Notre équipe cherche à comprendre les mécanismes moléculaires de la réplication des virus émergents par la caractérisation des activités enzymatiques et l’analyse structurale des protéines formant le complexe de réplication/transcription. Ces études sont un préalable au développement d’inhibiteurs spécifiques de ces enzymes et devraient permettre le développement de nouvelles stratégies antivirales.

Les virus à génome ARN sont régulièrement associés à l’émergence de maladies infectieuses. Parmi les plus connues, les épidémies liées aux Bunyavirales (LCMV, Lassa, Vallée du Rift…), au Filovirus (Ebola), aux Nidovirales (Coronavirus), aux Flavivirus ( Chikungunya ou le virus de la Dengue) et aux maladies chroniques (HIV, HCV, HBV, HEV) illustrent des problèmes de santé publique générés à l’échelle mondiale.

L’équipe multidisciplinaire « Réplicases Virales : structure, mécanisme et drug–design » s’intéresse à l’ensemble des enzymes de virus émergents impliquées dans la réplication de leur génome et à la synthèse (transcription) de leurs ARN messagers. Ces enzymes sont le plus souvent associées au sein d’un complexe de réplication/transcription (RTC). Nos études portent non seulement sur les polymérases virales qui coordonnent la réplication virale, mais également sur les enzymes impliquées dans des mécanismes de modifications des ARNs (coiffage, édition, correction …) ou encore sur les protéines impliquées dans la régulation de la réplication.

Au delà de l’analyse restreinte au complexe réplicatif, nous nous nous intéressons également à l’interférence entre cette machinerie enzymatique avec les mécanismes de l’immunité innée de la cellule. Les enzymes de la réplication sont donc à double titre des cibles antivirales privilégiées et la compréhension de leur mode de fonctionnement participe à la conception de molécules à haut potentiel antiviral. Pour soutenir ces projets de recherche, le laboratoire s’appuie sur la plateforme de criblage d’inhibiteurs (PCML) et sur une banque de protéines virales recombinantes.

Etude des ARN polymérases ARN-dépendantes

L’étude des polymérases constitue naturellement une des thématiques de recherche importante du laboratoire (HIV, HCV, dengue, West Nile, SARS, BVDV, Coxsackie virus). Nous disposons des outils permettant de suivre leur activité enzymatique. Nos travaux ont notamment permis ces dernières années de résoudre la structure de plusieurs enzymes, de déterminer des mécanismes de fonctionnement, et d’identifier les partenaires actifs dans les complexes multi-protéiques. Nous avons également développé des inhibiteurs originaux et étudié les mécanismes de résistance vis à vis de ces antiviraux.

Structure de la polymérase du virus West Nile

Développement d’antiviraux

Dans la recherche de molécules antivirales, nous utilisons 2 stratégies de découverte : l’une basée sur la synthèse de molécules conçues rationnellement, grâce à la biochimie et la biologie structurale et l’autre basée sur l’optimisation de molécules “hits” issues de résultats de criblages. Dans ces deux approches, nos cibles sont des protéines du système réplicatif des virus. L’originalité et la qualité du travail qui est réalisé sur ces sujets tiennent en grande partie à la multidisciplinarité des projets combinant biochimie, biologie structurale, biologie moléculaire, bio-informatique, modélisation moléculaire, cristallographie, enzymologie, virologie et chimie.

Domaines de recherche
  • activités enzymatiques
  • réplication/transcription
  • stratégies antivirales
  • ARN polymérases
  • nucléases
  • méthyltransférases
  • protéases
  • nucléoproteines

Publications

2022
Arenaviridae NP-exonuclease inhibition by bisphosphonate

Thi Hong van Nguyen, Elsie Yekwa, Barbara Selisko, Bruno Canard, Karine Alvarez, Francois Ferron

IUCrJ 9 (2022)10.1107/S2052252522005061

2022
A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases

Sergio Hernández, Mikael Feracci, Carolina Trajano de Jesus, Priscila El-Kazzi, Rafik Kaci, Laura Garlatti, Etienne Decroly, Bruno Canard, Francois Ferron, Karine Alvarez

(2022)10.1101/2021.04.02.437736

2022
Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues

Rostom Ahmed-Belkacem, Marcel Hausdorff, Adrien Delpal, Priscila Sutto-Ortiz, Agathe M G Colmant, Franck Touret, Natacha S Ogando, Eric J Snijder, Bruno Canard, Bruno Coutard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

Journal of Medicinal Chemistry 65:6231-6249 (2022)10.1021/acs.jmedchem.2c00120

Voir la liste complète des publications

Publications de l'équipe

2022
Arenaviridae NP-exonuclease inhibition by bisphosphonate

Thi Hong van Nguyen, Elsie Yekwa, Barbara Selisko, Bruno Canard, Karine Alvarez, Francois Ferron

IUCrJ 9 (2022)10.1107/S2052252522005061

2022
A high-throughput fluorescence polarization assay to discover inhibitors of arenavirus and coronavirus exoribonucleases

Sergio Hernández, Mikael Feracci, Carolina Trajano de Jesus, Priscila El-Kazzi, Rafik Kaci, Laura Garlatti, Etienne Decroly, Bruno Canard, Francois Ferron, Karine Alvarez

(2022)10.1101/2021.04.02.437736

2022
Potent Inhibition of SARS-CoV-2 nsp14 N 7-Methyltransferase by Sulfonamide-Based Bisubstrate Analogues

Rostom Ahmed-Belkacem, Marcel Hausdorff, Adrien Delpal, Priscila Sutto-Ortiz, Agathe M G Colmant, Franck Touret, Natacha S Ogando, Eric J Snijder, Bruno Canard, Bruno Coutard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

Journal of Medicinal Chemistry 65:6231-6249 (2022)10.1021/acs.jmedchem.2c00120

2022
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase

Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Adrien Delpal, Etienne Decroly, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Adel Moussa, Steven S Good, Paolo La Colla, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, Francois Ferron, Bruno Canard

Nature Communications 13 (2022)10.1038/s41467-022-28113-1

2022
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex

Daniel L Hurdiss, Priscila El Kazzi, Lisa Bauer, Nicolas Papageorgiou, Francois Ferron, Tim Donselaar, Arno L.W. van Vliet, Tatiana M Shamorkina, Joost Snijder, Bruno Canard, Etienne Decroly, Andrea Brancale, Tzviya Zeev-Ben-Mordehai, Friedrich Förster, Frank J.M. van Kuppeveld, Bruno Coutard

Science Advances 8 (2022)10.1126/sciadv.abj7615

2022
Synthesis, Structure–Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs As Inhibitors of SARS-CoV-2 Replication

Dorothée Bardiot, Laura Vangeel, Mohamed Koukni, Philippe Arzel, Marleen Zwaagstra, Heyrhyoung Lyoo, Patrick Wanningen, Shamshad Ahmad, Linlin Zhang, Xinyuanyuan Sun, Adrien Delpal, Cecilia Eydoux, Jean-Claude Guillemot, Eveline Lescrinier, Hugo Klaassen, Pieter Leyssen, Dirk Jochmans, Karolien Castermans, Rolf Hilgenfeld, Colin Robinson, Etienne Decroly, Bruno Canard, Eric J Snijder, Martijn J Van Hemert, Frank Van van Kuppeveld, Patrick Chaltin, Johan Neyts, Steven De de Jonghe, Arnaud Marchand

Molecules 27:1052 (2022)10.3390/molecules27031052

2022
A second type of N7-guanine RNA cap methyltransferase in an unusual locus of a large RNA virus genome

Ashleigh Shannon, Bhawna Sama, Pierre Gauffre, Théo Guez, Françoise Debart, J.J. Vasseur, Etienne Decroly, Bruno Canard, Francois Ferron

Nucleic Acids Research (2022)

2021
Structure-function analysis of the nsp14 N7-guanine methyltransferase reveals an essential role in Betacoronavirus replication

Natacha S Ogando, Priscila El Kazzi, Jessika C Zevenhoven-Dobbe, Brenda W Bontes, Alice Decombe, Clara C S Posthuma, Volker Thiel, Bruno Canard, Francois Ferron, Etienne Decroly, Eric J Snijder

Proceedings of the National Academy of Sciences of the United States of America (2021)10.1101/2021.05.17.444407

2021
System-oriented optimization of multi-target 2,6-diaminopurine derivatives: Easily accessible broad-spectrum antivirals active against flaviviruses, influenza virus and SARS-CoV-2

Ilaria Vicenti, Maria Grazia Martina, Adele Boccuto, Marta de Angelis, Giorgia Giavarini, Filippo Dragoni, Serena Marchi, Claudia Maria Trombetta, Emmanuele Crespan, Giovanni Maga, Cecilia Eydoux, Etienne Decroly, Emanuele Montomoli, Lucia Nencioni, Maurizio Zazzi, Marco Radi

European Journal of Medicinal Chemistry 224:113683 (2021)10.1016/j.ejmech.2021.113683

2021
Macros to Quantify Exosome Release and Autophagy at the Neuromuscular Junction of Drosophila Melanogaster

Irene Sanchez-Mirasierra, Sergio Hernandez-Diaz, Saurav Ghimire, Carla Montecinos-Oliva, Sandra-Fausia Soukup

Frontiers in Cell and Developmental Biology 9 (2021)10.3389/fcell.2021.773861

2021
Fragment-based drug design targeting syntenin PDZ2 domain involved in exosomal release and tumour spread

Manon Garcia, Laurent Hoffer, Raphaël Leblanc, Fatiha Benmansour, Mikael Feracci, Carine Derviaux, Antonio Luis Egea-Jimenez, Philippe Roche, Pascale Zimmermann, Xavier Morelli, Karine Barral

European Journal of Medicinal Chemistry 223:113601 (2021)10.1016/j.ejmech.2021.113601

2021
Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes the hexameric complex

Daniel L Hurdiss, Priscila El Kazzi, Lisa Bauer, Nicolas Papageorgiou, Francois Ferron, Tim Donselaar, Arno L W van Vliet, Bruno Canard, Etienne Decroly, Andrea Brancale, Tzviya Zeev-Ben-Mordehai, Friedrich Förster, Frank J M van Kuppeveld, Bruno Coutard

(2021)10.1101/2021.04.26.440876

2021
Protein-primed RNA synthesis in SARS-CoVs and structural basis for inhibition by AT-527

Ashleigh Shannon, Véronique Fattorini, Bhawna Sama, Barbara Selisko, Mikael Feracci, Camille Falcou, Pierre Gauffre, Priscila El Kazzi, Etienne Decroly, Nadia Rabah, Karine Alvarez, Cécilia Eydoux, Jean-Claude Guillemot, Françoise Debart, J.J. Vasseur, Mathieu Noel, Adel Moussa, Steven Good, Kai Lin, Jean-Pierre Sommadossi, Yingxiao Zhu, Xiaodong Yan, Hui Shi, François Ferron, Bruno Canard

(2021)10.1101/2021.03.23.436564

2021
An appeal for an objective, open, and transparent scientific debate about the origin of SARS-CoV-2

Jacques van Helden, Colin Butler, Guillaume Achaz, Bruno Canard, Didier Casane, Jean-Michel Claverie, Fabien Colombo, Virginie Courtier-Orgogozo, Richard Ebright, François Graner, Milton Leitenberg, Serge Morand, Nikolai Petrovsky, Rossana Segreto, Etienne Decroly, José Halloy

The Lancet 398:1402-1404 (2021)10.1016/S0140-6736(21)02019-5

2021
Structure and Sequence Requirements for RNA Capping at the Venezuelan Equine Encephalitis Virus RNA 5′ End

Oney Ortega Granda, Coralie Valle, Ashleigh Shannon, Etienne Decroly, Bruno Canard, Bruno Coutard, Nadia Rabah

Journal of Virology 95 (2021)10.1128/JVI.00777-21

2021
The enzymes for genome size increase and maintenance of large (+)RNA viruses

Francois Ferron, Bhawna Sama, Etienne Decroly, Bruno Canard

Trends in Biochemical Sciences (2021)10.1016/j.tibs.2021.05.006

2021
Simeprevir Potently Suppresses SARS-CoV-2 Replication and Synergizes with Remdesivir

Ho Sing Lo, Kenrie Pui yan Hui, Hei-Ming Lai, Xu He, Khadija Shahed Khan, Simranjeet Kaur, Junzhe Huang, Zhongqi Li, Anthony Chan, Hayley Hei-yin Cheung, Ka-Chun Ng, John Chi Wang Ho, yu Wai Chen, Bowen Ma, Peter Man-Hin Cheung, Donghyuk Shin, Kaidao Wang, Meng-Hsuan Lee, Barbara Selisko, Cecilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Kuen-Phon Wu, Po-Huang Liang, Ivan Dikic, Zhong Zuo, Francis Chan, David Hui, Vincent Mok, Kam-Bo Wong, Chris Ka Pun Mok, Ho Ko, Wei Shen Aik, Michael Chi Wai Chan, Wai-Lung Ng

ACS Central Science 7:792-802 (2021)10.1021/acscentsci.0c01186

2021
The methyltransferase domain of the Respiratory Syncytial Virus L protein catalyzes cap N7 and 2’-O-methylation

Priscila Sutto-Ortiz, Sergey Tcherniuk, Nina Ysebaert, Pravien Abeywickrema, Mathieu Noël, Alice Decombe, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard, Dirk Roymans, Peter Rigaux, Jean-François Eléouët, Etienne Decroly

PLoS Pathogens 17:e1009562 (2021)10.1371/journal.ppat.1009562

2021
Tracing the origins of SARS-COV-2 in coronavirus phylogenies: a review

Erwan Sallard, José Halloy, Didier Casane, Etienne Decroly, Jacques van Helden

Environmental Chemistry Letters 19:769-785 (2021)10.1007/s10311-020-01151-1

2021
Observation of arenavirus nucleoprotein heptamer assembly

Nicolas Papageorgiou, Afroditi Vaitsopoulou, Awa Diop, Thi Hong van Nguyen, Bruno Canard, Karine Alvarez, Francois Ferron

FEBS Open Bio (2021)10.1002/2211-5463.13106

2021
A fluorescence-based high throughput-screening assay for the SARS-CoV RNA synthesis complex

Cecilia Eydoux, Veronique Fattorini, Ashleigh Shannon, Thi-Tuyet-Nhung Le, Bruno Didier, Bruno Canard, Jean-Claude Guillemot

Journal of Virological Methods 288:114013 (2021)10.1016/j.jviromet.2020.114013

2021
Dengue Virus NS5 Transcribes Metabolite-Capped, RIG-I Sensitive vRNAs

Brandon Schweibenz, Mihai Solotchi, Etienne Decroly, Barbara Selisko, Bruno Canard, Smita Patel

Biophysical Journal 120:135a (2021)10.1016/j.bpj.2020.11.1017

2021
COVID-19 epidemiologic surveillance using wastewater

Virender Sharma, Chetan Jinadatha, Eric Lichtfouse, Etienne Decroly, Jacques van Helden, Hosoon Choi, Piyali Chatterjee

