting furin activity through in silico and in vitro drug repurposing strategy for SARS-CoV-2 spike glycoprotein cleavage repression

Bruno Villoutreix, John Creemers, Yannick Léger, Geraldine Siegfried, Etienne Decroly, Serge Evrard, Abdel-Majid Khatib

(2020)10.21203/rs.3.rs-25856/v1

2020
Drugs against SARS‐CoV ‐2: What do we know about their mode of action?

Coralie Valle, Baptiste Martin, Franck Touret, Ashleigh Shannon, Bruno Canard, Jean‐claude Guillemot, Bruno Coutard, Etienne Decroly

Reviews in Medical Virology 30:1-10 (2020)10.1002/rmv.2143

2020
Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro

Joy Thames, Charles Waters, Coralie Valle, Marcella Bassetto, Wahiba Aouadi, Baptiste Martin, Barbara Selisko, Arissa Falat, Bruno Coutard, Andrea Brancale, Bruno Canard, Etienne Decroly, Katherine Seley-Radtke

Bioorganic and Medicinal Chemistry Letters 28:115713 (2020)10.1016/j.bmc.2020.115713

2020
Mutations on VEEV nsP1 relate RNA capping efficiency to ribavirin susceptibility

Nadia Rabah, Oney Ortega Granda, Gilles Quérat, Bruno Canard, Etienne Decroly, Bruno Coutard

Antiviral Research 182:104883 (2020)10.1016/j.antiviral.2020.104883

2020
Structure-based drug repositioning over the human TMPRSS2 protease domain: search for chemical probes able to repress SARS-CoV-2 Spike protein cleavages

Natesh Singh, Etienne Decroly, Abdel-Majid Khatib, Bruno Villoutreix

European Journal of Pharmaceutical Sciences 153:105495 (2020)10.1016/j.ejps.2020.105495

2020
Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Ashleigh Shannon, Barbara Selisko, Nhung-Thi-Tuyet Le, Johanna Huchting, Franck Touret, Géraldine Piorkowski, Véronique Fattorini, Francois Ferron, Etienne Decroly, Chris Meier, Bruno Coutard, Olve Peersen, Bruno Canard

Nature Communications 11:4682 (2020)10.1038/s41467-020-18463-z

2020
Snapshots of ADp-ribose bound to Getah virus macro domain reveal an intriguing choreography

Ana Sofia Ferreira-Ramos, Gerlind Sulzenbacher, Bruno Canard, Bruno Coutard

Scientific Reports 10 (2020)10.1038/s41598-020-70870-w

2020
Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase

Rostom Ahmed-Belkacem, Priscila Sutto-Ortiz, Mathis Guiraud, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

European Journal of Medicinal Chemistry 201:112557 (2020)10.1016/j.ejmech.2020.112557

2020
In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

Franck Touret, Magali Gilles, Karine Barral, Antoine Nougairède, Jacques van Helden, Etienne Decroly, Xavier de Lamballerie, Bruno Coutard

Scientific Reports 10:13093 (2020)10.1038/s41598-020-70143-6

2020
Brothers in Arms: Structure, Assembly and Function of Arenaviridae Nucleoprotein

Nicolas Papageorgiou, Maria Spiliopoulou, Thi-Hong van Nguyen, Afroditi Vaitsopoulou, Elsie Yekwa Laban, Karine Alvarez, Irene Margiolaki, Bruno Canard, Francois Ferron

Viruses 12:772 (2020)10.3390/v12070772

2020
Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

Rana Abdelnabi, Kristina Kovacikova, Julia Moesslacher, Kim Donckers, Verena Battisti, Pieter Leyssen, Thierry Langer, Gerhard Puerstinger, Gilles Quérat, Changqing Li, Etienne Decroly, Ali Tas, Arnaud Marchand, Patrick Chaltin, Bruno Coutard, Martijn van Hemert, Johan Neyts, Leen Delang

Antimicrobial Agents and Chemotherapy 64 (2020)10.1128/AAC.00649-20

2020
To something, Covid is good: SFV 2.0

Grégory Caignard, Etienne Decroly, Maria Dimitrova, David Gilmer, Anne-Sophie Gosselin-Grenet, Henri Gruffat, Sandra Martin-Latil, Pascale Massin, Sandie Munier, Mylène Ogliastro, Aure Saulnier, Noël Tordo

Virologie 24:133-134 (2020)10.1684/vir.2020.0846

2020
Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

Ashleigh Shannon, Nhung Thi-Tuyet Le, Barbara Selisko, Cecilia Eydoux, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, Olve Peersen, Francois Ferron, Bruno Canard

Antiviral Research 178:104793 (2020)10.1016/j.antiviral.2020.104793

2020
Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1 H -pyrazole-5-carboxylate as an HIV-1 replication inhibitor

Jeanne Fichez, Cathia Soulié, Laurent Le Corre, Sophie Sayon, Stéphane Priet, Karine Alvarez, Olivier Delelis, Patrick Gizzi, Guillaume Prestat, Christine Gravier-Pelletier, Anne-Geneviève Marcelin, Vincent Calvez, Patricia Busca

RSC Medicinal Chemistry 11:577-582 (2020)10.1039/D0MD00025F

2020
Incretin combination therapy for the treatment of non-alcoholic steatohepatitis

Aimo Kannt, Andreas Nygaard Madsen, Claire Kammermeier, Ralf Elvert, Tim Klöckener, Martin Bossart, Torsten Haack, Andreas Evers, Katrin Lorenz, W. Hennerici, Corinne Rocher, Zsolt Böcskei, Jean-Claude Guillemot, Vincent Mikol, François Pattou, Bart Staels, Michael Wagner

Diabetes, Obesity and Metabolism Online ahead of print. (2020)10.1111/dom.14035

2020
A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae

Francois Ferron, Humberto Julio Debat, Ashleigh Shannon, Etienne Decroly, Bruno Canard

NAR Genomics and Bioinformatics 2 (2020)10.1093/nargab/lqz022

2020
Design, Synthesis and Discovery of N,N’ ‐Carbazoyl‐aryl‐urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication

Sharon Spizzichino, Giulio Mattedi, Kate Lauder, Coralie Valle, Wahiba Aouadi, Bruno Canard, Etienne Decroly, Suzanne Kaptein, Johan Neyts, Carl Graham, Zakary Sule, David Barlow, Romano Silvestri, Daniele Castagnolo

ChemMedChem 15:385-390 (2020)10.1002/cmdc.201900533

2020
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Bruno Coutard, Coralie Valle, Xavier de Lamballerie, Bruno Canard, Nabil G Seidah, Etienne Decroly

Antiviral Research 176:104742 (2020)10.1016/j.antiviral.2020.104742

2020
Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors

Laure-Anne Peyrat, Véronique Eparvier, Cecilia Eydoux, Jean-Claude Guillemot, Marc Litaudon, Didier Stien

Journal of Natural Products 83:2330-2336 (2020)10.1021/acs.jnatprod.9b01169

2020
The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation

Coralie Valle, Baptiste Martin, Françoise Debart, Jean-Jacques Vasseur, Isabelle Imbert, Bruno Canard, Bruno Coutard, Etienne Decroly

Journal of Virology 94:e00520-20 (2020)10.1128/JVI.00520-20

2020
In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

Jeremy Ariey‐bonnet, Kendall Carrasco, Marion Le Grand, Laurent Hoffer, Stéphane Betzi, Mikael Feracci, Philipp A Tsvetkov, François Devred, Yves Collette, Xavier Morelli, Pedro Ballester, Eddy Pasquier

Molecular Oncology 14:3083-3099 (2020)10.1002/1878-0261.12810

2019
Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6

Olivier Fuchsbauer, Paolo Swuec, Claire Zimberger, Beatrice Amigues, Sébastien Levesque, Daniel Agudelo, Alexis Duringer, Antonio Chaves-Sanjuan, Silvia Spinelli, Geneviève Rousseau, Minja Velimirovic, Martino Bolognesi, Alain Roussel, Christian Cambillau, Sylvain Moineau, Yannick Doyon, Adeline Goulet

Molecular Cell 76:922-937.e7 (2019)10.1016/j.molcel.2019.09.012

2019
Arenaviridae exoribonuclease presents genomic RNA edition capacity.

Elsie Laban Yekwa, Chutima Aphibanthammakit, Xavier Carnec, Caroline Picard, Bruno Canard, Sylvain Baize, Francois Ferron

(2019)10.1101/541698

2019
Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity

Edoardo Salladini, Claire Debarnot, Vincent Delauzun, Maria Grazia Murrali, Priscila Sutto-Ortiz, Silvia Spinelli, Roberta Pierattelli, Christophe Bignon, Sonia Longhi

(2019)

2019
Structure of the Respiratory Syncytial Virus Polymerase Complex

Morgan S A Gilman, Cheng Liu, Amy Fung, Ishani Behera, Paul Jordan, Peter Rigaux, Nina Ysebaert, Sergey Tcherniuk, Julien Sourimant, Jean-Francois Eleouet, Priscila Sutto-Ortiz, Etienne Decroly, Dirk Roymans, Zhinan Jin, Jason S Mclellan

Cell 179:193-204.e14 (2019)10.1016/j.cell.2019.08.014

2019
The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

Natacha S Ogando, Francois Ferron, Etienne Decroly, Bruno Canard, Clara C Posthuma, Eric J Snijder

Frontiers in Microbiology 10 (2019)10.3389/fmicb.2019.01813

2019
2019
Deciphering the Nucleotide and RNA Binding Selectivity of the Mayaro Virus Macro Domain

Aikaterini Tsika, Efstathios Melekis, Sofia-Antigoni Tsatsouli, Nicolas Papageorgiou, Maria Mate, Bruno Canard, Bruno Coutard, Detlef Bentrop, Georgios Spyroulias

Journal of Molecular Biology 431:2283-2297 (2019)10.1016/j.jmb.2019.04.013

2019
Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose

Garyfallia Makrynitsa, Dioni Ntonti, Konstantinos Marousis, Maria Birkou, Minos-Timotheos Matsoukas, Sam Asami, Detlef Bentrop, Nicolas Papageorgiou, Bruno Canard, Bruno Coutard, Georgios Spyroulias

Journal of Structural Biology 206:119-127 (2019)10.1016/j.jsb.2019.02.008

2019
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.

Antoine Frangeul, Cécile Bussetta, Jérôme Deval, Karine Barral, Karine Alvarez, Bruno Canard

Antiviral Therapy 13:115-24 (2019)

2019
Comparative study of chikungunya Virus-Like Particles and Pseudotyped-Particles used for serological detection of specific immunoglobulin M

Gérald Theillet, Jérôme Martinez, Christophe Steinbrugger, Dimitri Lavillette, Bruno Coutard, Nicolas Papageorgiou, Pascal Dalbon, Isabelle Leparc-Goffart, Frederic Bedin

Virology 529:195-204 (2019)10.1016/j.virol.2019.01.027

2019
C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system

Philippe H Jaïs, Etienne Decroly, Eric Jacquet, Marine Le boulch, Aurélien Jaïs, Olivier Jean-Jean, Heather Eaton, Prishila Ponien, Frédérique Verdier, Bruno Canard, Sergio Gonçalves, Stéphane Chiron, Maude Le Gall, Patrick Mayeux, Maya Shmulevitz

Nucleic Acids Research 47:2681-2698 (2019)10.1093/nar/gkz069

2019
Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain

Magali Saez-Ayala, Elsie Laban Yekwa, Clémence Mondielli, Loic Roux, Sergio Hernández, Fabrice Bailly, Philippe Cotelle, Dominga Rogolino, Bruno Canard, Francois Ferron, Karine Alvarez

Antiviral Research 162:79-89 (2019)10.1016/j.antiviral.2018.12.008

2019
Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach

Florent Olivon, Simon Remy, Gwendal Grelier, Cécile Apel, Cecilia Eydoux, Jean-Claude Guillemot, Johan Neyts, Leen Delang, David Touboul, Fanny Roussi, Marc Litaudon

Journal of Natural Products 82:330-340 (2019)10.1021/acs.jnatprod.8b00800

2019
Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay

Ana Ferreira-Ramos, Changqing Li, Cecilia Eydoux, Jean Marie Contreras, Christophe Morice, Gilles Querat, Alba Gigante, María-Jesús Pérez Pérez, Marie-Louise Jung, Bruno Canard, Jean-Claude Guillemot, Etienne Decroly, Bruno Coutard

Antiviral Research 163:59-69 (2019)10.1016/j.antiviral.2019.01.003

2019
FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing

Mathieu Ringeard, Virginie Marchand, Etienne Decroly, Yuri Motorin, Yamina Bennasser

Nature 565:500-504 (2019)10.1038/s41586-018-0841-4

2019
Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein

Thi Hong Van Nguyen, Julie Lichiere, Bruno Canard, Nicolas Papageorgiou, Sarah Attoumani, Francois Ferron, Bruno Coutard

Acta crystallographica Section D : Structural biology [1993-...] 75:8-15 (2019)10.1107/S2059798318014948

2019
Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors

Jessica Hernandez, Laurent Hoffer, Bruno Coutard, Gilles Quérat, Philippe Roche, Xavier Morelli, Etienne Decroly, Karine Barral

European Journal of Medicinal Chemistry 161:323-333 (2019)10.1016/j.ejmech.2018.09.056

2019
Synthesis of Adenine Dinucleosides 2′,5′-Bridged by Sulfur-Containing Linkers as Bisubstrate SAM Analogues for Viral RNA 2′- O -Methyltransferases

Rostom Ahmed-Belkacem, Priscila Sutto Ortiz, Etienne Decroly, Jean-Jacques Vasseur, Françoise Debart

European Journal of Organic Chemistry 2019 (2019)10.1002/ejoc.201901120

2019
Identification of a new natural gastric lipase inhibitor from star anise

Jannet Kamoun, Renaud Rahier, Mohamed Sellami, Imed Koubaa, Pascal Mansuelle, Régine Lebrun, Alexandra Berlioz-Barbier, Michele Fiore, Karine Alvarez, Abdelkarim Abousalham, Frédéric Carrière, Ahmed Aloulou

Food and Function 10:469-478 (2019)10.1039/c8fo02009d

2018
Ebola virus L protein harbors a new enzymatic activity involved in the internal methylation of RNAs

Baptiste Martin, Coralie Valle, Bruno Coutard, Bruno Canard, Françoise Debart, Etienne Decroly

Médecine/Sciences 34:919-921 (2018)10.1051/medsci/2018230

2018
The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

Baptiste Martin, Bruno Coutard, Théo Guez, Guido Paesen, Bruno Canard, Françoise Debart, Jean-Jacques Vasseur, Jonathan Grimes, Etienne Decroly

Nucleic Acids Research 46:7902-7912 (2018)10.1093/nar/gky637

2018
Galactolipase activity of Talaromyces thermophilus lipase on galactolipid micelles, monomolecular films and UV-absorbing surface-coated substrate

Inès Belhaj, Sawsan Amara, Goetz Parsiegla, Priscila Sutto-Ortiz, Moulay Sahaka, Hafedh Belghith, Audric Rousset, Dominique Lafont, Frédéric Carriere

Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863:1006-1015 (2018)10.1016/j.bbalip.2018.05.016

2018
Innate immunity evasion mechanisms of filoviruses

Baptiste Martin, Etienne Decroly

Med Sci (Paris) 34:671-677 (2018)10.1051/medsci/20183408013

2018
A Vaccine Platform against Arenaviruses Based on a Recombinant Hyperattenuated Mopeia Virus Expressing Heterologous Glycoproteins

Xavier Carnec, Mathieu Mateo, Audrey Page, Stéphanie Reynard, Jimmy Hortion, Caroline Picard, Elsie Yekwa, Laura Barrot, Stéphane Barron, Audrey Vallve, Hervé Raoul, Caroline Carbonnelle, Francois Ferron, Sylvain Baize

Journal of Virology 92:e02230-17 (2018)10.1128/JVI.02230-17

2018
Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors

Ludovic Halby, Nils Marechal, Dany Pechalrieu, Vincent Cura, Don-Marc Franchini, Céline Faux, Frédéric Alby, Nathalie Troffer-Charlier, Srikanth Kudithipudi, Albert Jeltsch, Wahiba Aouadi, Etienne Decroly, Jean-Claude Guillemot, Patrick Page, Clotilde Ferroud, Luc Bonnefond, Dominique Guianvarc'H, Jean Cavarelli, Paola Arimondo

Philosophical Transactions of the Royal Society B: Biological Sciences 373:20170072 (2018)10.1098/rstb.2017.0072

2018
IR spectroscopy analysis of pancreatic lipase-related protein 2 interaction with phospholipids: 3. Monitoring DPPC lipolysis in mixed micelles