Environmental Chemistry Letters 19:1911-1915 (2021)10.1007/s10311-021-01188-w

2021
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel Klionsky, Amal Kamal Abdel-Aziz, Sara Abdelfatah, Mahmoud Abdellatif, Asghar Abdoli, Steffen Abel, Hagai Abeliovich, Marie Abildgaard, Yakubu Princely Abudu, Abraham Acevedo-Arozena, Iannis Adamopoulos, Khosrow Adeli, Timon Adolph, Annagrazia Adornetto, Elma Aflaki, Galila Agam, Anupam Agarwal, Bharat Aggarwal, Maria Agnello, Patrizia Agostinis, Javed Agrewala, Alexander Agrotis, Patricia Aguilar, S. Tariq Ahmad, Zubair Ahmed, Ulises Ahumada-Castro, Sonja Aits, Shu Aizawa, Yunus Akkoc, Tonia Akoumianaki, Hafize Aysin Akpinar, Ahmed Al-Abd, Lina Al-Akra, Abeer Al-Gharaibeh, Moulay Alaoui-Jamali, Simon Alberti, Elísabet Alcocer-Gómez, Cristiano Alessandri, Muhammad Ali, M. Abdul Alim Al-Bari, Saeb Aliwaini, Javad Alizadeh, Eugènia Almacellas, Alexandru Almasan, Alicia Alonso, Guillermo Alonso, Nihal Altan-Bonnet, Dario Altieri, Élida Álvarez, Sara Alves, Cristine Alves da Costa, Mazen Alzaharna, Marialaura Amadio, Consuelo Amantini, Cristina Amaral, Susanna Ambrosio, Amal Amer, Veena Ammanathan, Zhenyi An, Stig Andersen, Shaida Andrabi, Magaiver Andrade-Silva, Allen Andres, Sabrina Angelini, David Ann, Uche Anozie, Mohammad Ansari, Pedro Antas, Adam Antebi, Zuriñe Antón, Tahira Anwar, Lionel Apetoh, Nadezda Apostolova, Toshiyuki Araki, Yasuhiro Araki, Kohei Arasaki, Wagner Araújo, Jun Araya, Catherine Arden, Maria-Angeles Arévalo, Sandro Arguelles, Esperanza Arias, Jyothi Arikkath, Hirokazu Arimoto, Aileen Ariosa, Darius Armstrong-James, Laetitia Arnauné-Pelloquin, Angeles Aroca, Daniela Arroyo, Ivica Arsov, Rubén Artero, Dalia Maria Lucia Asaro, Michael Aschner, Milad Ashrafizadeh, Osnat Ashur-Fabian, Atanas Atanasov, Alicia Au, Patrick Auberger, Holger Auner, Laure Aurelian, Riccardo Autelli, Laura Avagliano, Yenniffer Ávalos, Sanja Aveic, Célia Alexandra Aveleira, Tamar Avin-Wittenberg, Yucel Aydin, Scott Ayton, Srinivas Ayyadevara, Maria Azzopardi, Misuzu Baba, Jonathan Backer, Steven Backues, Dong-Hun Bae, Ok-Nam Bae, Soo Han Bae, Eric Baehrecke, Ahruem Baek, Seung-Hoon Baek, Sung Hee Baek, Giacinto Bagetta, Agnieszka Bagniewska-Zadworna, Hua Bai, Jie Bai, Xiyuan Bai, Yidong Bai, Nandadulal Bairagi, Shounak Baksi, Teresa Balbi, Cosima Baldari, Walter Balduini, Andrea Ballabio, Maria Ballester, Salma Balazadeh, Rena Balzan, Rina Bandopadhyay, Sreeparna Banerjee, Sulagna Banerjee, Ágnes Bánréti, Yan Bao, Mauricio Baptista, Alessandra Baracca, Cristiana Barbati, Ariadna Bargiela, Daniela Barilà, Peter Barlow, Sami Barmada, Esther Barreiro, George Barreto, Jiri Bartek, Bonnie Bartel, Alberto Bartolome, Gaurav Barve, Suresh Basagoudanavar, Diane Bassham, Robert Bast, Alakananda Basu, Henri Batoko, Isabella Batten, Etienne Baulieu, Bradley Baumgarner, Jagadeesh Bayry, Rupert Beale, Isabelle Beau, Florian Beaumatin, Luiz R.G. Bechara, George Beck, Michael Beers, Jakob Begun, Christian Behrends, Georg M.N. Behrens, Roberto Bei, Eloy Bejarano, Shai Bel, Christian Behl, Amine Belaid, Naïma Belgareh-Touzé, Cristina Bellarosa, Francesca Belleudi, Melissa Belló Pérez, Raquel Bello-Morales, Jackeline Soares de Oliveira Beltran, Sebastián Beltran, Doris Mangiaracina Benbrook, Mykolas Bendorius, Bruno Benitez, Irene Benito-Cuesta, Julien Bensalem, Martin Berchtold, Sabina Berezowska, Daniele Bergamaschi, Matteo Bergami, Andreas Bergmann, Laura Berliocchi, Clarisse Berlioz-Torrent, Amélie Bernard, Lionel Berthoux, Cagri Besirli, Sébastien Besteiro, Virginie Betin, Rudi Beyaert, Jelena Bezbradica, Kiran Bhaskar, Ingrid Bhatia-Kissova, Resham Bhattacharya, Sujoy Bhattacharya, Shalmoli Bhattacharyya, Md. Shenuarin Bhuiyan, Sujit Kumar Bhutia, Lanrong Bi, Xiaolin Bi, Trevor Biden, Krikor Bijian, Viktor Billes, Nadine Binart, Claudia Bincoletto, Asa Birgisdottir, Geir Bjorkoy, Gonzalo Blanco, Ana Blas-Garcia, Janusz Blasiak, Robert Blomgran, Klas Blomgren, Janice Blum, Emilio Boada-Romero, Mirta Boban, Kathleen Boesze-Battaglia, Philippe Boeuf, Barry Boland, Pascale Bomont, Paolo Bonaldo, Srinivasa Reddy Bonam, Laura Bonfili, Juan Bonifacino, Brian Boone, Martin Bootman, Matteo Bordi, Christoph Borner, Beat Bornhauser, Gautam Borthakur, Jürgen Bosch, Santanu Bose, Luis Botana, Juan Botas, Chantal Boulanger, Michael Boulton, Mathieu Bourdenx, Benjamin Bourgeois, Nollaig Bourke, Guilhem Bousquet, Patricia Boya, Peter Bozhkov, Luiz Bozi, Tolga Bozkurt, Doug Brackney, Christian Brandts, Ralf Braun, Gerhard Braus, Roberto Bravo-Sagua, José M. Bravo-San Pedro, Patrick Brest, Marie-Agnès Bringer, Alfredo Briones-Herrera, V. Courtney Broaddus, Peter Brodersen, Jeffrey Brodsky, Steven Brody, Paola Bronson, Jeff Bronstein, Carolyn Brown, Rhoderick Brown, Patricia Brum, John Brumell, Nicola Brunetti-Pierri, Daniele Bruno, Robert Bryson-Richardson, Cecilia Bucci, Carmen Buchrieser, Marta Bueno, Laura Elisa Buitrago-Molina, Simone Buraschi, Shilpa Buch, J. Ross Buchan, Erin Buckingham, Hikmet Budak, Mauricio Budini, Geert Bultynck, Florin Burada, Joseph Burgoyne, M. Isabel Burón, Victor Bustos, Sabrina Büttner, Elena Butturini, Aaron Byrd, Isabel Cabas, Sandra Cabrera-Benitez, Ken Cadwell, Jingjing Cai, Lu Cai, Qian Cai, Montserrat Cairó, Jose Calbet, Guy Caldwell, Kim Caldwell, Jarrod Call, Riccardo Calvani, Ana Calvo, Miguel Calvo-Rubio Barrera, Niels Os Camara, Jacques H. Camonis, Nadine Camougrand, Michelangelo Campanella, Edward Campbell, François-Xavier Campbell-Valois, Silvia Campello, Ilaria Campesi, Juliane Campos, Olivier Camuzard, Jorge Cancino, Danilo Candido de Almeida, Laura Canesi, Isabella Caniggia, Barbara Canonico, Carles Cantí, Bin Cao, Michele Caraglia, Beatriz Caramés, Evie Carchman, Elena Cardenal-Muñoz, Cesar Cardenas, Luis Cardenas, Sandra Cardoso, Jennifer Carew, Georges F. Carle, Gillian Carleton, Silvia Carloni, Didac Carmona-Gutierrez, Leticia Carneiro, Oliana Carnevali, Julian Carosi, Serena Carra, Alice Carrier, Lucie Carrier, Bernadette Carroll, A. Brent Carter, Andreia Neves Carvalho, Magali Casanova, Caty Casas, Josefina Casas, Chiara Cassioli, Eliseo Castillo, Karen Castillo, Sonia Castillo-Lluva, Francesca Castoldi, Marco Castori, Ariel Castro, Margarida Castro-Caldas, Javier Castro-Hernandez, Susana Castro-Obregon, Sergio Catz, Claudia Cavadas, Federica Cavaliere, Gabriella Cavallini, Maria Cavinato, Maria Cayuela, Paula Cebollada Rica, Valentina Cecarini, Francesco Cecconi, Marzanna Cechowska-Pasko, Simone Cenci, Victòria Ceperuelo-Mallafré, João Cerqueira, Janete Cerutti, Davide Cervia, Vildan Bozok Cetintas, Silvia Cetrullo, Han-Jung Chae, Andrei Chagin, Chee-Yin Chai, Gopal Chakrabarti, Oishee Chakrabarti, Tapas Chakraborty, Trinad Chakraborty, Mounia Chami, Georgios Chamilos, David Chan, Edmond Chan, Edward Chan, H.Y. Edwin Chan, Helen Chan, Hung Chan, Matthew T.V. Chan, Yau Sang Chan, Partha Chandra, Chih-Peng Chang, Chunmei Chang, Hao-Chun Chang, Kai Chang, Jie Chao, Tracey Chapman, Nicolas Charlet-Berguerand, Samrat Chatterjee, Shail Chaube, Anu Chaudhary, Santosh Chauhan, Edward Chaum, Frédéric Checler, Michael Cheetham, Chang-Shi Chen, Guang-Chao Chen, Jian-Fu Chen, Liam Chen, Leilei Chen, Lin Chen, Mingliang Chen, Mu-Kuan Chen, Ning Chen, Quan Chen, Ruey-Hwa Chen, Shi Chen, Wei Chen, Weiqiang Chen, Xin-Ming Chen, Xiong-Wen Chen, Xu Chen, Yan Chen, Ye-Guang Chen, Yingyu Chen, Yongqiang Chen, Yu-Jen Chen, Yue-Qin Chen, Zhefan Stephen Chen, Zhi Chen, Zhi-Hua Chen, Zhijian Chen, Zhixiang Chen, Hanhua Cheng, Jun Cheng, Shi-Yuan Cheng, Wei Cheng, Xiaodong Cheng, Xiu-Tang Cheng, Yiyun Cheng, Zhiyong Cheng, Zhong Chen, Heesun Cheong, Jit Kong Cheong, Boris Chernyak, Sara Cherry, Chi Fai Randy Cheung, Chun Hei Antonio Cheung, King-Ho Cheung, Eric Chevet, Richard Chi, Alan Kwok Shing Chiang, Ferdinando Chiaradonna, Roberto Chiarelli, Mario Chiariello, Nathalia Chica, Susanna Chiocca, Mario Chiong, Shih-Hwa Chiou, Abhilash Chiramel, Valerio Chiurchiù, Dong-Hyung Cho, Seong-Kyu Choe, Augustine M.K. Choi, Mary Choi, Kamalika Roy Choudhury, Norman Chow, Charleen Chu, Jason Chua, John Jia En Chua, Hyewon Chung, Kin Pan Chung, Seockhoon Chung, So-Hyang Chung, Yuen-Li Chung, Valentina Cianfanelli, Iwona Ciechomska, Mariana Cifuentes, Laura Cinque, Sebahattin Cirak, Mara Cirone, Michael Clague, Robert Clarke, Emilio Clementi, Eliana Coccia, Patrice Codogno, Ehud Cohen, Mickael M. Cohen, Tania Colasanti, Fiorella Colasuonno, Robert Colbert, Anna Colell, Miodrag Čolić, Nuria Coll, Mark Collins, María Colombo, Daniel Colón-Ramos, Lydie Combaret, Sergio Comincini, Márcia Cominetti, Antonella Consiglio, Andrea Conte, Fabrizio Conti, Viorica Raluca Contu, Mark Cookson, Kevin Coombs, Isabelle Coppens, Maria Tiziana Corasaniti, Dale Corkery, Nils Cordes, Katia Cortese, Maria Do Carmo Costa, Sarah Costantino, Paola Costelli, Ana Coto-Montes, Peter Crack, Jose Crespo, Alfredo Criollo, Valeria Crippa, Riccardo Cristofani, Tamas Csizmadia, Antonio Cuadrado, Bing Cui, Jun Cui, Yixian Cui, Yong Cui, Emmanuel Culetto, Andrea Cumino, Andrey Cybulsky, Mark Czaja, Stanislaw Czuczwar, Stefania D’adamo, Marcello D’amelio, Daniela D’arcangelo, Andrew D’lugos, Gabriella D’orazi, James da Silva, Hormos Salimi Dafsari, Ruben Dagda, Yasin Dagdas, Maria Daglia, Xiaoxia Dai, Yun Dai, Yuyuan Dai, Jessica Dal Col, Paul Dalhaimer, Luisa Dalla Valle, Tobias Dallenga, Guillaume Dalmasso, Markus Damme, Ilaria Dando, Nico Dantuma, April Darling, Hiranmoy Das, Srinivasan Dasarathy, Santosh Dasari, Srikanta Dash, Oliver Daumke, Adrian Dauphinee, Jeffrey Davies, Valeria Dávila, Roger Davis, Tanja Davis, Sharadha Dayalan Naidu, Francesca de Amicis, Karolien de Bosscher, Francesca de Felice, Lucia de Franceschi, Chiara de Leonibus, Mayara de Mattos Barbosa, Guido R.Y. de Meyer, Angelo de Milito, Cosimo de Nunzio, Clara de Palma, Mauro de Santi, Claudio de Virgilio, Daniela de Zio, Jayanta Debnath, Brian Debosch, Jean-Paul Decuypere, Mark Deehan, Gianluca Deflorian, James Degregori, Benjamin Dehay, Gabriel del Rio, Joe Delaney, Lea Delbridge, Elizabeth Delorme-Axford, M. Victoria Delpino, Francesca Demarchi, Vilma Dembitz, Nicholas Demers, Hongbin Deng, Zhiqiang Deng, Joern Dengjel, Paul Dent, Donna Denton, Melvin Depamphilis, Channing Der, Vojo Deretic, Albert Descoteaux, Laura Devis, Sushil Devkota, Olivier Devuyst, Grant Dewson, Mahendiran Dharmasivam, Rohan Dhiman, Diego Di Bernardo, Manlio Di Cristina, Fabio Di Domenico, Pietro Di Fazio, Alessio Di Fonzo, Giovanni Di Guardo, Gianni Di Guglielmo, Luca Di Leo, Chiara Di Malta, Alessia Di Nardo, Martina Di Rienzo, Federica Di Sano, George Diallinas, Jiajie Diao, Guillermo Diaz-Araya, Inés Díaz-Laviada, Jared Dickinson, Marc Diederich, Mélanie Dieudé, Ivan Dikic, Shiping Ding, Wen-Xing Ding, Luciana Dini, Jelena Dinić, Miroslav Dinic, Albena Dinkova-Kostova, Marc Dionne, Jörg H.W. Distler, Abhinav Diwan, Ian M.C. Dixon, Mojgan Djavaheri-Mergny, Ina Dobrinski, Oxana Dobrovinskaya, Radek Dobrowolski, Renwick C.J. Dobson, Jelena Đokić, Serap Dokmeci Emre, Massimo Donadelli, Bo Dong, Xiaonan Dong, Zhiwu Dong, Gerald 2nd Dorn, Volker Dotsch, Huan Dou, Juan Dou, Moataz Dowaidar, Sami Dridi, Liat Drucker, Ailian Du, Caigan Du, Guangwei Du, Hai-Ning Du, Li-Lin Du, André Du Toit, Shao-Bin Duan, Xiaoqiong Duan, Sónia Duarte, Anna Dubrovska, Elaine Dunlop, Nicolas Dupont, Raúl Durán, Bilikere Dwarakanath, Sergey Dyshlovoy, Darius Ebrahimi-Fakhari, Leopold Eckhart, Charles Edelstein, Thomas Efferth, Eftekhar Eftekharpour, Ludwig Eichinger, Nabil Eid, Tobias Eisenberg, N. Tony Eissa, Sanaa Eissa, Miriam Ejarque, Abdeljabar El Andaloussi, Nazira El-Hage, Shahenda El-Naggar, Anna Maria Eleuteri, Eman El-Shafey, Mohamed Elgendy, Aristides Eliopoulos, María Elizalde, Philip Elks, Hans-Peter Elsasser, Eslam Elsherbiny, Brooke Emerling, N. Emre, Christina Eng, Nikolai Engedal, Anna-Mart Engelbrecht, Agnete S.T. Engelsen, Jorrit Enserink, Ricardo Escalante, Audrey Esclatine, Mafalda Escobar-Henriques, Eeva-Liisa Eskelinen, Lucile Espert, Makandjou-Ola Eusebio, Gemma Fabrias, Cinzia Fabrizi, Antonio Facchiano, Francesco Facchiano, Bengt Fadeel, Claudio Fader, Alex Faesen, W. Douglas Fairlie, Alberto Falcó, Bjorn Falkenburger, Daping Fan, Jie Fan, Yanbo Fan, Evandro Fang, Yanshan Fang, Yognqi Fang, Manolis Fanto, Tamar Farfel-Becker, Mathias Faure, Gholamreza Fazeli, Anthony Fedele, Arthur Feldman, Du Feng, Jiachun Feng, Lifeng Feng, Yibin Feng, Yuchen Feng, Wei Feng, Thais Fenz Araujo, Thomas Ferguson, Álvaro Fernández, Jose Fernandez-Checa, Sonia Fernández-Veledo, Alisdair Fernie, Anthony Ferrante, Alessandra Ferraresi, Merari Ferrari, Julio C.B. Ferreira, Susan Ferro-Novick, Antonio Figueras, Riccardo Filadi, Nicoletta Filigheddu, Eduardo Filippi-Chiela, Giuseppe Filomeni, Gian Maria Fimia, Vittorio Fineschi, Francesca Finetti, Steven Finkbeiner, Edward Fisher, Paul Fisher, Flavio Flamigni, Steven Fliesler, Trude Flo, Ida Florance, Oliver Florey, Tullio Florio, Erika Fodor, Carlo Follo, Edward Fon, Antonella Forlino, Francesco Fornai, Paola Fortini, Anna Fracassi, Alessandro Fraldi, Brunella Franco, Rodrigo Franco, Flavia Franconi, Lisa Frankel, Scott Friedman, Leopold Fröhlich, Gema Frühbeck, Jose Fuentes, Yukio Fujiki, Naonobu Fujita, Yuuki Fujiwara, Mitsunori Fukuda, Simone Fulda, Luc Furic, Norihiko Furuya, Carmela Fusco, Michaela Gack, Lidia Gaffke, Sehamuddin Galadari, Alessia Galasso, Maria Galindo, Sachith Gallolu Kankanamalage, Lorenzo Galluzzi, Vincent Galy, Noor Gammoh, Boyi Gan, Ian Ganley, Feng Gao, Hui Gao, Minghui Gao, Ping Gao, Shou-Jiang Gao, Wentao Gao, Xiaobo Gao, Ana Garcera, Maria Noé Garcia, Verónica Garcia, Francisco García-del Portillo, Vega Garcia-Escudero, Aracely Garcia-Garcia, Marina Garcia-Macia, Diana García-Moreno, Carmen Garcia-Ruiz, Patricia García-Sanz, Abhishek Garg, Ricardo Gargini, Tina Garofalo, Robert Garry, Nils Gassen, Damian Gatica, Liang Ge, Wanzhong Ge, Ruth Geiss-Friedlander, Cecilia Gelfi, Pascal Genschik, Ian Gentle, Valeria Gerbino, Christoph Gerhardt, Kyla Germain, Marc Germain, David Gewirtz, Elham Ghasemipour Afshar, Saeid Ghavami, Alessandra Ghigo, Manosij Ghosh, Georgios Giamas, Claudia Giampietri, Alexandra Giatromanolaki, Gary Gibson, Spencer Gibson, Vanessa Ginet, Edward Giniger, Carlotta Giorgi, Henrique Girao, Stephen Girardin, Mridhula Giridharan, Sandy Giuliano, Cecilia Giulivi, Sylvie Giuriato, Julien Giustiniani, Alexander Gluschko, Veit Goder, Alexander Goginashvili, Jakub Golab, David Goldstone, Anna Golebiewska, Luciana Gomes, Rodrigo Gomez, Rubén Gómez-Sánchez, Maria Catalina Gomez-Puerto, Raquel Gomez-Sintes, Qingqiu Gong, Felix Goni, Javier González-Gallego, Tomas Gonzalez-Hernandez, Rosa Gonzalez-Polo, Jose Gonzalez-Reyes, Patricia González-Rodríguez, Ing Swie Goping, Marina Gorbatyuk, Nikolai Gorbunov, Kivanç Görgülü, Roxana Gorojod, Sharon Gorski, Sandro Goruppi, Cecilia Gotor, Roberta Gottlieb, Illana Gozes, Devrim Gozuacik, Martin Graef, Markus Gräler, Veronica Granatiero, Daniel Grasso, Joshua Gray, Douglas Green, Alexander Greenhough, Stephen Gregory, Edward Griffin, Mark Grinstaff, Frederic Gros, Charles Grose, Angelina Gross, Florian Gruber, Paolo Grumati, Tilman Grune, Xueyan Gu, Jun-Lin Guan, Carlos Guardia, Kishore Guda, Flora Guerra, Consuelo Guerri, Prasun Guha, Carlos Guillén, Shashi Gujar, Anna Gukovskaya, Ilya Gukovsky, Jan Gunst, Andreas Günther, Anyonya Guntur, Chuanyong Guo, Chun Guo, Hongqing Guo, Lian-Wang Guo, Ming Guo, Pawan Gupta, Shashi Kumar Gupta, Swapnil Gupta, Veer Bala Gupta, Vivek Gupta, Asa Gustafsson, David Gutterman, Ranjitha H.B., Annakaisa Haapasalo, James Haber, Aleksandra Hać, Shinji Hadano, Anders Hafrén, Mansour Haidar, Belinda Hall, Gunnel Halldén, Anne Hamacher-Brady, Andrea Hamann, Maho Hamasaki, Weidong Han, Malene Hansen, Phyllis I.  