Eduardo Mateos-Diaz, Priscila Sutto-Ortiz, Moulay Sahaka, Jorge Rodriguez, Frédéric Carrière

Chemistry and Physics of Lipids 211:77-85 (2018)10.1016/j.chemphyslip.2017.11.009

2018
IR spectroscopy analysis of pancreatic lipase-related protein 2 interaction with phospholipids: 2. Discriminative recognition of various micellar systems and characterization of PLRP2-DPPC-bile salt complexes

Eduardo Mateos-Diaz, Priscila Sutto-Ortiz, Moulay Sahaka, Deborah Byrne, Hélène Gaussier, Frédéric Carrière

Chemistry and Physics of Lipids 211:66-76 (2018)10.1016/j.chemphyslip.2017.11.012

2018
Crystal structures of Lymphocytic choriomeningitis virus endonuclease domain complexed with diketo-acid ligands

Magali Saez-Ayala, Elsie Laban Yekwa, Mauro Carcelli, Bruno Canard, Karine Alvarez, Francois Ferron

International Union of Crystallography journal 5:223-235 (2018)10.1107/S2052252518001021

2018
Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands

Magali Saez-Ayala, Elsie Yekwa, Mauro Carcelli, Bruno Canard, Karine Alvarez, Francois Ferron

International Union of Crystallography journal 5:223-235 (2018)10.1107/s2052252518001021

2018
Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

Barbara Selisko, Nicolas Papageorgiou, Francois Ferron, Bruno Canard

Viruses 10:59 (2018)10.3390/v10020059

2018
Filovirus proteins for antiviral drug discovery: Structure/function of proteins involved in assembly and budding

Baptiste Martin, Olivier Reynard, Viktor Volchkov, Etienne Decroly

Antiviral Research 150:183-192 (2018)10.1016/j.antiviral.2017.12.022

2018
Synthesis and substrate properties towards HIV-1 reverse transcriptase of new diphosphate analogues of 9-[(2-phosphonomethoxy)ethyl]adenine

Wolfgang Hg Laux, Stephane Priet, Karine Alvarez, Suzanne Peyrottes, Christian Perigaud

Antiviral Chemistry and Chemotherapy 26:204020661875763 (2018)10.1177/2040206618757636

2018
Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

Francois Ferron, Lorenzo Subissi, Ana Theresa Silveira de Morais, Nhung Thi Tuyet Le, Marion Sevajol, Laure Gluais, Etienne Decroly, Clemens Vonrhein, Gérard Bricogne, Bruno Canard, Isabelle Imbert

Proceedings of the National Academy of Sciences of the United States of America 115:E162-E171 (2018)10.1073/pnas.1718806115

2018
How to Control HTLV-1-Associated Diseases: Preventing de Novo Cellular Infection Using Antiviral Therapy

Amandine Pasquier, Sandrine Alais, Loic Roux, Maria-Isabel Thoulouze, Karine Alvarez, Chloé Journo, Hélène Dutartre, Renaud Mahieux

Frontiers in Microbiology 9:278 (2018)10.3389/fmicb.2018.00278

2018
A Continuous and Sensitive Spectrophotometric Assay for Lipase and Phospholipase A Activities using α-Eleostearic Acid-containing Substrates

Meddy El Alaoui, Laurent Soulère, Alexandre Noiriel, Priscila Sutto-Ortiz, Lucie Grand, Florence Popowycz, Jorge Alberto Rodríguez-González, Yves Queneau, Abdelkarim Abousalham

119-128 (2018)

2017
Toscana virus nucleoprotein oligomer organization observed in solution

Amal Baklouti, Adeline Goulet, Julie Lichiere, Bruno Canard, Remi Charrel, Francois Ferron, Bruno Coutard, Nicolas Papageorgiou

Acta crystallographica Section D : Structural biology [1993-...] 73:650-659 (2017)10.1107/S2059798317008774

2017
NF-L in cerebrospinal fluid and serum is a biomarker of neuronal damage in an inducible mouse model of neurodegeneration

Anthony Brureau, Véronique Blanchard-Bregeon, Catherine Pech, Stéphanie Hamon, Pascal Chaillou, Jean-Claude Guillemot, Pascal Barneoud, Philippe Bertrand, Laurent Pradier, Thomas Rooney, Nathalie Schussler

Neurobiology of Disease 104:73-84 (2017)10.1016/j.nbd.2017.04.007

2017
Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay

Wahiba Aouadi, C Ecilia Eydoux, Bruno Coutard, Baptiste Martin, Françoise Debart, Jean-Jacques Vasseur, Jean Marie Contreras, Christophe Morice, Gilles Quérat, Marie-Louise Jung, Bruno Canard, Jean-Claude Guillemot, Etienne Decroly

Antiviral Research 144:330-339 (2017)10.1016/j.antiviral.2017.06.021

2017
Activity inhibition and crystal polymorphism induced by active-site metal swapping

Elsie Yekwa, Joelle Khourieh, Bruno Canard, Nicolas Papageorgiou, Francois Ferron

Acta crystallographica Section D : Structural biology [1993-...] 73:641-649 (2017)10.1107/S205979831700866X

2017
Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

Rana Abdelnabi, Ana Theresa Silveira De Morais, Pieter Leyssen, Isabelle Imbert, Stéphanie Beaucourt, Hervé Blanc, Mathy Froeyen, Marco Vignuzzi, Bruno Canard, Johan Neyts, Leen Delang

Journal of Virology 91:e00487-17 (2017)10.1128/JVI.00487-17

2017
Biochemical principles and inhibitors to interfere with viral capping pathways

Etienne Decroly, Bruno Canard

Current Opinion in Virology 24:87-96 (2017)10.1016/j.coviro.2017.04.003

2017
2017
Binding site density enables paralog-specific activity of SLM2 and Sam68 proteins in Neurexin2 AS4 splicing control

Marina Danilenko, Caroline Dalgliesh, Vittoria Pagliarini, Chiara Naro, Ingrid Ehrmann, Mikael Feracci, Mahsa Kheirollahi-Chadegani, Alison Tyson-Capper, Gavin Clowry, Philippe Fort, Cyril Dominguez, Claudio Sette, David Elliott

Nucleic Acids Research 45:gkw1277 (2017)10.1093/nar/gkw1277

2017
Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins

Francois Ferron, Friedemann Weber, Juan de La Torre, Juan Reguera

Virus Research 234:118-134 (2017)10.1016/j.virusres.2017.01.018

2017
Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2′-modified nucleotide analogues

Supanee Potisopon, Francois Ferron, Véronique Fattorini, Barbara Selisko, Bruno Canard

Antiviral Research 140:25-36 (2017)10.1016/j.antiviral.2016.12.021

2017
Contribution to PNA-RNA Chimera Synthesis: One-Pot Microwave-Assisted Ugi Reaction to Obtain Dimeric Building Blocks

Reuben Ovadia, Clémence Mondielli, Jean-Jacques Vasseur, Carine Baraguey, Karine Alvarez

European Journal of Organic Chemistry 2017:469-475 (2017)10.1002/ejoc.201601190

2017
Binding of the Methyl Donor S -Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2′- O -Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10

Wahiba Aouadi, Alexandre Blanjoie, Jean-Jacques Vasseur, Françoise Debart, Bruno Canard, Etienne Decroly

Journal of Virology 91:1103-1119 (2017)10.1128/JVI.02217-16

2017
Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design

Fatiha Benmansour, Iuni Trist, Bruno Coutard, Etienne Decroly, Gilles Querat, Andrea Brancale, Karine Barral

European Journal of Medicinal Chemistry 125:865-880 (2017)10.1016/j.ejmech.2016.10.007

2017
Preparation of thiophenepropenamide derivatives as flavivirus inhibitors in treatment of viral infections

Karine Barral, Jean Claude Guillemot, Bruno Canard, Gilles Quérat, Karine Alvarez, Xavier de Lamballerie, Florence Mahuteau-Betzer, Cedric Poinsard

(2017)

2017
Antiviral activity of [1,2,3]triazolo[4,5- d ]pyrimidin-7(6 H )-ones against chikungunya virus targeting the viral capping nsP1

Alba Gigante, Asier Gómez-Sanjuan, Leen Delang, Changqing Li, Oskía Bueno, Ana-María Gamo, Eva-María Priego, María-José Camarasa, Dirk Jochmans, Pieter Leyssen, Etienne Decroly, Bruno Coutard, Gilles Querat, Johan Neyts, María-Jesús Pérez-Pérez

Antiviral Research 144:216-222 (2017)10.1016/j.antiviral.2017.06.003

2017
Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

Bruno Coutard, Karine Barral, Julie Lichiere, Barbara Selisko, Baptiste Martin, Wahiba Aouadi, Miguel Ortiz Lombardia, Françoise Debart, Jean-Jacques Vasseur, Jean Claude Guillemot, Bruno Canard, Etienne Decroly

Journal of Virology 91:2202-2218 (2017)10.1128/JVI.02202-16

2016
Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights

Stavroula Fili, Alexandros Valmas, Magdalini Christopoulou, Maria Spiliopoulou, Nikos Nikolopoulos, Julie Lichiere, Souzana Logotheti, Fotini Karavassili, Eleftheria Rosmaraki, Andrew Fitch, Jonathan Wright, Detlef Beckers, Thomas Degen, Gwilherm Nenert, Rolf Hilgenfeld, Nicolas Papageorgiou, Bruno Canard, Bruno Coutard, Irene Margiolaki

Acta crystallographica Section F : Structural biology communications [2014-...] 72:877-884 (2016)10.1107/S2053230X16018513

2016
2016
Viral Macro Domains Reverse Protein ADP-Ribosylation

Changqing Li, Yannick Debing, Gytis Jankevicius, Johan Neyts, Ivan Ahel, Bruno Coutard, Bruno Canard

Journal of Virology 90:8478-8486 (2016)10.1128/JVI.00705-16

2016
Betulinic Acid, The First Lupane-Type Triterpenoid Isolated from Both a Phomopsis sp. and Its Host Plant Diospyros carbonaria Benoist

Laure-Anne Peyrat, Véronique Eparvier, Cécilia Eydoux, Jean-Claude Guillemot, Marc Litaudon, Didier Stien

Chemistry and Biodiversity 14:e1600171 (2016)10.1002/cbdv.201600171

2016
Protein-Protein Interaction Inhibition (2P21)-Oriented Chemical Library Accelerates Hit Discovery

Sabine Milhas, Brigitt Raux, Stéphane Betzi, Carine Derviaux, Philippe Roche, Audrey Restouin, Marie-Jeanne Basse, Etienne Rebuffet, Adrien Lugari, Marion Badol, Rudra Kashyap, Jean-Claude Lissitzky, Cecilia Eydoux, Veronique Hamon, Marie -Edith Gourde, Sebastien Combes, Pascale Zimmermann, Michel Aurrand-Lions, Thomas Roux, Catherine Rogers, Susanne Muller, Stefan Knapp, Eric Trinquet, Yves Collette, Jean-Claude Guillemot, Xavier Morelli

ACS Chemical Biology 11:2140-2148 (2016)10.1021/acschembio.6b00286

2016
Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C

Rachel Ulferts, S. Matthijn De Boer, Lonneke van Der Linden, Lisa Bauer, Hey Rhyoung Lyoo, Maria J. Mate, Julie Lichiere, Bruno Canard, Daphne Lelieveld, Wienand Omta, David Egan, Bruno Coutard, Frank J. M. Van Kuppeveld

Antimicrobial Agents and Chemotherapy 60:2627-2638 (2016)10.1128/AAC.02182-15

2016
Predicting Conformational Disorder

Philippe Lieutaud, François Ferron, Sonia Longhi

1415:265-299 (2016)10.1007/978-1-4939-3572-7_14

2016
The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain (vol 42, pg 11642, 2014)

Supanee Potisopon, Stephane Priet, Axelle Collet, Etienne Decroly, Bruno Canard, Barbara Selisko

Nucleic Acids Research 44:2974 (2016)10.1093/nar/gkv1294

2016
Reevaluation of possible outcomes of infections with human immunodeficiency virus

C. Tamalet, Philippe Colson, Etienne Decroly, C. Dhiver, I. Ravaux, A. Stein, Didier Raoult

Clinical Microbiology and Infection 22:299-311 (2016)10.1016/j.cmi.2015.11.022

2016
Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase

Fatiha Benmansour, Cecilia Eydoux, Gilles Querat, Xavier de Lamballerie, Bruno Canard, Karine Alvarez, Jean-Claude Guillemot, Karine Barral

European Journal of Medicinal Chemistry 109:146-156 (2016)10.1016/j.ejmech.2015.12.046

2016
Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering

Nicolas Papageorgiou, Julie Lichiere, Amal Baklouti, Francois Ferron, Marion Sevajol, Bruno Canard, Bruno Coutard

Acta crystallographica Section D : Structural biology [1993-...] 72:192-202 (2016)10.1107/S2059798315024328

2016
Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

Brigitt Raux, Yuliia Voitovich, Carine Derviaux, Adrien Lugari, Etienne Rebuffet, Sabine Milhas, Stephane Priet, Thomas Roux, Eric Trinquet, Jean-Claude Guillemot, Stefan Knapp, Jean-Michel Brunel, Alexey Yu. Fedorov, Yves Collette, Philippe Roche, Stéphane Betzi, Sebastien Combes, Xavier Morelli

Journal of Medicinal Chemistry 59:1634-1641 (2016)10.1021/acs.jmedchem.5b01708

2016
How disordered is my protein and what is its disorder for? A guide through the “dark side” of the protein universe

Philippe Lieutaud, François Ferron, Alexey V Uversky, Lukasz Kurgan, Vladimir N Uversky, Sonia Longhi

Intrinsically Disordered Proteins 4:e1259708 (2016)10.1080/21690707.2016.1259708

2016
Chemical diversity and antiviral potential in the pantropical Diospyros genus

Laure-Anne Peyrat, Véronique Eparvier, Cécilia Eydoux, Jean-Claude Guillemot, Didier Stien, Marc Litaudon

Fitoterapia (2016)10.1016/j.fitote.2016.04.017

2016
The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection

L. Delang, C. Li, A. Tas, G. Querat, I. C. Albulescu, T. de Burghgraeve, N. A. Segura Guerrero, A. Gigante, G. Piorkowski, Etienne Decroly, D. Jochmans, B. Canard, E. J. Snijder, M. J. Perez-Perez, M. J. Van Hemert, B. Coutard, P. Leyssen, J. Neyts

Scientific Reports 6:31819 (2016)10.1038/srep31819

2016
Involvement of an Arginine Triplet in M1 Matrix Protein Interaction with Membranes and in M1 Recruitment into Virus-Like Particles of the Influenza A(H1N1)pdm09 Virus

Adeline Kerviel, Shantoshini Dash, Olivier Moncorgé, Baptiste Panthu, Jan Prchal, Didier Decimo, Théophile Ohlmann, Bruno Lina, Cyril Favard, Etienne Decroly, Michèle Ottmann, Philippe Roingeard, Delphine Muriaux

PLoS ONE 11:e0165421 (2016)10.1371/journal.pone.0165421

2015
Synthesis and structural characterization of monomeric and dimeric peptide nucleic acids prepared by using microwave-promoted multicomponent reactions

Reuben Ovadia, Aurelien Lebrun, Ivan Barvik, Jean-Jacques Vasseur, Carine Baraguey, Karine Alvarez

Organic & Biomolecular Chemistry 13:11052-11071 (2015)10.1039/c5ob01604e

2015
Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection

Rami Sommerstein, Lukas Flatz, Melissa M. Remy, Pauline Malinge, Giovanni Magistrelli, Nicolas Fischer, Mehmet Sahin, Andreas Bergthaler, Sebastien Igonet, Jan Ter Meulen, Dorothee Rigo, Paolo Meda, Nadia Rabah, Bruno Coutard, Thomas A. Bowden, Paul-Henri Lambert, Claire-Anne Siegrist, Daniel D. Pinschewer

PLoS Pathogens 11 (2015)10.1371/journal.ppat.1005276

2015
Modulation of violacein production and phenotypes associated with biofilm by exogenous quorum sensing N-acylhomoserine lactones in the marine bacterium Pseudoalteromonas ulvae TC14

Armande Mireille Ayé, Maryse Bonnin-Jusserand, Florence Brian-Jaisson, Annick Ortalo-Magné, Gérald Culioli, Rose Koffi Nevry, Nadia Rabah, Yves Blache, Maëlle Molmeret

Microbiology 161:2039-2051 (2015)10.1099/mic.0.000147

2015
NMR study of non-structural proteins-part II: H-1, C-13, N-15 backbone and side-chain resonance assignment of macro domain from Venezuelan equine encephalitis virus (VEEV)