Hanson, Zijian Hao, Masaru Harada, Ljubica Harhaji-Trajkovic, Nirmala Hariharan, Nigil Haroon, James Harris, Takafumi Hasegawa, Noor Hasima Nagoor, Jeffrey Haspel, Volker Haucke, Wayne Hawkins, Bruce Hay, Cole Haynes, Soren Hayrabedyan, Thomas Hays, Congcong He, Qin He, Rong-Rong He, You-Wen He, Yu-Ying He, Yasser Heakal, Alexander Heberle, J. Fielding Hejtmancik, Gudmundur Vignir  Helgason, Vanessa Henkel, Marc Herb, Alexander Hergovich, Anna Herman-Antosiewicz, Agustín Hernández, Carlos Hernandez, Sergio Hernandez-Diaz, Virginia Hernandez-Gea, Amaury Herpin, Judit Herreros, Javier Hervás, Daniel Hesselson, Claudio Hetz, Volker Heussler, Yujiro Higuchi, Sabine Hilfiker, Joseph Hill, William Hlavacek, Emmanuel Ho, Idy H.T. Ho, Philip Wing-Lok Ho, Shu-Leong Ho, Wan Yun Ho, G. Aaron Hobbs, Mark Hochstrasser, Peter H.M. Hoet, Daniel Hofius, Paul Hofman, Annika Höhn, Carina Holmberg, Jose Hombrebueno, Chang-Won Hong, Yi-Ren Hong, Lora Hooper, Thorsten Hoppe, Rastislav Horos, Yujin Hoshida, I-Lun Hsin, Hsin-Yun Hsu, Bing Hu, Dong Hu, Li-Fang Hu, Ming Chang Hu, Ronggui Hu, Wei Hu, Yu-Chen Hu, Zhuo-Wei Hu, Fang Hua, Jinlian Hua, Yingqi Hua, Chongmin Huan, Canhua Huang, Chuanshu Huang, Chuanxin Huang, Chunling Huang, Haishan Huang, Kun Huang, Michael L.H. Huang, Rui Huang, Shan Huang, Tianzhi Huang, Xing Huang, Yuxiang Jack Huang, Tobias Huber, Virginie Hubert, Christian Hubner, Stephanie Hughes, William Hughes, Magali Humbert, Gerhard Hummer, James Hurley, Sabah Hussain, Salik Hussain, Patrick Hussey, Martina Hutabarat, Hui-Yun Hwang, Seungmin Hwang, Antonio Ieni, Fumiyo Ikeda, Yusuke Imagawa, Yuzuru Imai, Carol Imbriano, Masaya Imoto, Denise Inman, Ken Inoki, Juan Iovanna, Renato Iozzo, Giuseppe Ippolito, Javier Irazoqui, Pablo Iribarren, Mohd Ishaq, Makoto Ishikawa, Nestor Ishimwe, Ciro Isidoro, Nahed Ismail, Shohreh Issazadeh-Navikas, Eisuke Itakura, Daisuke Ito, Davor Ivankovic, Saška Ivanova, Anand Krishnan V. Iyer, José Izquierdo, Masanori Izumi, Marja Jäättelä, Majid Sakhi Jabir, William Jackson, Nadia Jacobo-Herrera, Anne-Claire Jacomin, Elise Jacquin, Pooja Jadiya, Hartmut Jaeschke, Chinnaswamy Jagannath, Arjen Jakobi, Johan Jakobsson, Bassam Janji, Pidder Jansen-Dürr, Patric Jansson, Jonathan Jantsch, Sławomir Januszewski, Alagie Jassey, Steve Jean, Hélène Jeltsch-David, Pavla Jendelova, Andreas Jenny, Thomas Jensen, Niels Jessen, Jenna Jewell, Jing Ji, Lijun Jia, Rui Jia, Liwen Jiang, Qing Jiang, Richeng Jiang, Teng Jiang, Xuejun Jiang, Yu Jiang, Maria Jimenez-Sanchez, Eun-Jung Jin, Fengyan Jin, Hongchuan Jin, Li Jin, Luqi Jin, Meiyan Jin, Si Jin, Eun-Kyeong Jo, Carine Joffre, Terje Johansen, Gail V.W. Johnson, Simon Johnston, Eija Jokitalo, Mohit Kumar Jolly, Leo A.B. Joosten, Joaquin Jordan, Bertrand Joseph, Dianwen Ju, Jeong-Sun Ju, Jingfang Ju, Esmeralda Juárez, Delphine Judith, Gábor Juhász, Youngsoo Jun, Chang Hwa Jung, Sung-Chul Jung, Yong Keun Jung, Heinz Jungbluth, Johannes Jungverdorben, Steffen Just, Kai Kaarniranta, Allen Kaasik, Tomohiro Kabuta, Daniel Kaganovich, Alon Kahana, Renate Kain, Shinjo Kajimura, Maria Kalamvoki, Manjula Kalia, Danuta Kalinowski, Nina Kaludercic, Ioanna Kalvari, Joanna Kaminska, Vitaliy Kaminskyy, Hiromitsu Kanamori, Keizo Kanasaki, Chanhee Kang, Rui Kang, Sang Sun Kang, Senthilvelrajan Kaniyappan, Tomotake Kanki, Thirumala-Devi Kanneganti, Anumantha Kanthasamy, Arthi Kanthasamy, Marc Kantorow, Orsolya Kapuy, Michalis Karamouzis, Md. Razaul Karim, Parimal Karmakar, Rajesh Katare, Masaru Kato, Stefan H.E. Kaufmann, Anu Kauppinen, Gur Kaushal, Susmita Kaushik, Kiyoshi Kawasaki, Kemal Kazan, Po-Yuan Ke, Damien Keating, Ursula Keber, John Kehrl, Kate Keller, Christian Keller, Jongsook Kim Kemper, Candia Kenific, Oliver Kepp, Stephanie Kermorgant, Andreas Kern, Robin Ketteler, Tom Keulers, Boris Khalfin, Hany Khalil, Bilon Khambu, Shahid Khan, Vinoth Kumar Megraj Khandelwal, Rekha Khandia, Widuri Kho, Noopur Khobrekar, Sataree Khuansuwan, Mukhran Khundadze, Samuel Killackey, Dasol Kim, Deok Ryong Kim, Do-Hyung Kim, Dong-Eun Kim, Eun Young Kim, Eun-Kyoung Kim, Hak-Rim Kim, Hee-Sik Kim, Hyung-Ryong Kim, Jeong Hun Kim, Jin Kyung Kim, Jin-Hoi Kim, Joungmok Kim, Ju Hwan Kim, Keun Il Kim, Peter Kim, Seong-Jun Kim, Scot Kimball, Adi Kimchi, Alec Kimmelman, Tomonori Kimura, Matthew King, Kerri Kinghorn, Conan Kinsey, Vladimir Kirkin, Lorrie Kirshenbaum, Sergey Kiselev, Shuji Kishi, Katsuhiko Kitamoto, Yasushi Kitaoka, Kaio Kitazato, Richard Kitsis, Josef Kittler, Ole Kjaerulff, Peter Klein, Thomas Klopstock, Jochen Klucken, Helene Knævelsrud, Roland Knorr, Ben C.B. Ko, Fred Ko, Jiunn-Liang Ko, Hotaka Kobayashi, Satoru Kobayashi, Ina Koch, Jan Koch, Ulrich Koenig, Donat Kögel, Young Ho Koh, Masato Koike, Sepp Kohlwein, Nur Kocaturk, Masaaki Komatsu, Jeannette König, Toru Kono, Benjamin Kopp, Tamas Korcsmaros, Gözde Korkmaz, Viktor Korolchuk, Mónica Suárez Korsnes, Ali Koskela, Janaiah Kota, Yaichiro Kotake, Monica Kotler, Yanjun Kou, Michael Koukourakis, Evangelos Koustas, Attila Kovacs, Tibor Kovács, Daisuke Koya, Tomohiro Kozako, Claudine Kraft, Dimitri Krainc, Helmut Krämer, Anna Krasnodembskaya, Carole Kretz-Remy, Guido Kroemer, Nicholas Ktistakis, Kazuyuki Kuchitsu, Sabine Kuenen, Lars Kuerschner, Thomas Kukar, Ajay Kumar, Ashok Kumar, Deepak Kumar, Dhiraj Kumar, Sharad Kumar, Shinji Kume, Caroline Kumsta, Chanakya Kundu, Mondira Kundu, Ajaikumar Kunnumakkara, Lukasz Kurgan, Tatiana Kutateladze, Ozlem Kutlu, Seongae Kwak, Ho Jeong Kwon, Taeg Kyu Kwon, Yong Tae Kwon, Irene Kyrmizi, Albert La Spada, Patrick Labonté, Sylvain Ladoire, Ilaria Laface, Frank Lafont, Diane Lagace, Vikramjit Lahiri, Zhibing Lai, Angela Laird, Aparna Lakkaraju, Trond Lamark, Sheng-Hui Lan, Ane Landajuela, Darius Lane, Jon Lane, Charles Lang, Carsten Lange, Ülo Langel, Rupert Langer, Pierre Lapaquette, Jocelyn Laporte, Nicholas Larusso, Isabel Lastres-Becker, Wilson Chun Yu Lau, Gordon Laurie, Sergio Lavandero, Betty Yuen Kwan Law, Helen Ka-Wai Law, Rob Layfield, Weidong Le, Herve Le Stunff, Alexandre Leary, Jean-Jacques Lebrun, Lionel Y.W. Leck, Jean-Philippe Leduc-Gaudet, Changwook Lee, Chung-Pei Lee, Da-Hye Lee, Edward Lee, Erinna Lee, Gyun Min Lee, He-Jin Lee, Heung Kyu Lee, Jae Man Lee, Jason Lee, Jin-A Lee, Joo-Yong Lee, Jun Hee Lee, Michael Lee, Min Goo Lee, Min Jae Lee, Myung-Shik Lee, Sang Yoon Lee, Seung-Jae Lee, Stella Lee, Sung Bae Lee, Won Hee Lee, Ying-Ray Lee, Yong-Ho Lee, Youngil Lee, Christophe Lefebvre, Renaud Legouis, Yu Lei, Yuchen Lei, Sergey Leikin, Gerd Leitinger, Leticia Lemus, Shuilong Leng, Olivia Lenoir, Guido Lenz, Heinz Josef Lenz, Paola Lenzi, Yolanda León, Andréia Leopoldino, Christoph Leschczyk, Stina Leskelä, Elisabeth Letellier, Chi-Ting Leung, Po Sing Leung, Jeremy Leventhal, Beth Levine, Patrick Lewis, Klaus Ley, Bin Li, Da-Qiang Li, Jianming Li, Jing Li, Jiong Li, Ke Li, Liwu Li, Mei Li, Min Li, Ming Li, Mingchuan Li, Pin-Lan Li, Ming-Qing Li, Qing Li, Sheng Li, Tiangang Li, Wei Li, Wenming Li, Xue Li, Yi-Ping Li, Yuan Li, Zhiqiang Li, Zhiyong Li, Zhiyuan Li, Jiqin Lian, Chengyu Liang, Qiangrong Liang, Weicheng Liang, Yongheng Liang, Yongtian Liang, Guanghong Liao, Lujian Liao, Mingzhi Liao, Yung-Feng Liao, Mariangela Librizzi, Pearl Lie, Mary Lilly, Hyunjung Lim, Thania R.R. Lima, Federica Limana, Chao Lin, Chih-Wen Lin, Dar-Shong Lin, Fu-Cheng Lin, Jiandie Lin, Kurt Lin, Kwang-Huei Lin, Liang-Tzung Lin, Pei-Hui Lin, Qiong Lin, Shaofeng Lin, Su-Ju Lin, Wenyu Lin, Xueying Lin, Yao-Xin Lin, Yee-Shin Lin, Rafael Linden, Paula Lindner, Shuo-Chien Ling, Paul Lingor, Amelia Linnemann, Yih-Cherng Liou, Marta Lipinski, Saška Lipovšek, Vitor Lira, Natalia Lisiak, Paloma Liton, Chao Liu, Ching-Hsuan Liu, Chun-Feng Liu, Cui Hua Liu, Fang Liu, Hao Liu, Hsiao-Sheng Liu, Hua-Feng Liu, Huifang Liu, Jia Liu, Jing Liu, Julia Liu, Leyuan Liu, Longhua Liu, Meilian Liu, Qin Liu, Wei Liu, Wende Liu, Xiao-Hong Liu, Xiaodong Liu, Xingguo Liu, Xu Liu, Xuedong Liu, Yanfen Liu, Yang Liu, Yueyang Liu, Yule Liu, J. Andrew Livingston, Gerard Lizard, Jose Lizcano, Senka Ljubojevic-Holzer, Matilde Lleonart, David Llobet-Navàs, Alicia Llorente, Chih Hung Lo, Damián Lobato-Márquez, Qi Long, Yun Chau Long, Ben Loos, Julia Loos, Manuela López, Guillermo López-Doménech, José Antonio López-Guerrero, Ana López-Jiménez, Óscar López-Pérez, Israel López-Valero, Magdalena Lorenowicz, Mar Lorente, Peter Lorincz, Laura Lossi, Sophie Lotersztajn, Penny Lovat, Jonathan Lovell, Alenka Lovy, Péter Lőw, Guang Lu, Haocheng Lu, Jia-Hong Lu, Jin-Jian Lu, Mengji Lu, Shuyan Lu, Alessandro Luciani, John Lucocq, Paula Ludovico, Micah Luftig, Morten Luhr, Diego Luis-Ravelo, Julian Lum, Liany Luna-Dulcey, Anders Lund, Viktor Lund, Jan Lünemann, Patrick Lüningschrör, Honglin Luo, Rongcan Luo, Shouqing Luo, Zhi Luo, Claudio Luparello, Bernhard Lüscher, Luan Luu, Alex Lyakhovich, Konstantin Lyamzaev, Alf Håkon Lystad, Lyubomyr Lytvynchuk, Alvin Ma, Changle Ma, Mengxiao Ma, Ning-Fang Ma, Quan-Hong Ma, Xinliang Ma, Yueyun Ma, Zhenyi Ma, Ormond Macdougald, Fernando Macian, Gustavo Macintosh, Jeffrey Mackeigan, Kay Macleod, Sandra Maday, Frank Madeo, Muniswamy Madesh, Tobias Madl, Julio Madrigal-Matute, Akiko Maeda, Yasuhiro Maejima, Marta Magarinos, Poornima Mahavadi, Emiliano Maiani, Kenneth Maiese, Panchanan Maiti, Maria Chiara Maiuri, Barbara Majello, Michael Major, Elena Makareeva, Fayaz Malik, Karthik Mallilankaraman, Walter Malorni, Alina Maloyan, Najiba Mammadova, Gene Chi Wai Man, Federico Manai, Joseph Mancias, Eva-Maria Mandelkow, Michael Mandell, Angelo Manfredi, Masoud Manjili, Ravi Manjithaya, Patricio Manque, Bella Manshian, Raquel Manzano, Claudia Manzoni, Kai Mao, Cinzia Marchese, Sandrine Marchetti, Anna Maria Marconi, Fabrizio Marcucci, Stefania Mardente, Olga Mareninova, Marta Margeta, Muriel Mari, Sara Marinelli, Oliviero Marinelli, Guillermo Mariño, Sofia Mariotto, Richard Marshall, Mark Marten, Sascha Martens, Alexandre P.J. Martin, Katie Martin, Sara Martin, Shaun Martin, Adrián Martín-Segura, Miguel Martín-Acebes, Inmaculada Martin-Burriel, Marcos Martin-Rincon, Paloma Martin-Sanz, José Martina, Wim Martinet, Aitor Martinez, Ana Martinez, Jennifer Martinez, Moises Martinez Velazquez, Nuria Martinez-Lopez, Marta Martinez-Vicente, Daniel Martins, Joilson Martins, Waleska Martins, Tania Martins-Marques, Emanuele Marzetti, Shashank Masaldan, Celine Masclaux-Daubresse, Douglas Mashek, Valentina Massa, Lourdes Massieu, Glenn Masson, Laura Masuelli, Anatoliy Masyuk, Tetyana Masyuk, Paola Matarrese, Ander Matheu, Satoaki Matoba, Sachiko Matsuzaki, Pamela Mattar, Alessandro Matte, Domenico Mattoscio, José Mauriz, Mario Mauthe, Caroline Mauvezin, Emanual Maverakis, Paola Maycotte, Johanna Mayer, Gianluigi Mazzoccoli, Cristina Mazzoni, Joseph Mazzulli, Nami Mccarty, Christine Mcdonald, Mitchell Mcgill, Sharon Mckenna, Bethann Mclaughlin, Fionn Mcloughlin, Mark Mcniven, Thomas Mcwilliams, Fatima Mechta-Grigoriou, Tania Catarina Medeiros, Diego Medina, Lynn Megeney, Klara Megyeri, Maryam Mehrpour, Jawahar Mehta, Alfred Meijer, Annemarie Meijer, Jakob Mejlvang, Alicia Meléndez, Annette Melk, Gonen Memisoglu, Alexandrina Mendes, Delong Meng, Fei Meng, Tian Meng, Rubem Menna-Barreto, Manoj Menon, Carol Mercer, Anne Mercier, Jean-Louis Mergny, Adalberto Merighi, Seth Merkley, Giuseppe Merla, Volker Meske, Ana Cecilia Mestre, Shree Padma Metur, Christian Meyer, Hemmo Meyer, Wenyi Mi, Jeanne Mialet-Perez, Junying Miao, Lucia Micale, Yasuo Miki, Enrico Milan, Małgorzata Milczarek, Dana Miller, Samuel Miller, Silke Miller, Steven Millward, Ira Milosevic, Elena Minina, Hamed Mirzaei, Hamid Reza Mirzaei, Mehdi Mirzaei, Amit Mishra, Nandita Mishra, Paras Kumar Mishra, Maja Misirkic Marjanovic, Roberta Misasi, Amit Misra, Gabriella Misso, Claire Mitchell, Geraldine Mitou, Tetsuji Miura, Shigeki Miyamoto, Makoto Miyazaki, Mitsunori Miyazaki, Taiga Miyazaki, Keisuke Miyazawa, Noboru Mizushima, Trine Mogensen, Baharia Mograbi, Reza Mohammadinejad, Yasir Mohamud, Abhishek Mohanty, Sipra Mohapatra, Torsten Möhlmann, Asif Mohmmed, Anna Moles, Kelle Moley, Maurizio Molinari, Vincenzo Mollace, Andreas Buch Møller, Bertrand Mollereau, Faustino Mollinedo, Costanza Montagna, Mervyn Monteiro, Andrea Montella, L. Ruth Montes, Barbara Montico, Vinod Mony, Giacomo Monzio Compagnoni, Michael Moore, Mohammad Moosavi, Ana Mora, Marina Mora, David Morales-Alamo, Rosario Moratalla, Paula Moreira, Elena Morelli, Sandra Moreno, Daniel Moreno-Blas, Viviana Moresi, Benjamin Morga, Alwena Morgan, Fabrice Morin, Hideaki Morishita, Orson Moritz, Mariko Moriyama, Yuji Moriyasu, Manuela Morleo, Eugenia Morselli, Jose Moruno-Manchon, Jorge Moscat, Serge Mostowy, Elisa Motori, Andrea Felinto Moura, Naima Moustaid-Moussa, Maria Mrakovcic, Gabriel Muciño-Hernández, Anupam Mukherjee, Subhadip Mukhopadhyay, Jean Mulcahy Levy, Victoriano Mulero, Sylviane Muller, Christian Münch, Ashok Munjal, Pura Munoz-Canoves, Teresa Muñoz-Galdeano, Christian Münz, Tomokazu Murakawa, Claudia Muratori, Brona Murphy, J. Patrick Murphy, Aditya Murthy, Timo Myöhänen, Indira Mysorekar, Jennifer Mytych, Seyed Mohammad Nabavi, Massimo Nabissi, Péter Nagy, Jihoon Nah, Aimable Nahimana, Ichiro Nakagawa, Ken Nakamura, Hitoshi Nakatogawa, Shyam Nandi, Meera Nanjundan, Monica Nanni, Gennaro Napolitano, Roberta Nardacci, Masashi Narita, Melissa Nassif, Ilana Nathan, Manabu Natsumeda, Ryno Naude, Christin Naumann, Olaia Naveiras, Fatemeh Navid, Steffan Nawrocki, Taras Nazarko, Francesca Nazio, Florentina Negoita, Thomas Neill, Amanda Neisch, Luca Neri, Mihai Netea, Patrick Neubert, Thomas Neufeld, Dietbert Neumann, Albert Neutzner, Phillip Newton, Paul Ney, Ioannis Nezis, Charlene C.W. Ng, Tzi Bun Ng, Hang Nguyen, Long Nguyen, Hong-Min Ni, Clíona Ní Cheallaigh, Zhenhong Ni, M. Celeste Nicolao, Francesco Nicoli, Manuel Nieto-Diaz, Per Nilsson, Shunbin Ning, Rituraj Niranjan, Hiroshi Nishimune, Mireia Niso-Santano, Ralph Nixon, Annalisa Nobili, Clevio Nobrega, Takeshi Noda, Uxía Nogueira-Recalde, Trevor Nolan, Ivan Nombela, Ivana Novak, Beatriz Novoa, Takashi Nozawa, Nobuyuki Nukina, Carmen Nussbaum-Krammer, Jesper Nylandsted, Tracey O’donovan, Seónadh O’leary, Eyleen O’rourke, Mary O’sullivan, Timothy O’sullivan, Salvatore Oddo, Ina Oehme, Michinaga Ogawa, Eric Ogier-Denis, Margret Ogmundsdottir, Besim Ogretmen, Goo Taeg Oh, Seon-Hee Oh, Young Oh, Takashi Ohama, Yohei Ohashi, Masaki Ohmuraya, Vasileios Oikonomou, Rani Ojha, Koji Okamoto, Hitoshi Okazawa, Masahide Oku, Sara Oliván, Jorge Oliveira, Michael Ollmann, James Olzmann, Shakib Omari, M. Bishr Omary, Gizem Önal, Martin Ondrej, Sang-Bing Ong, Sang-Ging Ong, Anna Onnis, Juan Orellana, Sara Orellana-Muñoz, Maria del Mar Ortega-Villaizan, Xilma Ortiz-Gonzalez, Elena Ortona, Heinz Osiewacz, Abdel-Hamid Osman, Rosario Osta, Marisa Otegui, Kinya Otsu, Christiane Ott, Luisa Ottobrini, Jing-Hsiung James Ou, Tiago Outeiro, Inger Oynebraten, Melek Ozturk, Gilles Pagès, Susanta Pahari, Marta Pajares, Utpal Pajvani, Rituraj Pal, Simona Paladino, Nicolas Pallet, Michela Palmieri, Giuseppe Palmisano, Camilla Palumbo, Francesco Pampaloni, Lifeng Pan, Qingjun Pan, Wenliang Pan, Xin Pan, Ganna Panasyuk, Rahul Pandey, Udai Pandey, Vrajesh Pandya, Francesco Paneni, Shirley Pang, Elisa Panzarini, Daniela Papademetrio, Elena Papaleo, Daniel Papinski, Diana Papp, Eun Chan Park, Hwan Tae Park, Ji-Man Park, Jong-In Park, Joon Tae Park, Junsoo Park, Sang Chul Park, Sang-Youel Park, Abraham Parola, Jan Parys, Adrien Pasquier, Benoit Pasquier, João Passos, Nunzia Pastore, Hemal Patel, Daniel Patschan, Sophie Pattingre, Gustavo Pedraza-Alva, Jose Pedraza-Chaverri, Zully Pedrozo, Gang Pei, Jianming Pei, Hadas Peled-Zehavi, Joaquín Pellegrini, Joffrey Pelletier, Miguel Peñalva, Di Peng, Ying Peng, Fabio Penna, Maria Pennuto, Francesca Pentimalli, Cláudia Mf Pereira, Gustavo J.S. Pereira, Lilian Pereira, Luis Pereira de Almeida, Nirma Perera, Ángel Pérez-Lara, Ana Perez-Oliva, María Esther Pérez-Pérez, Palsamy Periyasamy, Andras Perl, Cristiana Perrotta, Ida Perrotta, Richard Pestell, Morten Petersen, Irina Petrache, Goran Petrovski, Thorsten Pfirrmann, Astrid Pfister, Jennifer Philips, Huifeng Pi, Anna Picca, Alicia Pickrell, Sandy Picot, Giovanna Pierantoni, Marina Pierdominici, Philippe Pierre, Valérie Pierrefite-Carle, Karolina Pierzynowska, Federico Pietrocola, Miroslawa Pietruczuk, Claudio Pignata, Felipe Pimentel-Muiños, Mario Pinar, Roberta Pinheiro, Ronit Pinkas-Kramarski, Paolo Pinton, Karolina Pircs, Sujan Piya, Paola Pizzo, Theo Plantinga, Harald Platta, Ainhoa Plaza-Zabala, Markus Plomann, Egor Plotnikov, Helene Plun-Favreau, Ryszard Pluta, Roger Pocock, Stefanie Pöggeler, Christian Pohl, Marc Poirot, Angelo Poletti, Marisa Ponpuak, Hana Popelka, Blagovesta Popova, Helena Porta, Soledad Porte Alcon, Eliana Portilla-Fernandez, Martin Post, Malia Potts, Joanna Poulton, Ted Powers, Thomas Wollert, Isabelle Vergne, Romeo Ricci