Garyfallia I. Makrynitsa, Dioni Ntonti, Konstantinos D. Marousis, Aikaterini C. Tsika, Julie Lichiere, Nicolas Papageorgiou, Bruno Coutard, Detlef Bentrop, Georgios A. Spyroulias

BIOMOLECULAR NMR ASSIGNMENTS 9:247-251 (2015)10.1007/s12104-014-9584-9

2015
mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research

Changqing Li, Jaime Guillen, Nadia Rabah, Alexandre Blanjoie, Francoise Debart, Jean-Jacques Vasseur, Bruno Canard, Etienne Decroly, Bruno Coutard

Journal of Virology 89:8292-8303 (2015)10.1128/JVI.00599-15

2015
Enzymatic synthesis of acyclic nucleoside thiophosphonate diphosphates: Effect of the alpha-phosphorus configuration on HIV-1 RT activity

Stephane Priet, Loic Roux, Magali Saez-Ayala, Francois Ferron, Bruno Canard, Karine Alvarez

Antiviral Research 117:122-131 (2015)10.1016/j.antiviral.2015.03.003

2015
NMR study of non-structural proteins-part I: H-1, C-13, N-15 backbone and side-chain resonance assignment of macro domain from Mayaro virus (MAYV)

Efstathios Melekis, Aikaterini C. Tsika, Julie Lichiere, Christos T. Chasapis, Irene Margiolaki, Nicolas Papageorgiou, Bruno Coutard, Detlef Bentrop, Georgios A. Spyroulias

BIOMOLECULAR NMR ASSIGNMENTS 9:191-195 (2015)10.1007/s12104-014-9572-0

2015
Structural and biophysical analysis of sequence insertions in the Venezuelan Equine Encephalitis Virus macro domain

Jaime Guillen, Julie Lichiere, Nadia Rabah, Brett F. Beitzel, Bruno Canard, Bruno Coutard

Virus Research 201:94-100 (2015)10.1016/j.virusres.2015.02.018

2015
Les années 2010

Michel Bouvier, Herve Chneiweiss, Bertrand Jordan, Gilbert Lagrue, Joël Ménard, Jean-Luc Teillaud, Guido Kroemer, Anne-Marie Moulin, Antoine Flahault, Laurence Lafanechère, Eric Maréchal, Jean-Claude Guillemot, Marie Gaille

Médecine/Sciences 31:91-111 (2015)10.1051/medsci/201531s1006

2015
The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

Lonneke van Der Linden, Laia Vives-Adrián, Barbara Selisko, Cristina Ferrer-Orta, Xinran Liu, Kjerstin Lanke, Rachel Ulferts, Armando M. de Palma, Federica Tanchis, Nesya Goris, David Lefebvre, Kris de Clercq, Pieter Leyssen, Céline Lacroix, Gerhard Pürstinger, Bruno Coutard, Bruno Canard, David D. Boehr, Jamie J. Arnold, Craig E. Cameron, Nuria Verdaguer, Johan Neyts, Frank J. M van Kuppeveld

PLoS Pathogens 11 (2015)10.1371/journal.ppat.1004733.s010

2015
X-ray structure and activities of an essential Mononegavirales L-protein domain

Guido C. Paesen, Axelle Collet, Corinne Sallamand, Francoise Debart, Jean-Jacques Vasseur, Bruno Canard, Etienne Decroly, Jonathan M. Grimes

Nature Communications 6:8749 (2015)10.1038/ncomms9749

2014
La chémobiologie : stratégies transfrontalières

Laurence Lafanechère, Eric Maréchal, Jean-Claude Guillemot

Médecine/Sciences 30:2 (2014)10.1051/medsci/20143012001

2014
Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus

Marion Sevajol, Lorenzo Subissi, Etienne Decroly, Bruno Canard, Isabelle Imbert

Virus Research 194:90-99 (2014)10.1016/j.virusres.2014.10.008

2014
The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

Supanee Potisopon, Stéphane Priet, Axelle Collet, Etienne Decroly, Bruno Canard, Barbara Selisko

Nucleic Acids Research 42 (2014)10.1093/nar/gku666

2014
One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Lorenzo Subissi, Clara Posthuma, Axelle Collet, Jessika Zevenhoven-Dobbe, Alexander Gorbalenya, Etienne Decroly, Eric Snijder, Bruno Canard, Isabelle Imbert

Proceedings of the National Academy of Sciences of the United States of America 111 (2014)10.1073/pnas.1323705111

2014
Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

Mickaël Bouvet, Adrien Lugari, Clara C. Posthuma, Jessika C. Zevenhoven, Stéphanie Bernard, Stéphane Betzi, Isabelle Imbert, Bruno Canard, Jean-Claude Guillemot, Patrick Lécine, Susanne Pfefferle, Christian Drosten, Eric J. Snijder, Etienne Decroly, Xavier Morelli

Journal of Biological Chemistry 289:25783-25796 (2014)10.1074/jbc.M114.577353

2014
Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase.

Olivier Bornet, Matthieu Nouailler, Michaël Feracci, Corinne Sebban-Kreuzer, Deborah Byrne, Hubert Halimi, Xavier Morelli, Ali Badache, Francoise Guerlesquin

FEBS Letters 588:2031-6 (2014)10.1016/j.febslet.2014.04.029

2014
Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

Bruno Coutard, Etienne Decroly, Changqing Li, Andrew Sharff, Julien Lescar, Gérard Bricogne, Karine Barral

Antiviral Research 106:61-70 (2014)10.1016/j.antiviral.2014.03.013

2014
Biodiversity as a source of potent and selective inhibitors of Chikungunya virus replication

Pieter Leyssen, Jacqueline Smadja, Philippe Rasoanaivo, Ameenah Gurib-Fakim, Mohamad Fawzi-Mahomoodally, Bruno Canard, Jean-Claude Guillemot, Marc Litaudon, Françoise Guéritte

151-160 (2014)10.1002/9781118460566.ch11

2013
Atomic resolution description of the interaction between the nucleoprotein and phosphoprotein of Hendra virus.

Guillaume Communie, Johnny Habchi, Filip Yabukarski, David Blocquel, Robert Schneider, Nicolas Tarbouriech, Nicolas Papageorgiou, Rob W H Ruigrok, Marc Jamin, Malene Ringkjøbing Jensen, Sonia Longhi, Martin Blackledge

PLoS Pathogens 9:e1003631 (2013)

2013
Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

Karine Barral, Corinne Sallamand, Christiane Petzold, Bruno Coutard, Axelle Collet, Yann Thillier, Jan Zimmermann, Jean-Jacques Vasseur, Bruno Canard, Jacques Rohayem, Françoise Debart, Etienne Decroly

Antiviral Research 99:292-300 (2013)10.1016/j.antiviral.2013.06.001

2013
Plasma Peptide Biomarker Discovery for Amyotrophic Lateral Sclerosis by MALDI –TOF Mass Spectrometry Profiling

Laurence Conraux, Catherine Pech, Halim Guerraoui, Denis Loyaux, Pascual Ferrara, Jean-Claude Guillemot, Vincent Meininger, Pierre-François Pradat, François Salachas, Gaelle Bruneteau, Nadine Le Forestier, Lucette Lacomblez

PLoS ONE 8:e79733 (2013)10.1371/journal.pone.0079733

2012
Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation

Latifa Elantak, Marion Espeli, Annie Boned, Olivier Bornet, Jeremy Bonzi, Laurent Gauthier, Mikael Feracci, Philippe Roche, Francoise Guerlesquin, Claudine Schiff

Journal of Biological Chemistry 287:44703-44713 (2012)10.1074/jbc.m112.395152

2012
Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri.

Pierre-Marie Allard, Pieter Leyssen, Marie-Thérèse Martin, Mélanie Bourjot, Vincent Dumontet, Cécilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Cyril Poullain, Françoise Guéritte, Marc Litaudon

Phytochemistry 84:160-8 (2012)10.1016/j.phytochem.2012.07.023

2012
Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation.

Latifa El Antak, Marion Espeli, Annie Boned, Olivier Bornet, Jeremy Bonzi, Laurent Gauthier, Mikael Feracci, Philippe Roche, Françoise Guerlesquin, Claudine Schiff

Journal of Biological Chemistry 287:44703-13 (2012)10.1074/jbc.M112.395152

2012
Chemical constituents of Anacolosa pervilleana and their antiviral activities.

Mélanie Bourjot, Pieter Leyssen, Cécilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Philippe Rasoanaivo, Françoise Guéritte, Marc Litaudon

Fitoterapia 83:1076-1080 (2012)10.1016/j.fitote.2012.05.004

2012
Flacourtosides A-F, Phenolic Glycosides Isolated from Flacourtia ramontchi.

Mélanie Bourjot, Pieter Leyssen, Cécilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Philippe Rasoanaivo, Françoise Guéritte, Marc Litaudon

Journal of Natural Products 75:752-8 (2012)10.1021/np300059n

2012
Validation of an Image Analysis Method for the Determination of the Parasitemia in Malaria-Infected Erythrocyte Cultures

German Gonzalez, Karine Alvarez, Mirko Zimic, Stephane Bertani, Michel Sauvain, Eric Deharo

(2012)

2012
Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

Barbara Selisko, Supanee Potisopon, Rym Agred, Stephane Priet, Isabelle Varlet, Yann Thillier, Corinne Sallamand, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard

PLoS Pathogens 8:e1002912 (2012)10.1371/journal.ppat.1002912

2012
Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N 7)-methyl transferase

Yann Thillier, Etienne Decroly, François Morvan, Bruno Canard, Jean-Jacques Vasseur, Françoise Debart

RNA 18:856-868 (2012)10.1261/rna.030932.111

2012
Single pH buffer refolding screen for protein from inclusion bodies

Bruno Coutard, Etienne Danchin, Rachid Oubelaid, Bruno Canard, Christophe Bignon

Protein Expression and Purification 82:352-359 (2012)10.1016/j.pep.2012.01.014

2012
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

H. Lahouassa, W. Daddacha, H. Hofmann, D. Ayinde, E. C. Logue, L. Dragin, N. Bloch, C. Maudet, M. Bertrand, T. Gramberg, G. Pancino, S. Priet, B. Canard, Nadine Laguette, M. Benkirane, C. Transy, Nr Landau, B. Kim, F. Margottin-Goguet

Nature Immunology 13:223-8. doi: 10.1038/ni.2236 (2012)10.1038/ni.2236

2011
Alkylated flavanones from the bark of Cryptocarya chartacea as dengue virus NS5 polymerase inhibitors.

Pierre-Marie Allard, Elise Tran Huu Dau, Cécilia Eydoux, Jean-Claude Guillemot, Vincent Dumontet, Cyril Poullain, Bruno Canard, Françoise Guéritte, Marc Litaudon

Journal of Natural Products 74:2446-53 (2011)10.1021/np200715v

2011
MEMO associated with an ErbB2 receptor phosphopeptide reveals a new phosphotyrosine motif.

Mikael Feracci, Cyril Pimentel, Olivier Bornet, Philippe Roche, Danièle Salaün, Ali Badache, Françoise Guerlesquin

FEBS Letters 585:2688-92 (2011)10.1016/j.febslet.2011.07.048

2011
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication

Karine Barral, Clément Weck, Nadine Payrot, Loic Roux, Céline Durafour, Fabien Zoulim, Johan Neyts, Jan Balzarini, Bruno Canard, Stephane Priet, Karine Alvarez

European Journal of Medicinal Chemistry 46:4281-4288 (2011)10.1016/j.ejmech.2011.06.034

2011
Crystallization and diffraction analysis of the SARS coronavirus nsp10-nsp16 complex.

Claire Debarnot, Isabelle Imbert, Francois Ferron, Laure Gluais, Isabelle Varlet, Nicolas Papageorgiou, Mickaël Bouvet, Julien Lescar, Etienne Decroly, Bruno Canard

Acta crystallographica Section F : Structural biology communications [2014-...] 67:404-8 (2011)10.1107/S1744309111002867

2011
PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication

Pieter Leyssen, Marc Litaudon, Jean-Claude Guillemot, Philippe Rasoanaivo, Jacqueline Smadja, Ameenah Gurib-Fakim, Bruno Canard, Françoise Guéritte

Antiviral Research 90:A36-A37 (2011)10.1016/j.antiviral.2011.03.048

2011
Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen.

Marc Le Breton, Laurène Meyniel-Schicklin, Alexandre Deloire, Bruno Coutard, Bruno Canard, Xavier de Lamballerie, Patrice Andre, Chantal Rabourdin-Combe, Vincent Lotteau, Nathalie Davoust

BMC Microbiology 11:234 (2011)10.1186/1471-2180-11-234

2010
Genomics and structure/function studies of Rhabdoviridae proteins involved in replication and transcription.

R. Assenberg, O Delmas, B Morin, C Graham, X de Lamballerie, C Laubert, B Coutard, J Grimes, J Neyts, R J Owens, B Brandt, A Gorbalenya, P Tucker, D I Stuart, Bruno Canard, Hervé Bourhy

Antiviral Research 87:149-61 (2010)10.1016/j.antiviral.2010.02.322

2010
Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates

Karine Barral, Stephane Priet, Céline de Michelis, Joséphine Sire, Johan Neyts, Jan Balzarini, Bruno Canard, Karine Alvarez

European Journal of Medicinal Chemistry 45:849-856 (2010)10.1016/j.ejmech.2009.11.012

2010
The 2C putative helicase of echovirus 30 adopts a hexameric ring-shaped structure

N. Papageorgiou, B. Coutard, V. Lantez, E. Gautron, Olivier Chauvet, C. Baronti, H. Norder, X. de Lamballerie, V. Heresanu, N. Ferte, S. Veesler, A.E. Gorbalenya, B. Canard

Acta crystallographica Section D : Structural biology [1993-...] 66:1116-1120 (2010)

2010
3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of Hepatitis C virus subgenomic replicon and NS5B polymerase activity.

Stephane Priet, Ivan Zlatev, Ivan Barvik, Katrien Geerts, Pieter Leyssen, Johan Neyts, Hélène Dutartre, Bruno Canard, Jean-Jacques Vasseur, François Morvan, Karine Alvarez

Journal of Medicinal Chemistry 53:6608-6617 (2010)10.1021/jm100102v

2009
NMR and MD investigations of human galectin-1/oligosaccharide complexes.

Christophe Meynier, Mikael Feracci, Marion Espeli, Florence Chaspoul, Philippe Gallice, Claudine Schiff, Françoise Guerlesquin, Roche Philippe

Biophysical Journal 97:3168-77 (2009)10.1016/j.bpj.2009.09.026

2009
Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.

Stéphane Betzi, Cécilia Eydoux, Cécile Bussetta, Marilyne Blemont, Pieter Leyssen, Claire Debarnot, Mohamed Ben-Rahou, Jacques Haiech, Marcel Hibert, Françoise Gueritte, David S. Grierson, Jean-Louis Romette, Jean-Claude Guillemot, Johan Neyts, Karine Alvarez, Xavier Morelli, Hélène Dutartre, Bruno Canard

Antiviral Research 84:48-59 (2009)10.1016/j.antiviral.2009.06.009

2009
The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

H. Malet, B. Coutard, S. Jamal, H. Dutartre, N. Papageorgiou, M. Neuvonen, T. Ahola, N. Forrester, E. A. Gould, D. Lafitte, F. Ferron, J. Lescar, A. Gorbalenya, X. de Lamballerie, B. Canard

Journal of Virology 83:6534-6545 (2009)10.1128/JVI.00189-09

2009
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase

Jan Paeshuyse, Carine Letellier, Matheus Froeyen, Hélène Dutartre, Robert Vrancken, Bruno Canard, Erik de Clercq, Alain Gueiffier, Jean-Claude Teulade, Piet Herdewijn, Gerhard Puerstinger, Frank Koenen, Pierre Kerkhofs, Pier Giovanni Baraldi, Johan Neyts

Antiviral Research 82:141-147 (2009)10.1016/j.antiviral.2009.02.192

2008
Structure of Human Pancreatic Lipase-Related Protein 2 with the Lid in an Open Conformation ,

Cécilia Eydoux, Silvia Spinelli, Tara Davis, John Walker, Alma Seitova, Sirano Dhe-Paganon, Alain de Caro, Christian Cambillau, Frédéric Carrière

Biochemistry 47:9553-9564 (2008)10.1021/bi8005576

2008
Occurrence of pancreatic lipase-related protein-2 in various species and its relationship with herbivore diet

Josiane de Caro, Cécilia Eydoux, Slim Chérif, Régine Lebrun, Youssef Gargouri, Frédéric Carrière, Alain de Caro

Comparative Biochemistry and Physiology. Part B, Biochemistry and Molecular Biology 150:1-9 (2008)10.1016/j.cbpb.2008.01.007