Autophagy 17:1-382 (2021)10.1080/15548627.2020.1797280

2021
The WHO mission report struggles to trace the origins of the SARS-CoV-2 epidemic

Etienne Decroly, Jean-Michel Claverie, Bruno Canard

Virologie 1-7 (2021)

2021
Combining Antivirals and Immunomodulators to Fight COVID-19

Vincent Feuillet, Bruno Canard, Alain Trautmann

Trends in Immunology 42:31-44 (2021)10.1016/j.it.2020.11.003

2021
First insights into the structural features of Ebola virus methyltransferase activities

Coralie Valle, Baptiste Martin, François Ferron, Véronique Roig-Zamboni, Aline Desmyter, Françoise Debart, Jean Jacques Vasseur, Bruno Canard, Bruno Coutard, Etienne Decroly

Nucleic Acids Research 49:1737-1748 (2021)10.1093/nar/gkaa1276

2020
Favipiravir strikes the SARS-CoV-2 at its Achilles heel, the RNA polymerase

A. Shannon, B. Selisko, Ntt Le, J. Huchting, F. Touret, G. Piorkowski, V. Fattorini, F. Ferron, Etienne Decroly, C Meier, B. Coutard, O. Peersen, B. Canard

(2020)10.1101/2020.05.15.098731

2020
Tracing the origins of SARS-CoV-2 in coronavirus phylogenies

Erwan Sallard, José Halloy, Didier Casane, Etienne Decroly, Jacques van Helden

médecine/sciences 36 (2020)10.1051/medsci/2020123

2020
Pharmacological inhibition of syntenin PDZ2 domain impairs breast cancer cell activities and exosome loading with syndecan and EpCAM cargo

R. Leblanc, R. Kashyap, K. Barral, A.L. Egea‐jimenez, D. Kovalskyy, M. Feracci, M. Garcia, C. Derviaux, S. Betzi, R. Ghossoub, M. Platonov, P. Roche, X. Morelli, L. Hoffer, Pascale Zimmermann

Journal of Extracellular Vesicles 10 (2020)10.1002/jev2.12039

2020
Targeting furin activity through in silico and in vitro drug repurposing strategy for SARS-CoV-2 spike glycoprotein cleavage repression

Bruno Villoutreix, John Creemers, yannick Léger, Geraldine Siegfried, Etienne Decroly, Serge Evrard, Abdel-Majid Khatib

(2020)10.21203/rs.3.rs-25856/v1

2020
Drugs against SARS‐CoV ‐2: What do we know about their mode of action?

Coralie Valle, Baptiste Martin, Franck Touret, Ashleigh Shannon, Bruno Canard, Jean‐claude Guillemot, Bruno Coutard, Etienne Decroly

Reviews in Medical Virology 30:1-10 (2020)10.1002/rmv.2143

2020
Synthesis and biological evaluation of novel flexible nucleoside analogues that inhibit flavivirus replication in vitro

Joy Thames, Charles Waters, Coralie Valle, Marcella Bassetto, Wahiba Aouadi, Baptiste Martin, Barbara Selisko, Arissa Falat, Bruno Coutard, Andrea Brancale, Bruno Canard, Etienne Decroly, Katherine Seley-Radtke

Bioorganic and Medicinal Chemistry Letters 28:115713 (2020)10.1016/j.bmc.2020.115713

2020
Mutations on VEEV nsP1 relate RNA capping efficiency to ribavirin susceptibility

Nadia Rabah, Oney Ortega Granda, Gilles Quérat, Bruno Canard, Etienne Decroly, Bruno Coutard

Antiviral Research 182:104883 (2020)10.1016/j.antiviral.2020.104883

2020
Structure-based drug repositioning over the human TMPRSS2 protease domain: search for chemical probes able to repress SARS-CoV-2 Spike protein cleavages

Natesh Singh, Etienne Decroly, Abdel-Majid Khatib, Bruno Villoutreix

European Journal of Pharmaceutical Sciences 153:105495 (2020)10.1016/j.ejps.2020.105495

2020
Rapid incorporation of Favipiravir by the fast and permissive viral RNA polymerase complex results in SARS-CoV-2 lethal mutagenesis

Ashleigh Shannon, Barbara Selisko, Nhung-Thi-Tuyet Le, Johanna Huchting, Franck Touret, Géraldine Piorkowski, Véronique Fattorini, Francois Ferron, Etienne Decroly, Chris Meier, Bruno Coutard, Olve Peersen, Bruno Canard

Nature Communications 11:4682 (2020)10.1038/s41467-020-18463-z

2020
Snapshots of ADp-ribose bound to Getah virus macro domain reveal an intriguing choreography

Ana Sofia Ferreira-Ramos, Gerlind Sulzenbacher, Bruno Canard, Bruno Coutard

Scientific Reports 10 (2020)10.1038/s41598-020-70870-w

2020
Synthesis of adenine dinucleosides SAM analogs as specific inhibitors of SARS-CoV nsp14 RNA cap guanine-N7-methyltransferase

Rostom Ahmed-Belkacem, Priscila Sutto-Ortiz, Mathis Guiraud, Bruno Canard, Jean-Jacques Vasseur, Etienne Decroly, Françoise Debart

European Journal of Medicinal Chemistry 201:112557 (2020)10.1016/j.ejmech.2020.112557

2020
In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

Franck Touret, Magali Gilles, Karine Barral, Antoine Nougairède, Jacques van Helden, Etienne Decroly, Xavier de Lamballerie, Bruno Coutard

Scientific Reports 10:13093 (2020)10.1038/s41598-020-70143-6

2020
Brothers in Arms: Structure, Assembly and Function of Arenaviridae Nucleoprotein

Nicolas Papageorgiou, Maria Spiliopoulou, Thi-Hong van Nguyen, Afroditi Vaitsopoulou, Elsie Yekwa Laban, Karine Alvarez, Irene Margiolaki, Bruno Canard, Francois Ferron

Viruses 12:772 (2020)10.3390/v12070772

2020
Novel Class of Chikungunya Virus Small Molecule Inhibitors That Targets the Viral Capping Machinery

Rana Abdelnabi, Kristina Kovacikova, Julia Moesslacher, Kim Donckers, Verena Battisti, Pieter Leyssen, Thierry Langer, Gerhard Puerstinger, Gilles Quérat, Changqing Li, Etienne Decroly, Ali Tas, Arnaud Marchand, Patrick Chaltin, Bruno Coutard, Martijn van Hemert, Johan Neyts, Leen Delang

Antimicrobial Agents and Chemotherapy 64 (2020)10.1128/AAC.00649-20

2020
Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites

Ashleigh Shannon, Nhung Thi-Tuyet Le, Barbara Selisko, Cecilia Eydoux, Karine Alvarez, Jean-Claude Guillemot, Etienne Decroly, Olve Peersen, Francois Ferron, Bruno Canard

Antiviral Research 178:104793 (2020)10.1016/j.antiviral.2020.104793

2020
To something, Covid is good: SFV 2.0

Grégory Caignard, Etienne Decroly, Maria Dimitrova, David Gilmer, Anne-Sophie Gosselin-Grenet, Henri Gruffat, Sandra Martin-Latil, Pascale Massin, Sandie Munier, Mylène Ogliastro, Aure Saulnier, Noël Tordo

Virologie 24:133-134 (2020)10.1684/vir.2020.0846

2020
Discovery, SAR study and ADME properties of methyl 4-amino-3-cyano-1-(2-benzyloxyphenyl)-1 H -pyrazole-5-carboxylate as an HIV-1 replication inhibitor

Jeanne Fichez, Cathia Soulié, Laurent Le Corre, Sophie Sayon, Stéphane Priet, Karine Alvarez, Olivier Delelis, Patrick Gizzi, Guillaume Prestat, Christine Gravier-Pelletier, Anne-Geneviève Marcelin, Vincent Calvez, Patricia Busca

RSC Medicinal Chemistry 11:577-582 (2020)10.1039/D0MD00025F

2020
Incretin combination therapy for the treatment of non-alcoholic steatohepatitis

Aimo Kannt, Andreas Nygaard Madsen, Claire Kammermeier, Ralf Elvert, Tim Klöckener, Martin Bossart, Torsten Haack, Andreas Evers, Katrin Lorenz, W. Hennerici, Corinne Rocher, Zsolt Böcskei, Jean-Claude Guillemot, Vincent Mikol, François Pattou, Bart Staels, Michael Wagner

Diabetes, Obesity and Metabolism Online ahead of print. (2020)10.1111/dom.14035

2020
A N7-guanine RNA cap methyltransferase signature-sequence as a genetic marker of large genome, non-mammalian Tobaniviridae

Francois Ferron, Humberto Julio Debat, Ashleigh Shannon, Etienne Decroly, Bruno Canard

NAR Genomics and Bioinformatics 2 (2020)10.1093/nargab/lqz022

2020
Design, Synthesis and Discovery of N,N’ ‐Carbazoyl‐aryl‐urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication

Sharon Spizzichino, Giulio Mattedi, Kate Lauder, Coralie Valle, Wahiba Aouadi, Bruno Canard, Etienne Decroly, Suzanne Kaptein, Johan Neyts, Carl Graham, Zakary Sule, David Barlow, Romano Silvestri, Daniele Castagnolo

ChemMedChem 15:385-390 (2020)10.1002/cmdc.201900533

2020
The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade

Bruno Coutard, Coralie Valle, Xavier de Lamballerie, Bruno Canard, Nabil G Seidah, Etienne Decroly

Antiviral Research 176:104742 (2020)10.1016/j.antiviral.2020.104742

2020
Carneic Acids from an Endophytic Phomopsis sp. as Dengue Virus Polymerase Inhibitors

Laure-Anne Peyrat, Véronique Eparvier, Cecilia Eydoux, Jean-Claude Guillemot, Marc Litaudon, Didier Stien

Journal of Natural Products (2020)10.1021/acs.jnatprod.9b01169

2020
In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

Jeremy Ariey‐bonnet, Kendall Carrasco, Marion Le Grand, Laurent Hoffer, Stéphane Betzi, Mikael Feracci, Philipp A Tsvetkov, François Devred, Yves Collette, Xavier Morelli, Pedro Ballester, Eddy Pasquier

Molecular Oncology 14:3083-3099 (2020)10.1002/1878-0261.12810

2020
The C-Terminal Domain of the Sudan Ebolavirus L Protein Is Essential for RNA Binding and Methylation

Coralie Valle, Baptiste Martin, Françoise Debart, Jean-Jacques Vasseur, Isabelle Imbert, Bruno Canard, Bruno Coutard, Etienne Decroly

Journal of Virology 94:e00520-20 (2020)10.1128/JVI.00520-20

2019
Cas9 Allosteric Inhibition by the Anti-CRISPR Protein AcrIIA6

Olivier Fuchsbauer, Paolo Swuec, Claire Zimberger, Beatrice Amigues, Sébastien Levesque, Daniel Agudelo, Alexis Duringer, Antonio Chaves-Sanjuan, Silvia Spinelli, Geneviève Rousseau, Minja Velimirovic, Martino Bolognesi, Alain Roussel, Christian Cambillau, Sylvain Moineau, Yannick Doyon, Adeline Goulet

Molecular Cell 76:922-937.e7 (2019)10.1016/j.molcel.2019.09.012

2019
Arenaviridae exoribonuclease presents genomic RNA edition capacity.

Elsie Laban Yekwa, Chutima Aphibanthammakit, Xavier Carnec, Caroline Picard, Bruno Canard, Sylvain Baize, Francois Ferron

(2019)10.1101/541698

2019
Phase transition and amyloid formation by a viral protein as an additional molecular mechanism of virus-induced cell toxicity

Edoardo Salladini, Claire Debarnot, Vincent Delauzun, Maria Grazia Murrali, Priscila Sutto-Ortiz, Silvia Spinelli, Roberta Pierattelli, Christophe Bignon, Sonia Longhi

(2019)

2019
Fluoxetine Inhibits Enterovirus Replication by Targeting the Viral 2C Protein in a Stereospecific Manner

Lisa Bauer, Roberto Manganaro, Birgit Zonsics, Jeroen Strating, Priscila El Kazzi, Moira Lorenzo Lopez, Rachel Ulferts, Clara van Hoey, Maria Mate, Thierry Langer, Bruno Coutard, Andrea Brancale, Frank van Kuppeveld

ACS Infectious Diseases 5:1609-1623 (2019)10.1021/acsinfecdis.9b00179

2019
Structure of the Respiratory Syncytial Virus Polymerase Complex

Morgan S A Gilman, Cheng Liu, Amy Fung, Ishani Behera, Paul Jordan, Peter Rigaux, Nina Ysebaert, Sergey Tcherniuk, Julien Sourimant, Jean-Francois Eleouet, Priscila Sutto-Ortiz, Etienne Decroly, Dirk Roymans, Zhinan Jin, Jason S Mclellan

Cell 179:193-204.e14 (2019)10.1016/j.cell.2019.08.014

2019
The Curious Case of the Nidovirus Exoribonuclease: Its Role in RNA Synthesis and Replication Fidelity

Natacha S Ogando, Francois Ferron, Etienne Decroly, Bruno Canard, Clara C Posthuma, Eric J Snijder

Frontiers in Microbiology 10 (2019)10.3389/fmicb.2019.01813

2019
2019
Deciphering the Nucleotide and RNA Binding Selectivity of the Mayaro Virus Macro Domain

Aikaterini Tsika, Efstathios Melekis, Sofia-Antigoni Tsatsouli, Nicolas Papageorgiou, Maria Mate, Bruno Canard, Bruno Coutard, Detlef Bentrop, Georgios Spyroulias

Journal of Molecular Biology 431:2283-2297 (2019)10.1016/j.jmb.2019.04.013

2019
Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose

Garyfallia Makrynitsa, Dioni Ntonti, Konstantinos Marousis, Maria Birkou, Minos-Timotheos Matsoukas, Sam Asami, Detlef Bentrop, Nicolas Papageorgiou, Bruno Canard, Bruno Coutard, Georgios Spyroulias

Journal of Structural Biology 206:119-127 (2019)10.1016/j.jsb.2019.02.008

2019
Recombinant HCV NS3 and NS5B enzymes exhibit multiple posttranslational modifications for potential regulation

Sergio Hernández, Ariel Díaz, Alejandra Loyola, Rodrigo Villanueva

Virus Genes 55:227-232 (2019)10.1007/s11262-019-01638-2

2019
Gln151 of HIV-1 reverse transcriptase acts as a steric gate towards clinically relevant acyclic phosphonate nucleotide analogues.

Antoine Frangeul, Cécile Bussetta, Jérôme Deval, Karine Barral, Karine Alvarez, Bruno Canard

Antiviral Therapy 13:115-24 (2019)

2019
Comparative study of chikungunya Virus-Like Particles and Pseudotyped-Particles used for serological detection of specific immunoglobulin M

Gérald Theillet, Jérôme Martinez, Christophe Steinbrugger, Dimitri Lavillette, Bruno Coutard, Nicolas Papageorgiou, Pascal Dalbon, Isabelle Leparc-Goffart, Frederic Bedin

Virology 529:195-204 (2019)10.1016/j.virol.2019.01.027

2019
C3P3-G1: first generation of a eukaryotic artificial cytoplasmic expression system

Philippe H Jaïs, Etienne Decroly, Eric Jacquet, Marine Le boulch, Aurélien Jaïs, Olivier Jean-Jean, Heather Eaton, Prishila Ponien, Frédérique Verdier, Bruno Canard, Sergio Gonçalves, Stéphane Chiron, Maude Le Gall, Patrick Mayeux, Maya Shmulevitz

Nucleic Acids Research 47:2681-2698 (2019)10.1093/nar/gkz069

2019
Metal chelators for the inhibition of the lymphocytic choriomeningitis virus endonuclease domain

Magali Saez-Ayala, Elsie Laban yekwa, Clémence Mondielli, Loic Roux, Sergio Hernández, Fabrice Bailly, Philippe Cotelle, Dominga Rogolino, Bruno Canard, Francois Ferron, Karine Alvarez

Antiviral Research 162:79-89 (2019)10.1016/j.antiviral.2018.12.008

2019
Antiviral Compounds from Codiaeum peltatum Targeted by a Multi-informative Molecular Networks Approach

Florent Olivon, Simon Remy, Gwendal Grelier, Cécile Apel, Cecilia Eydoux, Jean-Claude Guillemot, Johan Neyts, Leen Delang, David Touboul, Fanny Roussi, Marc Litaudon

Journal of Natural Products 82:330-340 (2019)10.1021/acs.jnatprod.8b00800

2019
Approved drugs screening against the nsP1 capping enzyme of Venezuelan equine encephalitis virus using an immuno-based assay

Ana Ferreira-Ramos, Changqing Li, Cecilia Eydoux, Jean Marie Contreras, Christophe Morice, Gilles Querat, Alba Gigante, María-Jesús Pérez Pérez, Marie-Louise Jung, Bruno Canard, Jean-Claude Guillemot, Etienne Decroly, Bruno Coutard

Antiviral Research 163:59-69 (2019)10.1016/j.antiviral.2019.01.003

2019
FTSJ3 is an RNA 2′-O-methyltransferase recruited by HIV to avoid innate immune sensing

Mathieu Ringeard, Virginie Marchand, Etienne Decroly, Yuri Motorin, Yamina Bennasser

Nature 565:500-504 (2019)10.1038/s41586-018-0841-4

2019
Structure and oligomerization state of the C-terminal region of the Middle East respiratory syndrome coronavirus nucleoprotein

Thi Hong Van Nguyen, Julie Lichiere, Bruno Canard, Nicolas Papageorgiou, Sarah Attoumani, Francois Ferron, Bruno Coutard

Acta crystallographica Section D : Structural biology [1993-...] 75:8-15 (2019)10.1107/S2059798318014948

2019
Optimization of a fragment linking hit toward Dengue and Zika virus NS5 methyltransferases inhibitors

Jessica Hernandez, Laurent Hoffer, Bruno Coutard, Gilles Quérat, Philippe Roche, Xavier Morelli, Etienne Decroly, Karine Barral

European Journal of Medicinal Chemistry 161:323-333 (2019)10.1016/j.ejmech.2018.09.056

2019
Synthesis of Adenine Dinucleosides 2′,5′-Bridged by Sulfur-Containing Linkers as Bisubstrate SAM Analogues for Viral RNA 2′- O -Methyltransferases

Rostom Ahmed-Belkacem, Priscila Sutto Ortiz, Etienne Decroly, Jean-Jacques Vasseur, Françoise Debart

European Journal of Organic Chemistry 2019 (2019)10.1002/ejoc.201901120

2019
Identification of a new natural gastric lipase inhibitor from star anise

Jannet Kamoun, Renaud Rahier, Mohamed Sellami, Imed Koubaa, Pascal Mansuelle, Régine Lebrun, Alexandra Berlioz-Barbier, Michele Fiore, Karine Alvarez, Abdelkarim Abousalham, Frédéric Carrière, Ahmed Aloulou

Food and Function 10:469-478 (2019)10.1039/c8fo02009d

2018
Ebola virus L protein harbors a new enzymatic activity involved in the internal methylation of RNAs

Baptiste Martin, Coralie Valle, Bruno Coutard, Bruno Canard, Françoise Debart, Etienne Decroly

médecine/sciences 34:919-921 (2018)10.1051/medsci/2018230

2018
The methyltransferase domain of the Sudan ebolavirus L protein specifically targets internal adenosines of RNA substrates, in addition to the cap structure

Baptiste Martin, Bruno Coutard, Théo Guez, Guido Paesen, Bruno Canard, Françoise Debart, Jean-Jacques Vasseur, Jonathan Grimes, Etienne Decroly

Nucleic Acids Research 46:7902-7912 (2018)10.1093/nar/gky637

2018
Galactolipase activity of Talaromyces thermophilus lipase on galactolipid micelles, monomolecular films and UV-absorbing surface-coated substrate

Inès Belhaj, Sawsan Amara, Goetz Parsiegla, Priscila Sutto-Ortiz, Moulay Sahaka, Hafedh Belghith, Audric Rousset, Dominique Lafont, Frédéric Carriere

Biochimica et Biophysica Acta Molecular and Cell Biology of Lipids 1863:1006-1015 (2018)10.1016/j.bbalip.2018.05.016

2018
Innate immunity evasion mechanisms of filoviruses

Baptiste Martin, Etienne Decroly

Med Sci (Paris) 34:671-677 (2018)10.1051/medsci/20183408013

2018
A Vaccine Platform against Arenaviruses Based on a Recombinant Hyperattenuated Mopeia Virus Expressing Heterologous Glycoproteins

Xavier Carnec, Mathieu Mateo, Audrey Page, Stéphanie Reynard, Jimmy Hortion, Caroline Picard, Elsie Yekwa, Laura Barrot, Stéphane Barron, Audrey Vallve, Hervé Raoul, Caroline Carbonnelle, Francois Ferron, Sylvain Baize

Journal of Virology 92:e02230-17 (2018)10.1128/JVI.02230-17

2018
Hijacking DNA methyltransferase transition state analogues to produce chemical scaffolds for PRMT inhibitors

Ludovic Halby, Nils Marechal, Dany Pechalrieu, Vincent Cura, Don-Marc Franchini, Céline Faux, Frédéric Alby, Nathalie Troffer-Charlier, Srikanth Kudithipudi, Albert Jeltsch, Wahiba Aouadi, Etienne Decroly, Jean-Claude Guillemot, Patrick Page, Clotilde Ferroud, Luc Bonnefond, Dominique Guianvarc'H, Jean Cavarelli, Paola Arimondo

Philosophical Transactions of the Royal Society B: Biological Sciences 373:20170072 (2018)10.1098/rstb.2017.0072

2018
IR spectroscopy analysis of pancreatic lipase-related protein 2 interaction with phospholipids: 2. Discriminative recognition of various micellar systems and characterization of PLRP2-DPPC-bile salt complexes

Eduardo Mateos-Diaz, Priscila Sutto-Ortiz, Moulay Sahaka, Deborah Byrne, Hélène Gaussier, Frédéric Carrière

Chemistry and Physics of Lipids 211:66-76 (2018)10.1016/j.chemphyslip.2017.11.012