2008
Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

D. Topalis, K. Alvarez, K. Barral, Hélène Munier-Lehmann, B. Schneider, M. Véron, C. Guerreiro, Laurence A Mulard, C. El-Amri, B. Canard, Dominique Deville-Bonne

Nucleosides, Nucleotides and Nucleic Acids 27:319-31 (2008)10.1080/15257770801941952

2007
Carboxyl-Terminal Disulfide Bond of Acid Sphingomyelinase Is Critical for Its Secretion and Enzymatic Function

Ching Yin Lee, Taku Tamura, Nadia Rabah, Dong-Young Donna Lee, Isabelle Ruel, Anouar Hafiane, Iulia Iatan, Dana Nyholt, Frédéric Laporte, Claude Lazure, Ikuo Wada, Larbi Krimbou, Jacques Genest

Biochemistry 46:14969-14978 (2007)10.1021/bi700817g

2007
The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

Jan Paeshuyse, Jean-Michel Chezal, Matheus Froeyen, Pieter Leyssen, Hélène Dutartre, Robert Vrancken, Bruno Canard, Carine Letellier, Tong Li, Harald Mittendorfer, Frank Koenen, Pierre Kerkhofs, Erik de Clercq, Piet Herdewijn, Gerhard Puerstinger, Alain Gueiffier, Olivier Chavignon, Jean-Claude Teulade, Johan Neyts

Journal of Virology 81:11046-11053 (2007)10.1128/JVI.00388-07

2007
Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells

Cécilia Eydoux, Josiane de Caro, Francine Ferrato, Paul Boullanger, Dominique Lafont, René Laugier, Frédéric Carrière, Alain de Caro

Journal of Lipid Research 48:1539-1549 (2007)10.1194/jlr.M600486-JLR200

2007
The C-terminal region of the proprotein convertase 1/3 (PC1/3) exerts a bimodal regulation of the enzyme activity in vitro

Nadia Rabah, Dany Gauthier, Jimmy Dikeakos, Timothy Reudelhuber, Claude Lazure

FEBS Journal 274:3482-3491 (2007)10.1111/j.1742-4658.2007.05883.x

2007
Crystal Structure of the RNA Polymerase Domain of the West Nile Virus Non-structural Protein 5

Hélène Malet, Marie-Pierre Egloff, Barbara Selisko, Rebecca E Butcher, Peter J Wright, Michael Roberts, Arnaud Gruez, Gerlind Sulzenbacher, Clemens Vonrhein, Gérard Bricogne, Jason M Mackenzie, Alexander A Khromykh, Andrew D Davidson, Bruno Canard

Journal of Biological Chemistry (2007)10.1074/jbc.M607273200

2007
High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'-O positions.

F. Peyrane, B. Selisko, Etienne Decroly, Jean-Jacques Vasseur, D. Benarroch, B. Canard, Karine Alvarez

Nucleic Acids Research 35:1-11 (2007)10.1093/nar/gkl1119

2007
Preparation of purine and pyrimidine acyclic nucleotide analogs as antiviral agents

Karine Barral, Bruno Canard, Karine Alvarez, Jean-Louis Romette, Johan Neyts, Jan Balzarini

(2007)

2007
High-yield production of short GppA- and 7Me GppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions.

F. Peyrane, B. Selisko, Etienne Decroly, J.-J. Vasseur, D. Benarroch, B. Canard, K. Alvarez

Nucleic Acids Research 35:1-11 (2007)

2006
Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Novel α-Borano-Nucleotide Analogues of 9-[2-(Phosphonomethoxy)ethyl]adenine and ( R )-9-[2-(Phosphonomethoxy)propyl]adenine

Karine Barral, Stephane Priet, Joséphine Sire, Johan Neyts, Jan Balzarini, Bruno Canard, Karine Alvarez

Journal of Medicinal Chemistry 49:7799-7806 (2006)10.1021/jm060030y

2006
General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues

Hélène Dutartre, Cécile Bussetta, Joëlle Boretto, Bruno Canard

Antimicrobial Agents and Chemotherapy 50:4161-4169 (2006)10.1128/AAC.00433-06

2006
SPINE bioinformatics and data-management aspects of high-throughput structural biology.

S. Albeck, Pedro Maria Alzari, C. Andreini, L. Banci, I. M. Berry, I. Bertini, C. Cambillau, B. Canard, L. Carter, S. X. Cohen, J. M. Diprose, O. Dym, R. M. Esnouf, C. Felder, F. Ferron, F. Guillemot, R. Hamer, M. Ben Jelloul, R. A. Laskowski, T. Laurent, S. Longhi, R. Lopez, C. Luchinat, H. Malet, T. Mochel, R. J. Morris, L. Moulinier, T. Oinn, A. Pajon, Y. Peleg, A. Perrakis, O. Poch, J. Prilusky, A. Rachedi, R. Ripp, A. Rosato, I. Silman, D. I. Stuart, J. L. Sussman, J. C. Thierry, J. D. Thompson, J. M. Thornton, T. Unger, B. Vaughan, W. Vranken, J. D. Watson, G. Whamond, K. Henrick

Acta crystallographica Section D : Structural biology [1993-...] 62:1184-95 (2006)10.1107/S090744490602991X

2006
Human pancreatic lipase-related protein 2: Tissular localization along the digestive tract and quantification in pancreatic juice using a specific ELISA

Cécilia Eydoux, Ahmed Aloulou, Josiane de Caro, Philippe Grandval, René Laugier, Frédéric Carrière, Alain de Caro

Biochimica et Biophysica Acta (BBA) - General Subjects 1760:1497-1504 (2006)10.1016/j.bbagen.2006.06.005

2006
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens

M. J. Fogg, P. Alzari, M. Bahar, I. Bertini, J.-M. Betton, W. P. Burmeister, C. Cambillau, B. Canard, M. Carrondo, M. Coll, S. Daenke, O. Dym, M.-P. Egloff, F. J. Enguita, A. Geerlof, A. Haouz, T. A. Jones, Q. Ma, S. N. Manicka, M. Migliardi, P. Nordlund, R. J. Owens, Y. Peleg, G. Schneider, R. Schnell, D. I. Stuart, N. Tarbouriech, T. Unge, A. J. Wilkinson, M. Wilmanns, K. S. Wilson, O. Zimhony, J. M. Grimes

Acta crystallographica Section D : Structural biology [1993-...] 62:1196-1207 (2006)10.1107/S0907444906030915

2006
Structural and Functional Basis for ADP-Ribose and Poly(ADP-Ribose) Binding by Viral Macro Domains

Marie-Pierre Egloff, Hélène Malet, Ákos Putics, Maarit Heinonen, Hélène Dutartre, Antoine Frangeul, Arnaud Gruez, Valérie Campanacci, Christian Cambillau, John Ziebuhr, Tero Ahola, Bruno Canard

Journal of Virology 80:8493-8502 (2006)10.1128/JVI.00713-06

2006
Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases

Barbara Selisko, Hélène Dutartre, Jean-Claude Guillemot, Claire Debarnot, Delphine Benarroch, Alexander Khromykh, Philippe Desprès, Marie-Pierre Egloff, Bruno Canard

Virology 351:145-158 (2006)10.1016/j.virol.2006.03.026

2006
Synthesis and Anti-BVDV Activity of Acridones As New Potential Antiviral Agents 1

Oriana Tabarrini, Giuseppe Manfroni, Arnaldo Fravolini, Violetta Cecchetti, Stefano Sabatini, Erik de Clercq, Jef Rozenski, Bruno Canard, Hélène Dutartre, Jan Paeshuyse, Johan Neyts

Journal of Medicinal Chemistry 49:2621-2627 (2006)10.1021/jm051250z

2006
Expression, purification and crystallization of the SARS-CoV macro domain

Hélène Malet, Karen Dalle, Nicolas Bremond, Fabienne Tocque, Stéphanie Blangy, Valérie Campanacci, Bruno Coutard, Sacha Grisel, Julie Lichiere, Violaine Lantez, Christian Cambillau, Bruno Canard, Marie-Pierre Egloff

Acta Crystallographica Section F: Structural Biology and Crystallization Communications 62:405-408 (2006)10.1107/S1744309106009274

2006
Single Amino Acid Substitution in the PC1/3 Propeptide Can Induce Significant Modifications of Its Inhibitory Profile toward Its Cognate Enzyme