2018
IR spectroscopy analysis of pancreatic lipase-related protein 2 interaction with phospholipids: 3. Monitoring DPPC lipolysis in mixed micelles

Eduardo Mateos-Diaz, Priscila Sutto-Ortiz, Moulay Sahaka, Jorge Rodriguez, Frédéric Carrière

Chemistry and Physics of Lipids 211:77-85 (2018)10.1016/j.chemphyslip.2017.11.009

2018
Crystal structures of Lymphocytic choriomeningitis virus endonuclease domain complexed with diketo-acid ligands

Magali Saez-Ayala, Elsie Laban Yekwa, Mauro Carcelli, Bruno Canard, Karine Alvarez, Francois Ferron

International Union of Crystallography journal 5:223-235 (2018)10.1107/S2052252518001021

2018
Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands

Magali Saez-Ayala, Elsie Yekwa, Mauro Carcelli, Bruno Canard, Karine Alvarez, Francois Ferron

International Union of Crystallography journal 5:223-235 (2018)10.1107/s2052252518001021

2018
Filovirus proteins for antiviral drug discovery: Structure/function of proteins involved in assembly and budding

Baptiste Martin, Olivier Reynard, Viktor Volchkov, Etienne Decroly

Antiviral Research 150:183-192 (2018)10.1016/j.antiviral.2017.12.022

2018
Structural and Functional Basis of the Fidelity of Nucleotide Selection by Flavivirus RNA-Dependent RNA Polymerases

Barbara Selisko, Nicolas Papageorgiou, Francois Ferron, Bruno Canard

Viruses 10:59 (2018)10.3390/v10020059

2018
Synthesis and substrate properties towards HIV-1 reverse transcriptase of new diphosphate analogues of 9-[(2-phosphonomethoxy)ethyl]adenine

Wolfgang Hg Laux, Stephane Priet, Karine Alvarez, Suzanne Peyrottes, Christian Perigaud

Antiviral Chemistry and Chemotherapy 26:204020661875763 (2018)10.1177/2040206618757636

2018
Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA

Francois Ferron, Lorenzo Subissi, Ana Theresa Silveira de Morais, Nhung Thi Tuyet Le, Marion Sevajol, Laure Gluais, Etienne Decroly, Clemens Vonrhein, Gérard Bricogne, Bruno Canard, Isabelle Imbert

Proceedings of the National Academy of Sciences of the United States of America 115:E162-E171 (2018)10.1073/pnas.1718806115

2018
How to Control HTLV-1-Associated Diseases: Preventing de Novo Cellular Infection Using Antiviral Therapy

Amandine Pasquier, Sandrine Alais, Loic Roux, Maria-Isabel Thoulouze, Karine Alvarez, Chloé Journo, Hélène Dutartre, Renaud Mahieux

Frontiers in Microbiology 9:278 (2018)10.3389/fmicb.2018.00278

2018
A Continuous and Sensitive Spectrophotometric Assay for Lipase and Phospholipase A Activities using α-Eleostearic Acid-containing Substrates

Meddy El Alaoui, Laurent Soulère, Alexandre Noiriel, Priscila Sutto-Ortiz, Lucie Grand, Florence Popowycz, Jorge Alberto Rodríguez-González, Yves Queneau, Abdelkarim Abousalham

119-128 (2018)

2017
NF-L in cerebrospinal fluid and serum is a biomarker of neuronal damage in an inducible mouse model of neurodegeneration

Anthony Brureau, Véronique Blanchard-Bregeon, Catherine Pech, Stéphanie Hamon, Pascal Chaillou, Jean-Claude Guillemot, Pascal Barneoud, Philippe Bertrand, Laurent Pradier, Thomas Rooney, Nathalie Schussler

Neurobiology of Disease 104:73-84 (2017)10.1016/j.nbd.2017.04.007

2017
Toscana virus nucleoprotein oligomer organization observed in solution

Amal Baklouti, Adeline Goulet, Julie Lichiere, Bruno Canard, Remi Charrel, Francois Ferron, Bruno Coutard, Nicolas Papageorgiou

Acta crystallographica Section D : Structural biology [1993-...] 73:650-659 (2017)10.1107/S2059798317008774

2017
Toward the identification of viral cap-methyltransferase inhibitors by fluorescence screening assay

Wahiba Aouadi, C Ecilia Eydoux, Bruno Coutard, Baptiste Martin, Françoise Debart, Jean-Jacques Vasseur, Jean Marie Contreras, Christophe Morice, Gilles Quérat, Marie-Louise Jung, Bruno Canard, Jean-Claude Guillemot, Etienne Decroly

Antiviral Research 144:330-339 (2017)10.1016/j.antiviral.2017.06.021

2017
Activity inhibition and crystal polymorphism induced by active-site metal swapping

Elsie Yekwa, Joelle Khourieh, Bruno Canard, Nicolas Papageorgiou, Francois Ferron

Acta crystallographica Section D : Structural biology [1993-...] 73:641-649 (2017)10.1107/S205979831700866X

2017
Understanding the Mechanism of the Broad-Spectrum Antiviral Activity of Favipiravir (T-705): Key Role of the F1 Motif of the Viral Polymerase

Rana Abdelnabi, Ana Theresa Silveira De Morais, Pieter Leyssen, Isabelle Imbert, Stéphanie Beaucourt, Hervé Blanc, Mathy Froeyen, Marco Vignuzzi, Bruno Canard, Johan Neyts, Leen Delang

Journal of Virology 91:e00487-17 (2017)10.1128/JVI.00487-17

2017
Biochemical principles and inhibitors to interfere with viral capping pathways

Etienne Decroly, Bruno Canard

Current Opinion in Virology 24:87-96 (2017)10.1016/j.coviro.2017.04.003

2017
2017
Binding site density enables paralog-specific activity of SLM2 and Sam68 proteins in Neurexin2 AS4 splicing control

Marina Danilenko, Caroline Dalgliesh, Vittoria Pagliarini, Chiara Naro, Ingrid Ehrmann, Mikael Feracci, Mahsa Kheirollahi-Chadegani, Alison Tyson-Capper, Gavin Clowry, Philippe Fort, Cyril Dominguez, Claudio Sette, David Elliott

Nucleic Acids Research 45:gkw1277 (2017)10.1093/nar/gkw1277

2017
Substrate selectivity of Dengue and Zika virus NS5 polymerase towards 2′-modified nucleotide analogues

Supanee Potisopon, Francois Ferron, Véronique Fattorini, Barbara Selisko, Bruno Canard

Antiviral Research 140:25-36 (2017)10.1016/j.antiviral.2016.12.021

2017
Transcription and replication mechanisms of Bunyaviridae and Arenaviridae L proteins

Francois Ferron, Friedemann Weber, Juan de La Torre, Juan Reguera

Virus Research 234:118-134 (2017)10.1016/j.virusres.2017.01.018

2017
Contribution to PNA-RNA Chimera Synthesis: One-Pot Microwave-Assisted Ugi Reaction to Obtain Dimeric Building Blocks

Reuben Ovadia, Clémence Mondielli, Jean-Jacques Vasseur, Carine Baraguey, Karine Alvarez

European Journal of Organic Chemistry 2017:469-475 (2017)10.1002/ejoc.201601190

2017
Betulinic Acid, The First Lupane-Type Triterpenoid Isolated from Both a Phomopsis sp. and Its Host Plant Diospyros carbonaria Benoist

Laure-Anne Peyrat, Véronique Eparvier, Cécilia Eydoux, Jean-Claude Guillemot, Marc Litaudon, Didier Stien

Chemistry & Biodiversity 14:e1600171 (2017)10.1002/cbdv.201600171

2017
Discovery of novel dengue virus NS5 methyltransferase non-nucleoside inhibitors by fragment-based drug design

Fatiha Benmansour, Iuni Trist, Bruno Coutard, Etienne Decroly, Gilles Querat, Andrea Brancale, Karine Barral

European Journal of Medicinal Chemistry 125:865-880 (2017)10.1016/j.ejmech.2016.10.007

2017
Preparation of thiophenepropenamide derivatives as flavivirus inhibitors in treatment of viral infections

Karine Barral, Jean Claude Guillemot, Bruno Canard, Gilles Quérat, Karine Alvarez, Xavier de Lamballerie, Florence Mahuteau-Betzer, Cedric Poinsard

(2017)

2017
Binding of the Methyl Donor S -Adenosyl-l-Methionine to Middle East Respiratory Syndrome Coronavirus 2′- O -Methyltransferase nsp16 Promotes Recruitment of the Allosteric Activator nsp10

Wahiba Aouadi, Alexandre Blanjoie, Jean-Jacques Vasseur, Françoise Debart, Bruno Canard, Etienne Decroly

Journal of Virology 91:1103-1119 (2017)10.1128/JVI.02217-16

2017
Antiviral activity of [1,2,3]triazolo[4,5- d ]pyrimidin-7(6 H )-ones against chikungunya virus targeting the viral capping nsP1

Alba Gigante, Asier Gómez-Sanjuan, Leen Delang, Changqing Li, Oskía Bueno, Ana-María Gamo, Eva-María Priego, María-José Camarasa, Dirk Jochmans, Pieter Leyssen, Etienne Decroly, Bruno Coutard, Gilles Querat, Johan Neyts, María-Jesús Pérez-Pérez

Antiviral Research 144:216-222 (2017)10.1016/j.antiviral.2017.06.003

2017
Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives

Bruno Coutard, Karine Barral, Julie Lichiere, Barbara Selisko, Baptiste Martin, Wahiba Aouadi, Miguel Ortiz Lombardia, Françoise Debart, Jean-Jacques Vasseur, Jean Claude Guillemot, Bruno Canard, Etienne Decroly

Journal of Virology 91:2202-2218 (2017)10.1128/JVI.02202-16

2016
Coxsackievirus B3 protease 3C: expression, purification, crystallization and preliminary structural insights

Stavroula Fili, Alexandros Valmas, Magdalini Christopoulou, Maria Spiliopoulou, Nikos Nikolopoulos, Julie Lichiere, Souzana Logotheti, Fotini Karavassili, Eleftheria Rosmaraki, Andrew Fitch, Jonathan Wright, Detlef Beckers, Thomas Degen, Gwilherm Nenert, Rolf Hilgenfeld, Nicolas Papageorgiou, Bruno Canard, Bruno Coutard, Irene Margiolaki

Acta crystallographica Section F : Structural biology communications [2014-...] 72:877-884 (2016)10.1107/S2053230X16018513

2016
2016
Viral Macro Domains Reverse Protein ADP-Ribosylation

Changqing Li, Yannick Debing, Gytis Jankevicius, Johan Neyts, Ivan Ahel, Bruno Coutard, Bruno Canard

Journal of Virology 90:8478-8486 (2016)10.1128/JVI.00705-16

2016
Protein-Protein Interaction Inhibition (2P21)-Oriented Chemical Library Accelerates Hit Discovery

Sabine Milhas, Brigitt Raux, Stéphane Betzi, Carine Derviaux, Philippe Roche, Audrey Restouin, Marie-Jeanne Basse, Etienne Rebuffet, Adrien Lugari, Marion Badol, Rudra Kashyap, Jean-Claude Lissitzky, Cecilia Eydoux, Veronique Hamon, Marie -Edith Gourde, Sebastien Combes, Pascale Zimmermann, Michel Aurrand-Lions, Thomas Roux, Catherine Rogers, Susanne Muller, Stefan Knapp, Eric Trinquet, Yves Collette, Jean-Claude Guillemot, Xavier Morelli

ACS Chemical Biology 11:2140-2148 (2016)10.1021/acschembio.6b00286

2016
Screening of a Library of FDA-Approved Drugs Identifies Several Enterovirus Replication Inhibitors That Target Viral Protein 2C

Rachel Ulferts, S. Matthijn De Boer, Lonneke van Der Linden, Lisa Bauer, Hey Rhyoung Lyoo, Maria J. Mate, Julie Lichiere, Bruno Canard, Daphne Lelieveld, Wienand Omta, David Egan, Bruno Coutard, Frank J. M. Van Kuppeveld

Antimicrobial Agents and Chemotherapy 60:2627-2638 (2016)10.1128/AAC.02182-15

2016
Predicting Conformational Disorder

Philippe Lieutaud, François Ferron, Sonia Longhi

1415:265-299 (2016)10.1007/978-1-4939-3572-7_14

2016
Reevaluation of possible outcomes of infections with human immunodeficiency virus

C. Tamalet, Philippe Colson, Etienne Decroly, C. Dhiver, I. Ravaux, A. Stein, Didier Raoult

Clinical Microbiology and Infection 22:299-311 (2016)10.1016/j.cmi.2015.11.022

2016
The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain (vol 42, pg 11642, 2014)

Supanee Potisopon, Stephane Priet, Axelle Collet, Etienne Decroly, Bruno Canard, Barbara Selisko

Nucleic Acids Research 44:2974 (2016)10.1093/nar/gkv1294

2016
Exploring Selective Inhibition of the First Bromodomain of the Human Bromodomain and Extra-terminal Domain (BET) Proteins

Brigitt Raux, Yuliia Voitovich, Carine Derviaux, Adrien Lugari, Etienne Rebuffet, Sabine Milhas, Stephane Priet, Thomas Roux, Eric Trinquet, Jean-Claude Guillemot, Stefan Knapp, Jean-Michel Brunel, Alexey Yu. Fedorov, Yves Collette, Philippe Roche, Stéphane Betzi, Sebastien Combes, Xavier Morelli

Journal of Medicinal Chemistry 59:1634-1641 (2016)10.1021/acs.jmedchem.5b01708

2016
Structural characterization of the N-terminal part of the MERS-CoV nucleocapsid by X-ray diffraction and small-angle X-ray scattering

Nicolas Papageorgiou, Julie Lichiere, Amal Baklouti, Francois Ferron, Marion Sevajol, Bruno Canard, Bruno Coutard

Acta crystallographica Section D : Structural biology [1993-...] 72:192-202 (2016)10.1107/S2059798315024328

2016
Novel 2-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,3,4-oxadiazole and 3-phenyl-5-[(E)-2-(thiophen-2-yl)ethenyl]-1,2,4-oxadiazole derivatives as dengue virus inhibitors targeting NS5 polymerase

Fatiha Benmansour, Cecilia Eydoux, Gilles Querat, Xavier de Lamballerie, Bruno Canard, Karine Alvarez, Jean-Claude Guillemot, Karine Barral

European Journal of Medicinal Chemistry 109:146-156 (2016)10.1016/j.ejmech.2015.12.046

2016
How disordered is my protein and what is its disorder for? A guide through the “dark side” of the protein universe

Philippe Lieutaud, François Ferron, Alexey V Uversky, Lukasz Kurgan, Vladimir N Uversky, Sonia Longhi

Intrinsically Disordered Proteins 4:e1259708 (2016)10.1080/21690707.2016.1259708

2016
The viral capping enzyme nsP1: a novel target for the inhibition of chikungunya virus infection

L. Delang, C. Li, A. Tas, G. Querat, I. C. Albulescu, T. de Burghgraeve, N. A. Segura Guerrero, A. Gigante, G. Piorkowski, Etienne Decroly, D. Jochmans, B. Canard, E. J. Snijder, M. J. Perez-Perez, M. J. Van Hemert, B. Coutard, P. Leyssen, J. Neyts

Scientific Reports 6:31819 (2016)10.1038/srep31819

2016
Involvement of an Arginine Triplet in M1 Matrix Protein Interaction with Membranes and in M1 Recruitment into Virus-Like Particles of the Influenza A(H1N1)pdm09 Virus

Adeline Kerviel, Shantoshini Dash, Olivier Moncorgé, Baptiste Panthu, Jan Prchal, Didier Decimo, Théophile Ohlmann, Bruno Lina, Cyril Favard, Etienne Decroly, Michèle Ottmann, Philippe Roingeard, Delphine Muriaux

PLoS ONE 11:e0165421 (2016)10.1371/journal.pone.0165421

2016
Chemical diversity and antiviral potential in the pantropical Diospyros genus

Laure-Anne Peyrat, Véronique Eparvier, Cécilia Eydoux, Jean-Claude Guillemot, Didier Stien, Marc Litaudon

Fitoterapia (2016)10.1016/j.fitote.2016.04.017

2015
Synthesis and structural characterization of monomeric and dimeric peptide nucleic acids prepared by using microwave-promoted multicomponent reactions

Reuben Ovadia, Aurelien Lebrun, Ivan Barvik, Jean-Jacques Vasseur, Carine Baraguey, Karine Alvarez

Organic & Biomolecular Chemistry 13:11052-11071 (2015)10.1039/c5ob01604e

2015
Arenavirus Glycan Shield Promotes Neutralizing Antibody Evasion and Protracted Infection

Rami Sommerstein, Lukas Flatz, Melissa M. Remy, Pauline Malinge, Giovanni Magistrelli, Nicolas Fischer, Mehmet Sahin, Andreas Bergthaler, Sebastien Igonet, Jan Ter Meulen, Dorothee Rigo, Paolo Meda, Nadia Rabah, Bruno Coutard, Thomas A. Bowden, Paul-Henri Lambert, Claire-Anne Siegrist, Daniel D. Pinschewer

PLoS Pathogens 11 (2015)10.1371/journal.ppat.1005276

2015
NMR study of non-structural proteins-part II: H-1, C-13, N-15 backbone and side-chain resonance assignment of macro domain from Venezuelan equine encephalitis virus (VEEV)

Garyfallia I. Makrynitsa, Dioni Ntonti, Konstantinos D. Marousis, Aikaterini C. Tsika, Julie Lichiere, Nicolas Papageorgiou, Bruno Coutard, Detlef Bentrop, Georgios A. Spyroulias

BIOMOLECULAR NMR ASSIGNMENTS 9:247-251 (2015)10.1007/s12104-014-9584-9

2015
mRNA Capping by Venezuelan Equine Encephalitis Virus nsP1: Functional Characterization and Implications for Antiviral Research

Changqing Li, Jaime Guillen, Nadia Rabah, Alexandre Blanjoie, Francoise Debart, Jean-Jacques Vasseur, Bruno Canard, Etienne Decroly, Bruno Coutard

Journal of Virology 89:8292-8303 (2015)10.1128/JVI.00599-15

2015
Enzymatic synthesis of acyclic nucleoside thiophosphonate diphosphates: Effect of the alpha-phosphorus configuration on HIV-1 RT activity

Stephane Priet, Loic Roux, Magali Saez-Ayala, Francois Ferron, Bruno Canard, Karine Alvarez

Antiviral Research 117:122-131 (2015)10.1016/j.antiviral.2015.03.003

2015
NMR study of non-structural proteins-part I: H-1, C-13, N-15 backbone and side-chain resonance assignment of macro domain from Mayaro virus (MAYV)

Efstathios Melekis, Aikaterini C. Tsika, Julie Lichiere, Christos T. Chasapis, Irene Margiolaki, Nicolas Papageorgiou, Bruno Coutard, Detlef Bentrop, Georgios A. Spyroulias

BIOMOLECULAR NMR ASSIGNMENTS 9:191-195 (2015)10.1007/s12104-014-9572-0

2015
Structural and biophysical analysis of sequence insertions in the Venezuelan Equine Encephalitis Virus macro domain

Jaime Guillen, Julie Lichiere, Nadia Rabah, Brett F. Beitzel, Bruno Canard, Bruno Coutard

Virus Research 201:94-100 (2015)10.1016/j.virusres.2015.02.018

2015
Les années 2010

Michel Bouvier, Herve Chneiweiss, Bertrand Jordan, Gilbert Lagrue, Joël Ménard, Jean-Luc Teillaud, Guido Kroemer, Anne-Marie Moulin, Antoine Flahault, Laurence Lafanechère, Eric Maréchal, Jean-Claude Guillemot, Marie Gaille

médecine/sciences 31:91-111 (2015)10.1051/medsci/201531s1006

2015
The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family

Lonneke van Der Linden, Laia Vives-Adrián, Barbara Selisko, Cristina Ferrer-Orta, Xinran Liu, Kjerstin Lanke, Rachel Ulferts, Armando M. de Palma, Federica Tanchis, Nesya Goris, David Lefebvre, Kris de Clercq, Pieter Leyssen, Céline Lacroix, Gerhard Pürstinger, Bruno Coutard, Bruno Canard, David D. Boehr, Jamie J. Arnold, Craig E. Cameron, Nuria Verdaguer, Johan Neyts, Frank J. M van Kuppeveld

PLoS Pathogens 11 (2015)10.1371/journal.ppat.1004733.s010

2015
X-ray structure and activities of an essential Mononegavirales L-protein domain

Guido C. Paesen, Axelle Collet, Corinne Sallamand, Francoise Debart, Jean-Jacques Vasseur, Bruno Canard, Etienne Decroly, Jonathan M. Grimes

Nature Communications 6:8749 (2015)10.1038/ncomms9749

2014
La chémobiologie : stratégies transfrontalières

Laurence Lafanechère, Eric Maréchal, Jean-Claude Guillemot

médecine/sciences 30:2 (2014)10.1051/medsci/20143012001

2014
Insights into RNA synthesis, capping, and proofreading mechanisms of SARS-coronavirus

Marion Sevajol, Lorenzo Subissi, Etienne Decroly, Bruno Canard, Isabelle Imbert

Virus Research 194:90-99 (2014)10.1016/j.virusres.2014.10.008

2014
The methyltransferase domain of dengue virus protein NS5 ensures efficient RNA synthesis initiation and elongation by the polymerase domain

Supanee Potisopon, Stéphane Priet, Axelle Collet, Etienne Decroly, Bruno Canard, Barbara Selisko

Nucleic Acids Research 42 (2014)10.1093/nar/gku666

2014
One severe acute respiratory syndrome coronavirus protein complex integrates processive RNA polymerase and exonuclease activities

Lorenzo Subissi, Clara Posthuma, Axelle Collet, Jessika Zevenhoven-Dobbe, Alexander Gorbalenya, Etienne Decroly, Eric Snijder, Bruno Canard, Isabelle Imbert

Proceedings of the National Academy of Sciences of the United States of America 111 (2014)10.1073/pnas.1323705111

2014
Coronavirus Nsp10, a critical co-factor for activation of multiple replicative enzymes

Mickaël Bouvet, Adrien Lugari, Clara C. Posthuma, Jessika C. Zevenhoven, Stéphanie Bernard, Stéphane Betzi, Isabelle Imbert, Bruno Canard, Jean-Claude Guillemot, Patrick Lécine, Susanne Pfefferle, Christian Drosten, Eric J. Snijder, Etienne Decroly, Xavier Morelli

Journal of Biological Chemistry 289:25783-25796 (2014)10.1074/jbc.M114.577353

2014
Identification of a Src kinase SH3 binding site in the C-terminal domain of the human ErbB2 receptor tyrosine kinase.

Olivier Bornet, Matthieu Nouailler, Michaël Feracci, Corinne Sebban-Kreuzer, Deborah Byrne, Hubert Halimi, Xavier Morelli, Ali Badache, Francoise Guerlesquin

FEBS Letters 588:2031-6 (2014)10.1016/j.febslet.2014.04.029

2014
Assessment of Dengue virus helicase and methyltransferase as targets for fragment-based drug discovery

Bruno Coutard, Etienne Decroly, Changqing Li, Andrew Sharff, Julien Lescar, Gérard Bricogne, Karine Barral

Antiviral Research 106:61-70 (2014)10.1016/j.antiviral.2014.03.013

2014
Biodiversity as a source of potent and selective inhibitors of Chikungunya virus replication

Pieter Leyssen, Jacqueline Smadja, Philippe Rasoanaivo, Ameenah Gurib-Fakim, Mohamad Fawzi-Mahomoodally, Bruno Canard, Jean-Claude Guillemot, Marc Litaudon, Françoise Guéritte

151-160 (2014)10.1002/9781118460566.ch11

2013
Atomic resolution description of the interaction between the nucleoprotein and phosphoprotein of Hendra virus.

Guillaume Communie, Johnny Habchi, Filip Yabukarski, David Blocquel, Robert Schneider, Nicolas Tarbouriech, Nicolas Papageorgiou, Rob W H Ruigrok, Marc Jamin, Malene Ringkjøbing Jensen, Sonia Longhi, Martin Blackledge

PLoS Pathogens 9:e1003631 (2013)

2013
Development of specific dengue virus 2'-O- and N7-methyltransferase assays for antiviral drug screening.

Karine Barral, Corinne Sallamand, Christiane Petzold, Bruno Coutard, Axelle Collet, Yann Thillier, Jan Zimmermann, Jean-Jacques Vasseur, Bruno Canard, Jacques Rohayem, Françoise Debart, Etienne Decroly

Antiviral Research 99:292-300 (2013)10.1016/j.antiviral.2013.06.001

2013
Plasma Peptide Biomarker Discovery for Amyotrophic Lateral Sclerosis by MALDI –TOF Mass Spectrometry Profiling

Laurence Conraux, Catherine Pech, Halim Guerraoui, Denis Loyaux, Pascual Ferrara, Jean-Claude Guillemot, Vincent Meininger, Pierre-François Pradat, François Salachas, Gaelle Bruneteau, Nadine Le Forestier, Lucette Lacomblez

PLoS ONE 8:e79733 (2013)10.1371/journal.pone.0079733

2012
Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation

Latifa Elantak, Marion Espeli, Annie Boned, Olivier Bornet, Jeremy Bonzi, Laurent Gauthier, Mikael Feracci, Philippe Roche, Francoise Guerlesquin, Claudine Schiff

Journal of Biological Chemistry 287:44703-44713 (2012)10.1074/jbc.m112.395152

2012
Structural basis for galectin-1-dependent pre-B cell receptor (pre-BCR) activation.

Latifa El Antak, Marion Espeli, Annie Boned, Olivier Bornet, Jeremy Bonzi, Laurent Gauthier, Mikael Feracci, Philippe Roche, Françoise Guerlesquin, Claudine Schiff

Journal of Biological Chemistry 287:44703-13 (2012)10.1074/jbc.M112.395152

2012
Antiviral chlorinated daphnane diterpenoid orthoesters from the bark and wood of Trigonostemon cherrieri.

Pierre-Marie Allard, Pieter Leyssen, Marie-Thérèse Martin, Mélanie Bourjot, Vincent Dumontet, Cécilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Cyril Poullain, Françoise Guéritte, Marc Litaudon

Phytochemistry 84:160-8 (2012)10.1016/j.phytochem.2012.07.023

2012
Chemical constituents of Anacolosa pervilleana and their antiviral activities.

Mélanie Bourjot, Pieter Leyssen, Cécilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Philippe Rasoanaivo, Françoise Guéritte, Marc Litaudon

Fitoterapia 83:1076-1080 (2012)10.1016/j.fitote.2012.05.004

2012
Flacourtosides A-F, Phenolic Glycosides Isolated from Flacourtia ramontchi.

Mélanie Bourjot, Pieter Leyssen, Cécilia Eydoux, Jean-Claude Guillemot, Bruno Canard, Philippe Rasoanaivo, Françoise Guéritte, Marc Litaudon

Journal of Natural Products 75:752-8 (2012)10.1021/np300059n

2012
Validation of an Image Analysis Method for the Determination of the Parasitemia in Malaria-Infected Erythrocyte Cultures

German Gonzalez, Karine Alvarez, Mirko Zimic, Stephane Bertani, Michel Sauvain, Eric Deharo

(2012)

2012
Single pH buffer refolding screen for protein from inclusion bodies

Bruno Coutard, Etienne Danchin, Rachid Oubelaid, Bruno Canard, Christophe Bignon

Protein Expression and Purification 82:352-359 (2012)10.1016/j.pep.2012.01.014

2012
SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

H. Lahouassa, W. Daddacha, H. Hofmann, D. Ayinde, E. C. Logue, L. Dragin, N. Bloch, C. Maudet, M. Bertrand, T. Gramberg, G. Pancino, S. Priet, B. Canard, Nadine Laguette, M. Benkirane, C. Transy, Nr Landau, B. Kim, F. Margottin-Goguet

Nature Immunology 13:223-8. doi: 10.1038/ni.2236 (2012)10.1038/ni.2236

2012
Molecular Basis for Nucleotide Conservation at the Ends of the Dengue Virus Genome

Barbara Selisko, Supanee Potisopon, Rym Agred, Stephane Priet, Isabelle Varlet, Yann Thillier, Corinne Sallamand, Françoise Debart, Jean-Jacques Vasseur, Bruno Canard

PLoS Pathogens 8:e1002912 (2012)10.1371/journal.ppat.1002912

2012
Synthesis of 5' cap-0 and cap-1 RNAs using solid-phase chemistry coupled with enzymatic methylation by human (guanine-N 7)-methyl transferase

Yann Thillier, Etienne Decroly, François Morvan, Bruno Canard, Jean-Jacques Vasseur, Françoise Debart

RNA 18:856-868 (2012)10.1261/rna.030932.111

2011
Alkylated flavanones from the bark of Cryptocarya chartacea as dengue virus NS5 polymerase inhibitors.

Pierre-Marie Allard, Elise Tran Huu Dau, Cécilia Eydoux, Jean-Claude Guillemot, Vincent Dumontet, Cyril Poullain, Bruno Canard, Françoise Guéritte, Marc Litaudon

Journal of Natural Products 74:2446-53 (2011)10.1021/np200715v

2011
Acyclic nucleoside thiophosphonates as potent inhibitors of HIV and HBV replication

Karine Barral, Clément Weck, Nadine Payrot, Loic Roux, Céline Durafour, Fabien Zoulim, Johan Neyts, Jan Balzarini, Bruno Canard, Stephane Priet, Karine Alvarez

European Journal of Medicinal Chemistry 46:4281-4288 (2011)10.1016/j.ejmech.2011.06.034

2011
MEMO associated with an ErbB2 receptor phosphopeptide reveals a new phosphotyrosine motif.

Mikael Feracci, Cyril Pimentel, Olivier Bornet, Philippe Roche, Danièle Salaün, Ali Badache, Françoise Guerlesquin

FEBS Letters 585:2688-92 (2011)10.1016/j.febslet.2011.07.048

2011
Crystallization and diffraction analysis of the SARS coronavirus nsp10-nsp16 complex.

Claire Debarnot, Isabelle Imbert, Francois Ferron, Laure Gluais, Isabelle Varlet, Nicolas Papageorgiou, Mickaël Bouvet, Julien Lescar, Etienne Decroly, Bruno Canard

Acta crystallographica Section F : Structural biology communications [2014-...] 67:404-8 (2011)10.1107/S1744309111002867

2011
PHYTOCHIK: Biodiversity As A Source of Selective Inhibitors of CHIKV Replication

Pieter Leyssen, Marc Litaudon, Jean-Claude Guillemot, Philippe Rasoanaivo, Jacqueline Smadja, Ameenah Gurib-Fakim, Bruno Canard, Françoise Guéritte

Antiviral Research 90:A36-A37 (2011)10.1016/j.antiviral.2011.03.048

2011
Flavivirus NS3 and NS5 proteins interaction network: a high-throughput yeast two-hybrid screen.

Marc Le Breton, Laurène Meyniel-Schicklin, Alexandre Deloire, Bruno Coutard, Bruno Canard, Xavier de Lamballerie, Patrice Andre, Chantal Rabourdin-Combe, Vincent Lotteau, Nathalie Davoust

BMC Microbiology 11:234 (2011)10.1186/1471-2180-11-234

2010
Genomics and structure/function studies of Rhabdoviridae proteins involved in replication and transcription.

R. Assenberg, O Delmas, B Morin, C Graham, X de Lamballerie, C Laubert, B Coutard, J Grimes, J Neyts, R J Owens, B Brandt, A Gorbalenya, P Tucker, D I Stuart, Bruno Canard, Hervé Bourhy

Antiviral Research 87:149-61 (2010)10.1016/j.antiviral.2010.02.322

2010
Synthesis and antiviral activity of boranophosphonate isosteres of AZT and d4T monophosphates

Karine Barral, Stephane Priet, Céline de Michelis, Joséphine Sire, Johan Neyts, Jan Balzarini, Bruno Canard, Karine Alvarez

European Journal of Medicinal Chemistry 45:849-856 (2010)10.1016/j.ejmech.2009.11.012

2010
3'-Deoxy phosphoramidate dinucleosides as improved inhibitors of Hepatitis C virus subgenomic replicon and NS5B polymerase activity.

Stephane Priet, Ivan Zlatev, Ivan Barvik, Katrien Geerts, Pieter Leyssen, Johan Neyts, Hélène Dutartre, Bruno Canard, Jean-Jacques Vasseur, François Morvan, Karine Alvarez

Journal of Medicinal Chemistry 53:6608-6617 (2010)10.1021/jm100102v

2010
The 2C putative helicase of echovirus 30 adopts a hexameric ring-shaped structure

N. Papageorgiou, B. Coutard, V. Lantez, E. Gautron, Olivier Chauvet, C. Baronti, H. Norder, X. de Lamballerie, V. Heresanu, N. Ferte, S. Veesler, A.E. Gorbalenya, B. Canard

Acta crystallographica Section D : Structural biology [1993-...] 66:1116-1120 (2010)

2009
NMR and MD investigations of human galectin-1/oligosaccharide complexes.

Christophe Meynier, Mikael Feracci, Marion Espeli, Florence Chaspoul, Philippe Gallice, Claudine Schiff, Françoise Guerlesquin, Roche Philippe

Biophysical Journal 97:3168-77 (2009)10.1016/j.bpj.2009.09.026

2009
Identification of allosteric inhibitors blocking the hepatitis C virus polymerase NS5B in the RNA synthesis initiation step.