Nadia Rabah, Dany Gauthier, Brian Wilkes, Daniel Gauthier, Claude Lazure

Journal of Biological Chemistry 281:7556-7567 (2006)10.1074/jbc.M510607200

2005
A Novel, Highly Selective Inhibitor of Pestivirus Replication That Targets the Viral RNA-Dependent RNA Polymerase

Jan Paeshuyse, Pieter Leyssen, Eric Mabery, Nina Boddeker, Robert Vrancken, Matheus Froeyen, Israrul Ansari, Hélène Dutartre, Jef Rozenski, Laura Gil, Carine Letellier, Robert Lanford, Bruno Canard, Frank Koenen, Pierre Kerkhofs, Ruben Donis, Piet Herdewijn, Julia Watson, Erik de Clercq, Gerhard Puerstinger, Johan Neyts

Journal of Virology 80:149-160 (2005)10.1128/JVI.80.1.149-160.2006

2005
Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance

Karine Alvarez, Jérôme Deval, Boulbaba Selmi, Karine Barral, Joelle Boretto, Catherine Guerreiro, Laurence S Mulard, Robert Sarfati, Bruno Canard

Nucleosides, Nucleotides and Nucleic Acids 24:419-422 (2005)10.1081/NCN-200059951

2005
VaZyMolO: a tool to define and classify modularity in viral proteins

François Ferron, Corinne Rancurel, Sonia Longhi, Christian Cambillau, Bernard Henrissat, Bruno Canard

Journal of General Virology 86:743-749 (2005)10.1099/vir.0.80590-0

2005
A Relaxed Discrimination of 2′- O -Methyl-GTP Relative to GTP between de Novo and Elongative RNA Synthesis by the Hepatitis C RNA-dependent RNA Polymerase NS5B

Hélène Dutartre, Joëlle Boretto, Jean Claude Guillemot, Bruno Canard

Journal of Biological Chemistry 280:6359-6368 (2005)10.1074/jbc.M410191200

2004
Improved PC1/3 production through recombinant expression in insect cells and larvae

Nadia Rabah, Daniel Gauthier, Dany Gauthier, Claude Lazure

Protein Expression and Purification 37:377-384 (2004)10.1016/j.pep.2004.06.014

2004
The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world

Marie-Pierre Egloff, Francois Ferron, Valérie Campanacci, Sonia Longhi, Corinne Rancurel, Hélène Dutartre, Eric J Snijder, Alexander Gorbalenya, Christian Cambillau, Bruno Canard

Proceedings of the National Academy of Sciences of the United States of America 101:3792-3796 (2004)10.1073/pnas.0307877101

2004
Crystal Structure of E. coli Alcohol Dehydrogenase YqhD: Evidence of a Covalently Modified NADP Coenzyme

Gerlind Sulzenbacher, Karine Alvarez, Robert H H van den Heuvel, Cees Versluis, Silvia Spinelli, Valé Rie Campanacci, Christel Valencia, Christian Cambillau, Hans Eklund, Mariella Tegoni

Journal of Molecular Biology 342:489-502 (2004)10.1016/j.jmb.2004.07.034

2003
Structural genomics of the SARS coronavirus: cloning, expression, crystallization and preliminary crystallographic study of the Nsp9 protein

Valérie Campanacci, Marie-Pierre Egloff, Sonia Longhi, François Ferron, Corinne Rancurel, Aurelia Salomoni, Cécile Durousseau, Fabienne Tocque, Nicolas Brémond, Jessika Dobbe, Eric Snijder, Bruno Canard, Christian Cambillau

Acta Crystallographica Section D: Biological Crystallography 59:1628-1631 (2003)10.1107/S0907444903016779

2003
Barley Serine Proteinase Inhibitor 2-Derived Cyclic Peptides as Potent and Selective Inhibitors of Convertases PC1/3 and Furin

Michèle Villemure, Alain Fournier, Dany Gauthier, Nadia Rabah, Brian Wilkes, Claude Lazure

Biochemistry 42:9659-9668 (2003)10.1021/bi034418w

2003
Structural Analysis of the Activation of Ribavirin Analogs by NDP Kinase: Comparison with Other Ribavirin Targets

Sarah Gallois-Montbrun, Yuxing Chen, Hélène Dutartre, Magali Sophys, Solange Moréra, Catherine Guerreiro, Benoit Schneider, Laurence S Mulard, Joël Janin, Michel Véron, Dominique Deville-Bonne, Bruno Canard

Molecular Pharmacology 63:538-546 (2003)10.1124/mol.63.3.538

2002
Identification of two tamoxifen target proteins by photolabeling with 4-(2-morpholinoethoxy)benzophenone.

Fabienne Mésange, Mohamed Sebbar, Joël Capdevielle, Jean-Claude Guillemot, Pascual Ferrara, Francis Bayard, Marc E. Poirot, Jean-Charles Faye

Bioconjug Chem 13:766-72 (2002)

2002
Porcine odorant-binding protein selectively binds to a human olfactory receptor

Valéry Matarazzo, Nicole Zsürger, Jean-Claude Guillemot, Olivier Clot-Faybesse, Jean-Marie Botto, Claude Dal Farra, Marc Crowe, Jacques Demaille, Jean-Pierre Vincent, Jean Mazella, Catherine Ronin

Chemical Senses 27:691-701 (2002)10.1093/chemse/27.8.691

2001
Interaction of human immunodeficiency virus type 1 Vif with Gag and Gag-Pol precursors : co-encapsidation and interference with viral protease-mediated Gag processing

Martine Bardy, Bernard Gay, Stéphanie Pébernard, Nathalie Chazal, Marianne Courcoul, Robert Vigne, Etienne Decroly, Pierre Boulanger

Journal of General Virology 82:2719-2733 (2001)10.1099/0022-1317-82-11-2719

1998
Tyrosine phosphorylation of the Wiskott-Aldrich Syndrome protein by Lyn and Btk is regulated by CDC42

Rodolphe r. Guinamard, Pontus Aspenström, Michel Fougereau, Philippe Chavrier, Jean-Claude Guillemot

FEBS Letters 434:431-436 (1998)10.1016/s0014-5793(98)01016-3

1998
The pro-oligonucleotide approach: solid phase synthesis and preliminary evaluation of model pro-dodecathymidylates

J.J. Vasseur, Guilhem Tosquellas, Karine Alvarez, Christelle Dell'Aquila, François Morvan, Jean-Jacques Vasseur, Jean-Louis Imbach, Bernard Rayner

Nucleic Acids Research 26:2069-2074 (1998)10.1093/nar/26.9.2069

1998
Microsomal epoxide hydrolase of rat liver is a subunit of the anti-oestrogen-binding site.

Fabienne Mésange, Mohamed Sebbar, Blandine Kedjouar, Joël Capdevielle, Jean-Claude Guillemot, Pascual Ferrara, Francis Bayard, Frédéric Delarue, Jean-Charles Faye, Marc E. Poirot

Biochemical Journal 334 ( Pt 1):107-12 (1998)

1998
Clostridium perfringens CPN50

Stewart Cole, Sei-Ichi Katayama, Bruno Dupuy, Thierry Garnier, Brigitte Saint-Joanis, Bruno Canard

645-647 (1998)10.1007/978-1-4615-6369-3_58

1996
Mismatch repair in Xenopus egg extracts: DNA strand breaks act as signals rather than excision points

I. Varlet, B. Canard, P. Brooks, G. Cerovic, M. Radman

Proceedings of the National Academy of Sciences of the United States of America 93:10156-10161 (1996)10.1073/pnas.93.19.10156

1995
Studies of recombinant amylosucrase

M. Remaud-Simeon, F. Albaret, B. Canard, I. Varlet, P. Colonna, R. M. Willemot, P. Monsan

313-320 (1995)

1992
Phylogenetic analysis of the pathogenic anaerobe Clostridium perfringens using the 16S rRNA nucleotide sequence.

Bruno Canard, Thierry Garnier, Bénédicte Lafay, Richard Christen, Stewart T. Cole

International Journal of Systematic Bacteriology 42:312-4 (1992)10.1099/00207713-42-2-312

1992
Autolysis of Clostridium acetobutylicum ATCC 824

Christian Croux, B. Canard, G. Goma, Philippe Soucaille

Journal of general microbiology 138:861-869 (1992)

1992
Purification and characterization of an extracellular muramidase of Clostridium acetobutylicum ATCC 824 that acts on non-n-acetylated pepticoglycan

Christian Croux, B. Canard, G. Goma, Philippe Soucaille

Applied and Environmental Microbiology 58:1075-1081 (1992)

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