Stéphane Betzi, Cécilia Eydoux, Cécile Bussetta, Marilyne Blemont, Pieter Leyssen, Claire Debarnot, Mohamed Ben-Rahou, Jacques Haiech, Marcel Hibert, Françoise Gueritte, David S. Grierson, Jean-Louis Romette, Jean-Claude Guillemot, Johan Neyts, Karine Alvarez, Xavier Morelli, Hélène Dutartre, Bruno Canard

Antiviral Research 84:48-59 (2009)10.1016/j.antiviral.2009.06.009

2009
The Crystal Structures of Chikungunya and Venezuelan Equine Encephalitis Virus nsP3 Macro Domains Define a Conserved Adenosine Binding Pocket

H. Malet, B. Coutard, S. Jamal, H. Dutartre, N. Papageorgiou, M. Neuvonen, T. Ahola, N. Forrester, E. A. Gould, D. Lafitte, F. Ferron, J. Lescar, A. Gorbalenya, X. de Lamballerie, B. Canard

Journal of Virology 83:6534-6545 (2009)10.1128/JVI.00189-09

2009
A pyrazolotriazolopyrimidinamine inhibitor of bovine viral diarrhea virus replication that targets the viral RNA-dependent RNA polymerase

Jan Paeshuyse, Carine Letellier, Matheus Froeyen, Hélène Dutartre, Robert Vrancken, Bruno Canard, Erik de Clercq, Alain Gueiffier, Jean-Claude Teulade, Piet Herdewijn, Gerhard Puerstinger, Frank Koenen, Pierre Kerkhofs, Pier Giovanni Baraldi, Johan Neyts

Antiviral Research 82:141-147 (2009)10.1016/j.antiviral.2009.02.192

2008
Structure of Human Pancreatic Lipase-Related Protein 2 with the Lid in an Open Conformation ,

Cécilia Eydoux, Silvia Spinelli, Tara Davis, John Walker, Alma Seitova, Sirano Dhe-Paganon, Alain de Caro, Christian Cambillau, Frédéric Carrière

Biochemistry 47:9553-9564 (2008)10.1021/bi8005576

2008
Occurrence of pancreatic lipase-related protein-2 in various species and its relationship with herbivore diet

Josiane de Caro, Cécilia Eydoux, Slim Chérif, Régine Lebrun, youssef Gargouri, Frédéric Carrière, Alain de Caro

Comparative Biochemistry and Physiology. Part B, Biochemistry and Molecular Biology 150:1-9 (2008)10.1016/j.cbpb.2008.01.007

2008
Acyclic phosphonate nucleotides and human adenylate kinases: impact of a borano group on alpha-P position.

D. Topalis, K. Alvarez, K. Barral, Hélène Munier-Lehmann, B. Schneider, M. Véron, C. Guerreiro, Laurence A Mulard, C. El-Amri, B. Canard, Dominique Deville-Bonne

Nucleosides, Nucleotides and Nucleic Acids 27:319-31 (2008)10.1080/15257770801941952

2007
The Imidazopyrrolopyridine Analogue AG110 Is a Novel, Highly Selective Inhibitor of Pestiviruses That Targets the Viral RNA-Dependent RNA Polymerase at a Hot Spot for Inhibition of Viral Replication

Jan Paeshuyse, Jean-Michel Chezal, Matheus Froeyen, Pieter Leyssen, Hélène Dutartre, Robert Vrancken, Bruno Canard, Carine Letellier, Tong Li, Harald Mittendorfer, Frank Koenen, Pierre Kerkhofs, Erik de Clercq, Piet Herdewijn, Gerhard Puerstinger, Alain Gueiffier, Olivier Chavignon, Jean-Claude Teulade, Johan Neyts

Journal of Virology 81:11046-11053 (2007)10.1128/JVI.00388-07

2007
Further biochemical characterization of human pancreatic lipase-related protein 2 expressed in yeast cells

Cécilia Eydoux, Josiane de Caro, Francine Ferrato, Paul Boullanger, Dominique Lafont, René Laugier, Frédéric Carrière, Alain de Caro

Journal of Lipid Research 48:1539-1549 (2007)10.1194/jlr.M600486-JLR200

2007
Crystal Structure of the RNA Polymerase Domain of the West Nile Virus Non-structural Protein 5

Hélène Malet, Marie-Pierre Egloff, Barbara Selisko, Rebecca E Butcher, Peter J Wright, Michael Roberts, Arnaud Gruez, Gerlind Sulzenbacher, Clemens Vonrhein, Gérard Bricogne, Jason M Mackenzie, Alexander A Khromykh, Andrew D Davidson, Bruno Canard

Journal of Biological Chemistry (2007)10.1074/jbc.M607273200

2007
High-yield production of short GpppA- and 7MeGpppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'-O positions.

F. Peyrane, B. Selisko, Etienne Decroly, Jean-Jacques Vasseur, D. Benarroch, B. Canard, Karine Alvarez

Nucleic Acids Research 35:1-11 (2007)10.1093/nar/gkl1119

2007
Preparation of purine and pyrimidine acyclic nucleotide analogs as antiviral agents

Karine Barral, Bruno Canard, Karine Alvarez, Jean-Louis Romette, Johan Neyts, Jan Balzarini

(2007)

2007
High-yield production of short GppA- and 7Me GppA-capped RNAs and HPLC-monitoring of methyltransfer reactions at the guanine-N7 and adenosine-2'O positions.

F. Peyrane, B. Selisko, Etienne Decroly, J.-J. Vasseur, D. Benarroch, B. Canard, K. Alvarez

Nucleic Acids Research 35:1-11 (2007)

2006
Synthesis, in Vitro Antiviral Evaluation, and Stability Studies of Novel α-Borano-Nucleotide Analogues of 9-[2-(Phosphonomethoxy)ethyl]adenine and ( R )-9-[2-(Phosphonomethoxy)propyl]adenine

Karine Barral, Stephane Priet, Joséphine Sire, Johan Neyts, Jan Balzarini, Bruno Canard, Karine Alvarez

Journal of Medicinal Chemistry 49:7799-7806 (2006)10.1021/jm060030y

2006
General Catalytic Deficiency of Hepatitis C Virus RNA Polymerase with an S282T Mutation and Mutually Exclusive Resistance towards 2'-Modified Nucleotide Analogues

Hélène Dutartre, Cécile Bussetta, Joëlle Boretto, Bruno Canard

Antimicrobial Agents and Chemotherapy 50:4161-4169 (2006)10.1128/AAC.00433-06

2006
Human pancreatic lipase-related protein 2: Tissular localization along the digestive tract and quantification in pancreatic juice using a specific ELISA

Cécilia Eydoux, Ahmed Aloulou, Josiane de Caro, Philippe Grandval, René Laugier, Frédéric Carrière, Alain de Caro

Biochimica et Biophysica Acta (BBA) - General Subjects 1760:1497-1504 (2006)10.1016/j.bbagen.2006.06.005

2006
SPINE bioinformatics and data-management aspects of high-throughput structural biology.

S. Albeck, Pedro Maria Alzari, C. Andreini, L. Banci, I. M. Berry, I. Bertini, C. Cambillau, B. Canard, L. Carter, S. X. Cohen, J. M. Diprose, O. Dym, R. M. Esnouf, C. Felder, F. Ferron, F. Guillemot, R. Hamer, M. Ben Jelloul, R. A. Laskowski, T. Laurent, S. Longhi, R. Lopez, C. Luchinat, H. Malet, T. Mochel, R. J. Morris, L. Moulinier, T. Oinn, A. Pajon, Y. Peleg, A. Perrakis, O. Poch, J. Prilusky, A. Rachedi, R. Ripp, A. Rosato, I. Silman, D. I. Stuart, J. L. Sussman, J. C. Thierry, J. D. Thompson, J. M. Thornton, T. Unger, B. Vaughan, W. Vranken, J. D. Watson, G. Whamond, K. Henrick

Acta crystallographica Section D : Structural biology [1993-...] 62:1184-95 (2006)10.1107/S090744490602991X

2006
Application of the use of high-throughput technologies to the determination of protein structures of bacterial and viral pathogens

M. J. Fogg, P. Alzari, M. Bahar, I. Bertini, J.-M. Betton, W. P. Burmeister, C. Cambillau, B. Canard, M. Carrondo, M. Coll, S. Daenke, O. Dym, M.-P. Egloff, F. J. Enguita, A. Geerlof, A. Haouz, T. A. Jones, Q. Ma, S. N. Manicka, M. Migliardi, P. Nordlund, R. J. Owens, Y. Peleg, G. Schneider, R. Schnell, D. I. Stuart, N. Tarbouriech, T. Unge, A. J. Wilkinson, M. Wilmanns, K. S. Wilson, O. Zimhony, J. M. Grimes

Acta crystallographica Section D : Structural biology [1993-...] 62:1196-1207 (2006)10.1107/S0907444906030915

2006
Structural and Functional Basis for ADP-Ribose and Poly(ADP-Ribose) Binding by Viral Macro Domains

Marie-Pierre Egloff, Hélène Malet, Ákos Putics, Maarit Heinonen, Hélène Dutartre, Antoine Frangeul, Arnaud Gruez, Valérie Campanacci, Christian Cambillau, John Ziebuhr, Tero Ahola, Bruno Canard

Journal of Virology 80:8493-8502 (2006)10.1128/JVI.00713-06

2006
Comparative mechanistic studies of de novo RNA synthesis by flavivirus RNA-dependent RNA polymerases

Barbara Selisko, Hélène Dutartre, Jean-Claude Guillemot, Claire Debarnot, Delphine Benarroch, Alexander Khromykh, Philippe Desprès, Marie-Pierre Egloff, Bruno Canard

Virology 351:145-158 (2006)10.1016/j.virol.2006.03.026

2006
Gene Expression Profile Related to the Progression of Preneoplastic Nodules toward Hepatocellular Carcinoma in Rats

Julio Isael Pérez-Carréon, Cristina López-García, Samia Fattel-Fazenda, Evelia Arce-Popoca, Leticia Alemán-Lazarini, Sergio Hernández-García, Véronique Le Berre, Serguei Sokol, Jean Marie François, Saul Villa-Trevino

Journal of Mammary Gland Biology and Neoplasia 8:373-IN7 (2006)10.1593/neo.05841

2006
Expression, purification and crystallization of the SARS-CoV macro domain

Hélène Malet, Karen Dalle, Nicolas Bremond, Fabienne Tocque, Stéphanie Blangy, Valérie Campanacci, Bruno Coutard, Sacha Grisel, Julie Lichiere, Violaine Lantez, Christian Cambillau, Bruno Canard, Marie-Pierre Egloff

Acta Crystallographica Section F: Structural Biology and Crystallization Communications 62:405-408 (2006)10.1107/S1744309106009274

2006
Synthesis and Anti-BVDV Activity of Acridones As New Potential Antiviral Agents 1

Oriana Tabarrini, Giuseppe Manfroni, Arnaldo Fravolini, Violetta Cecchetti, Stefano Sabatini, Erik de Clercq, Jef Rozenski, Bruno Canard, Hélène Dutartre, Jan Paeshuyse, Johan Neyts

Journal of Medicinal Chemistry 49:2621-2627 (2006)10.1021/jm051250z

2005
A Novel, Highly Selective Inhibitor of Pestivirus Replication That Targets the Viral RNA-Dependent RNA Polymerase

Jan Paeshuyse, Pieter Leyssen, Eric Mabery, Nina Boddeker, Robert Vrancken, Matheus Froeyen, Israrul Ansari, Hélène Dutartre, Jef Rozenski, Laura Gil, Carine Letellier, Robert Lanford, Bruno Canard, Frank Koenen, Pierre Kerkhofs, Ruben Donis, Piet Herdewijn, Julia Watson, Erik de Clercq, Gerhard Puerstinger, Johan Neyts

Journal of Virology 80:149-160 (2005)10.1128/JVI.80.1.149-160.2006

2005
Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance

Karine Alvarez, Jérôme Deval, Boulbaba Selmi, Karine Barral, Joelle Boretto, Catherine Guerreiro, Laurence S Mulard, Robert Sarfati, Bruno Canard

Nucleosides, Nucleotides and Nucleic Acids 24:419-422 (2005)10.1081/NCN-200059951

2005
A Relaxed Discrimination of 2′- O -Methyl-GTP Relative to GTP between de Novo and Elongative RNA Synthesis by the Hepatitis C RNA-dependent RNA Polymerase NS5B

Hélène Dutartre, Joëlle Boretto, Jean Claude Guillemot, Bruno Canard

Journal of Biological Chemistry 280:6359-6368 (2005)10.1074/jbc.M410191200

2004
The severe acute respiratory syndrome-coronavirus replicative protein nsp9 is a single-stranded RNA-binding subunit unique in the RNA virus world

Marie-Pierre Egloff, Francois Ferron, Valérie Campanacci, Sonia Longhi, Corinne Rancurel, Hélène Dutartre, Eric J Snijder, Alexander Gorbalenya, Christian Cambillau, Bruno Canard

Proceedings of the National Academy of Sciences of the United States of America 101:3792-3796 (2004)10.1073/pnas.0307877101

2004
Crystal Structure of E. coli Alcohol Dehydrogenase YqhD: Evidence of a Covalently Modified NADP Coenzyme

Gerlind Sulzenbacher, Karine Alvarez, Robert H H van den Heuvel, Cees Versluis, Silvia Spinelli, Valé Rie Campanacci, Christel Valencia, Christian Cambillau, Hans Eklund, Mariella Tegoni

Journal of Molecular Biology 342:489-502 (2004)10.1016/j.jmb.2004.07.034

2003
Structural Analysis of the Activation of Ribavirin Analogs by NDP Kinase: Comparison with Other Ribavirin Targets

Sarah Gallois-Montbrun, Yuxing Chen, Hélène Dutartre, Magali Sophys, Solange Moréra, Catherine Guerreiro, Benoit Schneider, Laurence S Mulard, Joël Janin, Michel Véron, Dominique Deville-Bonne, Bruno Canard

Molecular Pharmacology 63:538-546 (2003)10.1124/mol.63.3.538

2002
Identification of two tamoxifen target proteins by photolabeling with 4-(2-morpholinoethoxy)benzophenone.

Fabienne Mésange, Mohamed Sebbar, Joël Capdevielle, Jean-Claude Guillemot, Pascual Ferrara, Francis Bayard, Marc E. Poirot, Jean-Charles Faye

Bioconjug Chem 13:766-72 (2002)

2001
Interaction of human immunodeficiency virus type 1 Vif with Gag and Gag-Pol precursors : co-encapsidation and interference with viral protease-mediated Gag processing

Martine Bardy, Bernard Gay, Stéphanie Pébernard, Nathalie Chazal, Marianne Courcoul, Robert Vigne, Etienne Decroly, Pierre Boulanger

Journal of General Virology 82:2719-2733 (2001)10.1099/0022-1317-82-11-2719

1998
Tyrosine phosphorylation of the Wiskott-Aldrich Syndrome protein by Lyn and Btk is regulated by CDC42

Rodolphe r. Guinamard, Pontus Aspenström, Michel Fougereau, Philippe Chavrier, Jean-Claude Guillemot

FEBS Letters 434:431-436 (1998)10.1016/s0014-5793(98)01016-3

1998
Microsomal epoxide hydrolase of rat liver is a subunit of the anti-oestrogen-binding site.

Fabienne Mésange, Mohamed Sebbar, Blandine Kedjouar, Joël Capdevielle, Jean-Claude Guillemot, Pascual Ferrara, Francis Bayard, Frédéric Delarue, Jean-Charles Faye, Marc E. Poirot

Biochemical Journal 334 ( Pt 1):107-12 (1998)

1998
Clostridium perfringens CPN50

Stewart Cole, Sei-Ichi Katayama, Bruno Dupuy, Thierry Garnier, Brigitte Saint-Joanis, Bruno Canard

645-647 (1998)10.1007/978-1-4615-6369-3_58

1998
The pro-oligonucleotide approach: solid phase synthesis and preliminary evaluation of model pro-dodecathymidylates

J.J. Vasseur, Guilhem Tosquellas, Karine Alvarez, Christelle Dell'Aquila, François Morvan, Jean-Jacques Vasseur, Jean-Louis Imbach, Bernard Rayner

Nucleic Acids Research 26:2069-2074 (1998)10.1093/nar/26.9.2069

1996
Mismatch repair in Xenopus egg extracts: DNA strand breaks act as signals rather than excision points

I. Varlet, B. Canard, P. Brooks, G. Cerovic, M. Radman

Proceedings of the National Academy of Sciences of the United States of America 93:10156-10161 (1996)10.1073/pnas.93.19.10156

1995
Studies of recombinant amylosucrase

M. Remaud-Simeon, F. Albaret, B. Canard, I. Varlet, P. Colonna, R. M. Willemot, P. Monsan

313-320 (1995)

1992
Phylogenetic analysis of the pathogenic anaerobe Clostridium perfringens using the 16S rRNA nucleotide sequence.

Bruno Canard, Thierry Garnier, Bénédicte Lafay, Richard Christen, Stewart T. Cole

International Journal of Systematic Bacteriology 42:312-4 (1992)10.1099/00207713-42-2-312

1992
Autolysis of Clostridium acetobutylicum ATCC 824

Christian Croux, B. Canard, G. Goma, Philippe Soucaille

Journal of general microbiology 138:861-869 (1992)

1992
Purification and characterization of an extracellular muramidase of Clostridium acetobutylicum ATCC 824 that acts on non-n-acetylated pepticoglycan

Christian Croux, B. Canard, G. Goma, Philippe Soucaille

Applied and Environmental Microbiology 58:1075-1081 (1992)

Réseau

National
  • S. Baize I.Pasteur
International
  • I. Margiolaki U.Patras Grèce
  • N. Vassilaki I. Pasteur Athens Grèce

Financement

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